The 65 kDa mannoprotein gene of Candida albicans encodes a putative β-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity

Cellular Microbiology

Volumn 9, Issue 5, 2007, Pages 1223-1238

  Sandini, Silvia ^a   La Valle, Roberto ^a   De Bernardis, Flavia ^a   Macrì, Caterina ^a   Cassone, Antonio ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; BETA GLUCAN HYDROLASE; MANNOPROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL ADHESION; CONTROLLED STUDY; FUNGAL MORPHOLOGY; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS HYPHAE; FUNGUS MUTANT; HETEROZYGOTE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CANDIDA ALBICANS; CANDIDIASIS; FEMALE; FUNGAL PROTEINS; HOMOZYGOTE; HYPHAE; MEMBRANE GLYCOPROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR WEIGHT; MORPHOGENESIS; MUTATION; POLYMERASE CHAIN REACTION; RATS; VAGINA; VIRULENCE;

CANDIDA ALBICANS; FUNGI;

EID: 34047250154     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2006.00862.x     Document Type: Article

References (57)

1. Ausubel, F.M., Brent, R., Kigston, R.E., Moore, D.D., Seidam, J.G., Smith, J.A., and Struhl, K. (1997) Current Protocols in Molecular Biology. Chichester: Wiley.
2. Brand, A., MacCallum, D.M., Brown, A.J., Gow, N.A., and Odds, F.C. (2004) Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryot Cell 3: 900-909.
3. Bromuro, C., Torosantucci, A., Gomez, M.J., Urbani, F., and Cassone, A. (1994) Differential release of an immunodominant 65 kDa mannoprotein antigen from yeast and mycelial forms of Candida albicans. J Med Vet Mycol 32: 447-459.
4. Bromuro, C., La Valle, R., Sandini, S., Urbani, F., Ausiello, C.M., Morelli, L., et al. (1998) A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis. Infect Immun 66: 2154-2162.
5. Bromuro, C., Torosantucci, A., Chiani, P., Conti, S., Polonelli, L., and Cassone, A. (2002) Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine. Infect Immun 70: 5462-5470.
6. Brown, G.D., Herre, J., Williams, D.L., Willment, J.A., Marshall, A.S., and Gordon, S. (2003) Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 197: 1119-1124.
7. Calderone, R.A., and Fonzi, W.A. (2001) Virulence factors of Candida albicans. Trends Microbiol 9: 327-335.
8. Calderone, R., Suzuki, S., Cannon, R., Cho, T., Boyd, D., Calera, J., et al. (2000) Candida albicans: Adherence, signaling and virulence. Med Mycol 38 (Suppl. 1): 125-137.
9. Cassone, A. (1989) Cell wall of Candida albicans: Its functions and its impact on the host. Curr Top Med Mycol 3: 248-314.
10. Cassone, A., Torosantucci, A., Boccanera, M., Pellegrini, G., Palma, C., and Malavasi, F. (1988) Production and characterisation of a monoclonal antibody to a cell-surface, glucomannoprotein constituent of Candida albicans and other pathogenic Candida species. J Med Microbiol 27: 233-238.
11. Cassone, A., De Bernardis, F., Ausiello, C.M., Gomez, M.J., Boccanera, M., La Valle, R., and Torosantucci, A. (1998) Immunogenic and protective Candida albicans constituents. Res Immunol 149: 289-299. discussion 504.
12. Cheng, S., Clancy, C.J., Checkley, M.A., Handfield, M., Hillman, J.D., Progulske-Fox, A., et al. (2003) Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Mol Microbiol 48: 1275-1288.
13. Cutler, J.E. (1991) Putative virulence factors of Candida albicans. Annu Rev Microbiol 45: 187-218.
14. Davis, D., Edwards, J.E., Jr, Mitchell, A.P., and Ibrahim, A.S. (2000) Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect Immun 68: 5953-5959.
15. De Bernardis, F., Adriani, D., Lorenzini, R., Pontieri, E., Carruba, G., and Cassone, A. (1993) Filamentous growth and elevated vaginopathic potential of a nongerminative variant of Candida albicans expressing low virulence in systemic infection. Infect Immun 61: 1500-1508.
16. De Bernardis, F., Lorenzini, R., and Cassone, A. (1999) Rat model of Candida vaginal infection. In Handbook of Animal Models of Infection. Zack, O., and Sande, M. (eds). London: Academic Press, pp. 735-740.
17. De Bernardis, F., Sullivan, P.A., and Cassone, A. (2001) Aspartyl proteinases of Candida albicans and their role in pathogenicity. Med Mycol 39: 303-313.
18. De Bernardis, F., Liu, H., O'Mahony, R., La Valle, R., Bartollino, S., Sandini, S., et al. (2007) Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. J Infect Dis 195: 149-157.
19. Fidel, P.L., Jr, and Sobel, J.D. (1996) Immunopathogenesis of recurrent vulvovaginal candidiasis. Clin Microbiol Rev 9: 335-348.
20. Fonzi, W.A., and Irwin, M.Y. (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728.
21. Gale, C.A., Bendel, C.M., McClellan, M., Hauser, M., Becker, J.M., Berman, J., and Hostetter, M.K. (1998) Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science 279: 1355-1358.
22. Gantner, B.N., Simmons, R.M., and Underhill, D.M. (2005) Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 24: 1277-1286.
23. Ghannoum, M., and Abu Elteen, K. (1986) Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans. J Med Vet Mycol 24: 407-413.
24. Gomez, M.J., Torosantucci, A., Arancia, S., Maras, B., Parisi, L., and Cassone, A. (1996) Purification and biochemical characterization of a 65-kilodalton mannoprotein (MP65), a main target of anti- Candida cell-mediated immune responses in humans. Infect Immun 64: 2577-2584.
25. Gomez, M.J., Maras, B., Barca, A., La Valle, R., Barra, D., and Cassone, A. (2000) Biochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicans. Infect Immun 68: 694-701.
26. de Groot, P.W., de Boer, A.D., Cunningham, J., Dekker, H.L., de Jong, L., Hellingwerf, K.J., et al. (2004) Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins. Eukaryot Cell 3: 955-965.
27. Hube, B., Sanglard, D., Odds, F.C., Hess, D., Monod, M., Schafer, W., et al. (1997) Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect Immun 65: 3529-3538.
28. Klis, F.M., Boorsma, A., and De Groot, P.W. (2006) Cell wall construction in Saccharomyces cerevisiae. Yeast 23: 185-202.
29. La Valle, R., Bromuro, C., Ranucci, L., Muller, H.M., Crisanti, A., and Cassone, A. (1995) Molecular cloning and expression of a 70-kilodalton heat shock protein of Candida albicans. Infect Immun 63: 4039-4045.
30. La Valle, R., Sandini, S., Gomez, M.J., Mondello, F., Romagnoli, G., Nisini, R., and Cassone, A. (2000) Generation of a recombinant 65-kilodalton mannoprotein, a major antigen target of cell-mediated immune response to Candida albicans. Infect Immun 68: 6777-6784.
31. Leidich, S.D., Ibrahim, A.S., Fu, Y., Koul, A., Jessup, C., Vitullo, J., et al. (1998) Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans. J Biol Chem 273: 26078-26086.
32. Liu, H., Kohler, J., and Fink, G.R. (1994) Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726.
33. Lo, H.J., Kohler, J.R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., and Fink, G.R. (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
34. Mansour, M.K., and Levitz, S.M. (2003) Fungal mannoproteins: The sweet path to immunodominance. ASM News 69: 595-600.
35. Mencacci, A., Torosantucci, A., Spaccapelo, R., Romani, L., Bistoni, F., and Cassone, A. (1994) A mannoprotein constituent of Candida albicans that elicits different levels of delayed-type hypersensitivity, cytokine production, and anticandidal protection in mice. Infect Immun 62: 5353-5360.
36. Murad, A.M., Lee, P.R., Broadbent, I.D., Barelle, C.J., and Brown, A.J. (2000) CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16: 325-327.
37. Murad, A.M., Leng, P., Straffon, M., Wishart, J., Macaskill, S., MacCallum, D., et al. (2001) NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J 20: 4742-4752.
38. Nisini, R., Romagnoli, G., Gomez, M.J., La Valle, R., Torosantucci, A., Mariotti, S., et al. (2001) Antigenic properties and processing requirements of 65-kilodalton mannoprotein, a major antigen target of anti- Candida human T-cell response, as disclosed by specific human T-cell clones. Infect Immun 69: 3728-3736.
39. d'Ostiani, C.F., Del Sero, G., Bacci, A., Montagnoli, C., Spreca, A., Mencacci, A., et al. (2000) Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med 191: 1661-1674.
40. Pfaller, M.A., Jones, R.N., Doern, G.V., Sader, H.S., Hollis, R.J., and Messer, S.A. (1998) International surveillance of bloodstream infections due to Candida species: Frequency of occurrence and antifungal susceptibilities of isolates collected in 1997 in the United States, Canada, and South America for the SENTRY Program. The SENTRY Participant Group. J Clin Microbiol 36: 1886-1889.
41. Porta, A., Ramon, A.M., and Fonzi, W.A. (1999) PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicans. J Bacteriol 181: 7516-7523.
42. Romani, L. (1997) The T cell response against fungal infections. Curr Opin Immunol 9: 484-490.
43. Sandini, S., Melchionna, R., Arancia, S., Gomez, M.J., and La Valle, R. (1999) Generation of a highly immunogenic recombinant enolase of the human opportunistic pathogen Candida albicans. Biotechnol Appl Biochem 29 (Part 3): 223-227.
44. Sandini, S., d'Abusco, A.S., La Valle, R., and Pantosti, A. (2001) Production of a mouse antiserum to Bacteroides fragilis enterotoxin using a recombinant enterotoxin precursor. Clin Diagn Lab Immunol 8: 190-191.
45. Sandini, S., Melchionna, R., Bromuro, C., and La Valle, R. (2002) Gene expression of 70 kDa heat shock protein of Candida albicans: transcriptional activation and response to heat shock. Med Mycol 40: 471-478.
46. Sanglard, D., Hube, B., Monod, M., Odds, F.C., and Gow, N.A. (1997) A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Infect Immun 65: 3539-3546.
47. Saporito-Irwin, S.M., Birse, C.E., Sypherd, P.S., and Fonzi, W.A. (1995) PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis. Mol Cell Biol 15: 601-613.
48. Sestak, S., Hagen, I., Tanner, W., and Strahl, S. (2004) Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae. Microbiology 150: 3197-3208.
49. Sharkey, L.L., McNemar, M.D., Saporito-Irwin, S.M., Sypherd, P.S., and Fonzi, W.A. (1999) HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J Bacteriol 181: 5273-5279.
50. Soll, D.R. (2004) Mating-type locus homozygosis, phenotypic switching and mating: A unique sequence of dependencies in Candida albicans. Bioessays 26: 10-20.
51. Stoldt, V.R., Sonneborn, A., Leuker, C.E., and Ernst, J.F. (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16: 1982-1991.
52. Sugiyama, Y., Nakashima, S., Mirbod, F., Kanoh, H., Kitajima, Y., Ghannoum, M.A., and Nozawa, Y. (1999) Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans. Med Mycol 37: 61-67.
53. Sundstrom, P. (2002) Adhesion in Candida spp. Cell Microbiol 4: 461-469.
54. Torosantucci, A., Gomez, M.J., Bromuro, C., Casalinuovo, I., and Cassone, A. (1991) Biochemical and antigenic characterization of mannoprotein constituents released from yeast and mycelial forms of Candida albicans. J Med Vet Mycol 29: 361-372.
55. Torosantucci, A., Romagnoli, G., Chiani, P., Stringaro, A., Crateri, P., Mariotti, S., et al. (2004) Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: A novel dimorphism-dependent mechanism to escape the host's immune response. Infect Immun 72: 833-843.
56. Tsuchimori, N., Sharkey, L.L., Fonzi, W.A., French, S.W., Edwards, J.E., Jr, and Filler, S.G. (2000) Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells. Infect Immun 68: 1997-2002.
57. Yuan, R., Casadevall, A., Spira, G., and Scharff, M.D. (1995) Isotype switching from IgG3 to IgG1 converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody. J Immunol 154: 1810-1816.