Epithelium-dependent inhibition of cholinergic transmission in rat isolated trachea by potassium channel openers

Pharmacological Research

Volumn 33, Issue 4-5, 1996, Pages 261-272

  Fabiani, Maurizio E ^a   Vlahos, Ross ^a   Story, David F ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Acetylcholine release; Airway epithelium; Cholinergic transmission; Cromakalim; Pinacidil; Potassium channel openers; Potassium channels; Rat airways; Rat trachea

Indexed keywords

ACETYLCHOLINE; ATROPINE; CHOLINE; CROMAKALIM; GLIBENCLAMIDE; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; TETRODOTOXIN;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CHOLINERGIC TRANSMISSION; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY EPITHELIUM; TRACHEA;

EID: 0030130537     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0037     Document Type: Article

References (59)

1. 1. Allen SL, Boyle JP, Cortijo J, Foster RW, Morgan GP, Small RC. Electrical and mechanical effects of BRL 34915 in guinea-pig isolated trachealis. Br J Pharmacol 1986; 89: 395-405.
2. 2. Allen SL, Foster RW, Morgan GP, Small RC. The relaxant action of nicorandil in guinea-pig isolated trachealis. Br J Pharmacol 1986; 87: 117-27.
3. 3. Bray KM, Newgreen DT, Small RC, Southerton JS, Taylor SG, Weir SW, Weston AH. Evidence that the mechanism of the inhibitory action of pinacidil in rat and guinea-pig smooth muscle differs from that of glyceryl trinitrate. Br J Pharmacol 1987; 91: 421-9.
4. 4. Arch JRS, Buckle DR, Bumstead J, Clarke GD, Taylor JF, Taylor SG. Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in guinea-pig: comparison with nifedipine. Br J Pharmacol 1988; 95: 763-70.
5. 5. Baird A, Hamilton TC, Richards DH, Tasker T, Williams AJ. Inhibition of histamine induced broncho-constriction in normal healthy volunteers by a potassium channel activator, cromakalini, BRL 34915. Br J Clin Pharmacol 1988; 25: 114.
6. 6. Williams AJ, Vyse T, Richards DH, Lee TH. Cromakalini, a potassium channel activator, inhibits histamine-induced bronchoconstruction and nocturnal asthma. New Eng Allerg Proc 1988; 9: 429.
7. 7. Williams AJ, Hopkirk A, Vyse T, Chiew V, Lee TH. Inhibition of nocturnal asthma by relaxation of airway smooth muscle with a potassium channel activator. Am Rev Resp Dis 1989; 139: 140.
8. 8. Williams AJ, Lee TH, Cochrane GM, Hopkirk A, Lavender E, Richards D, Woodcock AA. Attenuation of nocturnal asthma by cromakalini. Lancet 1990; 336: 334-6.
9. 9. Nielsen-Kudsk JE, Mellemkjaer S, Siggaard C, Nielsen CB. Effects of pinacidil on guinea-pig airway smooth muscle contracted by asthma mediators. Eur J Pharmacol 1988; 157: 221-6.
10. 10. Paciorek PM, Cowlrick IS, Perkins RS, Taylor JC, Wilkinson GF, Waterfall JF. Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in guinea-pig. Br J Pharmacol 1990; 100: 289-94.
11. 11. Berry JL, Elliott KRF, Foster RW, Green KA, Murray MA, Small RC. Mechanical, biochemical and electrophysiological studies of RP 49356 and cromakalini in guinea-pig and bovine trachealis muscle. Pulmon Pharmacol 1991; 4: 91-8.
12. +-channel: a comparison with nifedipine. J Pharmacol Exp Ther 1991; 256: 492-9.
13. 13. Cook NS. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol Sci 1988; 9: 21-8.
14. 14. Hamilton TC, Weston AH. Cromakalini, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol 1989; 20: 1-9.
15. + channels. Trends Pharmacol Sci 1989; 10: 431-5.
16. + channel openers; their pharmacology and clinical potential. Pflugers Arch 1989; 414 (Suppl. 1): S99-105.
17. 17. Black JL, Barnes PJ. Potassium channels and airway function: new therapeutic prospects. Thorax 1990; 45: 213-8.
18. 18. Robertson DW, Steinberg MI. Potassium channel modulators: Scientific applications and therapeutic promise. J Med Chem 1990; 33: 1529-41.
19. 19. Triggle DJ. Potassium channels and potassium channel modulators. Neurotransmissions 1990; 6: 1-5.
20. 20. Kajioka S, Nakashima M, Kitamura K, Kuriyama H. Mechanisms of vasodilatation induced by potassium-channel activators. Clin Sci 1991; 81: 129-39.
21. 21. Hall AK, Maclagan J. Effect of cromakalini on cholinergic neurotransmission in the guinea-pig trachea. Br J Pharmacol 1988; 95: 792.
22. 22. McCaig DJ, De Jonckheere B. Effect of cromakalini on bronchoconstriction evoked by cholinergic nerve stimulation in guinea-pig isolated trachea. Br J Pharmacol 1989; 98: 662-8.
23. 23. Burka JF, Berry JL, Foster RW, Small RC, Watt AJ. Effects of cromakalini on neurally-mediated responses of guinea-pig tracheal smooth muscle. Br J Pharmacol 1991; 104: 263-9.
24. 24. Ichinose M, Barnes PJ. A potassium channel activator modulates both excitatory noncholinergic and cholinergic neurotransmission in guinea-pig airways. J Pharmacol Exp Ther 1990; 252: 1207-12.
25. 25. Good DM, Hamilton TC. Effects of BRL 38227 on neurally-mediated responses in guinea-pig isolated bronchus. Br J Pharmacol 1991; 102: 336.
26. 26. Lewis SA, Raeburn D. Preferential pre-junctional site of inhibition of non-cholinergic bronchospasm by potassium channel openers (KCOS). Br J Pharmacol 1990; 100: 474.
27. 3H]-acetylcholine release from parasympathetic nerves of the isolated rat trachea via an epithelium-dependent mechanism. Br J Pharmacol 1992; 105: 69.
28. 3H]-acetylcholine release from a tube-preparation of the rat isolated trachea by an epithelium-dependent mechanism. Naunyn-Schmiedeberg's Arch Pharmacol 1993; 348: 14-20.
29. 29. Barnes PJ. Neural control of human airways in health and disease. Am Rev Resp Dis 1986; 134: 1289-314.
30. 30. Barnes PJ. Modulation of neurotransmission in airways. Physiol Rev 1992; 72: 699-729.
31. 31. Barnes PJ. Modulation of neurotransmitter release from airways nerves. In: Raeburn D, Giembycz MA, eds. Airways Smooth Muscle: Structure, Innervation, Neurotransmission, Basel; Boston; Berlin: Birkhäuser Verlag, 1994: 209-259.
32. 32. Gabella G. Innervation of airway smooth muscle: fine structure. Ann Rev Physiol 1987; 49: 583-94.
33. 33. Leff AR. Endogenous regulation of bronchomotor tone. Am Rev Resp Dis 1988; 137: 1198-216.
34. 34. Canning BJ, Undem BJ. Parasympathetic innervation of airways smooth muscle. In: Raeburn D, Giembycz MA, eds. Airways Smooth Muscle: Structure, Innervation, Neurotransmission, Basel; Boston; Berlin: Birkhäuser Verlag, 1994: 43-78.
35. 35. Barnes PJ, Cuss FM, Palmer JB. The effect of airway epithelium on smooth muscle contractility in bovine trachea. Br J. Pharmacol 1985; 86: 685-91.
36. 36. Flavahan NA, Aarhus LL, Rimele TJ, Vanhoutte PM. Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol 1985; 58: 834-8.
37. 37. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtels T. Damage of airway epithelium and bronchial reactivity in patients with asthma. Am Rev Resp Dis 1985; 131: 599-606.
38. 38. Hay DWP, Farmer SG, Raeburn D, Robinson VA, Fleming WW, Fedan JS. Airway epithelium modulates the reactivity of guinea-pig respiratory smooth muscle. Eur J Pharmacol 1986; 129: 11-8.
39. 39. Holroyde MC. The influence of epithelium on the responsiveness of guinea-pig isolated trachea. Br J Pharmacol 1986; 87: 501-7.
40. 40. Raeburn DM, Hay DWP, Farmer SG, Fedan JS. Epithelium removal increases the reactivity of human isolated tracheal muscle to methacholine and reduces the effect of verapamil. Eur J Pharmacol 1986; 123: 451-3.
41. 41. Farmer SG. Airway smooth muscle responsiveness: modulation by the epithelium. Trends Pharmacol Sci 1987; 8: 8-10.
42. 42. Hay DWP, Farmer SG, Raeburn D, Muccitell RM, Wilson KA, Fedan JS. Differential effects of epithelium removal on the responsiveness of guinea-pig tracheal smooth muscle to bronchoconstrictors. Br J Pharmacol 1987; 92: 381-8.
43. 43. Vanhoutte PM. Airway epithelium and bronchial reactivity. Can J Physiol Pharmacol 1987; 65: 448-50.
44. 44. Vanhoutte PM. Epithelium-derived relaxing factor(s) and bronchial reactivity. Am Rev Resp Dis 1988; 138: 24-30.
45. 45. Aizawa H, Miyazaki N, Shigematsu N, Tomooka M. A possible role of airway epithelium in modulating hyper-responsiveness. Br J Pharamcol 1988; 93: 139-45.
46. 46. Munakata M, Huang I, Mitzner W, Menkes H. Protective role of epithelium in the guinea-pig airway. J Appl Physiol 1989; 66: 1547-52.
47. 47. Goldie RG, Fernandes LB, Farmer SG, Hay DWP. Airway epithelium-derived inhibitory factor. Trends Pharmacol Sci 1990; 11: 67-70.
48. 48. Farmer SG, Hay DWP. Airway epithelial modulation of smooth muscle function: The evidence of epithelium-derived inhibitory factor. In: Farmer SG, Hay DWP, eds. The airway epithelium: Physiology, Pathophysiology and Pharmacology, New York: Marcel Dekker, 1991: 437-483.
49. 49. Sparrow MP, Omari TI, Mitchell HW. The epithelial barrier and airway responsiveness. Can J Physiol Pharmacol 1995; 73: 180-90.
50. 3H]-acetylcholine release from the isolated guinea-pig trachea. Naunyn-Schmiedeberg's Arch Pharmacol 1990; 342: 387-93.
51. 3H]-acetylcholine from the isolated rat or guinea-pig trachea evoked by preganglionic nerve stimulation; a comparison with transmural stimulation. Naunyn-Schmiedeberg's Arch Pharmacol 1991; 344: 403-11.
52. 52. Fernandes LB, Goldie RG. Pharmacological evaluation of a guinea-pig tracheal epithelium-derived inhibitory factor (EpDIF). Br J Pharmacol 1990; 100: 614-8.
53. 53. Goldie RG, Fernandes LB. Bioassay of airway epithelium-derived inhibitory factors. In: Farmer SG, Hay DWP, eds. The airway epithelium: Physiology, Pathophysiology and Pharmacology, New York: Marcel Dekker, 1991: 505-26.
54. 54. Fabiani ME, Story DF. Effects of cromakalim, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria. Pharmacol Res 1995; 3: 155-63.
55. 55. Loiacono RE, Story DF. Effect of α-adrenoceptor agonists and antagonists on cholinergic transmission in guinea-pig isolated atria. Naunyn-Schmiedeberg's Arch Pharmacol 1986; 334: 40-7.
56. 56. Lindmar R, Löffelholz K, Weide W, Witzke J. Neuronal uptake of choline following release of acetylcholine in the perfused heart. J Pharmacol Exp Ther 1980; 215: 710-5.
57. 57. Muscholl E, Muth A. The effect of physostigmine on the vagally induced muscarinic inhibition of noradrenaline release from the isolated perfused rabbit atria. Naunyn-Schmiedeberg's Arch Pharmacol 1982; 320: 160-9.
58. 58. Wetzel GT, Brown JH. Relationships between choline uptake, acetylcholine synthesis and acetylcholine release in isolated rat atria. J Pharmacol Exp Ther 1983; 226: 343-8.
59. 59. Dieterich HA, Lindmar R, Löffelholz K. The role of choline in the release of acetylcholine in isolated hearts. Naunyn-Schmiedeberg's Arch Pharmacol 1978; 301: 207-15.