Management of severe falciparum malaria

Journal of Postgraduate Medicine

Volumn 50, Issue 1, 2004, Pages 45-50

  Njuguna, P W ^a,b   Newton, Charles R J C ^a,b,c  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NONE   (Kenya)

Author keywords

Critical care; Intensive care; Plasmodium falciparum; Severe malaria

Indexed keywords

ANTICONVULSIVE AGENT; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISIN DERIVATIVE; ARTEMISININ DERIVATIVE; BENZODIAZEPINE; CINCHONA ALKALOID; CLINDAMYCIN; CLOMETHIAZOLE; DOPAMINE; DOXYCYCLINE; FANSIDAR; FOSPHENYTOIN SODIUM; GLUCOSE; HALOFANTRINE; IBUPROFEN; INOTROPIC AGENT; MANNITOL; MEFLOQUINE; PARACETAMOL; PHENOBARBITAL; PHENYTOIN; PYRIMETHAMINE; QUINIDINE; QUININE; SULFADOXINE; TETRACYCLINE; THIOPENTAL; UNINDEXED DRUG;

ACUTE KIDNEY FAILURE; AFRICA; AGE DISTRIBUTION; ANEMIA; ARTICLE; BACTERIAL INFECTION; BLOOD SMEAR; CARDIOTOXICITY; CAUSE OF DEATH; CLINICAL TRIAL; COGNITIVE DEFECT; CONVULSION; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG ERUPTION; DYSPHORIA; EARLY DIAGNOSIS; EXCHANGE BLOOD TRANSFUSION; GEOGRAPHIC DISTRIBUTION; HEARING IMPAIRMENT; HOSPITAL ADMISSION; HUMAN; HYPERLACTATEMIA; HYPOGLYCEMIA; HYPOVOLEMIA; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; LUNG EDEMA; MALARIA FALCIPARUM; METABOLIC ACIDOSIS; MORTALITY; NAUSEA; NEUROTOXICITY; PERITONEAL DIALYSIS; PLASMODIUM FALCIPARUM; RESPIRATORY DISTRESS; SEIZURE; SHOCK; TINNITUS; VOMITING;

ANTIMALARIALS; ARTEMISININS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALARIA, FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; QUININE; SESQUITERPENES;

EID: 1942504773     PISSN: 00223859     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans Roy Soc Trop Med Hyg 2000;94:S1-90.
2. Mohanty S, Mishra SK, Patti SS, Pattnaik J, Des BS. Complications and mortality patterns due to Plasmodium falciparum malaria in hospitalized adults and children, Rourkela, Orissa, India. Trans R Soc Trop Med Hyg 2003;97:69-70.
3. Phu NH, Hien TT, Mai NT, Chau TT, Chuong LV, Loc PP, et al. Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam. N Engl J Med 2002:347:895-902.
4. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, et al. Indicators of life-threatening malaria in African children. N Engl J Med 1995;332:1399-404.
5. White NJ. The management of severe falciparum malaria. Am J Respir Crit Care Med 2003;167:673-4.
6. Bruneel F, Hocqueloux L, Alberti C, Wolff M, Chevret S, Bedos JP, et al. The clinical spectrum of severe imported falciparum malaria in the intensive care unit: Report of 188 cases in adults. Am J Respir Crit Care Med 2003;167:684-9.
7. WHO. Management of severe malaria. 2nd ed. Geneva, World Health Organisation. 2000.
8. Newton CR, Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther 1998;79:1-53.
9. Krishna S, White NJ. Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications. Clin Pharmacokinet 1996;30:263-99.
10. White NJ, Looareesuwan S, Warrell DA, Warrell MJ, Chanthavanich P, Bunnag D, et al. Quinine loading dose in cerebral malaria. Am J Trop Med Hyg 1983;32:1-5.
11. Lesi A, Meremikwu M. High first dose quinine regimen for treating severe malaria. Cochrane Database Syst Rev 2002;3:CD003341.
12. Winstanley PA, Mberu EK, Watkins WM, Murphy SA, Lowe B, Marsh K. Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen. Trans R Soc Trop Med Hyg 1994;88:577-80.
13. Phillips RE, Warrell DA, White NJ, Looareesuwan S, Karbwang J. Intravenous quinidine for the treatment of severe falciparum malaria. Clinical and pharmacokinetic studies. N Engl J Med 1985;312:1273-8.
14. Pittler MH, Ernst E. Artemether for severe malaria: a meta-analysis of randomized clinical trials. Clin Infect Dis 1999;28:597-601.
15. Newton PN, Angus BJ, Chierakul W, Dondorp A, Ruangveerayuth R, Silamut K, et al. Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria. Clin Infect Dis 2003;37:7-16.
16. Hien TT, Turner GD, Mai NT, Phu NH, Bethell D, Blackmore WF, et al. Neuropathological assessment of artemether-treated severe malaria. Lancet 2003;362:295-6.
17. White NJ, Nosten F, Looareesuwan S, Watkins WM, Marsh K, Snow RW, et al. Averting a malaria disaster. Lancet 1999;353:1965-7.
18. Karbwang J, White NJ. Clinical pharmacokinetics of mefloquine. Clin Pharmacokinet 1990;19:264-79.
19. Berkley J, Mwarumba S, Bramham K, Lowe B, Marsh K. Bacteraemia complicating severe anaemia in children. Trans R Soc Trop Med Hyg 1999;93:283-6.
20. Berkley JA, Mwangi I, Mellington F, Mwarumba S, Marsh K. Cerebral malaria versus bacterial meningitis in children with impaired consciousness. QJM 1999;92:151-7.
21. Mturi N, Musumba CO, Wamola BM, Ogutu BR, Newton CR. Cerebral malaria: optimising management. CNS Drugs 2003;17:153-65.
22. White NJ, Looareesuwan S, Phillips RE, Chanthavanich P, Warrell DA. Single dose phenobarbitone prevents convulsions in cerebral malaria. Lancet 1988;2:64-6.
23. Crawley J, Waruiru C. Mithwani S, Mwangi I, Watkins W, Ouma D, et al. Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. Lancet 2000;355:701-6.
24. Ogutu BR, Newton CR, Muchohi SN, Otieno GO, Edwards G, Watkins WM, et al. Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with falciparum malaria and status epilepticus. Br J Clin Pharmacol 2003;56:112-9.
25. English M. Life-threatening severe malarial anaemia. Trans R Soc Trop Med Hyg 2000;94:586-8.
26. Looareesuwan S, Phillips RE, Karbwang J, White NJ, Flegg PJ, Warrell DA. Plasmodium falciparum hyperparasitaemia: use of exchange transfusion in seven patients and a review of the literature. Q J Med 1990;75:471-81.
27. Riddle MS, Jackson JL, Sanders JW, Blazes DL. Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis. Clin Infect Dis 2002;34:1192-8.
28. Trang TT, Phu NH, Vinh H, Hien TT, Cuong BM, Chau TT, et al. Acute renal failure in patients with severe falciparum malaria. Clin Infect Dis 1992:15:874-80.
29. Maitland K, Levin M, English M, Mithwani S, Peshu N, Marsh K, et al. Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia. QJM 2003;96:427-34.
30. Day NP, Phu NH, Bethell DP, Mai NT, Chau TT, Hien TT, et al. The effects of dopamine and adrenaline infusions on acid-base balance and systemic haemodynamics in severe infection. Lancet 1996;348:219-23.
31. Pukrittayakamee S, Davis TM, Levy J, Looareesuwan S, Roche RJ, Jeerawathanapun P, et al. The metabolic response to rapid intravenous glucose injection in acute falciparum malaria. Trans R Soc Trop Med Hyg 1991;85:189-93.
32. Newton CR, Kirkham FJ, Winstanley PA, Pasvol G, Peshu N, Warrell DA, et al. Intracranial pressure in African children with cerebral malaria. Lancet 1991;337:573-6.
33. Warrell DA, Looareesuwan S, Phillips RE, White NJ, Warrell MJ, Chapel HM, et al. Function of the blood-cerebrospinal fluid barrier in human cerebral malaria: rejection of the permeability hypothesis. Am J Trop Med Hyg 1986;35:882-9.
34. Patankar TF, Karnad DR, Shetty PG, Desai AP, Prasad SR. Adult cerebral malaria: prognostic importance of imaging findings and correlation with postmortem findings. Radiology 2002;224:811-6.
35. Newton CR, Crawley J, Sowumni A, Waruiru C, Mwangi I, English M, et al. Intracranial hypertension in Africans with cerebral malaria. Arch Dis Child 1997;76: 219-26.
36. Looareesuwan S, Wilairatans P, Krishna S, Kendall B, Vannaphan S, Viravan C, et al. Magnetic resonance imaging of the brain in patients with cerebral malaria. Clin Infect Dis 1995;21:300-9.
37. Meremikwu M, Logan K, Garner P. Antipyretic measures for treating fever in malaria. Cochrane Database Syst Rev 2000;2:CD002151.
38. Krishna S, Pukrittayakamee S, Supanaranond W, ter Kuile F, Ruprah M, Sure T, et al. Fever in uncomplicated Plasmodium falciparum malaria: randomized double-'blind' comparison of ibuprofen and paracetamol treatment. Trans R Soc Trop Med Hyg 1995:89:507-9.
39. Warrell DA, Looareesuwan S, Warrell MJ, Kasemsarn P, Intaraprasert R, Bunnag D, et al. Dexamethasone proves deleterious in cerebral malaria. A double-blind trial in 100 comatose patients. N Engl J Med 1982;306:313-9.