Hyperfractionated or accelerated radiotherapy for head and neck cancer

Cochrane Database of Systematic Reviews

Volumn 2010, Issue 12, 2010, Pages

  Baujat, Bertrand ^a   Bourhis, Jean ^b   Blanchard, Pierre ^b   Overgaard, J ^s   Ang, Kian K ^d   Saunders, Michelle ^e   Le Maître, Aurélie ^b   Bernier, Jacques ^f   Horiot, Jean Claude ^g   Maillard, Emilie ^b   Pajak, Thomas F ^h   Poulsen, Michael G ⁱ   Bourredjem, Abderrahmane ^b   O'Sullivan, B ^s   Dobrowsky, Werner ^k   Andrzej, Hliniak ^l   Skladowski, Krzystof ^m   Hay, John H ⁿ   Pinto, Luiz Hj ^o   Fu, Karen K ^p   Fallai, Carlo ^q   Sylvester, Richard ^r   Pignon, Jean Pierre ^b   Audry, H ^s   Bourhis, J ^s,s   Bolla, M ^s   Duchateau, L ^s   Hill, C ^s   Pignon, J P ^s   Sylvester, R ^s   Syz, N ^s   Ang, K K ^s,s   Bernier, J ^s,s   Dische, S ^s,s   Eschwege, F ^s   Fu, K K ^s,s   Horiot, J C ^s   Parmar, M K B ^s   Awwad, H K ^s   Baerg, B ^s   Benhamou, E ^s   Collette, L ^s   Cummings, B J ^s   Dobrowsky, W ^s   Denham, J W ^s   Fallai, C ^s   Grau, C ^s   Hansen, H Sand ^s   Hay, J H ^s   Hliniak, A ^s   Jacskon, S M ^s   Kraszewska, E ^s   Lotayef, M ^s   Maciejewski, B ^s   Olmi, P ^s   Pajak, T F ^s   Pintilie, M ^s   Pinto, L H J ^s   Poulsen, M G ^s   Saunders, M ^s   Skladowski, K ^s   Tandon, N ^s   Torri, V ^s   Widder, J ^s   Baujat, B ^s   Blanchard, P ^s   Bourredjem, A ^s   more..

^a HÔPITAL TENON   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e MOUNT VERNON CANCER CENTRE   (United Kingdom)

^f Service de Radio Oncologie   (Switzerland)

^g Service de Radio Oncologie   (Switzerland)

^h RTOG   (United States)

ⁱ Queensland Radium Institute   (Australia)

^j Princess Margaret Hospital   (Canada)

^k NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^l INSTITUTE OF ONCOLOGY   (Poland)

^m INSTITUTE OF ONCOLOGY   (Poland)

ⁿ Vancouver Cancer Center   (Canada)

^o INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^p UNIVERSITY OF CALIFORNIA   (United States)

^q NATIONAL CANCER INSTITUTE   (Italy)

^r EORTC DATA CENTER   (Belgium)

^s NONE   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACCELERATED RADIOTHERAPY; AGE; CANCER CONTROL; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER SURVIVAL; DEATH; HEAD AND NECK CANCER; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HYPERFRACTIONATED RADIOTHERAPY; INTERMETHOD COMPARISON; LARYNX SQUAMOUS CELL CARCINOMA; META ANALYSIS; OROPHARYNX SQUAMOUS CELL CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; RADIATION DOSE REDUCTION; REVIEW; SURVIVAL RATE; SYSTEMATIC REVIEW; THERAPY EFFECT; HEAD AND NECK TUMOR; METHODOLOGY; MORTALITY; RADIATION DOSE FRACTIONATION; RADIOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SQUAMOUS CELL CARCINOMA;

AGE FACTORS; CARCINOMA, SQUAMOUS CELL; DOSE FRACTIONATION; HEAD AND NECK NEOPLASMS; HUMANS; RADIOTHERAPY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 79952202229     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD002026.pub2     Document Type: Review

References (63)

1. Jackson SM, Weir LM, Hay JH, Tsang VH, Durham JS. A randomized trial of accelerated versus conventional radiotherapy in head and neck cancer. Radiotherapy and Oncology 1997;43(1):39-46.
2. Skladowski K, Maciejewski B, Golen M, Pilecki, B, Przeorek W, Tarnawski R. Randomized clinical trial on 7-days-continuous accelerated irradiation (CAIR) of head and neck cancer - report on 3-year tumor control and normal tissue toxicity. Radiotherapy and Oncology 2000;55:101-10.
3. Dische S, Saunders M, Barrett A, Harvey A, Gibson D, Parmar M. A randomized multicentre trial of CHART vs conventional radiotherapy in head and neck cancer. Radiotherapy and Oncology 1997;44:123-36.
4. Overgaard J, Hansen HS, Specht L, Overgaard M, Grau C, Andersen E, et al. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial. Lancet 2003;362(9388):933-40.
5. Horiot JC, Le Fur R, N'Guyen T, Chenal C, Schraub S, Alfonsi S, et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiotherapy and Oncology 1992;25:231-41.
6. Horiot JC, Bontemps P, van den Bogaert W, Le Fur R, van den Weijngaert D, Bolla M, et al. Accelerated fractionation compared to conventional fractionation improves locoregional control in the radiotherapy of advanced head and neck cancer: results of the EORTC 22851 randomized trial. Radiotherapy and Oncology 1997;44:111-21.
7. Bourhis J, Lapeyre M, Tortochaux J, Rives M, Aghili M, Bourdin S, et al. Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial. Journal of Clinical Oncology 2006;24:2873-8.
8. Hliniak A, Gwiazdowska B, Szutkowski Z, Kraszewska E, Kukolowicz P, Jarzabski A, et al. A multicenter randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time. Radiotherapy and Oncology 2002;62:1-10.
9. Olmi P, Crispino S, Fallai C, Torri V, Rossi F, Bolner A, et al. Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus concomitant radiotherapy and chemotherapy - a multicenter randomized trial. International Journal of Radiation Oncology, Biology, Physics 2003;55:78-92.
10. Cummings B, Keane T, Pintilie M, Warde P, Waldron J, Payne D, et al. Five year results of a randomized trial comparing hyperfractionated to conventional radiotherapy over four weeks in locally advanced head and neck cancer. Radiotherapy and Oncology 2007;85(1):7-16.
11. Pinto LH, Canary PC, Araujo CM, Bacelar SC, Souhami L. Prospective randomized trial comparing hyperfractionated versus conventional radiotherapy in stage III and IV oropharyngeal carcinoma. International Journal of Radiation Oncology, Biology, Physics 1991;21:557-62.
12. Marcial VA, Pajak TF, Chang C, Tupchong L, Stetz J. Hyperfractionated photon radiation therapy in the treatment of advanced squamous cell carcinoma of the oral cavity, pharynx, larynx, and sinuses, using radiation therapy as the only planned modality: (preliminary report) by the Radiation Therapy Oncology Group (RTOG). International Journal of Radiation Oncology, Biology, Physics 1987;13:41-7.
13. Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL, et al. A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. International Journal of Radiation Oncology, Biology, Physics 2000;48:7-16.
14. Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL, et al. A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. International Journal of Radiation Oncology, Biology, Physics 2000;48:7-16.
15. Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL, et al. A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. International Journal of Radiation Oncology, Biology, Physics 2000;48:7-16.
16. Poulsen MG, Denham JW, Peters LJ, Lamb DS, Spry NA, Hindley A, et al. A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: a Trans-Tasman Radiation Oncology Group Study. Radiotherapy and Oncology 2001;60:113-22.
17. Dobrowsky W, Naudé J. Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancer. Radiotherapy and Oncology 2000;57:119-24.
18. Awwad HK. Personal communication 2002.
19. Datta NR, Dutta Choudhry A, Gupta S, Bose AK. Twice a day versus once a day radiation therapy in head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 1989;17(Suppl 1):132-3.
20. Overgaard J, Hansen HS, Andersen AP, Hjelm-Hansen M, Jorgens K, Sandberg E, et al. Misonidasole combined with split course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study. International Journal of Radiation Oncology, Biology, Physics 1989;16:1065-8.
21. Sanchiz F, Milla A, Torner J, Bonet F, Artola N, Carreno L, et al. Single fraction versus two fractions per day versus radio-chemotherapy in the treatment of HNSCC. International Journal of Radiation Oncology, Biology, Physics 1990;19:1347-50.
22. Sladowski K, Hutnik M, Wygoda A, Sasiadek W, Rutkowski T, Golen M, et al. Two accelerated radiation treatments have produced identical acute mucosal toxicity profile. An interim report on CAIR-2 Phase III trial for head and neck cancer patients. Radiotherapy and Oncology 2007;82(Suppl 1):S86-7.
23. Tandon N, Keshwar TS, Srivastava M, Mali HR. Continuous hyperfractionated accelerated radiotherapy (CHART) in head and neck malignancies. 15th Asia Pacific Cancer Conference; Chennai, India. 1999.
24. Van den Bogaert W, van der Schueren E, Horiot JC, Chaplain G, De Vilhena M, Raposo S, et al. Early results of the EORTC randomized clinical trial on multiple fraction per day (MFD) and misonidazole in advanced head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 1986;12:587-91.
25. Weissberg JB, Son YH, Percarpio B, Fischer JJ. Randomized trial of conventional versus high fractional dose radiation therapy in the treatment of advanced head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 1982;8:179-85.
26. Wiernik G, Alcock CJ, Bates TD, Brindle JM, Fowler JF, Gajek WR, et al. Final report on the second British Institute of Radiology fractionation study: short versus long overall treatment times for radiotherapy of carcinoma of the laryngo-pharynx. British Journal of Radiology 1991;64:232-41.
27. Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, et al. Randomized trial addressing risk feature and times factors of surgery plus radiotherapy in advanced head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 2001;51:571-8.
28. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. New England Journal of Medicine 2010;363(1):24-35.
29. Preoperative accelerated versus postoperative conventional radiotherapy in patients with resectable cancer of the oral cavity. http://www.controlled-trials.com/ISRCTN00608410/00608410 (accessed 30 September 2010).
30. Awwad HK, Khafagy Y, Barsoum M, Ezzat S, El-Attar I, Farag H, et al. Accelerated versus conventional fractionation in the postoperative irradiation of locally advanced head and neck cancer: influence of tumour proliferation. Radiotherapy and Oncology 1992;25:261-6.
31. Awwad HK, Lotayef M, Shouman T, Begg AC, Wilson G, Bentzen SM, et al. Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation. British Journal of Cancer 2002;86:517-23.
32. Bartelink H, Van den Bogaert W, Horiot JC, Jager J, Van Glabbeke M. Concomitant cisplatin and radiotherapy in a conventional and modified fractionation schedule in locally advanced head and neck cancer: a randomised phase II EORTC trial. European Journal of Cancer 2002;38:667-73.
33. Bourhis J, Sire C, Lapeyre M, Gregoire V, Maingon P, Calais G, et al. Accelerated versus conventional radiotherapy with concomitant chemotherapy in locally advanced head and neck carcinomas: results of a phase III randomized trial. Radiotherapy and Oncology 2010;72 (Suppl 1):S32.
34. Dische S, Saunders M. Phase III randomized study of adjuvant continuous hyperfractionated accelerated radiotherapy versus conventional radiotherapy in patients with head and neck cancer. PDQ database 2007.
35. Ezzat M, Shouman T, Zaza K, Safwat A, El-Khoudary A, El-Senosi M, et al. A randomized study of accelerated fractionation radiotherapy with and without mitomycin C in the treatment of locally advanced head and neck cancer. Journal of the Egyptian National Cancer Institute 2005;17:85-92.
36. Ghosh S, Agarwal J, Bhutani R, Vora A, Prabhash K, D'cruz A, et al. Randomized trial of conventional fractionated RT (CFRT) vs. concomitant chemo radiotherapy (CTRT) and accelerated radiotherapy (ACRT) in patients with advanced, non nasopharyngeal, squamous cell cancers of the head and neck region. International Journal of Radiation Oncology, Biology, Physics 2006;66(Suppl 1):S191.
37. Horiot JC. EORTC 22962: Phase III comparison study of conventional vs hyperfractioned radiotherapy in head and neck squamous cell carcinoma with or without concomitant chemotherapy. PDQ database 2007.
38. Johnson CR, Schmidt-Ullrich RK, Arthur DW, Huang DT, Duffy EW. Standard once daily versus thrice-daily concomitant boost accelerated superfractionated irradiation for advanced squamous cell carcinoma of the head and neck: preliminary results of a prospective randomized trial. International Journal of Radiation Oncology, Biology, Physics 1995;32:162.
39. Krstevska V, Crvenkova S. Altered and conventional fractionated radiotherapy in locoregional control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, and hypopharynx. Croatian Medical Journal 2006;47:42-52.
40. Langendijk J, on behalf of the NWHHT-SG. The Dutch head and neck cancer cooperative study group (NWHHT-SG). Radiotherapy and Oncology 2007;82(Suppl 1):S1.
41. Langendijk J, on behalf of the NWHHT-SG. The Dutch head and neck cancer cooperative study group (NWHHT-SG). Radiotherapy and Oncology 2007;82(Suppl 1):S1.
42. Overgaard J, Mohanti BK, Begum N, Ali R, Agarwal JP, Kuddu M, et al. Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial. Lancet Oncology 2010;11(6):553-60.
43. Sanguineti G, Richetti A, Bignardi M, Corvo' R, Gabriele P, Sormani MP, et al. Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter phase III study. International Journal of Radiation Oncology, Biology, Physics 2005;61:762-71.
44. Ghoshal S, Goda JS, Mallick I, Kehwar TS, Sharma SC. Concomitant boost radiotherapy compared with conventional radiotherapy in squamous cell carcinoma of the head and neck - a phase III trial from a single institution in India. Clinical Oncology 2008;20(3):212-20.
45. Slevin NJ. A randomised two arm trial of modestly accelerated radiotherapy with synchronous cisplatinum chemotherapy versus conventional radiotherapy with synchronous cisplatinum chemotherapy in the treatment of head and neck squamous cell carcinoma: a pilot study. http://www.controlled-trials.com/ISRCTN86478952/86478952 (accessed 28 September 2010).
46. Suwinski R, Bankowska-Wozniak M, Majewski W, Idasiak A, Maciejewski A, Ziólkowska E, et al. Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer. Radiotherapy and Oncology 2008;87(2):155-63.
47. Trotti A, Pajak T, Emami B, Hammond E, Jones C, Morrison W, et al. A randomized trial of hyperfractionation versus standard fractionation in T2 squamous cell carcinoma of the vocal cord. International Journal of Radiation Oncology, Biology, Physics 2006;66(Suppl 1):S15.
48. Zackrisson B, Kjellén E, Björk-Eriksson T, Friesland S, Reizenstein J, Lagerlund M, et al. Preliminary results from a Swedish study of conventional versus accelerated fractionated of squamous carcinoma of the head and neck (ARTSCAN). Radiotherapy and Oncology 2007;82(Suppl 1):S1-2.
49. Bourhis J, Armand C, Pignon JP, on behalf of the MACH-NC Collaborative Group. Update of MACH-NC (Meta-Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemo-radiotherapy. Proceedings of the American Society for Clinical Oncology 2004;22:488.
50. Early Breast Cancer Trialists Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31, 000 recurrences and 24, 000 deaths among 75, 000 women. Lancet 1992;339:1-15.
51. Early Breast Cancer Trialists Collaborative Group. Effects of radiotherapy and surgery in early breast cancer: an overview of randomized trials. New England Journal of Medicine 1995;333:1444-55.
52. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. IARC Cancer Base. Vol. 5, version 2.0, Lyon, France: IARC Press, 2004.
53. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
54. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002;21:1539-58.
55. Khalil AA, Bentzen SM, Bernier J, Saunders MI, Horiot JC, Van Den Bogaert W, et al. Compliance to the prescribed dose and overall treatment time in five randomized clinical trials of altered fractionation in radiotherapy for head-and-neck carcinomas. International Journal of Radiation Oncology, Biology, Physics 2003;55:568-75.
56. Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ 1995;311:899-909.
57. Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Lancet 2000;355:949-55.
58. Pignon JP, Le Maître A, Bourhis J, on behalf of the MACH-NC Collaborative Group. Meta-analyses of chemotherapy in head and neck cancer (MACH-NC): an update. International Journal of Radiation Oncology, Biology, Physics 2007;69(Suppl 1):S112-4.
59. Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Controlled Clinical Trials 1996;17:343-6.
60. Stewart LA, Parmar MK. Meta-analysis of the literature or meta-analysis of individual patient data: is there a difference?. Lancet 1993;341:418-22.
61. Sobin LH, Wittekind C. International Union Against Cancer (UICC): TNM Classification of Malignant Tumours. 6th Edition. New-York: Wiley-Liss, 2002.
62. Yusuf S, Peto R, Lewis J, Collins R, Sleight T. Beta blockade during and after myocardial infarction: an overview of randomised clinical trials. Progress in Cardiovascular Diseases 1985;27:335-71.
63. Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J et al on behalf of MARCH Collaborative Group. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 2006;368:843-54.