Synthesis and antiproliferative activity of 2,6-Dibenzylamino-3,5- dicyanopyridines on human cancer cell lines

European Journal of Medicinal Chemistry

Volumn 40, Issue 12, 2005, Pages 1365-1372

  Cocco, Maria Teresa ^a   Congiu, Cenzo ^a   Lilliu, Valentina ^a   Onnis, Valentina ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Anticancer activity; Cytostatic activity; Dicyanopyridines; Pyridines

Indexed keywords

2,6 BIS(BENZYLAMINO) 4 (2 CHLOROPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (2 PYRIDINYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (2,4 DICHLOROPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (2,5 DIMETHOXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (2,6 DICHLOROPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (3 HYDROXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (3 METHOXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (3 PYRIDINYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (3,4,5 TRIMETHOXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (4 CHLOROPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (4 HYDROXY 3 METHOXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (4 HYDROXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (4 METHOXYPHENYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (4 PYRIDINYL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 (5 METHYLFURAN 2 YL)PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 FURAN 2 YLPYRIDINE 3,5 DICARBONITRILE; 2,6 BIS(BENZYLAMINO) 4 THIOPHEN 2 YLPYRIDINE 3,5 DICARBONITRILE; ANTINEOPLASTIC AGENT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MALE;

CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744558547     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.07.005     Document Type: Article

References (23)

1. W.J. Scott, J. Dumas, S. Boyer, W. Lee, Y. Chen, B. Phillips, s. verna, J. Chen, J. Fan, B. Raudenbush, L. Yi, Q. Zhu, L. Adnane, US Patent 0235829A1 (2004).
2. K. Tatsumi, T. Yamanuchi, K. Kiyono, K. Kishi, Y. Yanagihara, T. Imaoka, and T. Kawaguchi J. Biochem. (Tokyo) 114 1993 912 918
3. J.M. Quintela, C. Peinador, L.M. Botana, M. Est̀vez, and R. Riguera Bioorg. Med. Chem. 5 1997 1543 1553
4. J.M. Quintela, C. Peinador, M.C. Veiga, L.M. Botana, A. Alfonso, and R. Riguera Eur. J. Med. Chem. 33 1998 887 897
5. J.M. Quintela, and C. Peinador Tetrahedron 52 1996 10497 10506
6. A.M.E. Attia, and A.E.-H.A.A. Ismail Tetrahedron 59 2003 1749 1752
7. V. Perrier, A.C. Wallace, K. Kaneko, J. Safar, S.B. Prusiner, and F.E. Cohen Proc. Natl. Acad. Sci. USA 97 2000 6073 6078
8. U. Rosentreter, R. Henning, M. Bauser, T. Kramer, A. Vaupel, W. Hubsch, K. Dembowsky, O. Salcher-Schrauf-Statter, J.-P. Stasch, T. Krahn, E. Perzborn, and P.C.T. Int Appl. WO 2001 A2 (01/25210)
9. H. Harada, W.S. Watanuki, K. Kawaguchi, T. Okazaki, Y. hirano, C. Saitoh, US Patent 0232860 A1 (2003).
10. M.T. Cocco, C. Congiu, and V. Onnis Eur. J. Med. Chem. 35 2000 545 552
11. M.T. Cocco, C. Congiu, and V. Onnis Eur. J. Med. Chem. 38 2003 37 47
12. L. Castedo, J.M. Quintela, and R. Riguera Eur. J. Med. Chem. 19 1984 555 558
13. T.J. Murray, S.C. Zimmermann, and S.V. Kolotuchin Tetrahedron 51 1995 635 648
14. M.M. Mashaly, and M. Hammouda Naturforsch. 54 1999 1205 1209
15. M.T. Cocco, C. Congiu, V. Onnis, M.L. Schivo, and A. De Logu Alessandro Farmaco 50 1995 73 76
16. M.R. Grever, S.A. Schepartz, and B.A. Chabner Semin. Oncol. 19 1992 622 638
17. M.R. Boyd, and K.D. Paull Drug Dev. Res. 34 1995 91 109
18. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. Mc Mahon, D. Vistica, J.T. Warren, H. Bokesh, S. Kenney, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1107 1112
19. M.R. Boyd Princ. Pract. Oncol. 3 1989 1
20. K.D. Paull, R.H. Shoemaker, L. Hodes, A. Monks, D.A. Scudiero, L. Rubinstein, J. Plowman, and M.R. Boyd J. Natl. Cancer Inst. 81 1989 1088 1092
21. J.N. Weinstein, T.G. Myers, P.M. O'Connor, S.H. Friend, A.J. Jr Fornace, K.W. Kohn, T. Fojo, S.E. Bates, L.V. Rubinstein, N.L. Anderson, J.K. Buolamwini, W.W. van Osdol, A.P. Monks, D.A. Scudiero, E.A. Sausville, D.W. Zaharevitz, B. Bunow, V.N. Viswanadhan, G.S. Johnson, R.E. Wittes, and K.D. Paull Science 275 1997 343 349
22. G.D. Gray, and E. Wickstrom Biotechniques 21 1996 780 782
23. A. Monks, D. Scudiero, P. Skehan, R. Shoemaker, K. Paull, D. Vistica, C. Hose, J. Langley, P. Cronise, A. Vaigro-Wolff, M. Gray-Goodrich, H. Campbell, J. Mayo, and M. Boyd J. Natl. Cancer Inst. 83 1991 757 766