Interventions for the treatment of oral and oropharyngeal cancers: Surgical treatment

Cochrane Database of Systematic Reviews

Volumn , Issue 4, 2007, Pages

  Oliver, Richard J ^a   Clarkson, J E ^b   Conway, D I ^b   Glenny, A ^b   Macluskey, M ^b   Pavitt, S ^b   Sloan, P ^b   Worthington, H V ^b   Baujat, B ^b   Blackburn, T ^b   Humphris, G ^b   Hutchison, I ^b   O'Brien, C ^b   Pignon, J P ^b   Robertson, G ^b   Rogers, S ^b   Shah, J ^b   Slevin, N ^b   Soutar, D ^b   Sturgis, E ^b   Tavender, E ^b   Vermorken, J B ^b   Wardell, S ^b   Warnakulasuriya, S ^b   Webster, K ^b   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NONE

Author keywords

Combined modality therapy methods ; Humans; Mouth neoplasms * surgery ; Oropharyngeal neoplasms *surgery ; Randomized controlled trials as topic

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOMODULATING AGENT; PLACEBO;

CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; HEALTH CARE COST; HUMAN; IMMUNOTHERAPY; MORTALITY; MOUTH CANCER; OROPHARYNX CANCER; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; REVIEW; TREATMENT OUTCOME;

EID: 40449099600     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD006205.pub2     Document Type: Review

References (194)

1. Ang 2001 {published and unpublished data} Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, et al.Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics 2001;51(3):571-8.
2. Bernier 2004 {published data only} Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, et al.Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. New England Journal of Medicine 2004;350(19): 1945-52.
3. Bier 1981 {published data only} Bier J, Rapp HJ, Borsos T. Randomized clinical study on intratumoral BCG-cell wall preparation (CWP) therapy in patients with squamous cell carcinoma in the head and neck region. Cancer Immunology & Immunotherapy 1981;12(1):71-9.
4. Bier 1994 {published data only} *Bier J. Radical neck dissection versus conservative neck dissection for squamous cell carcinoma of the oral cavity. Recent Results in Cancer Research 1994;134:57-62.
5. Bier J, Howaldt HP, Pitz H. [4th German-Austrian-Swiss Study Group therapy study. Prospective, randomized, clinical study of squamous cell cancer of themouth: "Radical neck dissection versus conservative neck dissection"]. Fortschritte der Kiefer- und Gesichts-Chirurgie 1992;37:108-10.
6. Bier J, Schlums D, Metelmann H, Howaldt HP, Pitz H. A comparison of radical and conservative neck dissection. International Journal of Oral & Maxillofacial Surgery 1993;22(2):102-7.
7. Cooper 2004 {published data only} Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al.Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. New England Journal of Medicine 2004;350(19):1937-44.
8. De Stefani 2002 {published data only} *De Stefani A, Forni G, Ragona R, Cavallo G, Bussi M, Usai A, et al.Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx. Cancer 2002;95(1):90-7.
9. De Stefani A, Valente G, Forni G, Lerda W, Ragona R, Cortesina G. Treatment of oral cavity and oropharynx squamous cell carcinoma with perilymphatic interleukin-2: clinical and pathologic correlations. Journal of Immunotherapy with Emphasis on Tumor Immunology 1996;19(2):125-33.
10. Fakih 1989a {published data only} Fakih AR, Rao RS, Borges AM, Patel AR. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. American Journal of Surgery 1989;158(4):309-13.
11. *Fakih AR, Rao RS, Patel AR. Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. Seminars in Surgical Oncology 1989;5(5):327-30.
12. Hintz 1979b {published data only} Hintz B, Charyulu K, Chandler JR, Sudarsanam A, Garciga C. Randomized study of control of the primary tumor and survival using preoperative radiation, radiation alone, or surgery alone in head and neck carcinomas. Journal of Surgical Oncology 1979;12(1):75-85.
13. Kligerman 1994 {published data only} Kligerman J, Lima RA, Soares JR, Prado L, Dias FL, Freitas EQ, et al.Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. American Journal of Surgery 1994;168(5):391-4.
14. Lam 2001 {published data only} Lam P, Yuen AP, Ho CM, Ho WK, Wei WI. Prospective randomized study of post-operative chemotherapy with levamisole and UFT for head and neck carcinoma. European Journal of Surgical Oncology 2001;27(8):750-3.
15. Laramore 1992 {published data only} Aref A, Berkey BA, Schwade JG, Ensley J, Schuller DE, Haselow RE, et al.The influence of beam energy on the outcome of postoperative radiotherapy in head and neck cancer patients: secondary analysis of RTOG 85-03. International Journal of Radiation Oncology, Biology, Physics 2000;47(2):389-94.
16. Jacobs JR, Casiano RR, Schuller DE, Pajak TF, Laramore GE, al-Sarraf M. Chemotherapy as predictor of compliance. Journal of Surgical Oncology 1994;55(3):143-8.
17. *Laramore GE, Scott CB, al-Sarraf M, Haselow RE, Ervin TJ, Wheeler R, et al.Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034. International Journal of Radiation Oncology, Biology, Physics 1992;23(4):705-13.
18. Lawrence 1974 {published data only} Lawrence W Jr, Terz JJ, Rogers C, King RE, Wolf JS, King ER. Proceedings: Preoperative irradiation for head and neck cancer: a prospective study. Cancer 1974;33(2):318- 23.
19. Licitra 2003 {published data only} Licitra L, Grandi C, Cavina R, Guzzo M, Mariani L, Lo Vullo S, et al.Primary chemotherapy (pCT) for patients with operable oral cavity cancer: Results of a randomized study. Proceedings of the American Society of Clinical Oncology (ASCO). 2001; Vol. 20:(Abs No 890).
20. Luboinski 1985 {published data only} Luboinski B. Preliminary results of a randomized study on preoperative intra-arterial chemotherapy combined with surgery and irradiation for carcinomas of the floor of the mouth. Progress in Clinical & Biological Research 1985;201:199-203.
21. Maipang 1995 {published data only} Maipang T, Maipang M, Geater A, Panjapiyakul C, Watanaarepornchai S, Punperk S. Combination chemotherapy as induction therapy for advanced resectable head and neck cancer. Journal of Surgical Oncology 1995;59(2):80-5.
22. Martin 1990 {published data only} Martin M, Hazan A, Vergnes L, Peytral C, Mazeron JJ, Senechaut JP, et al.Randomized study of 5 fluorouracil and cis platin as neoadjuvant therapy in head and neck cancer: a preliminary report. International Journal of Radiation Oncology, Biology, Physics 1990;19(4):973-5.
23. Mohr 1994 {published data only} Mohr C, Bohndorf W, Carstens J, Harle F, Hausamen JE, Hirche H, et al.Preoperative radiochemotherapy and radical surgery in comparison with radical surgery alone. A prospective,multicentric, randomized DOSAK study of advanced squamous cell carcinoma of the oral cavity and the oropharynx (a 3-year follow-up). International Journal of Oral & Maxillofacial Surgery 1994;23(3):140-8.
24. Neifeld 1985 {published data only} Neifeld JP, Terz JJ, Kaplan AM, Lawrence W Jr. Adjuvant Corynebacterium parvum immunotherapy for squamous cell epitheliomas of the oral cavity, pharynx, and larynx. Journal of Surgical Oncology 1985;28(2):137-45.
25. Paccagnella 1994 {published data only} Paccagnella A, Orlando A, Marchiori C, Zorat PL, Cavaniglia G, Sileni VC, et al.Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo. Journal of the National Cancer Institute 1994;86(4):265-72.
26. Rao 1991 {published data only} Rao RS, Parikh DM, Parikh HK, Bhansali MB, Deshmane VH, Fakih AR. Perioperative chemotherapy in patients with oral cancer. American Journal of Surgery 1994;168(3):262-7.
27. *Rao RS, Parikh DM, Parikh HK, Bhansali MB, Fakih AR. Perioperative chemotherapy in oral cancer. Journal of Surgical Oncology 1991;47(1):21-6.
28. Rentschler 1987 {published data only} Rentschler RE, Wilbur DW, Petti GH, Chonkich GD, Hilliard DA, Camacho ES, et al.Adjuvant methotrexate escalated to toxicity for resectable stage III and IV squamous head and neck carcinomas - a prospective, randomized study. Journal of Clinical Oncology 1987;5(2):278-85.
29. Richard 1991 {published data only} Richard J, Sancho GH. Intraarterial infusion. An adjuvant to surgery of oral carcinoma. A randomized EORTC study. Journal Europeen de Radiotherapie 1983;4:81-6.
30. *Richard JM, Kramar A, Molinari R, Lefebvre JL, Blanchet F, Jortay A, et al.Randomised EORTC head and neck cooperative group trial of preoperative intra-arterial chemotherapy in oral cavity and oropharynx carcinoma. European Journal of Cancer 1991;27(7):821-7.
31. Robertson 1998 {published data only} Robertson AG, Soutar DS, Paul J, Webster M, Leonard AG, Moore KP, et al.Early closure of a randomized trial: surgery and postoperative radiotherapy versus radiotherapy in the management of intra-oral tumours. Clinical Oncology (Royal College of Radiologists) 1998;10(3):155-60.
32. Sanguineti 2005 {published and unpublished data} Sanguineti G, Richetti A, Bignardi M, Corvo R, Gabriele P, Sormani MP, et al.Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter Phase III study. International Journal of Radiation Oncology, Biology, Physics 2005;61(3):762-71.
33. Schuller 1988 {published data only} *Schuller DE, Metch B, Stein DW, Mattox D, McCracken JD. Preoperative chemotherapy in advanced resectable head and neck cancer: final report of the Southwest Oncology Group. Laryngoscope 1988;98(11):1205-11.
34. Schuller DE, Stein DW, Metch B. Analysis of treatment failure patterns. A Southwest Oncology Group Study. Archives of Otolaryngology - Head & Neck Surgery 1989;115(7):834-6.
35. Szabo 1999 {published data only} Szabo G, Kreidler J, Hollmann K, Kovacs A, Nemeth G, Nemeth Z, et al.Intra-arterial preoperative cytostatic treatment versus preoperative irradiation: A prospective, randomized study of lingual and sublingual carcinomas. Cancer 1999;86(8): 1381-6.
36. Szpirglas 1978 {published data only} Szpirglas H, Chastang C, Bertrand JC. Adjuvant treatment of tongue and floor of the mouth cancers. Recent Results in Cancer Research 1978;68:309-17.
37. Terz 1981 {published data only} Terz JJ, King ER, Lawrence W Jr. Preoperative irradiation for head and neck cancer: results of a prospective study. Surgery 1981;89(4):449-53.
38. Vandenbrouck 1980 {published data only} Vandenbrouck C, Sancho-Garnier H, Chassagne D, Saravane D, Cachin Y, Micheau C. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial. Cancer 1980;46(2):386-90.
39. Volling 1999 {published data only} Volling P, Schroder M. [Preliminary results of a prospective randomized study of primary chemotherapy in carcinoma of the oral cavity and pharynx]. HNO 1995;43(2):58- 64.
40. *Volling P, Schroder M, Eckel H, Ebeling O, Stennert E. [Results of a prospective randomized trial with induction chemotherapy for cancer of the oral cavity and tonsils]. HNO 1999;47(10):899-906.
41. Volling P, Schroder M, Muller RP, Ebeling O, Quirin R, Stennert E. Induction chemotherapy in primary resectable head and neck tumors: A prospective randomized trial. International Journal of Oncology 1994;4:909- 14.
42. Weissler 1992 {published data only} Weissler MC, Melin S, Sailer SL, Qaqish F, Rosenman JG, Pillsbury HC. Simultaneous chemoradiation in the treatment of advanced head and neck cancer. Archives of Otolaryngology - Head & Neck Surgery 1992;118(8):806-10.
43. Awwad 1992 Awwad HK, Khafagy Y, Barsoum M, Ezzat S, el-Attar I, Farag H, et al.Accelerated versus conventional fractionation in the postoperative irradiation of locally advanced head and neck cancer: influence of tumour proliferation. Radiotherapy & Oncology 1992;25(4):261- 6.
44. Bachaud 1996 *Bachaud JM, Cohen-Jonathan E, Alzieu C, David JM, Serrano E, Daly-Schveitzer N. Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial. International Journal of Radiation Oncology, Biology, Physics 1996;36(5):999-1004.
45. Bachaud JM, David JM, Boussin G, Daly N. Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced squamous cell carcinoma of the head and neck: preliminary report of a randomized trial. International Journal of Radiation Oncology, Biology, Physics 1991;20(2):243-6.
46. Beatty 1978 Beatty JD, Terz JJ, Brown PW, Lawrence W Jr, Schuller GB, Kaplan AM. Adjuvant intralesional and systemic Corynebacterium parvum immunotherapy for surgically treated head and neck cancer. Surgical Forum 1978;29:155-7.
47. Bobtz 1997A Bobtz F. [Therapy study. Comparison of postoperative irradiation versus omission of irradiation in mouth cavity and supraglottic carcinomas]. HNO 1997;45(3):160.
48. Bolla 1994 Bolla M, Lefur R, Ton Van J, Domenge C, Badet JM, Koskas Y, et al.Prevention of second primary tumours with etretinate in squamous cell carcinoma of the oral cavity and oropharynx. Results of a multicentric double-blind randomised study. European Journal of Cancer 1994;30A(6):767-72.
49. Browman 1983A Browman GP, Archibald SD, Young JE, Hryniuk WM, Russell R, Kiehl K, et al.Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer. Journal of Clinical Oncology 1983;1(12):787-92.
50. Buentzel 2006 Buentzel J, Micke O, Adamietz IA, Monnier A, Glatzel M, de Vries A. Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: A randomized placebo-controlled phase III study. International Journal of Radiation Oncology, Biology, Physics 2006;64(3):684-91.
51. Buntzel 1998A Buntzel J, Kuttner K, Frohlich D, Glatzel M. Selective cytoprotection with amifostine in concurrent radiochemotherapy for head and neck cancer. Annals of Oncology 1998;9(5):505-9.
52. Carugati 1988A Carugati A, Pracher R, De La Torre A. Combination chemotherapy pre-radical treatment for head and neck squamous cell carcinoma. Proceedings of the American Society of Clinical Oncology (ASCO). 1988; Vol. 7:589.
53. Dalley 1995A Dalley D, Beller E, Aroney R, Dewar J, Philip, R, Simes J. The value of chemotherapy (CT) prior to definitive local therapy (DTL) in patients with locally advanced squamous cell carcinoma (SCC) of the head and neck (HN). Proceedings of the American Society of Clinical Oncology (ASCO). 1995; Vol. 14:297.
54. Denaro 1994 Denaro A, Stivala F, Mazzarino MC. [Immunologic study on patients with head and neck cancer treated with thymopentin associated with surgery, chemotherapy and radiotherapy]. Acta Otorhinolaryngologica Italica 1994;14(6):611-25.
55. Depondt 1993 Depondt J, Gehanno P, Martin M, Lelievre G, Guerrier B, Peytral C, et al.Neoadjuvant chemotherapy with carboplatin/5-fluorouracil in head and neck cancer. Oncology 1993;50 Suppl 2:23-7.
56. Di Blasio 1994A Di Blasio B, Barbier IW, Bozzetti A, Lotti C, DiSarra S, Cocconi G. A prospective randomized trial in resectable head and neck carcinoma: Loco-regional treatment with and without neoadjuvant chemotherapy. Proceedings of the American Society of Clinical Oncology (ASCO). 1994; Vol. 13:279 (Abs No 899).
57. Dieckmann 1990A Dieckmann J. Combined pre-and postoperative radiotherapy (RT) in the treatment of carcinomas of the floor of the mouth. Journal of Cancer Research & Clinical Oncology 1990;116:797.
58. Domenge 1988A Domenge C, Marandas P, Vignoud J, et al.Post-surgical adjuvant chemotherapy in extracapsular spread invaded lymph nodes (N+R+) of epidermoid carcinoma of the head and neck: a randomized multicentric trial. Second international conference on head and neck cancer, Boston USA. American Society of Head and Neck Surgery 1988;74:(Abstract).
59. Domenge 2000 Domenge C, Hill C, Lefebvre JL, De Raucourt D, Rhein B, Wibault P, et al.Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma. French Groupe d'Etude des Tumeurs de la Tete et du Cou (GETTEC). British Journal of Cancer 2000;83(12):1594-8.
60. Gedouin 1996T Gedouin D, Desprez P, Perron JJ, Fleury F, Leclech G, Miglianico L, et al.[Cancers of the base of the tongue and hypopharynx: results of a multicenter randomized trial of chemotherapy prior to locoregional treatment]. Bulletin du Cancer Radiotherapie 1996;83(2):104-7.
61. Gehanno 1988 Gehanno P, Moisy N, Guedon C. Cefotaxime in the prophylaxis of otorhinolaryngological cancer surgery. Long term versus short term administration, results of a multicentre study. Drugs 1988;35 Suppl 2:111-5.
62. Gehanno 1992 Gehanno P, Depondt J, Peynegre R, Peytral C, Martin M, Baillet F, et al.Neoadjuvant combination of carboplatin and 5-FU in head and neck cancer: a randomized study. Annals of Oncology 1992;3 Suppl 3:43-6.
63. Grandi 1993A Grandi C, Molinari R, Bonadonna G, Licitra L, Cavina R, Guzzo M, et al.Surgery versus primary chemotherapy plus surgery in squamous cell carcinoma of the oral cavity: preliminary report of a randomized study. European Journal of Cancer 1993;29Y:S145.
64. H&N Contract 1987 *Head and Neck Contracts Program. Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the Head and Neck Contracts Program. Cancer 1987;60(3):301-11.
65. Jacobs C, Makuch R. Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the Head and Neck Contracts Program. Journal of Clinical Oncology 1990;8(5):838-47.
66. Haas 1985A Haas C, Byhardt R, Cox J, Duncovage J, Grossman T, Haas J, et al.Randomized study of 5-fluorouracil (F) and cis-platinum(P) as initial therapy of locally advanced squamous carcinoma of the head and neck (LASCHN): a preliminary analysis. Proceedings of the American Society of Clinical Oncology (ASCO). 1985; Vol. 4:143.
67. Haffty 1993 Haffty BG, Son YH, Sasaki CT, Papac R, Fischer D, Rockwell S, et al.Mitomycin C as an adjuvant to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomised trials. International Journal of Radiation Oncology, Biology, Physics 1993;27(2):241-50.
68. Haffty 2005 Haffty BG, Wilson LD, Son YH, Cho EI, Papac RJ, Fischer DB, et al.Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial. International Journal of Radiation Oncology, Biology, Physics 2005;61(1):119-28.
69. Hasegawa 1996A Hasegawa Y, Matsuura H, Fukushima M, Kano M, Shimozato K. Potential suppression of distant and node metastasis by neoadjuvant chemotherapy in advanced head and neck cancer: result of a randomized trial. Proceedings of the American Society of Clinical Oncology (ASCO). 1996; Vol. 15:318.
70. Hintz 1979a Hintz B, Charyulu K, Chandler JR, Sudarsanam A, Garciga C. Randomized study of local control and survival following radical surgery or radiation therapy in oral and laryngeal carcinomas. Journal of Surgical Oncology 1979;12(1):61-74.
71. Holoye 1985 Holoye PY, Grossman TW, Toohill RJ, Kun LE, Byhardt RW, Duncavage JA. Randomized study of adjuvant chemotherapy for head and neck cancer. Otolaryngology - Head and Neck Surgery 1985;93(6):712-7.
72. Holtje 1990A Holtje WJ, Schwipper V. Five-year survival rate of patients with squamous-cell-carcinoma of the oral cavity. -A comparison of two groups of patients: radical surgery plus postoperative radiotherapy versus preoperative chemotherapy plus radical surgery. Journal of Cancer Research & Clinical Oncology 1990;116:696.
73. Homma 2004 Homma A, Shirato H, Furuta Y, Nishioka T, Oridate N, Tsuchiya K, et al.Randomized phase II trial of concomitant chemoradiotherapy using weekly carboplatin or daily low-dose cisplatin for squamous cell carcinoma of the head and neck. Cancer Journal 2004;10(5):326-32.
74. Huang 2003T Huang X, Li L, Wen Y. [Basic research on neck dissection with external jugular vein and cervical plexus preserved]. Hua Xi Kou Qiang Yi Xue Za Zhi 2003;21(2):118-20.
75. Jacobs 1999 Jacobs JR, Logemann J, Pajak TF, Pauloski BR, Collins S, Casiano RR, et al.Failure of cricopharyngeal myotomy to improve dysphagia following head and neck cancer surgery. Archives of Otolaryngology - Head & Neck Surgery 1999;125(9):942-6.
76. Kapstad 1978 Kapstad B, Bang G, Rennaes S, Dhaler A. Combined preoperative treatment with cobalt and bleomycin in patients with head and neck carcinoma: a controlled clinical study. International Journal of Radiation Oncology, Biology, Physics 1978;4(1-2):85-9.
77. Ketcham 1969 Ketcham AS, Hoye RC, Chretien PB, Brace KC. Irradiation twenty-four hours preoperatively. American Journal of Surgery 1969;118(5):691-7.
78. Kokal 1988 Kokal WA, Neifeld JP, Eisert D, Lipsett JA, Lawrence W Jr, Beatty JD, et al.Postoperative radiation as adjuvant treatment for carcinoma of the oral cavity, larynx, and pharynx: preliminary report of a prospective randomized trial. Journal of Surgical Oncology 1988;38(2):71-6.
79. Kotani 1994T Kotani A, Sunada O, Tamura M, Takaku S, Kobayashi A, Asakura A, et al.[Multiple cooperative study of UFT-adjuvant chemotherapy for malignant tumor in the jaw and oral cavities. The Oral Surgery Malignant Tumor Research Association in Kanto Kohshinetsu District]. Gan To Kagaku Ryoho 1994;21(7):987-92.
80. Kramer 1987 *Kramer S, Gelber RD, Snow JB, Marcial VA, Lowry LD, Davis LW, et al.Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group. Head & Neck Surgery 1987;10(1):19-30.
81. Snow JB, Gelber RD, Kramer S, Davis LW, Marcial VA, Lowry LD. Comparison of preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck. Interim report. Acta Oto-Laryngologica 1981;91(5-6):611-26.
82. Snow JB Jr, Gelber RD, Kramer S, Davis LW, Marcial VA, Lowry LD. Randomized preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck: preliminary report. Laryngoscope 1980;90(6 Pt 1):930-45.
83. Tupchong L, Scott CB, Blitzer PH, Marcial VA, Lowry LD, Jacobs JR, et al.Randomized study of preoperative versus postoperative radiation therapy in advanced head and neck carcinoma: long-term follow-up of RTOG study 73-03. International Journal of Radiation Oncology, Biology, Physics 1991;20(1):21-8.
84. Lavertu 1998 Lavertu P, Adelstein DJ, Saxton JP, Secic M, Wanamaker JR, Eliachar I, et al.Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer. Head & Neck 1997;19(7):559-66.
85. *Lavertu P, Bonafede JP, Adelstein DJ, Saxton JP, Strome M, Wanamaker JR, et al.Comparison of surgical complications after organ-preservation therapy in patients with stage III or IV squamous cell head and neck cancer. Archives of Otolaryngology - Head & Neck Surgery 1998;124(4):401-6.
86. Lewin 1997 Lewin F, Damber L, Jonsson H, Andersson T, Berthelsen A, Biorklund A, et al.Neoadjuvant chemotherapy with cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the head and neck: a randomized phase III study. Radiotherapy & Oncology 1997;43(1):23-8.
87. Lim 2003A Lim DT, Tai BC, Wee JT, Tan EH, Leong SS, Goh CH, et al.Randomised trial comparing surgery and adjuvant radiotherapy with concurrent chemoirradiation and salvage surgery in resectable stage III and IV squamous cell carcinoma of the head and neck. Proceedings of the American Society of Clinical Oncology (ASCO). 2003; Vol. 22:(Abs No 2013).
88. Martin 1993A Martin M, Depondt J, Gehanno P, Lelievre P, Guerrier B, Peytral C, et al.A phase II study comparing induction chemotherapy by Carboplatin (CBDCA) and 5 Fluorouracil (5 FU) before locoregional treatment (LRT) versus locoregional treatment alone in head and neck carcinomas. European Journal of Cancer 1993;29(Suppl 6):S139.
89. Martin 1994 Martin M, Vergnes L, Lelièvre G, Michel-Langlet P, Paytral C, Mazeron JJ, et al.A randomized study of CDDP and 5-FU as neoadjuvant chemotherapy in head and neck cancer: an interim analysis. In: BanzetP, HollandJF, KhayatD, WeilM editor(s). Cancer treatment: an update. Paris: Springer-Verlag, 1994:214-8.
90. Mazeron 1992 Mazeron JJ, Martin M, Brun B, Grimard L, Lelievre G, Vergnes L, et al.Induction chemotherapy in head and neck cancer: results of a phase III trial. Head & Neck 1992;14(2):85-91.
91. Mishra 1996 Mishra RC, Singh DN, Mishra TK. Post-operative radiotherapy in carcinoma of buccal mucosa, a prospective randomized trial. European Journal of Surgical Oncology 1996;22(5):502-4.
92. Misra 1991A Misra NC, Chaturvedi A, Bhattacharya S, Mahendra NN, Dhulia N, Agarwal GN, et al.Neoadjuvant therapy in advanced (T3-T4) oral cancer. Results of two prospective and one randomized study. European Journal of Cancer 1991;27:S152.
93. Németh 2005 Németh Z, Szigeti K, Máthé M, Szabó G, Velich N, Suba Z. Effect of induction chemotherapy on changes of laminin and syndecan expression in oral squamous cell carcinomas: a prospective, randomized, clinicopathologic and immunohistochemical study. The Journal of Craniofacial Surgery 2005;16(2):205-12.
94. Olivari 1979 Olivari AJ, Glait HM, Guardo A, Califano L, Pradier R. Levamisole in squamous cell carcinoma of the head and neck. Cancer Treatment Reports 1979;63(6):983-90.
95. Parvinen 1985a Parvinen LM, Parvinen M, Nordman E, Kortekangas AE. Combined bleomycin treatment and radiation therapy in squamous cell carcinoma of the head and neck region. Acta Radiologica - Oncology 1985;24(6):487-9.
96. Parvinen 1985b Parvinen LM, Kortekangas AE, Nordman E. Prospidin combined to preoperative irradiation in head and neck cancer. Strahlentherapie 1985;161(10):623-4.
97. Pearlman 1982 Pearlman NW, Meyers AD, Johnson FB, DiBella NJ. Preoperative chemo-radiotherapy in advanced head and neck cancer. Head & Neck Surgery 1982;5(1):10-4.
98. Pearlman 1985 Pearlman NW, Johnson FB, Braun TJ, Kennaugh RC, Spofford BF, Borlase BC, et al.A prospective study of preoperative chemotherapy and split-course irradiation for locally advanced or recurrent oral/pharyngeal squamous carcinoma. American Journal of Clinical Oncology 1985;8(6):490-6.
99. Proto 1993T Proto E, Puxeddu P, Curreli L, Bianchi A, Puxeddu R, Mantovani G. Combined modality therapy (chemoimmunotherapy + radiotherapy +/- surgery) in advanced neoplasias of the head and neck. Otorinolaringologia 1993;43(4):165-9.
100. Rodrigo 2004 Rodrigo JP, Maseda E, Maldonado M, Aldama P, Puente M, Llorente JL, et al.[Efficacy of postoperative radiation therapy for squamous cell carcinoma of the head and neck: results of a prospective randomised clinical trial]. Acta Otorrinolaringologica Espanola 2004;55(9): 415-9.
101. Schroder 1981 Schroder M, von Heyden HW, Beyer JH, Klee M. [Treatment of epidermoid head and neck cancer with cisplatinum/bleomycin vs methotrexate/vindesine]. Laryngologie, Rhinologie, Otologie 1981;60(6):331-3.
102. Schroder 1983 Schroder M, von Heyden HW, Scherpe A, Borghardt J, Beyer JH, Nagel GA, et al.[2d interim evaluation of a chemotherapy study on patients with squamous cell carcinomas of the head-neck area. A comparison of 2 therapy regimens: cis-diamminedichloroplatinum (II) and bleomycin versus methotrexate and vindesine]. Onkologie 1983;6(3):114-7.
103. Schroder 1993A Schroder M, Muller RP, Knufermann H, Volling P. Improved survival after neoadjuvant Carboplatin/5 FU in resectable stage II and III squamous cell carcinomas of the oral cavity and tonsil. European Journal of Cancer 1993;29Y:S144.
104. Schuff-Werner 1987T Schuff-Werner P, Lohr G, Rauschning W, Schroder M, Musil J, Nagel GA. [Effect of thymostimulin on chemotherapy-induced changes in lymphocyte subset distribution. A longitudinal study in patients with primary inoperable oropharyngeal cancers]. Onkologie 1987;10(3 Suppl):17-21.
105. Scott 2002a Scott SN, Boeve TJ, McCulloch TM, Fitzpatrick KA, Karnell LH. The effects of epoetin alfa on transfusion requirements in head and neck cancer patients: a prospective, randomized, placebo-controlled study. Laryngoscope 2002;112(7 Pt 1):1221-9.
106. SECOG 1986 SECOG (South-East Co-operative Oncology Group). A randomized trial of combined multidrug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. An interim report from the SECOG participants (South-East Co-operative Oncology Group). European Journal of Surgical Oncology 1986;12(3):289-95.
107. Smid 2003 Smid L, Budihna M, Zakotnik B, Soba E, Strojan P, Fajdiga I, et al.Postoperative concomitant irradiation and chemotherapy with mitomycin C and bleomycin for advanced head-and-neck carcinoma. International Journal of Radiation Oncology, Biology, Physics 2003;56(4):1055-62.
108. Soo 2005 Soo KC, Tan EH, Wee J, Lim D, Tai BC, Khoo ML, et al.Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison. British Journal of Cancer 2005;93(3):279-86.
109. Steuer-Vogt 2001 Kiene H, Buschel G, Hornebar M. [Mistletoe or not mistletoe is still the question]. Forschende Komplementarmedizin und Klassische Naturheilkunde 2001;8(5):309-12.
110. *Steuer-Vogt MK, Bonkowsky V, Ambrosch P, Scholz M, Neiss A, Strutz J, et al.The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients: a randomised controlled clinical trial. European Journal of Cancer 2001;37(1):23-31.
111. Stolwijk 1985 Stolwijk C, Wagener DJ, Van Den Broek P, Levendag PC, Kazem I, Bruaset I, et al.Randomized neo-adjuvant chemotherapy trial for advanced head and neck cancer. Netherlands Journal of Medicine 1985;28(9):347-51.
112. Strassl 1990T Strassl H, Gritzmann N, Braun O, Schratter A. [Questionable indication for radical neck dissection in carcinomas of the tongue and floor of the mouth. Results after 4 years]. Deutsche Zeitschrift fur Mund-, Kiefer-, und Gesichts-Chirurgie 1990;14(4):250-3.
113. Strong 1978 Strong MS, Vaughan CW, Kayne HL, Aral IM, Ucmakli A, Feldman M, et al.A randomized trial of preoperative radiotherapy in cancer of the oropharynx and hypopharynx. American Journal of Surgery 1978;136(4):494-500.
114. Tandon 1992 Tandon DA, Bahadur S, Laldina HC, Sundaram KR. Role of prophylactic antibiotics in surgery for advanced head and neck cancer. Journal of Laryngology & Otology 1992;106(7):621-4.
115. Taylor 1985 Taylor SG 4th, Applebaum E, Showel JL, Norusis M, Holinger LD, Hutchinson JC Jr, et al.A randomized trial of adjuvant chemotherapy in head and neck cancer. Journal of Clinical Oncology 1985;3(5):672-9.
116. Toohill 1987a *Toohill RJ, Anderson T, Byhardt RW, Cox JD, Duncavage JA, Grossman TW, et al.Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. A preliminary report. Archives of Otolaryngology - Head & Neck Surgery 1987;113(7):758-61.
117. Toohill RJ, Duncavage JA, Grossmam TW, Malin TC, Teplin RW, Wilson JF, et al.The effects of delay in standard treatment due to induction chemotherapy in two randomized prospective studies. Laryngoscope 1987;97(4):407- 12.
118. Tsukuda 1994T Tsukuda M, Ogasawara H, Kaneko S, Komiyama S, Horiuchi M, Inuyama Y, et al.[A prospective randomized trial of adjuvant chemotherapy with UFT for head and neck carcinoma. Head and Neck UFT Study Group]. Japanese Journal of Cancer & Chemotherapy 1994;21(8):1169-77.
119. Tsukuda 2005 Tsukuda M, Kida A, Fujii M, Kono N, Yoshihara T, Hasegawa Y, et al.Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer. British Journal of Cancer 1993;93(8):884-9.
120. Vermund 1985 Vermund H, Kaalhus O, Winther F, Trausjo J, Thorud E, Harang R. Bleomycin and radiation therapy in squamous cell carcinoma of the upper aero-digestive tract: a phase III clinical trial. International Journal of Radiation Oncology, Biology, Physics 1985;11(11):1877-86.
121. Villarreal 2004 Villarreal-Renedo PM, Monje-Gil F, Junquera-Gutierrez LM, De Vicente-Rodriguez JC, Morillo-Sanchez AJ. [Treatment of oral and oropharyngeal epidermoid carcinomas by means of CO2 laser]. Medicina Oral 2004;9(2):168-76.
122. Wahlberg 1992A Wahlberg P, Wennerberg J. A phase-III study of adjuvant 13-cis retinoic acid in squamous cell carcinomas of the mouth, pharynx and larynx. Clinical Otolaryngology 1992;17:101.
123. Wanebo 1978 Wanebo HJ, Hilal EY, Pinsky CM, Strong EW, Mike V, Hirshaut Y, et al.Randomized trial of levamisole in patients with squamous cancer of the head and neck: a preliminary report. Cancer Treatment Reports 1978;62(11):1663-9.
124. *Wanebo HJ, Hilal EY, Strong EW, Pinsky CM, Mike V, Oettgen HF. Adjuvant trial of levamisole in patients with squamous cancer of the head and neck: a preliminary report. Recent Results in Cancer Research 1978;68:324-33.
125. Weissberg 1989 Weissberg JB, Son YH, Papac RJ, Sasaki C, Fischer DB, Lawrence R, et al.Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 1989;17(1):3-9.
126. Yoshino 1991 Yoshino K, Sato T, Nakai Y, Tanabe M, Matsunaga T, Kozuka T, et al.[A comparative clinical study of adjuvant chemotherapy of tumors in the head and neck areas by means of HCFU]. Gan To Kagaku Ryoho 1991;18(15):2581-8.
127. Yoshino 1994T Yoshino K, Sato T, Nakai Y, Tanabe M, Matsunaga T, Kozuka T, et al.[A comparative clinical study on the treatment of head and neck tumors by adjuvant chemotherapy with HCFU - Second Study by Kinki Head and Neck Tumor Study Group]. Gan To Kagaku Ryoho 1994;21(6):777-83.
128. Zorat 2004 Zorat PL, Paccagnella A, Cavaniglia G, Loreggian L, Gava A, Mione CA, et al.Randomized phase III trial of neoadjuvant chemotherapy in head and neck cancer: 10-year follow-up. Journal of the National Cancer Institute 2004;96(22):1714-7.
129. Arguis 2006SU Arguis M, del Campo JM, Giralt J. [Simultaneous chemoradiotherapy in tumors treatment: Head and neck]. Revisiones en Cancer 2006;20(6):279-88.
130. Bergermann 1992T Bergermann M, Dieckmann J, Machtens E. [Preoperative short-term preliminary irradiation with 3 x 6 Gy, immediate radical tumor resection and postoperative booster irradiation to 60 Gy as an effective therapy concept for the treatment of T2 squamous cell carcinomas of the mouth. Results of a prospective randomized bi-center study]. Fortschritte der Kiefer- und Gesichts-Chirurgie 1992;37:17-20.
131. Bernier 2007SU Bernier J, Schneider D. Cetuximab combined with radiotherapy: an alternative to chemoradiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck?. European Journal of Cancer 2007;43(1):35-45.
132. Bitter 1979T *Bitter K. [Comparison of a post-operative chemotherapy with postoperative Co-60 radiotherapy in patients with advanced oral cavity carcinomas. Report of a randomised study]. Deutsche Zeitschrift fur Mund, Kiefer und Gesichtschirurgie 1979;3:55S-58S.
133. Bitter K. Postoperative chemotherapy versus postoperative cobalt 60 radiation in patients with advanced oral carcinoma. Report on a randomized study. Head and Neck Surgery 1981;3:264.
134. BNH 003 B Nanavati Hospital Group. BNH 003. Anterior (neoadjuvant) chemotherapy in advanced resectable cancers of the oral cavity and oropharynx. Unpublished trial identified in Pignon 2000a.
135. Cheshuk 2004SU Cheshuk VE, Kravchenko AV, Lobanova OE, Medinets IuR, Maloed LG. [Local hyperthermia by means of ballon-type electrodes in combined therapy of patients with locally spread cancer of the mouth mucosa and lower lip]. Likars'ka Sprava/Ministerstvo Okhorony Zdorov'ia Ukraïny 2004;(1):32-4.
136. Deo 2005SU Deo S, Hazarika S, Shukla NK, Kar M, Samaiya A. A prospective randomized trial comparing harmonic scalpel versus electrocautery for pectoralis major myocutaneous flap dissection. Plastic and Reconstructive Surgery 2005;115(4):1006-9.
137. Eckardt 2006SU Eckardt A, Wegener G, Karstens JH. [Preoperative radiochemotherapy of advanced resectable cancer of the oral cavity with cisplatin vs paclitaxel/carboplatin. Analysis of two multimodality treatment concepts]. Mund, Kiefer- und Gesichtschirurgie 2006;10(1):30-6.
138. EORTC 24844 EORTC Head and Neck Cancer Co-operative Group. EORTC 24844 trial. Randomized trial of induction chemotherapy followed by surgery and postoperative radiotherapy versus surgery and postoperative radiotherapy alone in advanced squamous cell carcinoma of the lateral oropharynx and lateral posterior oral cavity. Unpublished trial identified in Pignon 2000a.
139. GETTEC neo GETTEC (Groupe d'Etude des Tumeurs de la Tête Et du Cou, Paris). GETTEC neo1. Induction chemotherapy before surgery plus radiotherapy in oropharyngeal carcinoma: a randomized trial. Unpublished trial identified in Pignon 2000a.
140. Hering 1981T Hering KG, Dieckmann J, Morgenroth K, Will CH. Preoperative short-time irradiation with telecobalt in case of squamous cell carcinoma of the floor of themouth. Strahlentherapie 1981;157:699- 704.
141. Rink 1989T Rink B, Neumann HJ, Kuchler I. [Clinical experience with different modes of preoperative radiotherapy in advanced carcinomas of the tongue and the floor of the mouth]. Deutsche Zeitschrift fur Mund-, Kiefer-, und Gesichts-Chirurgie 1989;13(4):286-90.
142. Saarilahti 2006SU Saarilahti K, Kouri M, Collan J, Kangasmaki A, Atula T, Joensuu H, et al.Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer. Radiotherapy and Oncology 2006;78(3):270-5.
143. SECOG II South-East Co-operative Oncology Group. SECOGII. Randomized trial comparing radiotherapy alone, synchronous chemoradiotherapy, and sequential chemoradiotherapy in squamous cell carcinoma of the head and neck. Unpublished trial identified in Pignon 2000a.
144. Zakotnik 2007SU Zakotnik B, Budihna M, Smid L, Soba E, Strojan P, Fajdiga I, et al.Patterns of failure in patients with locally advanced head and neck cancer treated postoperatively with irradiation or concomitant irradiation with Mitomycin C and Bleomycin. International Journal of Radiation Oncology, Biology, Physics 2007;67(3):685-90.
145. Allen 2003 Allen PF. Assessment of oral health related quality of life. Health and Quality of Life Outcomes 2003;1(1):40.
146. Batsakis 1999 Batsakis JG. Surgical excision margins: a pathologist's perspective. Advances in Anatomic Pathology 1999;6(3):140-8.
147. Bitter 1981 Bitter K. Postoperative chemotherapy versus postoperative cobalt 60 radiation in patients with advanced oral carcinoma. Report on a randomized study. Head and Neck Surgery 1981;3:264.
148. Bjordal 1992 Bjordal K, Kaasa S. Psychometric validation of the EORTC Core Quality of Life Questionnaire, 30-item version and a diagnosis-specific module for head and neck cancer patients. Acta Oncologica 1992;31(3):311-21.
149. Bourhis 2006 Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, et al.Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. The Lancet 2006;368(9538):843-54.
150. Bourhis 2007 Bourhis J, Le Maitre A, Baujat B, Audry H, Pignon J-P. Individual patients' data meta-analyses in head and neck cancer. Current Opinions in Oncology 2007;19(3):188-94.
151. Carew 2003 Carew JF, Singh B, Shah JP. Cervical lymph nodes. In: Shah JP, Johnson NW, Batsakis JG editor(s). Oral cancer. London: Martin Dunitz, 2003:215-49.
152. Carlson 2006 Carlson ER, Miller I. Surgical management of the neck in oral cancer. Oral Maxillofacial Surgery Clinics of North America 2006;18:533-46.
153. Conway 2006 Conway DI, Stockton DL, Warnakulasuriya KA, Ogden G, Macpherson LM. M. Incidence of oral and oropharyngeal cancer in United Kingdom (1990-1999) - recent trends and regional variation. Oral Oncology 2006;42(6):586-92.
154. Day 2003 Day TA, Davis BK, Gillespie MB, Joe JK, Kibbey M, Martin-Harris B, et al.Oral cancer treatment. Current Treatment Options in Oncology 2003;4(1):27-41.
155. Deleyiannis 1997 Deleyiannis FW, Weymuller EA Jr, Coltrera MD. Quality of life of disease-free survivors of advanced (stage III or IV) oropharyngeal cancer. Head & Neck 1997;19(6):466-73.
156. Devereaux 2005 Devereaux PJ, Bhandari M, Clarke M, Montori VM, Cook DJ, Yusuf S, et al.Need for expertise based randomised controlled trials. BMJ 2005;330(7482):88.
157. Funk 2002 Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK, Hoffman HT. Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head & Neck 2002;24(2):165- 80.
158. Garg 2004 Garg M, Beitler JJ. Controversies in management of the neck in head and neck cancer. Current Treatment Options in Oncology 2004;5(1):35-40.
159. Haddadin 1999 Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG. Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head & Neck 1999;21(6):517-25.
160. Haddadin 2000 Haddadin KJ, Soutar DS, Webster MH, Robertson AG, Oliver RJ, MacDonald DG. Natural history and patterns of recurrence of tongue tumours. British Journal of Plastic Surgery 2000;53(4):279-85.
161. Hammerlid 1997 Hammerlid E, Bjordal K, Ahlner-Elmqvist M, Jannert M, Kaasa S, Sullivan M, et al.Prospective, longitudinal quality-of-life study of patients with head and neck cancer: a feasibility study including the EORTC QLQ-C30. Otolaryngology Head and Neck Surgery 1997;116(6 Pt 1):666-73.
162. Hassan 1993 Hassan SJ, Weymuller EA. Assessment of quality of life in head and neck cancer patients. Head & Neck 1993;15(6):485- 96.
163. Higgins 2006 Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]. The Cochrane Library Issue 4. Chichester, UK: John Wiley & Sons, Ltd, 2006.
164. Hindle 1996 Hindle I, Downer MC, Speight PM. The epidemiology of oral cancer. British Journal of Oral and Maxillofacial Surgery 1996;34(5):471-6.
165. Huang 1992 Huang DT, Johnson CR, Schmidt-Ullrich R, Grimes M. Postoperative radiotherapy in head and neck cancer carcinoma with extracapsular lymph node extension and/or positive resection margins: a comparitive study. International Journal of Radiation Oncology, Biology, Physics 1992;23(4):737-42.
166. Hughes 1993 Hughes CJ, Gallo O, Spiro RH, Shah JP. Management of occult neck metastases in oral cavity squamous carcinoma. American Journal of Surgery 1993;166(4):380-3.
167. Kogevinas 1997 Kogevinas M, Pearce N, Susser M, Boffetta P. Social inequalities and cancer. Lyon: IARC Scientific Publications No 138. International Agency for Research in Cancer, 1997.
168. La Vecchia 1997 La Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G, Negri E. Epidemiology and prevention of oral cancer. Oral Oncology 1997;33(5):302-12.
169. Macfarlane 1995 Macfarlane GJ, Zheng T, Marshall JR, Boffetta P, Niu S, Brasure J, et al.Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies. Oral Oncology 1995;31B(3):181-7.
170. McCulloch 2005 McCulloch P, Kaul A, Wagstaff GH, Wheatcroft J. Tolerance of uncertainty, extroversion, neuroticism and attitudes to randomized controlled trials among surgeons and physicians. British Journal of Surgery 2005;92(10):1293-7.
171. NCI NCI. Common toxicity criteria for adverse events. http://ctep.info.nih.gov (accessed January 2007).
172. NICE 2004 National Institute for Health and Clinical Excellence. Guidance on cancer services: Improving outcomes in head and neck cancers - the research evidence. http://guidance.nice.org.uk/download.aspx?o=233553.
173. Parkin 1999 Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. International Journal of Cancer 1999;80(6):827-41.
174. Parkin 2001 Parkin DM. Global cancer statistics in the year 2000. Lancet Oncology 2001;2(9):533-43.
175. Parkin 2005 Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians 2005;55(2):74-108.
176. Parmar 1998 Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815-34.
177. Partridge 2000 Partridge M, Li SR, Pateromichelakis S, Francis R, Phillips E, Huang XH, et al.Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment. Clinical Cancer Research 2000;6(7):2718-25.
178. Pentenero 2005 Pentenero M, Gandolfo S, Carrozzo M. Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature. Head & Neck 2005;27(12):1080-91.
179. Pignon 2000a Pignon JP, Bourhis J, Domenge C, Designé L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. The Lancet 2000;355(9208):949-55.
180. Pignon 2000b Pignon J-P, Sylvester R, Bourhis J. Hyperfractionated and/or accelerated radiotherapy versus conventional radiotherapy for head and neck cancer. Cochrane Database of Systematic Reviews 2000, Issue 2.Art. No.: CD002026. DOI:10.1002/14651858.CD002026.
181. Pitman 2003 Pitman KT, Ferlito A, Devaney KO, Shaha AR, Rinaldo A. Sentinel lymph node biopsy in head and neck cancer. Oral Oncology 203;39(4):343-9.
182. Robbins 2002 Robbins KT, Clayman G, Levine PA, Medina J, Sessions R, Shaha A, et al.Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Archives of Otolaryngology - Head & Neck Surgery 2002;128(7):751-8.
183. Robinson 2003 Robinson KL, Macfarlane GJ. Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing?. Oral Oncology 2003;39(1):31-6.
184. Rogers 1998 Rogers SN, Humphris G, Lowe D, Brown JS, Vaughan ED. The impact of surgery for oral cancer on quality of life as measured by the Medical Outcomes Short Form 36. Oral Oncology 1998;34(3):171-9.
185. Rogers 2002 Rogers SN, Lowe D, Fisher SE, Brown JS, Vaughan ED. Health-related quality of life and clinical function after primary surgery for oral cancer. British Journal of Oral and Maxillofacial Surgery 2002;40(1):11-8.
186. Rogers 2007 Rogers SN, Ahad SA, Murphy AP. A structured review and theme analysis of papers published on 'quality of life' in head and neck cancer: 2000-2005. Oral Oncology [Epub ahead of print].
187. Shah 1990 Shah JP. Cervical lymph node metastases - diagnostic, therapeutic, and prognostic implications. Oncology (Williston Park, NY) 1990;4(10):61-9.
188. Short 1984 Short SO, Kaplan JN, Laramore GE, Cummings CW. Shoulder pain and function after neck dissection with or without preservation of the spinal accessory nerve. The American Journal of Surgery 1984;148(4):478-82.
189. SIGN 2006 SIGN (Scottish Intercollegiate Guidelines Network). Diagnosis and management of head and neck cancer. http://www.sign.ac.uk/pdf/ sign90.
190. Sutton 2003 Sutton DN, Brown JS, Rogers SN, Vaughan ED, Woolgar JA. The prognostic implications of the surgical margin in oral squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery 2003;32(1):30-4.
191. Trotti 2004 Trotti A, Bentzen SM. The need for adverse effects reporting standards in oncology clinical trials. Journal of Clinical Oncology 2004;22(1):19-22.
192. WHO 1992 WHO. ICD-O. International statistical classification of diseases and related health problems, 1989 revision. Geneva: World Health Organization, 1992.
193. Woolgar 2003 Woolgar JA, Rogers SN, Lowe D, Brown JS, Vaughan ED. Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncology 2003;39(2):130-7.
194. Xi 2003 Xi S, Grandis JR. Gene therapy for the treatment of oral squamous cell carcinoma. Journal of Dental Research 2003;82(1):11- 6.