Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products

Journal of Chromatographic Science

Volumn 46, Issue 2, 2008, Pages 144-149

  Srdjenovic, Branislava ^a   Djordjevic Milic, Vukosava ^a   Grujic, Nevena ^a   Injac, Rade ^b   Lepojevic, Zika ^c  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 40849085508     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/46.2.144     Document Type: Article

References (22)

1. J.B. Thomas, J.H. Yen, M.M. Schantz, B.J. Porter, and K.E. Sharpless. Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography. J. Agric. Food Chem. 52: 3259-63 (2004).
2. P.D. Tzanavaras and D.G. Themelis. Development and validation of a high-throughput high-performance liquid chromatography assay for the determination of caffeine in food samples using a monolithic column. Anal. Chim. Acta 581: 94-8 (2007).
3. D. Satinsky, I. Neto, P. Solich, H. Sklenárova, M. Conceição, B.S. Montenegro, and A.N. Araújo. Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets. J. Sep. Sci. 27: 529-36 (2004).
4. M. Kartal. LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations. J. Pharm. Biomed. Anal. 26: 857-64 (2001).
5. F.L. Coco, F. Lanuzza, G. Micali, and G. Cappellano. Determination of theobromine, theophylline, and caffeine in by-products of cupuacu and cacao seeds by high-performance liquid chromatography. J. Chromatogr. Sci. 45: 273-5 (2007).
6. n analysis of phenolic compounds and purine alkaloids in green and black tea. J. Agric. Food Chem. 52: 2807-15 (2004).
7. C.I. Rodrigues, L. Marta, R. Maia, M. Miranda, M. Ribeirinho, and C. Maguas. Application of solid-phase extraction to brewed coffe caffeine and organic acid determination by UV-HPLC. J. Food Compost. Anal. 20: 440-8 (2007).
8. M.R. Brunetto, L. Gutierrez, Y. Delgado, M. Gallignani, A. Zambrano, A. Gomez, G. Ramos, and C. Romero. Determination of theobromine, theophylline and caffeine in cocoa samples by a high-performance liquid cromatografphic method with on-line sample cleanup in a switching-column system. Food Chem. 100: 459-67 (2007).
9. J.P. Naik. Imporoved high-performance liquid chromatography method to determine theobromine and caffeine in cocoa and cocoa products. J. Agric. Food Chem. 49: 6579-83 (2001).
10. A.R. Khanchi, M.K. Mahani, M. Hajihosseini, M.G. Maragheh, M. Chaloosi, and F. Bani. Simultaneous spectrophotometric determination of caffeine and theobromine in Iranian tea by artificial neural networks and its comparison with PLS. Food Chem. 103: 1062-8 (2007).
11. D.K. Sinhg and A. Sahu. Spectrophotometric determination of caffeine and theophylline in pure alkaloids and its application in pharmaceutical formulations. Anal. Biochem. 349: 176-80 (2006).
12. M. Arenda and G. Morlock. Simultaneous determination of caffeine, ergotamine and metamizol in solid pharmaceutical formulation by HPTLC-UV-FLD with mass confirmation by online HPTLC-ESI-MS. J. Chromatogr. Sci. 45: 251-5 (2007).
13. M.J. Ford, M.A. Deibel, B.A. Tomkins, and G.J. Van Berkel. Quantitative thin-layer chromatography-mass spectrometry analysis of caffeine using a surface sampling probe electrospray ionization tandem mass spectrometry system. Anal. Chem. 77: 4385-9 (2005).
14. M. Aranda and G. Morlock. Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry. J. Chromatogr. A 1131: 253-60 (2006.)
15. V.V. Khasanov, K.A. Dychko, T.T. Kuryaeva, G.L. Ryzhova, and E.V. Maltseva. A new procedure for caffeine determination. Russ. J. Appl. Chem. 78: 1427-9 (2005).
16. S. Armenta, S. Garrigues, and M. Guardia. Solid-phase FT-Raman determination of caffeine in energy drinks. Anal. Chim. Acta 547: 197-203 (2005).
17. M.M. Paradkar and J. Irudayaraj. Rapid determination of caffeine content in soft drinks using FTIR-ATR spectroscopy. Food Chem. 78: 261-6 (2002).
18. M.S. Bispo, M.C.C. Veloso, H.L.C. Pinheiro, R.F.S. De Oliveira, J.O.N. Reis, and J.B. De Andrade. Simultaneouos determination of caffeine, theobromine, and theophylline by High performance liquid chromatography. J. Chromatogr. Sci. 40: 45-8 (2002).
19. United States Pharmacopoeia, 24th edition, NF 19, United States Pharmacopoeial Convention, Rockville, MD 2002.
20. International Conference on Harmonization, guideline Q2A, Text on validation of analytical procedures. Federal Register 1995, 60, 11260.
21. International Conference on Harmonization, guideline Q2B, Validation of analytical procedures: methodology. Federal Register 1997, 62, 27463.
22. Y.V. Heyden, A. Nijhuis, J. Smeyers-Verbeke, B.G.M. Vandeginste, and D.L. Massart. Guidance for robustness/ruggedness tests in method validation. J. Pharm. Biomed. Anal. 24: 723-53 (2001).