Unravelling the enigma of dehydroepiandrosterone: Moving forward step by step

Endocrinology

Volumn 149, Issue 3, 2008, Pages 886-888

  Komesaroff, Paul A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTROGEN; NITRIC OXIDE SYNTHASE; PRASTERONE;

AGING; ANGIOGENESIS; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; HORMONE ACTION; HORMONE METABOLISM; HUMAN; IMMUNOPATHOLOGY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SEXUAL FUNCTION; SMOOTH MUSCLE; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULAR ENDOTHELIUM;

ANIMALS; CELL PROLIFERATION; DEHYDROEPIANDROSTERONE; ENDOTHELIUM, VASCULAR; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, STEROID; SIGNAL TRANSDUCTION;

EID: 40849083779     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1787     Document Type: Review

References (43)

1. Ebeling P, Koivisto VA 1994 Physiological importance of dehydroepiandrosterone. Lancet 343:1479-1481
2. Labrie F, Luu-The V, Bélanger A, Lin SX, Simard J, Pelletier G, Labrie C 2005 Is dehydroepiandrosterone a hormone? J Endocrinol 187:169-196
3. Liu D, Iruthayanathan M, Homan LL, Wang Y, Yang L, Wang Y, Dillon JS 2008 Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through ERK 1/2-mediated mechanisms. Endocrinology 149:889-898
4. Haning Jr RV, Carlson IH, Flood CA, Hackett RJ, Longcope C 1991 Metabolism of dehydroepiandrosterone sulfate (DS) in normal women and women with high DS concentrations. J Clin Endocrinol Metab 73:1210-1215
5. Orentreich N, Brind JL, Rizer RL, Vogelman JH 1984 Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59:551-555
6. Rao MS, Subbarao V, Yeldandi AV, Reddy JK 1992 Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. Cancer Lett 65:123-126
7. Maurice T, Grégoire C, Espallergues J 2006 Neuro(active)steroids actions at the neuromodulatory sigma1 (σ1) receptor: biochemical and physiological evidences, consequences in neuroprotection. Pharmacol Biochem Behav 84:581-597
8. Crosbie D, Black C, McIntyre L, Royle PL, Thomas S 2007 Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane Database Syst Rev 4:CD005114
9. Allolio B, Arlt W, Hahner S 2007 DHEA: why, when, and how much-DHEA replacement in adrenal insufficiency. Ann Endocrinol (Paris) 68:268-273
10. Flood JF, Roberts E 1988 Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 448:178-181
11. Grimley Evans J, Malouf R, Huppert F, van Niekerk JK 2006 Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people. Cochrane Database Syst Rev 4:CD006221
12. Raven PW, Hinson JP 2007 Dehydroepiandrosterone (DHEA) and the menopause: an update. Menopause Int 13:75-78
13. Panjari M, Davis SR 2007 DHEA therapy for women: effect on sexual function and wellbeing. Hum Reprod Update 13:239-248
14. LaCroix AZ, Yano K, Reed DM 1992 Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men. Circulation 86:1529-1535
15. Tchernof A, Labrie F 2004 Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies. Eur J Endocrinol 151:1-14
16. Thijs L, Fagard R, Forette F, Nawrot T, Staessen JA 2003 Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies. Acta Cardiol 58:403-410
17. Eich DM, Nestler JE, Johnson DE, Dworkin GH, Ko D, Wechsler AS, Hess ML 1993 Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. Circulation 87:261-269
18. Hayashi T, Esaki T, Muto E, Kano H, Asai Y, Thakur NK, Sumi D, Jayachandran M, Iguchi A 2000 Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. Arterioscler Thromb Vasc Biol 20:782-792
19. Kurzman ID, Panciera DL, Miller JB, MacEwen EG 1998 The effect of dehydroepiandrosterone combined with a low-fat diet in spontaneously obese dogs: a clinical trial. Obes Res 6:20-28
20. Mohan PF, Benghuzzi H 1997 Effect of dehydroepiandrosterone on endothelial cell proliferation. Biomed Sci Instrum 33:550-555
21. Yoneyama A, Kamiya Y, Kawaguchi M, Fujinami T 1997 Effects of dehydroepiandrosterone on proliferation of human aortic smooth muscle cells. Life Sci 60:833-838
22. Williams MR, Dawood T, Ling S, Dai A, Lew R, Myles K, Funder JW, Sudhir K, Komesaroff PA 2004 Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 89:4708-4715
23. Williams MR, Ling S, Dawood T, Hashimura K, Dai A, Li H, Liu JP, Funder JW, Sudhir K, Komesaroff PA 2002 Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs. J Clin Endocrinol Metab 87:176-181
24. Hinson JP, Khan M 2004 Dehydroepiandrosterone sulphate (DHEAS) inhibits growth of human vascular endothelial cells. Endocr Res 30:667-671
25. Ling S, Dai A, Williams MR, Myles K, Dilley RJ, Komesaroff PA, Sudhir K 2002 Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells. Endocrinology 143:1119-1125
26. Simoncini T, Mannella P, Fornari L, Varone G, Caruso A, Genazzani AR 2003 Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 144:3449-3455
27. Kawano H, Yasue H, Kitagawa A, Hirai N, Yoshida T, Soejima H, Miyamoto S, Nakano M, Ogawa H 2003 Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab 88:3190-3195
28. Mortola JF, Yen SS 1990 The effects of oral dehydroepiandrosterone on endocrine metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 71:696-704
29. Beer NA, Jakubowicz DJ, Matt DW, Beer RM, Nestler JE 1996 Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men. Am J Med Sci 311:205-210
30. Yoshimata T, Yoneyama A, Jin-no Y, Tamai N, Kamiya Y 1999 Effects of dehydroepiandrosterone on mitogen-activated protein kinase in human aortic smooth muscle cells. Life Sci 65:431-440
31. Peter W, Benten M, Lieberherr M, Giese G, Sekeris C, Wunderlich F 1998 Estradiol binding to cell surface raises cytosolic free calcium in T cells. FEBS Lett 422:349-353
32. Kim H, Lee J, Jeong J, Bae S, Lee H, Jo I 1999 Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor α localized in caveolae. Biochem Biophys Res Commun 263:257-262
33. Norman A, Mizwicki M, Norman D 2004 Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 3:27-41
34. i2,3. J Biol Chem 277:21379-21388
35. Liu D, Dillon JS 2004 Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor. Steroids 69:279-289
36. Matsumoto T, Turesson I, Book M, Gerwins P, Claesson-Welsh L 2002 p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol 156:149-160
37. Jo H, Sipos K, Go Y, Law R, Rong J, McDonald J 1997 Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gβ/γ-dependent signaling pathways. J Biol Chem 272:1395-1401
38. Pedram A, Razandi M, Levin ER 1998 Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation. J Biol Chem 273:26722-26728
39. Manabe A, Hata T, Yanagihara T, Hashimoto M Yamada Y, Irkoma S, Aoki S, Masumura S, Miyazakin K 1999 Nitric oxide synthesis is increased after dehydroepiandrosterone sulphate administration in term human pregnancy. Hum Reprod 14:2116-2119
40. Webb SJ, Geoghegan TE, Prough RA, Michael Miller KK 2006 The biological actions of dehydroepiandrosterone involves multiple receptors. Drug Metab Rev 38:89-116
41. Geraldes P, Sirois MG, Bernatchez P, Tanguay J 2002 Estrogen regulation of endothelial and smooth muscle cell migration and proliferation: role of p38 and p42/44 mitogen-activated protein kinase. Arterioscler Thromb Vasc Biol 22:1585-1590
42. Shi J, Schulze S, Lardy HA 2000 The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids 65:124-129
43. Padgett DA, Loria RM, Sheridan JF 1997 Endocrine regulation of the immune response to influenza virus infection with a metabolite of DHEA-androstenediol. J Neuroimmunol 78:203-211