Dietary nucleotides protect thymocyte DNA from damage induced by cyclophosphamide in mice

Journal of Animal Physiology and Animal Nutrition

Volumn 92, Issue 2, 2008, Pages 211-218

  Wang, L F ^a   Gong, X ^b   Le, G W ^c   Shi, Y H ^c  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI BUSINESS SCHOOL   (China)

^c JIANGNAN UNIVERSITY   (China)

Author keywords

Comet assay; Cyclophosphamide; DNA damage; Nucleotides; Thymocyte

Indexed keywords

CYCLOPHOSPHAMIDE; MUTAGENIC AGENT; NUCLEOTIDE;

ANIMAL; ANIMAL FOOD; ARTICLE; CELL SURVIVAL; COMET ASSAY; CYTOLOGY; DNA DAMAGE; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METHODOLOGY; MOUSE; ORGAN SIZE; RANDOMIZATION; SPLEEN; THYMUS; TIME;

ANIMAL FEED; ANIMALS; CELL SURVIVAL; COMET ASSAY; CYCLOPHOSPHAMIDE; DNA DAMAGE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MUTAGENS; NUCLEOTIDES; ORGAN SIZE; RANDOM ALLOCATION; SPLEEN; THYMUS GLAND; TIME FACTORS;

MUS;

EID: 40649112690     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2007.00728.x     Document Type: Article

References (44)

1. Adjei, A. A. Jones, J. T. Enriquez, F. J. Yamamoto, S., 1999 : Dietary nucleosides and nucleotides reduce cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice. Experimental Parasitology 92, 199 208.
2. Axelsson, I. Flodmark, C. E. Raiha, N. Tacconi, M. Visentin, M. Minoli, I. Moro, G. Warm, A., 1997 : The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants. Acta Paediatrica 86, 539 544.
3. Boza, J. Jimenez, J. Faus, M. J. Gil, A., 1992 : Influence of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat. Journal of Pediatric Gastroenterology and Nutrition 16, 322 326.
4. Brock, N., 1989 : Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award Lecture. Cancer Research 49, 1 7.
5. Carver, J. D. Cox, W. I. Barness, L. A., 1990 : Dietary nucleotide effect upon murine natural killer cell activity and macrophage activation. Journal of Pediatric Gastroenterology and Nutrition 14, 18 22.
6. Cohen, A. Barankiewicz, J. Lederman, H. M. Gelfand, E. W., 1984 : Purine metabolism in human T lymphocytes: role of the purine nucleoside cycle. Canadian Journal of Biochemistry and Cell Biology 62, 577 583.
7. Cui, D. X. Zhang, G. Y. Wang, F. Tian, F. R. Guo, Y. H. Xu, J. R., 2001 : Analysis of genes associated with exogenous nucleic acids improving the repair of intestinal epithelium after γ irradiation in mice. Progress in Biochemistry and Biophysics 28, 353 357.
8. Drablos, F. Feyzi, E. Aas, P. A. Vaagbo, C. B. Kavli, B. Bratlie, M. S. Pena-Diaz, J. Otterlei, M. Slupphaug, G. Krokan, H. E., 2004 : Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair 3, 1389 1407.
9. Frankič, T. Pajk, T. Rezar, V. Levart, A. Salobir, J., 2006 : The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. Food and Chemical Toxicology 44, 1838 1844.
10. Hartmann, A. Herkommer, K. Glück, M. Speit, G., 1995 : DNA-damaging effect of cyclophosphamide on human blood cells in vivo and in vitro studied with the single-cell gel test (comet assay). Environmental and Molecular Mutagenesis 25, 180 187.
11. Hawkes, J. S. Gibson, R. A. Roberton, D. Makrides, M., 2006 : Effect of dietary nucleotide supplementation on growth and immune function in term infants: a randomized controlled trial. European Journal of Clinical Nutrition 60, 254 264.
12. Hengstler, J. G. Hengst, A. Fuchs, J. Tanner, B. Pohl, J. Oesch, F., 1997 : Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1. Mutation Research 373, 215 223.
13. Ho, C. Y. Miller, K. V. Savaiano, D. A. Crane, R. T. Ericson, K. A. Clifford, A. J., 1979 : Absorption and metabolism of orally administered purines in fed and fasted rats. Journal of Nutrition 109, 1377 1382.
14. Holen, E. Bjørge, O. Jonsson, R., 2005 : Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion. Nutrition 21, 1003 1009.
15. Iijima, S. Tsujinaka, T. Kido, Y. Hayashida, Y. Ishida, H. Homma, T. Yokoyama, H. Mori, T., 1993 : Intravenous administration of nucleosides and a nucleotide mixture diminishes intestinal mucosal atrophy induced by total parenteral nutrition. Journal of Pediatric Gastroenterology and Nutrition 17, 265 270.
16. Jyonouchi, H. Sun, S., 1996 : An orally supplemented mononucleotide mixture prevents the decrease in T cell-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet. Journal of Nutrition 126, 1586 1593.
17. Jyonouchi, H. Zhang-Shanbhag, L. Tomita, Y. Yokoyama, H., 1994 : Nuclotide-free diet impairs T-helper cell functions in antibody production in response to T-dependent antigens in normal C57BL/6 mice. Journal of Nutrition 124, 475 484.
18. Jyonouchi, H. Sun, S. Abiru, T. Winship, T. Kuchan, M., 2000 : Dietary nucleotides modulate antigen-specific type 1 and type 2 t-cell responses in young c57bl/6 mice. Nutrition 16, 442 446.
19. Jyonouchi, H. Sun, S. Winship, T. Kuchan, M., 2001 : Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice. Journal of Nutrition 131, 1165 1170.
20. Kvam, E. Tyrrell, R. M., 1997 : Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation. Carcinogenesis 18, 2379 2384.
21. Lopez-Navarro, A. T. Bueno, I. D. Gil, A. Sanchez-Pozo, A., 1996 : Morphological changs in hepatocytes of rats deprived of dietary nucleotides. British Journal of Nutrition 76, 579 589.
22. Ma, A. G. Liu, S. C. Du, W. Zhang, X. Z., 2000 : Effect of nucleosides supplementation on the repair of DNA oxidative damage in lymphocytes. Acta Nutrimenta Sinica 22, 40 42.
23. Maldonado, J. Navarro, J. Narbona, E. Gil, A., 2001 : The influence of dietary nucleotides on humoral and cell immunity in the neonate and lactating infant. Early Human Development 65 (Suppl. 69 74.
24. Matalon, S. T. Ornoy, A. Lishner, M., 2004 : Review of the potential effects of three commonly used antineoplastic and immunosuppressive drugs (cyclophosphamide, azathioprine, doxorubicin on the embryo and placenta). Reproductive Toxicology 18, 219 230.
25. Nagafuchi, S. Katayanagi, T. Nakagawa, E. Takahashi, T. Yajima, T. Yonekubo, A. Kuwata, T., 1997 : Effects of dietary nucleotides on serum antibody and cytokine production in mice. Nutrition Research 17, 1163 1174.
26. Nagafuchi, S. Hachimura, S. Totsuka, M. Takahash, T. Goto, T. Yajima, T. Kuwata, T. Habu, S. Kaminogawa, S., 2000 : Dietary nucleotides can up-regulate antigen-specific Th1 immune responses and suppress antigen-specific IgE responses in mice. International Archives of Allergy and Immunology 122, 33 41.
27. Navarro, J. Ruiz-Bravo, A. Jiménez-Valera, M. Gil, A., 1996 : Modulation of antibody-forming cell and mitogen-driven lymphoproliferative responses by dietary nucleotides in mice. Immunology Letters 53, 141 145.
28. Pérez, M. J. Sánchez-Medina, F. Torres, M. Gil, A. Suárez, A., 2004 : Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats. Journal of Nutrition 134, 2504 2508.
29. Pérignon, J. L. Bories, D. M. Houllier, A. M. Thuillier, L. Cartier, P. H., 1987 : Metabolism of pyrimidine bases and nucleosides by pyrimidine-nucleoside phosphorylases in cultured human lymphoid cells. Biochimca et Biophysica Acta 928, 130 136.
30. Piperakis, S. M. Visvardis, E. E. Sagnou, M. Tassiou, A. M., 1998 : Effects of smoking and aging on oxidative DNA damage of human lymphocytes. Carcinogenesis 19, 695 698.
31. Rudolph, F. B. Kulkarni, A. D. Fanslow, W. C. Pizzini, R. P. Kumar, S. Van Buren, C. T., 1990 : Role of RNA as a dietary source of pyrimidines and purines in immune function. Nutrition 6, 45 52.
32. Sakai, M. Taniguchi, K. Mamoto, K. Ogawa, H. Tabata, M., 2001 : Immunostimulant effects of nucleotide isolated from yeast RNA on carp, Cyprinus carpio L. Journal of Fish Diseases 24, 433 438.
33. Salobir, J. Rezar, V. Pajk, T. Levart, A., 2005 : Effect of nucleotide supplementation on lymphocyte DNA damage induced by dietary oxidative stress in pigs. Animal Science 81, 135 140.
34. Sato, N. Murakami, Y. Nakano, T. Sugawara, M. Kawakami, H. Idota, T. Nakajima, I., 1995 : Effects of dietary nucleotides on lipid metabolism and learning ability of rats. Bioscience, Biotechnology-and-Biochemistry 59, 1267 1271.
35. Savaiano, D. A. Clifford, A. J., 1981. Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo. Journal of Nutrition 111, 1816 1822.
36. Singh, N. P. McCoy, M. T. Tice, R. R. Schneider, E. L., 1988 : Simple technique for quantitation of low levels of DNA damage in individual cells. Experimental Cell Research 175, 184 191
37. Sirota, N. P. Bezlepkin, V. G. Kuznetsova, E. A. Lomayeva, M. G. Milonova, I. N. Ravin, V. K. Gaziev, A. I. Bradbury, R. J., 1996 : Modifying effect in vivo of interferon alpha on induction and repair of lesions in DNA of lymphoid cells of gamma-irradiated mice. Radiation Research 146, 100 105.
38. Sudo, N. Aiba, Y. Takaki, A. Tanaka, K. Yu, X.-N. Oyama, N. Koga, Y. Kubo, C., 2000 : Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity. Clinical and Experimental Allergy 30, 979 987.
39. Tanaka, M. Lee, K. Martinez-Augustin, O. He, Y. Sanderson, I. R. Walker, W. A., 1996 : Exogenous nucleotides alter the proliferation, differentiation and apoptosis of human small intestinal epithelium. Journal of Nutrition 126, 424 433.
40. Tang, X. L. Xu, S. B. Zhou, Y. H., 1998 : The radio-protective and DNA-repairing action of exotic DNA from carp spermary. Acta Scientiarum Naturalium Universitatis Sunyatseni 37, 125 127.
41. Uauy, R., 1990 : Effect of dietary nucleotides on growth and maturation of the developing gut in the rat. Journal of Pediatric Gastroenterology and Nutrition 10, 497 503.
42. Van Buren, C. T. Rudolph, F., 1997 : Dietary nucleotides: a conditional requirement. Nutrition 13, 470 472.
43. Yamauchi, N. Adjei, A. A. Ameho, C. K. Chan, Y. C. Kulkarni, A. D. Sato, S. Okamoto, K. Yamamoto, S., 1996 : A nucleoside-nucleotide mixture and its components increase lymphoproliferative and delayed hypersensitivity response in mice. Journal of Nutrition 126, 1571 1577.
44. Yamauchi, K. Hales, N. W. Robinson, S. M. Niehoff, M. L. Ramesh, V. Pellis, N. R. Kulkarni, A. D., 2002 : Dietary nucleotides prevent decrease in cellular immunity in ground-based microgravity analog. Journal of Applied Physiology 93, 161 166.