Proteinuria developing after clinical islet transplantation resolves with sirolimus withdrawal and increased tacrolimus dosing

American Journal of Transplantation

Volumn 5, Issue 9, 2005, Pages 2318-2323

  Senior, Peter A ^a   Paty, Breay W ^a   Cockfield, Sandra M ^b   Ryan, Edmond A ^a   Shapiro, A M James ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Islets; Nephrotoxicity; Proteinuria; Sirolimus; Transplantation

Indexed keywords

MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ADULT; ARTICLE; BLOOD GLUCOSE MONITORING; CLINICAL ARTICLE; DIABETIC NEPHROPATHY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY BIOPSY; KIDNEY DYSFUNCTION; MICROALBUMINURIA; OVARY CYST; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEINURIA; RECURRENT DISEASE; TREATMENT WITHDRAWAL;

ADULT; ALBUMINURIA; DIABETES MELLITUS, TYPE 1; FEMALE; GLOMERULONEPHRITIS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; KIDNEY; KIDNEY TRANSPLANTATION; LIVING DONORS; MIDDLE AGED; MYCOPHENOLIC ACID; PROTEINURIA; SIROLIMUS; TACROLIMUS; TIME FACTORS; TREATMENT OUTCOME;

EID: 27844461589     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2005.01013.x     Document Type: Article

References (18)

1. Nair S, Eason J, Loss G. Sirolimus monotherapy in nephrotoxicity due to calcineurin inhibitors in liver transplant recipients. Liver Transpl 2003; 9: 126-129.
2. Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
3. Dittrich E, Schmaldienst S, Soleiman A, Horl WH, Pohanka E. Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy. Transpl Int 2004; 17: 215-220.
4. Lakey JR, Warnock GL, Shapiro AM et al. Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion. Cell Transplant 1999; 8: 285-292.
5. Owen RJ, Ryan EA, O'Kelly K et al. Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects. Radiology 2003; 229: 165-170.
6. Cure P, Pileggi A, Froud T et al. Alterations of the female reproductive system in recipients of islet grafts. Transplantation 2004; 78: 1576-1581.
7. Duncan N, Dhaygude A, Owen J et al. Treatment of focal and segmental glomerulosclerosis in adults with tacrolimus monotherapy. Nephrol Dial Transplant 2004; 19: 3062-3067.
8. Paleologo G, Tregnaghi C, Bianchi AM et al. Solitary pancreas transplantation: preliminary findings about early reduction of proteinuria in incipient or evident diabetic type I nephropathy. Transplant Proc 2004; 36: 591-596.
9. Day CJ, Cockwell P, Lipkin GW, Savage CO, Howie AJ, Adu D. Mycophenolate mofetil in the treatment of resistant idiopathic nephrotic syndrome. Nephrol Dial Transplant 2002; 17: 2011-2013.
10. Daniel C, Ziswiler R, Frey B, Pfister M, Marti HP. Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative. Exp Nephrol 2000; 8: 52-62.
11. DiJoseph JF, Mihatsch MJ, Sehgal SN. Renal effects of rapamycin in the spontaneously hypertensive rat. Transpl Int 1994; 7: 83-88.
12. Reitamo S, Spuls P, Sassolas B, Lahfa M, Claudy A, Griffiths CE. Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial. Br J Dermatol 2001; 145: 438-445.
13. Stepkowski SM. Preclinical results of sirolimus treatment in transplant models. Transplant Proc 2003; 35 (3 Suppl): 219S-226S.
14. Fervenza FC, Fitzpatrick PM, Mertz J et al. Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies. Nephrol Dial Transplant 2004; 19: 1288-1292.
15. Smith KD, Wrenshall LE, Nicosia RF et al. Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. JAm Soc Nephrol 2003; 14: 1037-1045.
16. Andoh TF, Burdmann EA, Fransechini N, Houghton DC, Bennett WM. Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. Kidney Int 1996; 50: 1110-1117.
17. Morelon E, Kreis H. Sirolimus therapy without calcineurin inhibitors: Necker hospital 8-year experience. Transplant Proc 2003; 35 (3 Suppl): 52S-57S.
18. Senior PA, Zeman M, Paty BW, Shapiro AM, Ryan EA. Renal outcomes after clinical islet allotransplantation at the University of Alberta - 4 year follow up. Diabetes 2004; 53 (Suppl 2): A69.