Increase of virulence and its phenotypic traits in drug-resistant strains of Candida albicans

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 3, 2008, Pages 927-936

  Angiolella, Letizia ^a   Stringaro, Anna Rita ^b   De Bernardis, Flavia ^b   Posteraro, Brunella ^c   Bonito, Mariantonietta ^a   Toccacieli, Laura ^b   Torosantucci, Antonella ^b   Colone, Marisa ^b   Sanguinetti, Maurizio ^c   Cassone, Antonio ^b   Palamara, Anna Teresa ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; FLUCONAZOLE; MICAFUNGIN; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BIOFILM; CANDIDA ALBICANS; CELL WALL; DNA MODIFICATION; FEMALE; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS HYPHAE; GENE EXPRESSION; GENE MUTATION; IN VITRO STUDY; MORTALITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; VAGINITIS; VIRULENCE;

ANIMALS; ANTIFUNGAL AGENTS; BIOFILMS; CANDIDA ALBICANS; CANDIDIASIS; CANDIDIASIS, VULVOVAGINAL; CELL ADHESION; DRUG RESISTANCE, FUNGAL; ECHINOCANDINS; FEMALE; FLUCONAZOLE; FUNGAL PROTEINS; HOST-PATHOGEN INTERACTIONS; HUMANS; LIPOPROTEINS; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, SCANNING; PHENOTYPE; RATS; RATS, WISTAR; VIRULENCE;

EID: 40549118810     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01223-07     Document Type: Article

References (42)

1. Angiolella, L., B. Maras, A. R. Stringaro, G. Arancia, F. Mondello, A. Girolamo, A. T. Palamara, and A. Cassone. 2005. Glucan-associated protein modulations and ultrastructural changes of the cell wall in Candida albicans treated with micafungin, a water-soluble, lipopeptide antimycotic. J. Chemother. 17:409-416.
2. Balashov, S. V., S. Park, and D. S. Perlin. 2006. Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FSK1. Antimicrob. Agents Chemother. 50:2058-2063.
3. Bastert, J., M. Schaller, H. C. Korting, and E. G. V. Evans. 2001. Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts. Int. J. Antimicrob. Agents 17:81-89.
4. Calabrese, D., J. Bille, and D. Sanglard. 2000. A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole. Microbiology 146:2743-2754.
5. Calderone, R. A., and P. C. Braun. 1991. Adherence and receptor relationships of Candida albicans. Microbiol. Res. 55:1-20.
6. Cassone, A., A. Torosantucci, M. Boccanera, G. Pellegrini, C. Palma, and F. Malavasi. 1988. Production and characterization of a monoclonal antibody to a cell surface, glucomannoprotein constituents of Candida albicans and other pathogenic Candida species. J. Med. Microbiol. 27:233-238.
7. Cassone, A., F. De Bernardis, E. Pontieri, G. Carruba, C. Girmenia, P. Martino, M. Fernandez-Rodriguez, G. Quindos, and J. Ponton. 1995. Biotype diversity of Candida parapsilosis and its relationship to the clinical source and experimental pathogenicity. J. Infect. Dis. 171:967-975.
8. Chaffin, W. L., J. L. Lopez-Ribot, M. Casanova, D. Gozalbo, and J. P. Martinez. 1998. Cell wall and secreted proteins of Candida albicans. Identification, functions and expression. Microbiol. Mol. Biol. Rev. 62:130-180.
9. Cowen, L. E., L. M. Kohn, and J. B. Anderson. 2001. Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans. J. Bacteriol. 183:2971-2978.
10. Cowen, L. E., J. B. Anderson, and L. M. Kohn. 2002. Evolution of drug resistance in Candida albicans. Annu. Rev. Microbiol. 56:139-165.
11. Cowen, L. E., A. E. Carpenter, O. Matangkasombut, G. R. Fink, and S. Lindquist. 2006. Genetic architecture of Hsp90-dependent drug resistance. Eukaryot. Cell 5:2184-2188.
12. Cutler, J. E. 1991. Putative virulence factor of Candida albicans. Annu. Rev. Microbiol. 45:187-218.
13. De Bernardis, F., D. Adriani, R. Lorenzini, E. Pontieri, G. Carruba, and A. Cassone. 1993. Filamentous growth and elevated vaginopathic potential of a nongerminative variant of Candida albicans expressing low virulence in systemic infection. Infect. Immun. 61:1500-1508.
14. De Bernardis, F., R. Lorenzini, and A. Cassone. 1999. Rat model of Candida vaginal infection, p. 735-740. In Handbook of animal models of infection. Academic Press, New York, NY.
15. Dijkgraaf, G. J., M. Abe, Y. Ohyab, and H. Bussey. 2002. Mutations in FSK1p affect the cell wall content of beta-1,3- and beta-1,6-glucan in Saccharomyces cerevisiae. Yeast 15:671-690.
16. Dubois, M., K. A. Gilles, J. K. Hamilton, P. A. Rebers, and F. Smith. 1956. Colorimetric method for determination of sugars and related substances. Anal. Chem. 28:350-356.
17. Fekete-Forgacs, K., L. Gyure, and B. Lenkey. 2000. Changes of virulence factors accompanying the phenomenon of induced fluconazole resistance in Candida albicans. Mycoses 43:273-279.
18. Fleet, G. H., and D. J. Manners. 1976. Isolation and composition of an alkali-soluble glucan from the cell wall of Saccharomyces cerevisiae. J. Gen. Microbiol. 94:80-92.
19. Fleet, G. H., and D. J. Manners. 1977. The enzymatic degradation of an alkali-soluble glucan from the cell walls of Saccharomyces cerevisiae. J. Gen. Microbiol. 98:315-345.
20. Gow, N. A., A. J. Brown, and F. C. Odds. 2002. Fungal morphogenesis and host invasion. Curr. Opin. Microbiol. 5:366-371.
21. Jabra-Rizk, M. A., W. A. Falkler, Jr., W. G. Merz, A. A. M. A. Baqui, J. I. Kelley, and T. E. Meiller. 2001. Cell surface hydrophobicity- associated adherence of Candida dubliniensis to human buccal epithelial cells. Rev. Iberoam. Micol. 18:17-22.
22. Kelly, M. T., D. M. MacCallum, S. D. Clancy, F. C. Odds, A. J. P. Brown, and G. Butler. 2004. The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence. Mol. Microbiol. 53:969-983.
23. Kumamoto, C. A. 2002. Candida biofilms. Curr. Opin. Microbiol. 5:608-611.
24. Kurtz, M. B., G. Abruzzo, A. Flattery, K. Bartizal, J. A. Marrinan, W. Li, J. Milligan, K. Nollstadt, and C. M. Douglas. 1996. Characterization of echino-candin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies. Infect. Immun. 64:3244-3251.
25. Kurtz, M. B., and C. M. Douglas. 1997. Lipopeptide inhibitors of glucan synthase. J. Med. Vet. Mycol. 35:79-86.
26. Lo, H. J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90:939-949.
27. Martinez, M., J. L. López-Ribot, W. R. Kirkpatrick, B. J. Coco, S. P. Bachmann, and T. F. Pattersons. 2002. Replacement of Candida albicans and C. dubliniensis in human immunodeficiency virus-infected patients with oropharyngeal candidiasis treated with fluconazole. J. Clin. Microbiol. 40:3135-3139.
28. Martinez-Lopez, R., H. Park, C. L. Meyers, C. Gil, and S. G. Filler. 2006. Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cell. Eukaryot. Cell 5:140-147.
29. Meyerink, J., C. Mandingers, L. van de Locht, E. Tonnissen, F. Goodsaid, and J. Raemaekers. 2001. A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR. J. Mol. Diagn. 3:55-61.
30. Nett J., L. Lincoln, K. Marchillo, R. Massey, K. Holoyda, B. Hoff, M. VanHandel, and D. Andes. 2007. Putative role of β-1,3 glucans in Candida albicans biofilm resistance. Antimicrob. Agents Chemother. 51:510-520.
31. Perea, S., J. L. Lopez-Ribot, W. R. Kirkpatrick, R. K. McAtee, R. A Santillán, M. Martínez, D. Calabrese, D. Sanglard, and T. F. Patterson. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 45:2676-2684.
32. Perea, S., and T. F. Patterson. 2002. Antifungal resistance in pathogenic fungi. Clin. Infect. Dis. 35:1073-1080.
33. Pfaller, M. A., D. J. Diekema, R. N. Jones, H. S. Sader, A. C. Fluit, R. J. Hollis, S. A Messer, and the SENTRY Participant Group. 2001. International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J. Clin. Microbiol. 39:3254-3259.
34. Ramage, G., K. V. Walle, B. L. Wickes, and J. L. Lopez-Ribot. 2001. Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob. Agents Chemother. 45:2475-2479.
35. Reynolds, T. B., and G. R. Fink. 2001. Bakers' yeast, a model for fungal biofilm formation. Science 291:878-881.
36. Romani, L. 2004. Immunity to fungal infections. Nat. Rev. Immunol. 4:1-23.
37. Sandini, S., R. La Valle, F. De Bernardis, C. Macri, and A. Cassone. 2007. The 65 kDa mannoprotein gene of Candida albicans encodes a putative beta-glucanase adhesion required for hyphal morphogenesis and experimental pathogenicity. Cell. Microbiol. 9:1223-1238.
38. Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405-416.
39. Sanguinetti, M., B. Posteraro, B. Fiori, S. Ranno, R. Torelli, and G. Fadda. 2005. Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance. Antimicrob. Agents Chemother. 49:668-679.
40. Sanguinetti, M., B. Posteraro, M. La Sorda, R. Torelli, R. Santangelo, G. Delogu, and G. Fadda. 2006. Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans. Infect. Immun. 74:1352-1359.
41. Sudstrom, P. 2002. Adhesion in Candida spp. Cell. Microbiol. 4:461-469.
42. Sullivan, D. J., G. P. Moran, E. Pinjon, A. Al-Mosaid, C. Stokes, C. Vaughan, and D. Coleman. 2004. Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida dubliniensis and Candida albicans. FEMS Yeast Res. 4:369-376.