Targeting K+ channels for cancer therapy

Journal of Experimental Therapeutics and Oncology

Volumn 4, Issue 2, 2004, Pages 161-166

  Conti, Matteo ^a,b  

^a SANTA MARIA DELLE CROCI HOSPITAL   (Italy)

^b NONE   (Italy)

Author keywords

Cancer progression; Cancer therapy; Cellular proliferation; Chemosensitisation; K + channels modulators; K+ channels; Multidrug resistance; Proteomics

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG;

ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER INHIBITION; CANCER THERAPY; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DEPOLARIZATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE STEADY POTENTIAL; NONHUMAN; POTASSIUM CHANNEL EAG; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TUMOR CELL;

ANTINEOPLASTIC AGENTS; HUMANS; NEOPLASMS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 4043165553     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (81)

1. Miller C. An overview of the potassium channel family. Genome Biol 1: reviews 0004.0001 - 0004.0005, 2000.
2. Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R. The principle of gating charge movement in a voltage-dependent K+ channel. Nature 423:42-48, 2003.
3. Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R. X-ray structure of a voltage-dependent K+ channel. Nature 423:33-41, 2003.
4. Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S. Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med 160:369-385, 1984.
5. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature 307:465-468, 1984.
6. Amigorena S, Choquet D, Teillaud JL, Korn H, Fridman WH. Ion channels and B cell mitogenesis. Mol Immunol 27:1259-1268, 1990.
7. Amigorena S, Choquet D, Teillaud JL, Korn H, Fridman WH. Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels. J Immunol 144:2038-2045, 1990.
8. Mauro T, Dixon DB, Komuves L, Hanley K, Pappone PA. Keratinocyte K+ channels mediate Ca2+-induced differentiation. J Invest Dermatol 108:864-870, 1997.
9. Pappas CA, Ritchie JM. Effect of specific ion channel blockers on cultured Schwann cell proliferation. Glia 22:113-120, 1998.
10. Strobl JS, Wonderlin WF, Flynn DC. Mitogenic signal transduction in human breast cancer cells. Gen Pharmacol 26:1643-1649, 1995.
11. Zhou Q, Kwan HY, Chan HC, Jiang JL, Tam SC, Yao X. Blockage of voltage-gated K+ channels inhibits adhesion and proliferation of hepatocarcinoma cells. Int J Mol Med 11:261-266, 2003.
12. Wegman EA, Young JA, Cook DI. A 23-pS Ca2(+)-activated K+ channel in MCF-7 human breast carcinoma cells: an apparent correlation of channel incidence with the rate of cell proliferation. Pflugers Arch 417:562-570, 1991.
13. Nilius B, Wohlrab W. Potassium channels and regulation of proliferation of human melanoma cells. J Physiol 445:537-548, 1992.
14. Lepple-Wienhues A, Berweck S, Bohmig M, Leo CP, Meyling B, Garbe C, Wiederholt M. K+ channels and the intracellular calcium signal in human melanoma cell proliferation. J Membr Biol 151:149-157, 1996.
15. Skryma RN, Prevarskaya NB, Dufy-Barbe L, Odessa MF, Audin J, Dufy B. Potassium conductance in the androgen-sensitive prostate cancer cell line, LNCaP: involvement in cell proliferation. Prostate 33:112-122, 1997.
16. Abdul M, Hoosein N. Voltage-gated potassium ion channels in colon cancer. Oncol Rep 9:961-964, 2002.
17. Gerard V, Rouzaire-Dubois B, Dubois JM. Contribution of a H+ pump in determining the resting potential of neuroblastoma cells. J Membr Biol 137:119-125, 1994.
18. Zhou ZH, Unlap T, Li L, Ma HP. Incomplete inactivation of voltage-dependent K+ channels in human B lymphoma cells. J Membr Biol 188:97-105, 2002.
19. Pancrazio JJ, Viglione MP, Tabbara IA, Kim YI. Voltage-dependent ion channels in small-cell lung cancer cells. Cancer Res 49:5901-5906, 1989.
20. Wang L, Shao G, Zhang W, Guo X, Wang C, An J, Zhong G, Zhao H. [Influence of 4-aminopyridine on voltage-activated K(+) current and cell proliferation in small cell lung cancer]. Zhonghua Zhong Liu Za Zhi 24:230-233, 2002.
21. Xu D, Wang L, Dai W, Lu L. A requirement for K+-channel activity in growth factor-mediated extracellular signal-regulated kinase activation in human myeloblastic leukemia ML-1 cells. Blood 94:139-145, 1999.
22. Wang L, Xu B, White RE, Lu L. Growth factor-mediated K+ channel activity associated with human myeloblastic ML-1 cell proliferation. Am J Physiol 273:C1657-1665, 1997.
23. Preussat K, Beetz C, Schrey M, Kraft R, Wolfl S, Kalff R, Patt S. Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. Neurosci Lett 346:33-36, 2003.
24. Parihar AS, Coghlan MJ, Gopalakrishnan M, Shieh CC. Effects of intermediate-conductance Ca(2+)-activated K(+) channel modulators on human prostate cancer cell proliferation. Eur J Pharmacol 471:157-164, 2003.
25. Inglis V, Karpinski E, Benishin C. Gamma-dendrotoxin blocks large conductance Ca2+-activated K+ channels in neuroblastoma cells. Life Sci 73:2291-2305, 2003.
26. Carignani C, Roncarati R, Rimini R, Terstappen GC. Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line. Brain Res 939:11-18, 2002.
27. Wu H, Wu K, Han Y, Shi Y, Yao L, Wang J, Fan D. [Delayed rectifier K(+) channel regulated by cyclooxygenase-2 in human gastric cancer cell]. Zhonghua Zhong Liu Za Zhi 24:440-443, 2002.
28. Soliven B, Ma L, Bae H, Attali B, Sobko A, Iwase T. PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Am J Physiol Cell Physiol 284:C85-93, 2003.
29. Sakai H, Shimizu T, Hori K, Ikari A, Asano S, Takeguchi N. Molecular and pharmacological properties of inwardly rectifying K+ channels of human lung cancer cells. Eur J Pharmacol 435:125-133, 2002.
30. Wischmeyer E, Lentes KU, Karschin A. Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line. Pflugers Arch 429:809-819, 1995.
31. Arcangeli A, Faravelli L, Bianchi L, Rosati B, Gritti A, Vescovi A, Wanke E, Olivotto M. Soluble or bound laminin elicit in human neuroblastoma cells short- or long-term potentiation of a K+ inwardly rectifying current: relevance to neuritogenesis. Cell Adhes Commun 4:369-385, 1996.
32. Arcangeli A, Becchetti A, Mannini A, Mugnai G, De Filippi P, Tarone G, Del Bene MR, Barletta E, Wanke E, Olivotto M. Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels. J Cell Biol 122:1131-1143, 1993.
33. Pancrazio JJ, Ma W, Grant GM, Shaffer KM, Kao WY, Liu QY, Manos P, Barker JL, Stenger DA. A role for inwardly rectifying K+ channels in differentiation of NG108-15 neuroblastoma x glioma cells. J Neurobiol 38:466-474, 1999.
34. Hu Q, Shi YL. Characterization of an inward-rectifying potassium current in NG108-15 neuroblastoma x glioma cells. Pflugers Arch 433:617-625, 1997.
35. Pardo LA, Bruggemann A, Camacho J, Stuhmer W. Cell cycle-related changes in the conducting properties of r-eag K+ channels. J Cell Biol 143:767-775, 1998.
36. Pardo LA, del Camino D, Sanchez A, Alves F, Bruggemann A, Beckh S, Stuhmer W. Oncogenic potential of EAG K(+) channels. Embo J 18:5540-5547, 1999.
37. Bauer CK, Wulfsen I, Schafer R, Glassmeier G, Wimmers S, Flitsch J, Ludecke DK, Schwarz JR. HERG K(+) currents in human prolactin-secreting adenoma cells. Pflugers Arch 445:589-600, 2003.
38. Ouadid-Ahidouch H, Le Bourhis X, Roudbaraki M, Toillon RA, Delcourt P, Prevarskaya N. Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether.a-gogo K+ channel. Receptors Channels 7:345-356, 2001.
39. Gavrilova-Ruch O, Schonherr K, Gessner G, Schonherr R, Klapperstuck T, Wohlrab W, Heinemann SH. Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol 188:137-149, 2002.
40. Wang H, Zhang Y, Cao L, Han H, Wang J, Yang B, Nattel S, Wang Z. HERG K+ channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res 62:4843-4848, 2002.
41. Zhou W, Cayabyab FS, Pennefather PS, Schlichter LC, DeCoursey TE. HERG-like K+ channels in microglia. J Gen Physiol 111:781-794, 1998.
42. Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, Wymore RS, Arcangeli A. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem 278:2947-2955, 2003.
43. D'Amico M, Biagiotti T, Fontana L, Restano-Cassulini R, Lasagna N, Arcangeli A, Wanke E, Olivotto M. A HERG current sustains a cardiac-type action potential in neuroblastoma S cells. Biochem Biophys Res Commun 302:101-108, 2003.
44. Cayabyab FS, Schlichter LC. Regulation of an ERG K+ current by Src tyrosine kinase. J Biol Chem 277:13673-13681, 2002.
45. Cherubini A, Taddei GL, Crociani O, Paglierani M, Buccoliero AM, Fontana L, Noci I, Borri P, Borrani E, Giachi M, Becchetti A, Rosati B, Wanke E, Olivotto M, Arcangeli A. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br J Cancer 83:1722-1729, 2000.
46. Cone CD, Jr., Tongier M, Jr. Control of somatic cell mitosis by simulated changes in the transmembrane potential level. Oncology 25:168-182, 1971.
47. Kubo Y, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362:127-133, 1993.
48. Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362:31-38, 1993.
49. Barry DM, Nerbonne JM. Myocardial potassium channels: electrophysiological and molecular diversity. Annu Rev Physiol 58:363-394, 1996.
50. Rouzaire-Dubois B, Dubois JM. K+ channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation. J Physiol 510(Pt 1):93-102, 1998.
51. Rouzaire-Dubois B, Dubois JM. A quantitative analysis of the role of K+ channels in mitogenesis of neuroblastoma cells. Cell Signal 3:333-339, 1991.
52. Rouzaire-Dubois B, Milandri JB, Bostel S, Dubois JM. Control of cell proliferation by cell volume alterations in rat C6 glioma cells. Pflugers Arch 440:881-888, 2000.
53. Jansson B. Potassium, sodium, and cancer: a review. J Environ Pathol Toxicol Oncol 15:65-73, 1996.
54. Nagy IZ, Lustyik G, Nagy VZ, Zarandi B, Bertoni-Freddari C. Intracellular Na+:K+ ratios in human cancer cells as revealed by energy dispersive x-ray microanalysis. J Cell Biol 90:769-777, 1981.
55. Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T. Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proc Natl Acad Sci U S A 100:7803-7807, 2003.
56. Stevenson D, Binggeli R, Weinstein RC, Keck JG, Lai MC, Tong MJ. Relationship between cell membrane potential and natural killer cell cytolysis in human hepatocellular carcinoma cells. Cancer Res 49:4842-4845, 1989.
57. Binggeli R, Weinstein RC, Stevenson D. Calcium ion and the membrane potential of tumor cells. Cancer Biochem Biophys 14:201-210, 1994.
58. Bianchi L, Wible B, Arcangeli A, Taglialatela M, Morra F, Castaldo P, Crociani O, Rosati B, Faravelli L, Olivotto M, Wanke E. herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? Cancer Res 58:815-822, 1998.
59. Fontana L, D'Amico M, Crociani O, Biagiotti T, Solazzo M, Rosati B, Arcangeli A, Wanke E, Olivotto M. Long-term modulation of HERG channel gating in hypoxia. Biochem Biophys Res Commun 286:857-862, 2001.
60. Pappas CA, Ullrich N, Sontheimer H. Reduction of glial proliferation by K+ channel blockers is mediated by changes in pHi. Neuroreport 6:193-196, 1994.
61. Gillies RJ. The tumour microenvironment: causes and consequences of hypoxia and acidity. Introduction. Novartis Found Symp 240:1-6, 2001.
62. Stubbs M, McSheehy PM, Griffiths JR, Bashford CL. Causes and consequences of tumour acidity and implications for treatment. Mol Med Today 6:15-19, 2000.
63. Ningaraj NS, Rao M, Black KL. Calcium-dependent potassium channels as a target protein for modulation of the blood-brain tumor barrier. Drug News Perspect 16:291-298, 2003.
64. Fan D. PG, Ruffoli R. R., Jr., Dong Z., Seid C., Earnest L. E., Campbell T. E., Clyne R. K., Beltran P. J., Fidler I. Circumvention of multidrug resistance in murine fibrosarcoma and colon carcinoma cells by treatment with the -adrenoceptor antagonist furobenzepine. Int. J. Oncol. 4:789-798, 1994.
65. Jirsch J, Deeley RG, Cole SP, Stewart AJ, Fedida D. Inwardly rectifying K+ channels and volume-regulated anion channels in multidrug-resistant small cell lung cancer cells. Cancer Res 53:4156-4160, 1993.
66. Luckie DB KM, Harper KL, Law TC, Wine JJ. Selection for MDR1/P-glycoprotein enhances swelling-activated K+ and Cl-currents in NIH/3T3 cells. Am J Physiol. 267:C650-658, 1994.
67. Fan SF, Yazulla S. Modulation of voltage-dependent K+ currents (IK(V)) in retinal bipolar cells by ascorbate is mediated by dopamine D1 receptors. Vis Neurosci 16:923-931, 1999.
68. Fan SF, Yazulla S. Suppression of voltage-dependent K+ currents in retinal bipolar cells by ascorbate. Vis Neurosci 16:141-148, 1999.
69. Abdul M, Santo A, Hoosein N. Activity of potassium channel-blockers in breast cancer. Anticancer Res 23:3347-3351, 2003.
70. Malhi H, Irani AN, Rajvanshi P, Suadicani SO, Spray DC, McDonald TV, Gupta S. KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting. J Biol Chem 275:26050-26057, 2000.
71. Weaver JL SGJ, Pine PS, Gottesman MM, Goldenberg S, Aszalos A. The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter. Int J Cancer. 54:456-461, 1993.
72. Fan D PG, O'Brian CA, Seid C, Ward NE, Earnest LE, Fidler IJ. Chemosensitization of murine fibrosarcoma cells to drugs affected by the multidrug resistance phenotype by the antidepressant trazodone: an experimental model for the reversal of intrinsic drug resistance. Int J Oncol 1:735-742, 1992.
73. Rouzaire-Dubois B, Gerard V, Dubois JM. Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth. Pflugers Arch 423:202-205, 1993.
74. Demo SD, Yellen G. Ion effects on gating of the Ca(2+)-activated K+ channel correlate with occupancy of the pore. Biophys J 61:639-648, 1992.
75. Bianchi L, Arcangeli A, Bartolini P, Mugnai G, Wanke E, Olivotto M. An inward rectifier K+ current modulates in neuroblastoma cells the tyrosine phosphorylation of the pp125FAK and associated proteins: role in neuritogenesis. Biochem Biophys Res Commun 210:823-829, 1995.
76. Tufte MJ, Tufte FW, Brewer AK. The response of colon carcinoma in mice to cesium, zinc and vitamin A. Pharmacol Biochem Behav 21 Suppl 1:25-26, 1984.
77. Messiha FS, Stocco DM. Effect of cesium and potassium salts on survival of rats bearing Novikoff hepatoma. Pharmacol Biochem Behav 21 Suppl 1:31-34, 1984.
78. Messiha FS. Biochemical aspects of cesium administration in tumor-bearing mice. Pharmacol Biochem Behav 21 Suppl 1:27-30, 1984.
79. Brewer AK. The high pH therapy for cancer tests on mice and humans. Pharmacol Biochem Behav 21 Suppl 1:1-5, 1984.
80. Sartori HE. Cesium therapy in cancer patients. Pharmacol Biochem Behav 21 Suppl 1:11-13, 1984.
81. Sartori HE. Nutrients and cancer: an introduction to cesium therapy. Pharmacol Biochem Behav 21 Suppl 1:7-10, 1984.