Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2276-2285

  Kumar, Ritesh ^a   Srivastava, Richa ^a   Singh, Ramendra Kumar ^b   Surolia, Avadhesha ^a   Rao, Desirazu N ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b UNIVERSITY OF ALLAHABAD   (India)

Author keywords

Activation; DNA methyltransferase; Inhibition; S Adenosyl l homocysteine

Indexed keywords

5' ALLYLTHIO 5' DEOXY 9 (1' BETA DEXTRO RIBOFURANOSYL) 6 NITRODIDEAZAADENINE; 5' CHLORO 5' DEOXYADENOSINE; 5' S (ETHYLPROPIONATE) 5' DEOXY 9 (1' BETA DEXTRO RIBOFURANOSYL)ADENINE; 5' S (PROPIONAMIDE) 5' DEOXY 9 (1' BETA DEXTRO RIBOFURANOSYL)ADENINE; 5' S (PROPIONIC ACI) 5' DEOXY 9 (1' BETA DEXTRO RIBOFURANOSYL) 1,3 DIDEAZA ADENINE; 5' S (PROPIONIC ACID) 5' DEOXY 9 (1' BETA DEXTRO RIBOFURANOSYL)ADENINE; 5' S 5' METHYLTHIO DEOXYADENOSINE; 5' S ALLENYLTHIO ADENOSINE; 5' S PROPARGYLTHIO ADENOSINE; 5' S PROPYNYLTHIO ADENOSINE; 9 (1' BETA DEXTRO RIBOFURANOSYL) 6 NITRO 1,3 DIDEAZAADENINE; DNA METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

DNA MODIFICATION METHYLASES; ENZYME ACTIVATION; KINETICS; MOLECULAR STRUCTURE; S-ADENOSYLHOMOCYSTEINE; SERRATIA MARCESCENS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749158220     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.075     Document Type: Article

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