The role of potassium ion channels in cough and other reflexes of the airways

Journal of Physiology and Pharmacology

Volumn 58, Issue SUPPL. 5, 2007, Pages 673-683

  Sutovska, Martina ^a   Nosalova, G ^a   Franova, S ^a  

^a University Hospital in Martin   (Slovakia)

Author keywords

Airways; Cough; Pinacidil; Potassium channels; Sensory nerves

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); CITRIC ACID; GLIBENCLAMIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; PINACIDIL; POTASSIUM CHANNEL; TETRYLAMMONIUM;

AIRWAY DYNAMICS; AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COUGHING; DRUG MECHANISM; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MUSCLE CONTRACTION; NONHUMAN; SMOOTH MUSCLE;

ACETYLCHOLINE; AEROSOLS; AIRWAY RESISTANCE; ANIMALS; BENZIMIDAZOLES; CITRIC ACID; COUGH; GLYBURIDE; GUINEA PIGS; HISTAMINE; KATP CHANNELS; MUSCLE, SMOOTH; PINACIDIL; PLETHYSMOGRAPHY; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; REFLEX; RESPIRATORY MECHANICS; RESPIRATORY MUSCLES; RESPIRATORY PHYSIOLOGY; VASODILATOR AGENTS;

EID: 40449134973     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Thorneloe KS, Nelson MT. Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Can J Physiol Pharmacol 2005; 83: 215-242.
2. Rodrigo GC, Standen NB. ATP-sensitive potassium channels. Curr Pharm Des 2005; 11: 1915-1940.
3. Nielsen-Kudsk JE. Potassium channel modulation: a new drug principle for regulation of smooth muscle contractility. Studies on isolated airways and arteries. Dan Med Bull 1996; 43: 429-447.
4. Fabiani ME, Vlahos R, Story DF. Epithelium-dependent inhibition of cholinergic transmission in rat isolated trachea by potassium channel openers. Pharmacol Res 1996; 33: 261-272.
5. + channels in the anti-tussive effect of moguisteine. Eur J Pharmacol 2000; 395: 161-164.
6. Zhu FX, Zhang XY, Olszewski MA, Robinson NE. Mechanism of capsaicin-induced relaxation in equine tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol 1997; 273: 997-1001.
7. Fox AJ, Barnes PJ, Venkatesan P, Belvisi MG. Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. J Clin Invest 1997; 99: 513-519.
8. Patel HJ, Giemgycz MA, Keeling JE, Barnes PJ, Belvisi MG. Inhibition of cholinergic neurotransmission in guinea pig trachea by NS1619, a putative activator of large-conductance, calcium-activated potassium channels. J Pharmacol Exp Ther 1998; 286: 952-958.
9. Pennock BE, Cox CP, Rogers RM, Cain WA, Wells JH. A noninvasive technique for measurement of changes in specific airway resistance. J Appl Physiol 1979; 46: 399-406.
10. Tohda Y, Muraki M, Ywanaga T, Haraguchi R, Fukuoka M, Nakajima S. Dual-phase response model for bronchial asthma. Allergy Asthma Proc 2000; 21: 79-84.
11. Morita K, Onodera K, Kamei J. Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs. Jpn J Pharmacol 2002; 89: 171-175.
12. Karlsson JA, Sant' Ambrogio G, Widdicombe J. Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol 1988; 65: 1007-1023.
13. Stretton D, Miura M, Belvisi MG, Barnes PJ. Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc Natl Acad Sci USA 1992; 89: 1325-1329.
14. Fozard JR, Manley PW. Potassium channel openers: Agents for the treatment of airway hyperreactivity. In New Dmgs for Asthma, Allergy and COPD, TT Hansel, PJ Barnes (eds). Basel, Prog Respir Res, Karger, 2001, 31: 77-80.
15. + channel openers. Eur J Pharmacol 1999; 371: 39-42.
16. Widdicombe J. Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs). Anat Rec A Discov Mol Cell Evol Biol 2003; 270: 2-10.
17. Song P, Rocchi D, Lazzarotti M, Crimi E, Rehder K, Brusasco V. Postjunctional effect of pinacidil on contractility of isolated bovine trachealis. Eur Respir J 1996; 9: 2057-2063.
18. + channels and sodium pump in the vasodilation induced by acetylcholine, nitric oxide, and cyclic GMP in the rabbit aorta. Gen Pharmacol 1999; 33: 35-41.
19. Garry A, Sigaudo-Roussel D, Merzeau S, Dumont O, Saumet JL, Fromy B. Cellular mechanisms underlying cutaneous pressure-induced vasodilation: in vivo involvement of potassium channels. Am J Physiol Heart Circ Physiol 2005; 289: H174-H180.
20. Buchheit KH, Hofmann A, Pfannkuche HJ. In vitro and in vivo effects of SCA 40 on guinea pig airways. Naunyn Schmiedebergs Arch Pharmacol 1997; 355: 217-223.
21. + channel blockers on beta-adrenergic- and NO-donor-mediated relaxations of human and guinea-pig airway smooth muscles. Naunyn Schmiedebergs Arch Pharmacol 1998; 357: 77-86.
22. 2+. Am J Physiol Lung Cell Mol Physiol 2000; 278: L899-905.
23. + channel. Exp Physiol 1999; 84: 835-846.