The post-stimulation undershoot in BOLD fMRI of human brain is not caused by elevated cerebral blood volume

NeuroImage

Volumn 40, Issue 2, 2008, Pages 473-481

  Frahm, Jens ^a   Baudewig, Jürgen ^b   Kallenberg, Kai ^b   Kastrup, Andreas ^b   Merboldt, K Dietmar ^a   Dechent, Peter ^b  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Bolus tracking; Brain; Cerebral blood volume; Human; Oxidative metabolism; Post stimulation undershoot

Indexed keywords

CONTRAST MEDIUM; DEOXYHEMOGLOBIN; GADOLINIUM PENTETATE;

ADULT; AEROBIC METABOLISM; ARTICLE; BLOOD OXYGENATION; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; VISUAL STIMULATION;

ADULT; BRAIN; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN;

EID: 40649101165     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2007.12.005     Document Type: Article

References (40)

1. Bandettini P.A., Wong E.C., Hinks R.S., Tikofsky R.S., and Hyde J.S. Time course EPI of human brain function during task activation. Magn. Reson. Med. 25 (1992) 390-397
2. Belliveau J.W., Kennedy Jr. D.N., McKinstry R.C., Buchbinder B.R., Weisskoff R.M., Cohen M.S., Vevea J.M., Brady T.J., and Rosen B.R. Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254 (1991) 716-719
3. Blamire A.M., Ogawa S., Ugurbil K., Rothman D., McCarthy G., Ellermann J.M., Hyder F., Rattner Z., and Shulman R.G. Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 11069-11073
4. Buxton R.B., Wong E.C., and Frank L.R. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn. Reson. Med. 39 (1998) 855-864
5. Donahue M.J., Lu H., Jones C.K., Edden R.A., Pekar J.J., and van Zijl P.C. Theoretical and experimental investigation of the VASO contrast mechanism. Magn. Reson. Med. 56 (2006) 1261-1273
6. Frahm J., Bruhn H., Merboldt K.D., and Hänicke W. Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J. Magn. Reson. Imaging 2 (1992) 501-505
7. Frahm J., Krüger G., Merboldt K.D., and Kleinschmidt A. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magn. Reson. Med. 35 (1996) 143-148
8. Francis S.T., Pears J.A., Butterworth S., Bowtell R.W., and Gowland P.A. Measuring the change in CBV upon cortical activation with high temporal resolution using Look-Locker EPI and Gd-DTPA. Magn. Reson. Med. 50 (2003) 483-492
9. Frank J.A., Mattay V.S., Duyn J., Sobering G., Barrios F.A., Zigun J., Sexton R., Kwok P., Woo J., Moonen C., et al. Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentetate-dimeglumine-enhanced dynamic magnetic resonance imaging. Invest. Radiol. 29 Suppl 2 (1994) S157-S160
10. Hoge R.D., Atkinson J., Gill B., Crelier G.R., Marret S., and Pike G.B. Stimulus-dependent BOLD and perfusion dynamics in human V1. NeuroImage 9 (1999) 573-585
11. Jasdzewski G., Strangman G., Wagner J., Kwong K.K., Poldrack R.A., and Boas D.A. Differences in the hemodynamic response to event-related motor and visual paradigms as measured by near-infrared spectroscopy. NeuroImage 20 (2003) 479-488
12. Jones M., Berwick J., Johnston D., and Mayhew J. Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex. NeuroImage 13 (2001) 1002-1015
13. Jones M., Berwick J., and Mayhew J. Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex. NeuroImage 15 (2002) 474-487
14. Kastrup A., Krüger G., Neumann-Haefelin T., Glover G.H., and Moseley M.E. Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation. NeuroImage 15 (2002) 74-82
15. Kennan R.P., and Jäger H.R. T2- and T2*-w DCE-MRI: blood perfusion and volume estimation using bolus tracking. In: Tofts P. (Ed). Quantitative MRI of the Brain: Measuring Changes Caused by Disease (2003), John Wiley & Sons, Chichester 365-412
16. Kennan R.P., Scanley B.E., Innis R.B., and Gore J.C. Physiological basis for BOLD MR signal changes due to neuronal stimulation: separation of blood volume and magnetic susceptibility effects. Magn. Reson. Med. 40 (1998) 840-846
17. Kida I., Rothman D.L., and Hyder F. Dynamics of changes in blood flow, volume, and oxygenation: implications for dynamic functional magnetic resonance imaging calibration. J. Cereb. Blood Flow Metab. 27 (2007) 690-696
18. Kim T., Hendrich K.S., Masamoto K., and Kim S.G. Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI. J. Cereb. Blood Flow Metab. 27 (2007) 1235-1247
19. Krüger G., Kleinschmidt A., and Frahm J. Stimulus dependence of oxygenation-sensitive MRI responses to sustained visual activation. NMR Biomed. 11 (1998) 75-79
20. Krüger G., Kastrup A., Takahashi A., and Glover G.H. Simultaneous monitoring of dynamic changes in cerebral blood flow and oxygenation during sustained activation of the human visual cortex. NeuroReport 10 (1999) 2939-2943
21. Kwong K.K., Belliveau J.W., Chesler D.A., Goldberg I.E., Weisskoff R.M., Poncelet B.P., Kennedy D.N., Hoppel B.E., Cohen M.S., Turner R., et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 5675-5679
22. Leite F.P., Tsao D., Vanduffel W., Fize D., Sasaki Y., Wald L.L., Dale A.M., Kwong K.K., Orban G.A., Rosen B.R., Tootell R.B., and Mandeville J.B. Repeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 Tesla. NeuroImage 16 (2002) 283-294
23. Levin J.M., Kaufman M.J., Ross M.H., Mendelson J.H., Maas L.C., Cohen B.M., and Renshaw P.F. Sequential dynamic susceptibility contrast MR experiments in human brain: residual contrast agent effect, steady state, and hemodynamic perturbation. Magn. Reson. Med. 34 (1995) 655-663
24. Li T.Q., Haefelin T.N., Chan B., Kastrup A., Jonsson T., Glover G.H., and Moseley M.E. Assessment of hemodynamic response during focal neural activity in human using bolus tracking, arterial spin labeling and BOLD techniques. NeuroImage 12 (2000) 442-451
25. Lu H., Golay X., Pekar J.J., and Van Zijl P.C. Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn. Reson. Med. 50 (2003) 263-274
26. Lu H., Golay X., Pekar J.J., and Van Zijl P.C. Sustained poststimulus elevation in cerebral oxygen utilization after vascular recovery. J. Cereb. Blood Flow Metab. 24 (2004) 764-770
27. Mandeville J.B., Marota J.J., Kosofsky B.E., Keltner J.R., Weissleder R., Rosen B.R., and Weisskoff R.M. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn. Reson. Med. 39 (1998) 615-624
28. Mandeville J.B., Marota J.J., Ayata C., Moskowitz M.A., Weisskoff R.M., and Rosen B.R. MRI measurement of the temporal evolution of relative CMRO2 during rat forepaw stimulation. Magn. Reson. Med. 42 (1999) 944-951
29. Mandeville J.B., Marota J.J., Ayata C., Zaharchuk G., Moskowitz M.A., Rosen B.R., and Weisskoff R.M. Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J. Cereb. Blood Flow Metab. 19 (1999) 679-689
30. Martin C., Martindale J., Berwick J., and Mayhew J. Investigating neural-hemodynamic coupling and the hemodynamic response function in the awake rat. NeuroImage 32 (2006) 33-48
31. Moonen C.T., Barrios F.A., Zigun J.R., Gillen J., Liu G., Sobering G., Sexton R., Woo J., Frank J., and Weinberger D.R. Functional brain MR imaging based on bolus tracking with a fast T2*-sensitized gradient-echo method. Magn. Reson. Imaging 12 (1994) 379-385
32. Ogawa S., Lee T.M., Kay A.R., and Tank D.W. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 9868-9872
33. Ogawa S., Lee T.M., Nayak A.S., and Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn. Reson. Med. 14 (1990) 68-78
34. Ogawa S., Tank D.W., Menon R., Ellermann J.M., Kim S.G., Merkle H., and Ugurbil K. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 5951-5955
35. Poser B.A., and Norris D.G. Measurement of activation-related changes in cerebral blood volume: VASO with single-shot HASTE. Magn. Reson. Mater. Phys. 20 (2007) 63-67
36. Schroeter M.L., Kupka T., Mildner T., Uludag K., and von Cramon D.Y. Investigating the post-stimulus undershoot of the BOLD signal-a simultaneous fMRI and fNIRS study. NeuroImage 30 (2006) 349-358
37. Scouten A., and Constable R.T. Applications and limitations of whole-brain MAGIC VASO functional imaging. Magn. Reson. Med. 58 (2007) 306-315
38. Toronov V., Walker S., Gupta R., Choi J.H., Gratton E., Hueber D., and Webb A. The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal. NeuroImage 19 (2003) 1521-1531
39. Tuunanen P.I., Vidyasagar R., and Kauppinen R.A. Effects of mild hypoxic hypoxia on poststimulus undershoot of blood-oxygenation-level-dependent fMRI signal in the human visual cortex. Magn. Reson. Imaging 24 (2006) 993-999
40. Zigun J.R., Frank J.A., Barrios F.A., Jones D.W., Foo T.K., Moonen C.T., Press D.Z., and Weinberger D.R. Measurement of brain activity with bolus administration of contrast agent and gradient-echo MR imaging. Radiology 186 (1993) 353-356