Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permeability

Microbial Pathogenesis

Volumn 44, Issue 4, 2008, Pages 311-319

  Flynn, Andrew N ^a   Buret, Andre G ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Intestinal permeability; Programmed cell death; Tight junction

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; DEXTRAN; OCCLUDIN; PROTEIN ZO1;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; ENTEROPATHOGENIC ESCHERICHIA COLI; EPITHELIUM CELL; HUMAN; HUMAN CELL; INTESTINE MUCOSA PERMEABILITY; PRIORITY JOURNAL; TIGHT JUNCTION;

APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; ENTEROPATHOGENIC ESCHERICHIA COLI; ENZYME INHIBITORS; EPITHELIAL CELLS; ESCHERICHIA COLI INFECTIONS; HUMANS; MEMBRANE PROTEINS; OLIGOPEPTIDES; PHOSPHOPROTEINS;

ESCHERICHIA COLI;

EID: 40749163043     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2007.10.007     Document Type: Article

References (34)

1. Chen H.D., and Frankel G. Enteropathogenic Escherichia coli: unravelling pathogenesis. FEMS Microbiol Rev 29 (2005) 83-98
2. Muza-Moons M.M., Koutsouris A., and Hecht G. Disruption of cell polarity by enteropathogenic Escherichia coli enables basolateral membrane proteins to migrate apically and to potentiate physiological consequences. Infect Immun 71 (2003) 7069-7078
3. Philpott D.J., McKay D.M., Sherman P.M., and Perdue M.H. Infection of T84 cells with enteropathogenic Escherichia coli alters barrier and transport functions. Am J Physiol 270 (1996) G634-G645
4. Crane J.K., Majumdar S., and Pickhardt III D.F. Host cell death due to enteropathogenic Escherichia coli has features of apoptosis. Infect Immun 67 (1999) 2575-2584
5. Crane J.K., McNamara B.P., and Donnenberg M.S. Role of EspF in host cell death induced by enteropathogenic Escherichia coli. Cell Microbiol 3 (2001) 197-211
6. McNamara B.P., Koutsouris A., O'Connell C.B., Nougayrede J.P., Donnenberg M.S., and Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J Clin Invest 107 (2001) 621-629
7. Clayburgh D.R., Shen L., and Turner J.R. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 84 (2004) 282-291
8. Turner J.R., Rill B.K., Carlson S.L., Carnes D., Kerner R., Mrsny R.J., et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 273 (1997) C1378-C1385
9. Katz K.D., Hollander D., Vadheim C.M., McElree C., Delahunty T., Dadufalza V.D., et al. Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology 97 (1989) 927-931
10. van Elburg R.M., Uil J.J., Mulder C.J., and Heymans H.S. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 34 (1993) 354-357
11. Dean P., and Kenny B. Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein. Mol Microbiol 54 (2004) 665-675
12. Yuhan R., Koutsouris A., Savkovic S.D., and Hecht G. Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology 113 (1997) 1873-1882
13. Abreu M.T., Palladino A.A., Arnold E.T., Kwon R.S., and McRoberts J.A. Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells. Gastroenterology 119 (2000) 1524-1536
14. Bojarski C., Gitter A.H., Bendfeldt K., Mankertz J., Schmitz H., Wagner S., et al. Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis. J Physiol 535 (2001) 541-552
15. Chin A.C., Teoh D.A., Scott K.G., Meddings J.B., Macnaughton W.K., and Buret A.G. Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner. Infect Immun 70 (2002) 3673-3680
16. Chin A.C., Flynn A.N., Fedwick J.P., and Buret A.G. The role of caspase-3 in lipopolysaccharide-mediated disruption of intestinal epithelial tight junctions. Can J Physiol Pharmacol 84 (2006) 1043-1050
17. Abul-Milh M., Wu Y., Lau B., Lingwood C.A., and Barnett Foster D. Induction of epithelial cell death including apoptosis by enteropathogenic Escherichia coli expressing bundle-forming pili. Infect Immun 69 (2001) 7356-7364
18. Fedwick J.P., Lapointe T.K., Meddings J.B., Sherman P.M., and Buret A.G. Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect Immun 73 (2005) 7844-7852
19. Czerucka D., Dahan S., Mograbi B., Rossi B., and Rampal P. Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Infect Immun 68 (2000) 5998-6004
20. Nougayrede J.P., and Donnenberg M.S. Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway. Cell Microbiol 6 (2004) 1097-1111
21. Nougayrede J.P., Foster G.H., and Donnenberg M.S. Enteropathogenic Escherichia coli effector EspF interacts with host protein Abcf2. Cell Microbiol 9 (2007) 680-693
22. Spitz J., Yuhan R., Koutsouris A., Blatt C., Alverdy J., and Hecht G. Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function. Am J Physiol 268 (1995) G374-G379
23. Willott E., Balda M.S., Heintzelman M., Jameson B., and Anderson J.M. Localization and differential expression of two isoforms of the tight junction protein ZO-1. Am J Physiol 262 (1992) C1119-C1124
24. Bullen T.F., Forrest S., Campbell F., Dodson A.R., Hershman M.J., Pritchard D.M., et al. Characterization of epithelial cell shedding from human small intestine. Lab Invest 86 (2006) 1052-1063
25. Watson A.J., Chu S., Sieck L., Gerasimenko O., Bullen T., Campbell F., et al. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 129 (2005) 902-912
26. Bruewer M., Luegering A., Kucharzik T., Parkos C.A., Madara J.L., Hopkins A.M., et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 171 (2003) 6164-6172
27. Klumpp D.J., Rycyk M.T., Chen M.C., Thumbikat P., Sengupta S., and Schaeffer A.J. Uropathogenic Escherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apoptosis. Infect Immun 74 (2006) 5106-5113
28. Cao C., Subhawong T., Albert J.M., Kim K.W., Geng L., Sekhar K.R., et al. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 66 (2006) 10040-10047
29. Scheller C., Knoferle J., Ullrich A., Prottengeier J., Racek T., Sopper S., et al. Caspase inhibition in apoptotic T cells triggers necrotic cell death depending on the cell type and the proapoptotic stimulus. J Cell Biochem 97 (2006) 1350-1361
30. Nagai T., Abe A., and Sasakawa C. Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16th leucine residue in EspF. J Biol Chem 280 (2005) 2998-3011
31. Quitard S., Dean P., Maresca M., and Kenny B. The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targeting. Cell Microbiol 8 (2006) 972-981
32. Parkos C.A., Colgan S.P., Delp C., Arnaout M.A., and Madara J.L. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol 117 (1992) 757-764
33. Simonovic I., Rosenberg J., Koutsouris A., and Hecht G. Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. Cell Microbiol 2 (2000) 305-315
34. Bojarski C., Weiske J., Schoneberg T., Schroder W., Mankertz J., Schulzke J.D., et al. The specific fates of tight junction proteins in apoptotic epithelial cells. J Cell Sci 117 (2004) 2097-2107