No infiuence of SLC22A4 C6607T and RUNX1 G24658C genotypic variants on the circulating carnitine ester profile in patients with rheumatoid arthritis

Clinical and Experimental Rheumatology

Volumn 26, Issue 1, 2008, Pages 61-66

  Komlósi, Katalin ^a   Talián, Gábor Csaba ^a   Faragó, Bernadett ^a   Magyari, Lili ^a   Cserép, Veronika ^a   Kovács, Beáta ^a   Bene, Judit ^a   Havasi, Viktória ^a   Kiss, Csaba Gábor ^a   Czirják, László ^a   Melegh, Béla ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Carnitine profile; OCTN1; Rheumatoid arthritis; RUNX1; SLC22A4

Indexed keywords

CARNITINE; CYTOSINE; GUANINE; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 4; THYMINE; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; RUNX1 PROTEIN, HUMAN; SLC22A4 PROTEIN, HUMAN; SLC22A5 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUNGARY; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; TANDEM MASS SPECTROMETRY; BLOOD; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED;

ARTHRITIS, RHEUMATOID; CARNITINE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; ORGANIC CATION TRANSPORT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTORS;

EID: 40749147226     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. JARVINEN P, AHO K: Twin studies in rheumatic diseases. Semin Arthritis Rheum 1994; 24: 19-28.
2. KISS CG, LOVEI C, SUTO G et al.: Prevalence of rheumatoid arthritis in the South-Transdanubian region of Hungary based on a representative survey of 10,000 inhabitants. J Rheumatol 2005; 32: 1688-90.
3. TURESSON C, MATTESON EL: Genetics of rheumatoid arthritis. Mayo Clin Proc 2006; 81: 94-101.
4. DIEUDE P, CORNELIS F: Genetic basis of rheumatoid arthritis. Joint Bone Spine 2005; 72: 520-6.
5. YAMAMOTO K, YAMADA R: Genome-wide single nucleotide polymorphism analyses of rheumatoid arthritis. J Autoimmun 2005; 25 (Suppl.): 12-15.
6. VAN DER HELM-VAN MIL AH, WESOLY JZ, HUIZINGA TW: Understanding the genetic contribution to rheumatoid arthritis. Curr Opin Rheumatol 2005; 17: 299-304.
7. BARTON A, OLLIER W: Genetic approaches to the investigation of rheumatoid arthritis. Curr Opin Rheumatol 2002; 14: 260-9.
8. DEIGHTON CM, WALKER DJ, GRIFFITHS ID, ROBERTS DF: The contribution of HLA to rheumatoid arthritis. Clin Genet 1989; 36: 178-82.
9. BARTON A, JOHN S, OLLIER WE, SILMAN A, WORTHINGTON J: Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians. Arthritis Rheum 2001; 44: 61-5.
10. SUZUKI A, YAMADA R, CHANG X et al.: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003; 34: 395-402.
11. BEGOVICH AB, CARLTON VE, HONIGBERG LA et al.: A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004; 75: 330-7.
12. TOKUHIRO S, YAMADA R, CHANG X et al.: An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 2003; 35: 341-8.
13. ARMAN A, YILMAZ B, COKER A, INANC N, DIRESKENELI H: Interleukin-1 receptor antagonist (IL-1RN) and interleukin-1B gene polymorphisms in Turkish patients with rheumatoid arthritis. Clin Exp Rheumatol 2006; 24: 643-8.
14. MORINOBU S, MORINOBU A, KANAGAWA S, HAYASHI N, NISHIMURA K, KUMAGAI S: Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis. Clin Exp Rheumatol 2006; 24: 268-73.
15. TAMAI I, OHASHI R, NEZU JI et al.: Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem 2000; 275: 40064-72.
16. ARNETT FC, EDWORTHY SM, BLOCH DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
17. BENE J, KOMLOSI K, GASZTONYI B, JUHASZ M, TULASSAY Z, MELEGH B: Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet. World J Gastroenterol 2005; 11: 6671-5.
18. MORI M, YAMADA R, KOBAYASHI K, KAWAIDA R, YAMAMOTO K: Ethnic differences in allele frequency of autoimmune-disease-associated SNPs. J Hum Genet 2005; 50: 264-6.
19. NEWMAN B, WINTLE RF, VAN OENE M et al.: SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population. Arthritis Rheum 2005; 52: 425-9.
20. BARTON A, EYRE S, BOWES J, HO P, JOHN S, WORTHINGTON J: Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients. Arthritis Rheum 2005; 52: 752-8.
21. OROZCO G, SANCHEZ E, GONZALEZ-GAY MA et al.: SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: A case-control study in a Spanish population. J Rheumatol 2006; 33: 1235-9.
22. NEZU J, TAMAI I, OKU A et al.: Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 1999; 21: 91-4.
23. GRUNDEMANN D, HARLFINGER S, GOLZ S et al.: Discovery of the ergothioneine transporter. Proc Natl Acad Sci USA 2005; 102: 5256-61.