Fucoidin prevents Clostridium difficile toxin-A-induced ileal enteritis in mice

Digestive Diseases and Sciences

Volumn 53, Issue 4, 2008, Pages 990-996

  Barreto, A R F ^a   Cavalcante, I C ^a   Castro, M V ^a   Junqueira, A F T A ^a   Vale, M R ^a   Ribeiro, R A ^a   Souza, M H L P ^a   Brito, G A C ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

ADA activity; Clostridium difficile toxin A; Fucoidin; Inflammation

Indexed keywords

ADENOSINE DEAMINASE; CLOSTRIDIUM DIFFICILE TOXIN A; FUCOIDIN; MYELOPEROXIDASE; PHOSPHATE BUFFERED SALINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENTERITIS; ENZYME ACTIVITY; HISTOPATHOLOGY; ILEUM DISEASE; INTESTINE FLUID; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE DEAMINASE; ANIMALS; ANTI-ULCER AGENTS; BACTERIAL TOXINS; ENTEROTOXINS; GASTRIC MUCOSA; ILEITIS; MALE; MICE; PEROXIDASE; POLYSACCHARIDES;

EID: 40749120528     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9957-3     Document Type: Article

References (49)

1. Bartlett JG (2002) Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 346:334-339
2. Kelly CP, Pothoulakis C, LaMont JT (1994) Clostridium difficile colitis. N Engl J Med 330:257-262
3. Kyne L, Warny M, Qamar A, Kelly CP (2000) Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 342:390-397
4. Just I, Wilm M, Selzer J, Rex G, von Eichel-Streiber C, Mann M, Aktories K (1995) The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J Biol Chem 270:13932-13936
5. Just I, Selzer J, von Eichel-Streiber C, Aktories K (1995) The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile. J Clin Invest 95:1026-1031
6. Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375:500-503
7. Popoff MR, Rubin EJ, Gill DM, Boquet P (1988) Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infect Immun 56:2299-2306
8. Rubin MS, Bodenstein LE, Kent KC (1995) Severe Clostridium difficile colitis. Dis Colon Rectum 38:350-354
9. Archibald LK, Banerjee SN, Jarvis WR (2004) Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001. J Infect Dis 189:1585-1589
10. Dallal RM, Harbrecht BG, Boujoukas AJ, Sirio CA, Farkas LM, Lee KK, Simmons RL (2002) Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 235:363-372
11. Muto CA, Pokrywka M, Shutt K, Mendelsohn AB, Nouri K, Posey K, Roberts T, Croyle K, Krystofiak S, Patel-Brown S, Pasculle AW, Paterson DL, Saul M, Harrison LH (2005) A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect Control Hosp Epidemiol 26:273-280
12. McEllistrem MC, Carman RJ, Gerding DN, Genheimer CW, Zheng L (2005) A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin Infect Dis 40:265-272
13. Johnson S, Samore MH, Farrow KA, Killgore GE, Tenover FC, Lyras D, Rood JI, DeGirolami P, Baltch AL, Rafferty ME, Pear SM, Gerding DN (1999) Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals. N Engl J Med 341:1645-1651
14. McDonald LC, Killgore GE, Thompson A, Owens RC Jr, Kazakova SV, Sambol SP, Johnson S, Gerding DN (2005) An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 353:2433-2441
15. Warny M, Pepin J, Fang A, Killgore G, Thompson A, Brazier J, Frost E, McDonald LC (2005) Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 366:1079-1084
16. Spigaglia P, Mastrantonio P (2002) Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates. J Clin Microbiol 40:3470-3475
17. Spigaglia P, Mastrantonio P (2004) Comparative analysis of Clostridium difficile clinical isolates belonging to different genetic lineages and time periods. J Med Microbiol 53:1129-1136
18. Berteau O, Mulloy B (2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13:29R-40R
19. Parkin J, Cohen B (2001) An overview of the immune system. Lancet 357:1777-1789
20. Shimaoka M, Ikeda M, Iida T, Taenaka N, Yoshiya I, Honda T (1996) Fucoidin, a potent inhibitor of leukocyte rolling, prevents neutrophil influx into phorbol-ester-induced inflammatory sites in rabbit lungs. Am J Respir Crit Care Med 153:307-311
21. Castagliuolo I, Riegler M, Pasha A, Nikulasson S, Lu B, Gerard C, Gerard NP, Pothoulakis C (1998) Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. J Clin Invest 101:1547-1550
22. Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O'Keane JC, Snider RM, Leeman SE (1994) CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci U S A 91:947-951
23. Souza MH, Troncon LE, Cunha FQ, Oliveira RB (2003) Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats. Braz J Med Biol Res 36:1383-1390
24. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
25. Giusti G (1974) Adenosine deaminase. In: Bergmeyer HU (ed). Methods of enzymatic analysis. Academic, New York, pp 1092-1099
26. Lasky LA (1995) Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu Rev Biochem 64:113-139
27. Brito GA, Fujji J, Carneiro-Filho BA, Lima AA, Obrig T, Guerrant RL (2002) Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cells. J Infect Dis 186:1438-1447
28. Alcantara CS, Jin XH, Brito GA, Carneiro-Filho BA, Barrett LJ, Carey RM, Guerrant RL (2005) Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model. J Infect Dis 191:2090-2096
29. Humphrey CD, Condon CW, Cantey JR, Pittman FE (1979) Partial purification of a toxin found in hamsters with antibiotic-associated colitis. Reversible binding of the toxin by cholestyramine. Gastroenterology 76:468-476
30. Lima AA, Innes DJ Jr, Chadee K, Lyerly DM, Wilkins TD, Guerrant RL (1989) Clostridium difficile toxin A. Interactions with mucus and early sequential histopathologic effects in rabbit small intestine. Lab Invest 61:419-425
31. Lima AA, Lyerly DM, Wilkins TD, Innes DJ, Guerrant RL (1988) Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro. Infect Immun 56:582-588
32. Lyerly DM, Krivan HC, Wilkins TD (1988) Clostridium difficile: its disease and toxins. Clin Microbiol Rev 1:1-18
33. Lyerly DM, Lockwood DE, Richardson SH, Wilkins TD (1982) Biological activities of toxins A and B of Clostridium difficile. Infect Immun 35:1147-1150
34. Rehg JE (1980) Cecal toxin(s) from guinea pigs with clindamycin- associated colitis, neutralized by Clostridium sordellii antitoxin. Infect Immun 27:387-390
35. Brito GA, Sullivan GW, Ciesla WP Jr, Carper HT, Mandell GL, Guerrant RL (2002) Clostridium difficile toxin A alters in vitro-adherent neutrophil morphology and function. J Infect Dis 185:1297-1306
36. Kelly CP, Becker S, Linevsky JK, Joshi MA, O'Keane JC, Dickey BF, LaMont JT, Pothoulakis C (1994) Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit. J Clin Invest 93:1257-1265
37. Kurose I, Pothoulakis C, LaMont JT, Anderson DC, Paulson JC, Miyasaka M, Wolf R, Granger DN (1994) Clostridium difficile toxin A-induced microvascular dysfunction. Role of histamine. J Clin Invest 94:1919-1926
38. Assreuy AM, Martins GJ, Moreira ME, Brito GA, Cavada BS, Ribeiro RA, Flores CA (1999) Prevention of cyclophosphamide-induced hemorrhagic cystitis by glucose-mannose binding plant lectins. J Urol 161:1988-1993
39. Hsu HY, Hajjar DP, Khan KM, Falcone DJ (1998) Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway. J Biol Chem 273:1240-1246
40. Heinzelmann M, Polk HC Jr, Miller FN (1998) Modulation of lipopolysaccharide-induced monocyte activation by heparin-binding protein and fucoidan. Infect Immun 66:5842-5847
41. Omata M, Matsui N, Inomata N, Ohno T (1997) Protective effects of polysaccharide fucoidin on myocardial ischemia-reperfusion injury in rats. J Cardiovasc Pharmacol 30:717-724
42. Granert C, Raud J, Waage A, Lindquist L (1999) Effects of polysaccharide fucoidin on cerebrospinal fluid interleukin-1 and tumor necrosis factor alpha in pneumococcal meningitis in the rabbit. Infect Immun 67:2071-2074
43. Colgan SP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Frendl G, Madara JL (1995) Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem 270:10531-10539
44. Di RM, Papadimitriou JM, Willoughby DA (1971) A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs. J Pathol 105:239-256
45. Cavalcante IC, Castro MV, Barreto AR, Sullivan GW, Vale M, Almeida PR, Linden J, Rieger JM, Cunha FQ, Guerrant RL, Ribeiro RA, Brito GA (2006) Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis. Infect Immun 74:2606-2612
46. Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, Camaioni E (2001) Adenosine deaminase: functional implications and different classes of inhibitors. Med Res Rev 21:105-128
47. Piras MA, Gakis C, Budroni M, Andreoni G (1978) Adenosine deaminase activity in pleural effusions: an aid to differential diagnosis. Br Med J 2:1751-1752
48. Sari RA, Taysi S, Yilmaz O, Bakan N (2003) Correlation of serum levels of adenosine deaminase activity and its isoenzymes with disease activity in rheumatoid arthritis. Clin Exp Rheumatol 21:87-90
49. Frode TS, Medeiros YS (2001) Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy. Mediators Inflamm 10:223-227