Synthesis and evaluation of antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2367-2378

  Onnis, Valentina ^a   Cocco, Maria T ^a   Lilliu, Valentina ^a   Congiu, Cenzo ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Amide derivatives; Antitumoral activity; Ester derivatives; SAR; Synthesis; Trifluoromethylpyridine

Indexed keywords

2 (4 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL) N [3,4,5 (TRIMETHOXY)PHENYL]NICOTINAMIDE; 2 (4 CHLORO 2 METHYLPHENYLAMINO) N (3 CHLORO 4 METHOXYPHENYL) 6 (TRIFLUOROMETHYL)NICOTINAMIDE; 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL) N [3,4,5 (TRIMETHOXY)PHENYL]NICOTINAMIDE; 2 [(4 CHLORO 2 METHYLPHENYL)AMINO] 6 TRIFLUOROMETHYLPYRIDINE 3 CARBOXAMIDE; 2 ARYLAMINO 6 TRIFLUOROMETHYL 3 PYRIDINECARBOXYLIC ACID DERIVATIVE; 2 CHLOROPHENYL 2 (4 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 2 CHLOROPHENYL 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 2,4 DICHLOROPHENYL 2 (4 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 2,4 DICHOLOROPHENYL 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 2,4,6 TRICHLOROPHENYL 2 (4 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 2,4,6 TRICHLOROPHENYL 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 3 METHOXYPHENYL 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 3 METHOXYPHYENL 2 (4 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 4 CHLOROPHENYL 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 4 METHOXYPHENYL 2 (4 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 4 METHOXYPHENYL 2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINIC ACID; 5 CHLOROSULFAQUINOXALINE; [2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)PYRIDIN 3 YL] [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHANONE; AMIDE; ANTINEOPLASTIC AGENT; BUTHIONINE SULFOXIMINE; DACTINOMYCIN; DIACETOXYSCIRPENOL; DIDEMNIN A; ESTER DERIVATIVE; ETHYL 2 [(4 CHLORO 2 METHYLPHENYL)AMINO] 6 TRIFLUOROMETHYLPYRIDINE 3 CARBOXYLIC ACID; ETHYL 4 [2 (5 CHLORO 2 METHYLPHENYLAMINO) 6 (TRIFLUOROMETHYL)NICOTINOYL]PIPERAZINE 1 CARBOXYLIC ACID; MENOGARIL; TRICIRIBINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE;

AMIDES; AMINATION; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; ESTERS; FLUORINE COMPOUNDS; HUMANS; METHYLATION; MOLECULAR STRUCTURE; NIACIN; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749153864     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.069     Document Type: Article

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