Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida dubliniensis and Candida albicans

FEMS Yeast Research

Volumn 4, Issue 4-5, 2004, Pages 369-376

  Sullivan, Derek J ^a   Moran, Gary P ^a   Pinjon, Emmanuelle ^a   Al Mosaid, Asmaa ^a   Stokes, Cheryl ^a   Vaughan, Claire ^a   Coleman, David C ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Candida albicans; Candida dubliniensis; Epidemiology; Resistance; Virulence

Indexed keywords

ANTIFUNGAL AGENT; FLUCONAZOLE; FUNGAL PROTEIN; HYDROGEN PEROXIDE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN CDR1P; PYRROLE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; CANDIDA ALBICANS; CANDIDA DUBLINIENSIS; CANDIDIASIS; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS IDENTIFICATION; FUNGUS ISOLATION; GENE OVEREXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; MOLECULAR DYNAMICS; MOUTH FLORA; NONHUMAN; OROPHARYNX; PREVALENCE; PROTEIN FUNCTION; SHORT SURVEY; SPECIES DIFFERENCE; STRESS; TEMPERATURE; THRUSH;

CANDIDA; CANDIDA ALBICANS; CANDIDA DUBLINIENSIS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0742269683     PISSN: 15671356     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-1356(03)00240-X     Document Type: Short Survey

References (63)

1. Krcmery V., Barnes A.J. Non-albicans Candida spp. causing fungaemia pathogenicity and antifungal resistance. J. Hosp. Infect. 50:2002;243-260.
2. Sullivan D.J., Westerneng T.J., Haynes K.A., Bennett D.E., Coleman D.C. Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology. 141:1995;1507-1521.
3. Gilfillan G.D., Sullivan D.J., Haynes K., Parkinson T., Coleman D.C., Gow N.A.R. Candida dubliniensis: phylogeny and putative virulence factors. Microbiology. 144:1998;829-838.
4. Donnelly S.A., Sullivan D.J., Shanley D.B., Coleman D.C. Phylogenetic analysis and rapid identification of Candida dubliniensis based on analysis of ACT1 intron and exon sequences. Microbiology. 145:1999;1871-1882.
5. Moran G.P., Sanglard D., Donnelly S.M., Shanley D.B., Sullivan D.J., Coleman D.C. Identification and expression of multidrug transporters responsible for fluconazole resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 42:1998;1819-1830.
6. Moran G., Sullivan D., Morrschhaüser J., Coleman D. The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance. Antimicrob. Agents Chemother. 46:2002;2829-2941.
7. Pinjon E., Moran G.P., Jackson C.J., Kelly S.L., Sanglard D., Coleman D.C., Sullivan D.J. Molecular mechanisms of itraconazole resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 47:2003;2424-2437.
8. Sullivan D., Coleman D. Candida dubliniensis: an emerging opportunistic pathogen. Curr. Top. Med. Mycol. 8:1997;15-25.
9. Sullivan D., Coleman D. Candida dubliniensis: characteristics and identification. J. Clin. Microbiol. 36:1998;329-334.
10. Sullivan D.J., Moran G., Donnelly S., Gee S., Pinjon E., McCarton B., Shanley D.B., Coleman D.C. Candida dubliniensis: an update. Rev. Iberoam. Micol. 16:1999;72-76.
11. Al-Mosaid A., Sullivan D.J., Coleman D.C. Differentiation of Candida dubliniensis from Candida albicans on Pal's Agar. J. Clin. Microbiol. 41:2003;4787-4789.
12. Park S., Wong M., Marras S.A., Cross E.W., Kiehn T.E., Chaturvedi V., Tyagi S., Perlin D.S. Rapid identification of Candida dubliniensis using a species-specific molecular beacon. J. Clin. Microbiol. 38:2000;2829-2836.
13. Selvarangan R., Limaye A.P., Cookson B.T. Rapid identification and differentiation of Candida albicans and Candida dubliniensis by capillary-based amplification and fluorescent probe hybridization. J. Clin. Microbiol. 40:2002;4308-4312.
14. Tamura M., Watanabe K., Imai T., Mikami Y., Nishimura K. New PCR primer pairs specific for Candida dubliniensis and detection of the fungi from the Candida albicans clinical isolates in Japan. Clin. Lab. 46:2000;33-40.
15. Kurzai O., Heinz W.J., Sullivan D.J., Coleman D.C., Frosch M., Muhlschlegel F.A. Rapid PCR test for discriminating between Candida albicans and Candida dubliniensis isolates using primers derived from the pH-regulated PHR1 and PHR2 genes of C. albicans. J. Clin. Microbiol. 37:1999;1587-1590.
16. Elie C.M., Lott T.J., Reiss E., Morrison C.J. Rapid identification of Candida species with species-specific DNA probes. J. Clin. Microbiol. 36:1998;3260-3265.
17. Joly S., Pujol C., Rysz M., Vargas K., Soll D.R. Development and characterization of complex DNA fingerprinting probes for the infectious yeast Candida dubliniensis. J. Clin. Microbiol. 37:1999;1035-1044.
18. Gee S.F., Joly S., Soll D.R., Meis J.F., Verweij P.E., Polacheck I., Sullivan D.J., Coleman D.C. Identification of four distinct genotypes of Candida dubliniensis and detection of microevolution in vitro and in vivo. J. Clin. Microbiol. 40:2002;556-574.
19. Joly S., Pujol C., Soll D.R. Microevolutionary changes and chromosomal translocations are more frequent at RPS loci in Candida dubliniensis than in Candida albicans. Infect. Genet. Evol. 2:2002;19-37.
20. Polacheck I., Strahilevitz J., Sullivan D., Donnelly S., Salkin I.F., Coleman D.C. Recovery of Candida dubliniensis from non-human immunodeficiency virus-infected patients in Israel. J. Clin. Microbiol. 38:2000;170-174.
21. Sullivan D., Haynes K., Bille J., Boerlin P., Rodero L., Lloyd S., Henman M., Coleman D. Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals. J. Clin. Microbiol. 35:1997;960-964.
22. Kamei K., McCullough M.J., Stevens D.A. Initial case of Candida dubliniensis infection from Asia: non-mucosal infection. Med. Mycol. 38:2000;81-83.
23. Fisher J.M., Basson N.J., van Zyl A. Identification of Candida dubliniensis in a HIV-positive South African population. S. Afr. Dent. J. 56:2001;599-601.
24. Ponton J., Ruchel R., Clemons K.V., Coleman D.C., Grillot R., Guarro J., Aldebert D., Ambroise-Thomas P., Cano J., Carrillo-Munoz A.J., Gene J., Pinel C., Stevens D.A., Sullivan D.J. Emerging pathogens. Med. Mycol. 38:(Suppl. 1):2000;225-236.
25. Tintelnot K., Haase G., Seibold M., Bergmann F., Staemmler M., Franz T., Naumann D. Evaluation of phenotypic markers for selection and identification of Candida dubliniensis. J. Clin. Microbiol. 38:2000;1599-1608.
26. Lasker B.A., Elie C.M., Lott T.J., Espinel-Ingroff A., Gallagher L., Kuykendall R.J., Kellum M.E., Pruitt W.R., Warnock D.W., Rimland D., McNeil M.M., Reiss E. Molecular epidemiology of Candida albicans strains isolated from the oropharynx of HIV-positive patients at successive clinic visits. Med. Mycol. 39:2001;341-352.
27. Meiller T.F., Jabra-Rizk M.A., Baqui A., Kelley J.I., Meeks V.I., Merz W.G., Falkler W.A. Oral Candida dubliniensis as a clinically important species in HIV-seropositive patients in the United States. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 88:1999;573-580.
28. Vargas K.G., Joly S. Carriage frequency, intensity of carriage, and strains of oral yeast species vary in the progression to oral candidiasis in human immunodeficiency virus-positive individuals. J. Clin. Microbiol. 40:2002;341-350.
29. Blignaut E., Pujol C., Joly S., Soll D.R. Racial distribution of Candida dubliniensis colonization among South Africans. J. Clin. Microbiol. 41:2003;1838-1842.
30. Willis A.M., Coulter W.A., Sullivan D.J., Coleman D.C., Hayes J.R., Bell P.M., Lamey P.J. Isolation of C. dubliniensis from insulin-using diabetes mellitus patients. J. Oral Pathol. Med. 29:2000;86-90.
31. Peltroche-Llacsahuanga H., Dohmen H., Haase G. Recovery of Candida dubliniensis from sputum of cystic fibrosis patients. Mycoses. 45:2002;15-18.
32. Gottlieb G.S., Limaye A.P., Chen Y.C., Van Voorhis W.C. Candida dubliniensis fungemia in a solid organ transplant patient: case report and review of the literature. Med. Mycol. 39:2001;483-485.
33. Meis J.F., Ruhnke M., De Pauw B.E., Odds F.C., Siegert W., Verweij P.E. Candida dubliniensis candidemia in patients with chemotherapy-induced neutropenia and bone marrow transplantation. Emerg. Infect. Dis. 5:1999;150-153.
34. Sebti A., Kiehn T.E., Perlin D., Chaturvedi V., Wong M., Doney A., Park S., Sepkowitz K.A. Candida dubliniensis at a cancer center. Clin. Infect. Dis. 32:2001;1034-1038.
35. Brandt M.E., Harrison L.H., Pass M., Sofair A.N., Huie S., Li R.K., Morrison C.J., Warnock D.W., Hajjeh R.A. Candida dubliniensis fungemia: the first four cases in North America. Emerg. Infect. Dis. 6:2000;46-49.
36. Kibbler C.C., Ainscough S., Barnes R.A., Gransden W.R., Holliman R.E., Johnson E.M., Perry J.D., Sullivan D.J., Wilson J.A. Management and outcome of blood stream infections due to Candida species in England and Wales. J. Hosp. Infect. 54:2003;18-24.
37. Odds F.C., Van Nuffel L., Dams G. Prevalence of Candida dubliniensis isolates in a yeast stock collection. J. Clin. Microbiol. 36:1998;2869-2873.
38. Martins-Nishikawa M., Trilles L., Symoens F., Swinne D., Nolard N. Prevalence of Candida dubliniensis in the BCCM/IHEM Biomedical Fungi/Yeasts culture collection (isolates before 1990). Med. Mycol. 40:2002;443-445.
39. Martinez M., Lopez-Ribot J.L., Kirkpatrick W.R., Coco B.J., Bachmann S.P., Patterson T.F. Replacement of Candida albicans with C. dubliniensis in human immunodeficiency virus-infected patients with oropharyngeal candidiasis treated with fluconazole. J. Clin. Microbiol. 40:2002;3135-3139.
40. Moran G.P., Sullivan D.J., Henman M.C., McCreary C.E., Harrington B.J., Shanley D.B., Coleman D.C. Antifungal drug susceptibilities of oral Candida dubliniensis isolates from human immunodeficiency virus (HIV)-infected and non-HIV-infected subjects and generation of stable fluconazole-resistant derivatives in vitro. Antimicrob. Agents Chemother. 41:1997;617-623.
41. Pfaller M.A., Messer S.A., Gee S., Joly S., Pujol C., Sullivan D.J., Coleman D.C., Soll D.R. In vitro susceptibilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents. J. Clin. Microbiol. 37:1999;870-872.
42. Perea S., Perea S., Lopez-Ribot J.L., Wickes B.L., Kirkpatrick W.R., Dib O.P., Bachmann S.P., Keller S.M., Martinez M., Patterson T.F. Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from Human Immunodeficiency Virus-infected patients with oropharyngeal candidiasis. Antimicrob. Agents Chemother. 46:2002;1695-1703.
43. Ruhnke M., Schmidt-Westhausen A., Morschhaüser J. Development of simultaneous resistance to fluconazole in Candida albicans and Candida dubliniensis in a patient with AIDS. J. Antimicrob. Chemother. 46:2000;291-295.
44. Borg-Von Zepelin M., Niederhaus T., Gross U., Seibold M., Monod M., Tintelnot K. Adherence of different Candida dubliniensis isolates in the presence of fluconazole. AIDS. 16:2002;1237-1244.
45. Wirsching S., Moran G.P., Sullivan D.J., Coleman D.C., Morschhauser J. MDR1-mediated drug resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 45:2001;3416-3421.
46. Miyazaki Y., Geber A., Miyazaki H., Falconer D., Parkinson T., Hitchock C., Grimberg B., Nyswaner K., Bennett J.E. Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans. Gene. 236:1999;43-51.
47. Vilela M.M., Kamei K., Sano A., Tanaka R., Uno J., Takahashi I., Ito J., Yarita K., Miyaji M. Pathogenicity and virulence of Candida dubliniensis: comparison with C. albicans. Med. Mycol. 40:2002;249-257.
48. McCullough M., Ross B., Reade P. Characterization of genetically distinct subgroup of Candida albicans strains from oral cavities of patients infected with human immunodeficiency virus. J. Clin. Microbiol. 33:1995;696-700.
49. Jabra-Rizk M.A., Falkler W.A., Merz W.G., Baqui A.A.M.A., Kelley J.I., Meiller T.F. Cell surface hydrophobicity-associated adherence of Candida dubliniensis to human buccal epithelial cells. Rev. Iberoam. Micol. 18:2001;17-22.
50. Hazen K.C., Wu J.G., Masuoka J. Comparison of the hydrophobic properties of Candida albicans and Candida dubliniensis. Infect. Immun. 69:2001;779-786.
51. Hazen K.C., Glee P.M. Cell surface hydrophobicity and medically important fungi. Curr. Top. Med. Mycol. 6:1995;1-31.
52. Peltroche-Llacsahuanga H., Schnitzler N., Schmidt S., Tintelnot K., Lutticken R., Haase G. Phagocytosis, oxidative burst, and killing of Candida dubliniensis and Candida albicans by human neutrophils. FEMS Microbiol. Lett. 191:2000;151-155.
53. de Repentigny L., Aumont F., Bernard K., Belhumeur P. Characterization of binding of Candida albicans to small intestinal mucin and its role in adherence to mucosal epithelial cells. Infect. Immun. 68:2000;3172-3179.
54. Hoyer L.L., Fundyga R., Hecht J.E., Kapteyn J.C., Klis F.M., Arnold J. Characterization of agglutinin-like sequence genes from non-albicans Candida and phylogenetic analysis of the ALS family. Genetics. 157:2001;1555-1567.
55. Hannula J., Saarela M., Dogan B., Paatsama J., Koukila-Kahkola P., Pirinen S., Alakomi H.L., Perheentupa J., Asikainen S. Comparison of virulence factors of oral Candida dubliniensis and Candida albicans isolates in healthy people and patients with chronic candidosis. Oral Microbiol. Immunol. 15:2000;238-244.
56. Slifkin M. Tween 80 opacity test responses of various Candida species. J. Clin. Microbiol. 38:2000;4626-4628.
57. Ramage G., Vande Walle K., Wickes B.L., Lopez-Ribot J.L. Biofilm formation by Candida dubliniensis. J. Clin. Microbiol. 39:2001;3234-3240.
58. Kirkpatrick W.R., Lopez-Ribot J.L., McAtee R.K., Patterson T.F. Growth competition between Candida dubliniensis and Candida albicans under broth and biofilm growing conditions. J. Clin. Microbiol. 38:2000;902-904.
59. Pinjon E., Sullivan D., Salkin I., Shanley D., Coleman D. Simple, inexpensive, reliable method for differentiation of Candida dubliniensis from Candida albicans. J. Clin. Microbiol. 36:1998;2093-2095.
60. Alves S.H., Milan E.P., de Laet Sant'Ana P., Oliveira L.O., Santurio J.M., Colombo A.L. Hypertonic Sabouraud broth as a simple and powerful test for Candida dubliniensis screening. Diagn. Microbiol. Infect. Dis. 43:2002;85-86.
61. Martins M.D., Lozano-Chiu M., Rex J.H. Declining rates of oropharyngeal candidiasis and carriage of Candida albicans associated with trends toward reduced rates of carriage of fluconazole-resistant C. albicans in human immunodeficiency virus-infected patients. Clin. Infect. Dis. 27:1998;1291-1294.
62. Pincus D.H., Coleman D.C., Pruitt W.R., Padhye A.A., Salkin I.F., Geimer M., Bassel A., Sullivan D.J., Clarke M., Hearn V. Rapid identification of Candida dubliniensis with commercial yeast identification systems. J. Clin. Microbiol. 37:1999;3533-3539.
63. Coleman D., Sullivan D., Harrington B., Haynes K., Henman M., Shanley D., Bennett D., Moran G., McCreary C., O'Neill L. Molecular and phenotypic analysis of Candida dubliniensis: a recently identified species linked with oral candidosis in HIV-infected and AIDS patients. Oral Dis. 3:(Suppl. 1):1997;S96-S101.