Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 Newly diagnosed patients and review of previous cases

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 7, 2008, Pages 767-773

  Hoffmann, L A ^a   Jarius, S ^a,d   Pellkofer, H L ^a   Schueller, M ^a   Krumbholz, M ^a   Koenig, F ^b   Johannis, W ^c   La Fougere, C ^a   Newman, T ^d   Vincent, A ^d   Voltz, R ^a,c,e  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AUTOANTIBODY; FLUORODEOXYGLUCOSE F 18; HU ANTIBODY; IMMUNOGLOBULIN; MA ANTIBODY; STEROID; TA ANTIBODY;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; BREAST TUMOR; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENCEPHALITIS; FEMALE; GASTROINTESTINAL TUMOR; GERM CELL TUMOR; HUMAN; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; KIDNEY TUMOR; LUNG TUMOR; MALE; MELANOMA; NONHODGKIN LYMPHOMA; ORCHIECTOMY; PARANEOPLASTIC NEUROPATHY; PLASMAPHERESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TREATMENT RESPONSE; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS; ANTIGENS, NEOPLASM; AUTOANTIBODIES; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PARANEOPLASTIC SYNDROMES, NERVOUS SYSTEM; RETROSPECTIVE STUDIES;

EID: 40749118387     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.118588     Document Type: Article

References (27)

1. Darnell RB, Posner JB. Paraneoplastic syndromes involving the nervous system. N Engl J Med 2003;349:1543-54.
2. Voltz R. Paraneoplastic neurological syndromes: an update on diagnosis, pathogenesis, and therapy. Lancet Neurol 2002;1:294- 305.
3. Graus F, Delattre JY, Antoine JC, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004;75:1135-40.
4. Dalmau J, Gultekin SH, Voltz R, et al. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain 1999;122:27-39.
5. Voltz R, Gultekin SH, Rosenfeld MR, et al. A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. N Engl J Med 1999;340:1788-95.
6. Dalmau J, Graus F, Villarejo A, et al. Clinical analysis of anti-Ma2-associated encephalitis. Brain 2004;127:1831-44.
7. Rosenfeld MR, Eichen JG, Wade DF, et al. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. Ann Neurol 2001;50:339-48.
8. Overeem S, Dalmau J, Bataller L, et al. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis. Neurology 2004;62:138-40.
9. Blumenthal DT, Salzman KL, Digre KB, et al. Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis. Neurology 2006;67:146-9.
10. Barnett M, Prosser J, Sutton I, et al. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody. J Neurol Neurosurg Psychiatry 2001;70:222-5.
11. Bennett JL, Galetta SL, Frohman LP, et al. Neuro-ophthalmologic manifestations of a paraneoplastic syndrome and testicular carcinoma. Neurology 1999;52:864-7.
12. Landolfi JC, Nadkami M. Paraneoplastic limbic encephalitis and possible narcolepsy in a patient with testicular cancer: case study. Neurooncol 2003;5:214-16.
13. Sahashi K, Sakai K, Mano K, et al. Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs. J Neurol Neurosurg Psychiatry 2003;74:1332-5.
14. Scheid R, Voltz R, Guthke T, et al. Neuropsychiatric findings in anti-Ma2-positive paraneoplastic limbic encephalitis. Neurology 2003;61:1159-61.
15. Sutton I, Winer J, Rowlands D, et al. Limbic encephalitis and antibodies to Ma2: a paraneoplastic presentation of breast cancer. J Neurol Neurosurg Psychiatry 2000;69:266-8.
16. Wong AM, Musallam S, Tomlinson RD, et al. Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlates. J Neurol Sci 2001;189:71-81.
17. Waragai M, Chiba A, Uchibori A, et al. Anti-Ma2 associated paraneoplastic neurological syndrome presenting as encephalitis and progressive muscular atrophy. J Neurol Neurosurg Psychiatry 2006;77:111-13.
18. Schuller M, Jenne D, Voltz R. The human PNMA family: Novel neuronal proteins implicated in paraneoplastic neurological disease. J Neuroimmunol 2005;169:172-6.
19. Mathew RM, Vandenberghe R, Garcia-Merino A, et al. Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis. Neurology 2007;68:900-5.
20. Voltz R. Can antibodies in serum predict the presence of microscopic tumors? Neurology 2007;20;68:887-8.
21. Darnell RB. Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. Arch Neurol 2004;61:30-2.
22. Linke R, Schroeder M, Helmberger T, et al. Antibody-positive paraneoplastic neurologic syndromes: value of CT and PET for tumor diagnosis. Neurology 2004;63:282-6.
23. Albert ML, Darnell RB. Paraneoplastic neurological degenerations: keys to tumour immunity. Nat Rev Cancer 2004;4:36-44.
24. Voltz R, Dalmau J, Posner JB, et al. T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology 1998;51:1146-50.
25. Albert ML, Darnell JC, Bender A, et al. Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat Med 1998;4:1321-4.
26. Jellinger KA, Paulus W. Primary central nervous system lymphomas - new pathological developments. J Neurooncol 1995;24:33-6.
27. Pellkofer H, Schubart AS, Hoftberger B, et al. Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat. Brain 2004;127:1822-30.