Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model

Journal of Infectious Diseases

Volumn 191, Issue 12, 2005, Pages 2090-2096

  Alcantara, Cirle S ^a,b   Jin, Xiao Hong ^a   Brito, Gerly Anne C ^a,c   Carneiro Filho, Benedito A ^a,c   Barrett, Leah J ^a   Carey, Robert M ^a   Guerrant, Richard L ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BACTERIAL TOXIN; CHOLERA TOXIN; CLOSTRIDIUM DIFFICILE TOXIN A; LOSARTAN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; DIARRHEA; HISTOPATHOLOGY; ILEUM; INTESTINE SECRETION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR BLOCKING; TOXIN ANALYSIS; WESTERN BLOTTING;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROTOXINS; ILEITIS; INTESTINAL MUCOSA; LOSARTAN; RABBITS;

EID: 20444407608     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/430316     Document Type: Article

References (25)

1. Flegel WA, Muller F, Daubener W, Fischer HG, Hadding U, Northoff H. Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect Immun 1991; 59:3659-66.
2. Pothoulakis C, Sullivan R, Melnick DA, et al. Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes. J Clin Invest 1988; 81:1741-5.
3. Alcantara C, Stenson WF, Steiner TS, Guerrant RL. Role of inducible cyclooxygenase and prostaglandins in Clostridium difficile toxin A-induced secretion and inflammation in an animal model. J Infect Dis 2001; 184:648-52.
4. Alfa MJ, Kabani A, Lyerly D, et al. Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea. J Clin Microbiol 2000; 38:2706-14.
5. Just I, Wilm M, Selzer J, et al. The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the rho proteins. J Biol Chem 1995; 270: 13932-6.
6. Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K. Glucosylation of rho proteins by Clostridium difficile toxin B. Nature 1995; 375:500-3.
7. Brito GAC, Sullivan GW, Ciesla WP Jr, Carper HT, Mandell GL, Guerrant RL. Clostridium difficile toxin A alters in vitro-adherent neutrophil morphology and function. J Infect Dis 2002; 185:1297-306.
8. 125I]-bradykinin binding sites in rat intestinal epithelia. Br J Pharmacol 1986; 87:201-9.
9. Duggan KA, Mendelsohn FA, Levens NR. Angiotensin receptors and angiotensin I-converting enzyme in rat intestine. Am J Physiol 1989; 257:G504-10.
10. Sechi LA, Valentin JP, Griffin CA, Schambelan M. Autoradiographic characterization of angiotensin II receptor subtypes in rat intestine. Am J Physiol 1993; 265:G21-7.
11. Schinke M, Doods HN, Ganten D, Wienen W, Entzeroth M. Characterization of rat intestinal angiotensin II receptors. Eur J Pharmacol 1991; 204:165-70.
12. Timmermans PB, Wong PC, Chiu AT, et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993; 45:205-51.
13. Jin X-H, Wang Z-Q, Siragy HM, Guerrant RL, Carey RM. Regulation of jejunal sodium and water absorption by angiotensin subtype receptors. Am J Physiol 1998; 275:R515-23.
14. Levens NR, Peach MJ, Carey RM, Poat JA, Munday KA. Response of rat jejunum to angiotensin II: role of norepinephrine and prostaglandins. Am J Physiol 1981; 240:G17-24.
15. Levens NR, Peach MJ, Carey RM. Interactions between angiotensin peptides and the sympathetic nervous system mediating intestinal sodium and water absorption in the rat. J Clin Invest 1981; 67:1197-207.
16. Lima AAM, Lyerly DM, Wilkins TD, Innes DJ, Guerrant RL. Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro. Infect Immun 1988; 56:582-8.
17. Jaszewski R, Tolia V, Ehrinpreis MN, et al. Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis. Gastroenterology 1990; 98:1543-8.
18. Wershil BK, Castagliuolo I, Pothoulakis C. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 1998; 114:956-64.
19. Tonnesen MG, Klempner MS, Austen KF, Wintroub BU. Identification of a human neutrophil angiotension II-generating protease as cathepsin G. J Clin Invest 1982; 69:25-30.
20. Fukami H, Okunishi H, Miyazaki M. Chymase: its pathophysiological roles and inhibitors. Curr Pharm Des 1998; 4:439-53.
21. Graciano ML, Cavaglieri R de C, Delle H, et al. Intrarenal rennin-angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. J Am Soc Nephrol 2004; 15:1805-15.
22. Shinozaki K, Ayajiki K, Nishio Y, Sugaya T, Kashiwagi A, Okamura T. Evidence for a causal role of the rennin-angiotensin system in vascular dysfunction associated with insulin resistance. Hypertension 2004; 43: 255-62.
23. Levens NR, Peach MJ, Carey RM, Poat JA, Munday KA. Stimulation of intestinal sodium and water transport in vivo by angiotensin II and analogs. Endocrinology 1980; 107:1946-53.
24. Ewert S, Laesser M, Johansson B, Holm M, Aneman A, Fandriks L. The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa. BMC Pharmacol 2003; 3:1-8.
25. Wallace JL, Miller MJ. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology 2000; 119:512-20.