Synthesis and biological evaluation of pyrroloiminoquinone derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2431-2438

  Passarella, Daniele ^a   Belinghieri, Francesca ^a   Scarpellini, Michele ^a   Pratesi, Graziella ^b   Zunino, Franco ^b   Gia, Ornella Maria ^c   Via, Lisa Dalla ^c   Santoro, Giuseppe ^a   Danieli, Bruno ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antiproliferative activity; DNA fragmentation; Pyrroloiminoquinone derivatives; Topoisomerase II

Indexed keywords

1,3,4,5 TETRAHYDRO 7,8 DIMETHOXY 1 METHYLPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 2'H SPIRO CYCLOHEXA[2.5]DIENE 1 METHYL 8 OXOPYRROLO[4,3,2 DE] 1,7 PHENANTROLYNE 12,3' DIONE; 1,3,4,8 TETRAHYDRO 7 (1 PHENYLETHYLAMINO) 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 (3 METHOXYPHENETHYLAMINO) 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 (4 HYDROXYPHENETHYLAMINO) 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 (BENZYLAMINO) 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 [3 (2 AMINOETHYL)INDOLYL] 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 [5 FLUORO 3 (2 AMINOETHYL)INDOLYL] 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 [5 HYDROXY 3 (2 AMINOETHYL)INDOLYL] 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 [5 METHOXY 3 (2 AMINOETHYL)INDOLYL] 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,3,4,8 TETRAHYDRO 7 METHOXY 1 METHYL 8 OXOPYRROLO[4,3,2 DE]QUINOLINE; 1,5 DIFORMYL 1,3,4,5 TETRAHYDRO 7,8 DIMETHOXY 2,3 DIHYDROPYRROLO[4,3,2 DE]QUINOLINE; 5 FORMYL 1,3,4,5 TETRAHYDRO 7,8 DIMETHOXY 1 METHYLPYRROLO[4,3,2 DE]QUINOLINE; 5 FORMYL 1,3,4,5 TETRAHYDRO 7,8 DIMETHOXY 2,3 DIHYDROPYRROLO[4,3,2 DE]QUINOLINE; 5 METHYL 3,5,9,8,10 TETRAHYDRO 2H,8H 7 THIA 1,5,10 TRIAZA ACEPHENANTRYLEN 6 ONE; AMINE; CISPLATIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; PYRROLOIMINOQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PYRROLOIMINOQUINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749086302     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.063     Document Type: Article

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