Gamma-Dendrotoxin blocks large conductance Ca2+-activated K + channels in neuroblastoma cells

Life Sciences

Volumn 73, Issue 18, 2003, Pages 2291-2305

  Inglis, V ^a   Karpinski, E ^a   Benishin, C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Calcium activated potassium channel; Dendroaspis; Dendrotoxin; Electrophysiology; Neuroblastoma

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; DENDROTOXIN; GAMMA DENDROTOXIN; IBERIOTOXIN; IONOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE CONDUCTANCE; CONTROLLED STUDY; IC 50; NEUROBLASTOMA CELL; NONHUMAN; PIPETTE; POTASSIUM CURRENT; RAT;

DENDROASPIS; STAPHYLOCOCCUS PHAGE 187;

EID: 0042071538     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00643-X     Document Type: Article

References (32)

1. Adelman J.P., Shen K.Z., Kavanaugh M.P., Warren R.A., Wu Y.N., Lagrutta A., Bond C.T., North R.A. Calcium-activated potassium channels expressed from cloned complimentary DNAs. Neuron. 9:1992;209-216.
2. Atkinson N.S., Robertson G.A., Ganetzky B. A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science. 253:1991;551-554.
3. Awan K.A., Dolly J.O. Potassium channel subtypes in rat brain: characteristic locations revealed using β-bungaratoxin, α- and δ-dendrotoxins. Neuroscience. 40:1991;29-39.
4. Benishin C.G., Sorenson R.G., Brown W.E., Krueger B.K., Blaustein M.P. Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Molecular Pharmacology. 34:1988;152-159.
5. Benoit E., Dubois J.-M. Toxin I from the snake Dendroaspis polylepis polylepis: a highly specific blocker of one type of potassium channel in myelinated nerve fibre. Brain Research. 377:1986;374-377.
6. Bowlby M.R., Levitan I.B. Kinetic variability and modulation of dslo, a cloned calcium-dependent potassium channel. Neuropharmacology. 35:1996;867-875.
7. Disbero M., Antonny B., Verdetti J. Biophysical and pharmacological properties of large conductance Ca2+-activated K+ channels in N1E-115 cells. Biochemical and Biophysical Research Communications. 205:1994;596-602.
8. Dworetzky S.I., Trojnacki J.T., Gribkoff V.K. Cloning and expression of a human large-conductance calcium-activated potassium channel. Molecular Brain Research. 27:1994;189-193.
9. Goldstein S.A.N., Miller C. Mechanisms of charybdotoxin block of a Shaker K+ channel. Biophysical Journal. 65:1993;1613-1619.
10. Grynkiewicz G., Poenie M., Tsien R.Y. A new generation of Ca2+ indicators with greatly improved florescence properties. Journal of Biological Chemistry. 260:1985;2440-2450.
11. Hall A., Stow J., Sorenson R., Dolly J.O., Owen D. Blockade by DTX homologues of voltage-dependent K+ currents in cultured sensory neurons from neonatal rats. British Journal of Pharmacology. 113:1994;959-967.
12. Halliwell J.V., Othman I.B., Pelchen-Matthews A., Dolly J.O. Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized receptors. Proceedings of the National Academy of Science USA. 83:1986;493-497.
13. Hamil O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 39:1981;85-100.
14. Hanner M., Schmalhofer W.A., Munujos P., Knaus H.G., Kaczorowski G.J., Garcia M. The β-subunit of the high-conductance calcium-activated potassium channel contributes to the high affinity receptor for charybdotoxin. Proceedings of the National Academy of Science USA. 94:1997;2853-2858.
15. Harvey A.L. Recent studies on dendrotoxins and potassium ion channels. General Pharmacology. 28:1997;7-12.
16. Leonard R.J., Garcia M.L., Slaughter R.S., Renkin J.P. Selective blockers of voltage-gated K+ channels depolarize human t-lymphocytes: mechanism of the antiproliferative effect of charybdotoxin. Proceedings of the National Academy of Science USA. 89:1992;10094-10098.
17. MacKinnon R., Reinhart P.H., White M.M. Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features. Neuron. 1:1988;997-1001.
18. Miller C. Competition for block of a Ca2+-activated K+ channel by charybdotoxin and tetraethylammonium. Neuron. 1:1988;1003-1006.
19. Owen D.G., Hall A., Stephens G., Stow J., Robertson B. The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells. British Journal of Pharmacology. 120:1997;1029-1034.
20. Parcej D.N., Scott V.E.S., Dolly J.O. Oligomeric properties of an α-dendrotoxin-sensitive potassium channels purified from bovine brain. Biochemistry. 31:1992;11084-11088.
21. Reinhart P.H., Chung S., Levitan I.B. A family of calcium-dependent potassium channels from rat brain. Neuron. 2:1989;1031-1041.
22. Ren J., Karpinski E., Benishin C. Inhibition of a K+ current by β-dendrotoxin in primary and subcultures vascular smooth muscle cells. Journal of Pharmacology and Experimental. Therapeutics. 269:1995;209-214.
23. Robertson B., Owen D., Stow J., Butler C., Newland C. Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes. FEBS Letters. 383:1997;26-30.
24. Robitaille R., Garcia M.L., Kaczorowski G.J., Charlton M.P. Functional co-localization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron. 11:1993;645-655.
25. Silberberg S.D., Lagutta A., Adelman J.P., Magleby K.L. Wanderlust kinetics and variable Ca2+-sensitivity of dslo, a large conductance Ca2+-activated K+ channel expressed in oocytes. Biophysical Journal. 70:1996;2640-2651.
26. Smith L.A., Lafaye P.J., LaPontiere H.F., Spain T., Dolly J.O. Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker. Biochemistry. 32:1993;5692-5697.
27. Sprunger L.K., Stewig N.J., O'Grady S.M. Effects of charybdotoxin on K+ channel (Kv1.2) deactivation and inactivation kinetics. European Journal of Pharmacology. 314:1996;357-364.
28. Swaminathan P., Hariharan M., Murali R., Singh C.U. Molecular structure, conformational analysis, and structure-activity studies of Dendrotoxin and its homologues using molecular mechanics and molecular dynamics techniques. Journal of Molecular Chemistry. 39:1996;2141-2155.
29. Tauc M., Gastineau M., Poujeol P. Toxin sensitivity of the calcium-dependent rubidium efflux in Mabin-Darby canine kidney cells. Biochemical Biophysical Research Communications. 190:1993;596-601.
30. Tseng-Crank J., Foster C.D., Krauz J.D., Mertz R., Godinot N., Dilhara T.J., Reinhart P.H. Cloning, expression and distribution of functionally distinct Ca2+-activated K+ channel isoforms from human brain. Neuron. 13:1994;1315-1330.
31. Tygat J., Debont T., Carmeliet E., Daenens P. The α-dendrotoxin footprint on a mammalian potassium channel. Journal of Biological Chemistry. 270:1995;24776-24781.
32. Wei A., Solaro C., Lingle C., Salfoff L. Calcium sensitivity of BK-type KCa channels determined by a separable domain. Neuron. 13:1994;671-681.