Cisplatin and Fluorouracil as Neoadjuvant Therapy in Head and Neck Cancer: A Preliminary Report

Archives of Otolaryngology--Head and Neck Surgery

Volumn 113, Issue 7, 1987, Pages 758-761

  Toohill, Robert J ^a,b   Anderson, Tom ^a,c   Byhardt, Roger W ^a,c   Cox, James D ^a,c,e   Duncavage, James A ^a,b,d   Grossman, Thomas W ^a,b   Haas, Charles D ^a,c   Haas, Judith S ^a,c   Hartz, Arthur J ^a,f   Libnoch, Joseph A ^a,c   Malin, Thomas C ^a,b   Ritch, Paul S ^a,c   Wilson, J Frank ^a,c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b Veterans Administration   (United States)

^c CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f Department of Hematology/Oncology Veterans Administration Medical Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADVERSE DRUG REACTION; BLOOD AND HEMOPOIETIC SYSTEM; BONE MARROW DEPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER SURGERY; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG THERAPY; ELECTROLYTE BALANCE; GASTROINTESTINAL TOXICITY; HEAD AND NECK CANCER; HEARING LOSS; HUMAN; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; LARYNX; MAJOR CLINICAL STUDY; MOUTH; MUCOSA INFLAMMATION; NAUSEA; OTOTOXICITY; PHARYNX; PRIORITY JOURNAL; RADIOTHERAPY; SURVIVAL; THERAPY; VOMITING;

CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; FLUOROURACIL; HEAD AND NECK NEOPLASMS; HUMANS; PROGNOSIS; PROSPECTIVE STUDIES; RANDOM ALLOCATION;

EID: 0023187933     PISSN: 08864470     EISSN: 1538361X     Source Type: Journal    
DOI: 10.1001/archotol.1987.01860070072019     Document Type: Article

References (20)

1. Cancer Patient Survival, report 5. Bethesda, Md, US Dept of Health, Education and Welfare, Public Health Service, National Institutes of Health, 1976, p 4.
2. Randolph VL, Vallejo A, Spiro RH, et al: Combination therapy of advanced head and neck cancer: Induction of remissions with diamminedichloroplatinum (II), bleomycin and radiation therapy. Cancer 1978;41:460–467.
3. Hong WK, Shapshay S, Bhutani R, et al: Induction chemotherapy in advanced previously untreated squamous cell head and neck cancer with cisplatin and bleomycin, in Prestayko AW, Crooke ST, Carter SK (eds): Cisplatin: Current Status and New Developments. Orlando, Fla, Academic Press Inc, 1980, pp 431–444.
4. Spaulding MB, Klotch D, Grillo J: Adjuvant chemotherapy in the treatment of advanced tumors of the head and neck. Am J Surg 1980;140:538–542.
5. Ervin TJ, Karp DD, Weichelbaum RR, et al: Adjuvant chemotherapy for squamous carcinoma of the head and neck, in Salmon S, Jones S (eds): Adjuvant Therapy of Cancer III. New York, Grune & Stratton, 1981, pp 183–189.
6. Al-Sarraf M, Drelichman A, Jacobs J, et al: Adjuvant chemotherapy with cisplatin, bleomycin, and Oncovin followed by surgery and/or radiotherapy in patients with advanced previously untreated head and neck cancer, in Salmon S, Jones S (eds): Adjuvant Therapy of Cancer III. New York, Grune & Stratton, 1981, pp 145–152.
7. Kish J, Drelichman A, Jacobs J, et al: Clinical trials of cisplatin and 5-FU infusion as initial treatment of advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 1982; 11:471–474.
8. Staging of Cancer of Head and Neck Sites and of Melanoma. Chicago, American Joint Committee for Cancer Staging and End-Results Reporting, 1980.
9. Lee E, Desu M: Computer program for comparing k samples with right-censored data. Comput Programs Biomed 1972;2:315–322.
10. Lehman RH, Cox JD, Belson TP, et al: Recurrence patterns by modality of carcinoma of the floor of mouth and oral tongue. Am J Otolaryngol 1982;3:174–181.
11. Byhardt RW, Cox, JD: Patterns of failure and results of preoperative irradiation vs radiation therapy alone in carcinoma of the pyriform sinus. Int J Radiat Oncol Biol Phys 1980;6:1135–1141.
12. Holoye PY, Byers RM, Gard DA, et al: Combination chemotherapy of head and neck cancer. Cancer 1978;42:1661–1669.
13. Kun LE, Toohill RJ, Holoye PY, et al: Effect of induction chemotherapy in advanced cancers of the upper aerodigestive tract: A prospective, randomized trial. Int J Radiat Oncol Biol Phys 1983;9(suppl 1):138.
14. Al-Sarraf M, Drelichman A, Peppard S, et al: Adjuvant cisplatinum and 5-fluorouracil 96-hour infusion in previously untreated epidermoid cancers of the head and neck, abstract C-376. Program and abstracts of the 72nd Annual Meeting of the American Association for Cancer Research, April 27-30, 1981, along with the 17th Annual Meeting of the American Society of Clinical Oncology, April 30-May 2, 1981, Washington, DC.
15. Weaver A, Flemming S, Kish J, et al: Cis-platinum and 5-fluorouracil as induction therapy for advanced head and neck cancer. Am J Surg 1982;144:445–448.
16. Van Den Broek P, Wagener DJ, Levendag PC, et al: Randomized adjuvant chemotherapy trial in advanced head and neck cancer, abstract 23, in Sisson GA (ed): Program and abstracts of the 25th Annual Meeting of the American Society for Head and Neck Surgery—The Head and Neck Story, Palm Springs, Calif, March 10-13, 1983.
17. Oye RK, Shapiro MF: Reporting results from chemotherapy trials. JAMA 1984;252:2722–2725.
18. Glick JH, Marcial V, Richter M, et al: Adjuvant treatment of inoperable stage III and IV epidermoid carcinoma of the head and neck with platinum and bleomycin infusions prior to definitive radiotherapy. Cancer 1980;46:1919–1924.
19. Ensley J, Jacobs J, Weaver A, et al: Initial cisplatin combination predicting response to radiotherapy in patients with advanced epidermoid cancers of the head and neck. Proc Am Soc Clin Oncol 1982;1:197.
20. Price LA, Hill BT: Integration of safe initial combination chemotherapy with a high response rate and local therapy for untreated stage III and IV epidermoid cancer of the head and neck. Cancer Treat Rep 1983;67:535–539.