Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity

Pharmaceutical Research

Volumn 25, Issue 3, 2008, Pages 598-604

  Iwamoto, Takuya ^a   Hiraku, Yusuke ^b   Okuda, Masahiro ^a   Kawanishi, Shosuke ^b,c  

^a MIE UNIVERSITY HOSPITAL   (Japan)

^b MIE UNIVERSITY   (Japan)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Aryl radical; Carbene; Dacarbazine; DNA damage; Photogenotoxicity

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTINEOPLASTIC AGENT; CARBENE; CATALASE; CUPRIC ION; DACARBAZINE; DNA FRAGMENT; GUANINE; PHOSPHORUS 32; REACTIVE OXYGEN METABOLITE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; SPIN TRAPPING; THYMUS; ULTRAVIOLET IRRADIATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CATTLE; CHELATING AGENTS; COPPER; DACARBAZINE; DEOXYGUANOSINE; DNA; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; MOLECULAR STRUCTURE; MUTAGENS; NUCLEIC ACID CONFORMATION; PHENANTHROLINES; PHOTOCHEMISTRY; ULTRAVIOLET RAYS;

EID: 40549131631     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9413-2     Document Type: Article

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