An orally supplemented mononucleotide mixture prevents the decrease in T cell-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet

Journal of Nutrition

Volumn 126, Issue 6, 1996, Pages 1586-1593

  Jyonouchi, Harumi ^a   Sun, Sining ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

antibody secreting cells; C57BL 6 mice; mononucleotide; T cell dependent humoral immunity; T helper cells

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; NUCLEOSIDE; NUCLEOTIDE; OG VI; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; ARTIFICIAL MILK; CELLULAR IMMUNITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; FEMALE; HELPER CELL; HUMORAL IMMUNITY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PLAQUE FORMING CELL; SPLEEN CELL;

EID: 0029989030     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.6.1586     Document Type: Article

References (31)

1. Carter, B. G. & Rector E. S. (1976) Age-dependent changes in sensitivity to antigen: its relationship with the antigen processing system. J. Immunol. 116: 218-222.
2. Czerkinsky, C., Nilsson, L. A., Nygren, H., Ouchterlony, O. & Tarkowski, A. (1983) A solid phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody secreting cells. J. Immunol. Methods 65: 109-121.
3. Daniel, W. W. (1983) Biostatistics, 2nd ed. John Wiley & Sons, New York, NY.
4. Dialynas, D. P., Wuan, Z. A., Sall, K. A., Pierres, A., Quintans, J., Loken, M. R., Pierres, M. &. Fitch, F. W. (1983) Characterization of the murine T cell surface molecules, designated L3T4, identified by monoclonal antibody GK 1.5: similarity of L3T4 to the human Leu-3/T4 molecules. J. Immunol. 131: 2445-2451.
5. Gil, A. & Sánchez-Medina, F. (1981) Acid-soluble nucleotides of cow's, goat's, and sheep's milks, at different stages of lactation. J. Diary Res. 48: 35-44.
6. Harkness, R. A., Simmonds, R. J., Gough, P., Priscott, P. K. & Squire, J. A. (1980) Purine bases and nucleoside, cytidine and uridine concentrations in foetal calf and other sera. Biochem. Soc. Trans. 8: 139.
7. Janas, L. M. & Picciano, M. F. (1982) The nucleotide profile of human milk. Pediatr. Res. 16: 659-662.
8. Jyonouchi, H. (1994) Nucleotide actions on humoral immune responses. J. Nutr. 124: 138S-143S.
9. Jyonouchi, H., Hill, R. J. & Good, R. A. (1992) RNA/Nucleotide enhances antibody production in vitro and is moderately mitogenic to murine spleen lymphocytes. Proc. Soc. Exp. Biol. Med. 200: 101-108.
10. Jyonouchi, H., Hill, R.J., Voss, R.M. & Ishii, E. (1993a) Immunomodulating actions of RNA and nucleotides on murine lymphocytes in vitro. Augmentation of antibody production to T-dependent antigens and expansion of T-helper cells. J. Nutr. Immunol. 2: 5-24.
11. Jyonouchi, H., Sun, S., Zhnag-Shanbhag, L. & Yokoyama, H. (1995) Polynucleotides can compensate for impaired T-dependent antibody production induced by a nucleotide-free diet both in vivo and in vitro in C57Bl/6 mice, but mononucleotide/nucleoside mixture (OGVI) is effective only in vivo. J. Nutr. 125: 1578-1586.
12. Jyonouchi, H., Zhang-Shanbhag, L., Georgieff, M. & Tomita, Y. (1993b) Immunomodulating actions of nucleotides: enhancement of immunoglobulin production by human cord blood lymphocytes. Pediatr. Res. 34: 565-571.
13. Jyonouchi, H., Zhang-Shanbhag, L., Tomita, Y. & Yokoyama, H. (1994) Nucleotide-free diet impairs T-helper cell functions for antibody production in response to T-dependent antigens in normal C57Bl/6 mice. J. Nutr. 124: 475-484.
14. Kulkarni, A. D., Fanslow, W. C., Rudolph, F. B. & Van Buren, C. T. (1992) Immunohemopoietic effects of dietary nucleotide restriction in mice. Transplantation 53: 467-472.
15. Leach, J. L., Baxter, J. H., Molitor, B. E., Ramstack, M. B. & Masor, M. L. (1995) Total potentially available nucleosides of human milk by stage of lactation. Am. J. Clin. Nutr. 61: 1224-1230.
16. Mills, E. L., Regelmann, W. E. & Quie, P. G. (1988) Immunology of the newborn. In: Pediatric Infectious Diseases (Feigin, R. D. & Cherry, J. D., eds.), pp. 729-746. W.B. Saunders, Philadelphia, PA.
17. Mond, J. J. & Brunswick, M. (1991) Assay for B cell functions. In vitro antibody production. In: Current Protocols in Immunology. (Coligan, J. E., Kruisbeek, A. M., Bargulies, D. H., Shevach, E. M. & Strober, W., eds.), pp. 3.8.1-3.8.16. Green and Wiley-Interscience, New York, NY.
18. Ogoshi, S., Iwasa, M., Mizobuchi, S., Iwasa, Y., Martiz, A. & Tamiya, T. (1990) Effect of a nucleoside-nucleotide mixture on protein metabolism in rats given total parental nutrition after 70% hepatectomy. In: Nutritional Support in Organ Failure (Tanaka, T. & Okada, A., eds.), pp. 309-317. Elsevier Science Publishers, Amsterdam, The Netherlands.
19. Pickering, L. K., Granoff, D. M., Erickson, J., Masor, M. L. & Hilty, M. D. (1995) Dietary modulation of the immune system by human milk (HM) and infant formula containing HM levels of nucleotides. Pediatr. Res. 37: 131A (abs.).
20. Rudolph, F. B., Kulkarni, A. D., Fanslow, W. E., Pizzini, R. P., Kumar, S. & Van Buren, C. T. (1990) Role of RNA as a dietary source of pyrimidines and purines in immune function. Nutrition 6: 45-52.
21. Sanderson, I. R. & He, Y. (1994) Nucleotide uptake and metabolism by intestinal epithelial cells. J. Nutr. 124: 131S-137S.
22. Sedgwick, J. D. & Holt, P. G. (1983) A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J. Immunol. Methods 57: 301-309.
23. Snedecor, G. W. & Cochran, W. G. (1980) Statistical Methods, 7th ed. Iowa State University Press, Ames, IA.
24. Sonoda, T. & Tatibana, M. (1978) Metabolic fate of pyrimidines and purine in dietary nucleic acids ingested by mice. Biochim. Biophys. Acta 521: 55-66.
25. Splawski, J. B., Jelinek, D. F. & Lipsky, P. E. (1991) Delineation of the functional capacity of human neonatal lymphocytes. J. Clin. Invest. 87: 545-553.
26. Swain, S. L., Bradley, L. M., Croft, M., Tonkongy, S., Atkins, G., Weinberg, A. D., Duncan, D. D., Hendrick, S. M., Dutton, R. W. & Huston, G. (1991) Helper T-cell subsets: phenotype, function and the role of lymphokine in regulating their development. Immunol. Rev. 123: 115-144.
27. Uauy, R. (1994) Nonimmune system responses to dietary nucleotides. J. Nutr. 124: 157S-159S.
28. Van Buren, C. T., Kim, E., Kulkarni, A. D., Fanslow, W. C. & Rudolph, F. B. (1987) Nucleotide-free diet and suppression of immune response. Transplant. Proc. 19: 57S-59S.
29. Van Buren, C. T., Kulkarni, A. D. & Rudolph, F. B. (1994) The role of nucleotides in adult nutrition. J. Nutr. 124: 160S-164S.
30. Van Buren, C. T., Kulkarni, A. D., Schandle, V. B. & Rudolph, F. B. (1993) The influence of dietary nucleotides on cell-mediated immunity. Transplant 36: 350S-352S.
31. Watson, W., Oen, K., Ramdahin, R. & Harman, C. (1991) Immunoglobulin and cytokine production by neonatal lymphocytes. Clin. Exp. Immunol. 83: 169-174.