메뉴 건너뛰기




Volumn 13, Issue 1, 2004, Pages 107-115

Why are angiotensin concentrations so high in the kidney?

Author keywords

Intrarenal angiotensin II; Intrarenal angiotensinogen; Renal AT1 receptors; Renal interstitial fluid; Tubular angiotensin II

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN I; ANGIOTENSINOGEN; MESSENGER RNA;

EID: 4043157826     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200401000-00015     Document Type: Review
Times cited : (100)

References (85)
  • 1
    • 0029995999 scopus 로고    scopus 로고
    • Paracrine regulation of the renal microcirculation
    • Review; 1214 refs
    • Navar LG, Inscho EW, Majid SA, et al. Paracrine regulation of the renal microcirculation [Review; 1214 refs]. Physiol Rev 1996; 76:425-536.
    • (1996) Physiol Rev , vol.76 , pp. 425-536
    • Navar, L.G.1    Inscho, E.W.2    Majid, S.A.3
  • 2
    • 0037390589 scopus 로고    scopus 로고
    • The intracrine hypothesis and intracellular peptide hormone action
    • Re RN. The intracrine hypothesis and intracellular peptide hormone action. Bioessays 2003; 25:401-409. An interesting commentary on the role of intraceullular peptides to activate intracellular signaling mechanisms. The intracellular RAS is reviewed to illustrate intracrine mechanisms.
    • (2003) Bioessays , vol.25 , pp. 401-409
    • Re, R.N.1
  • 4
    • 0036181980 scopus 로고    scopus 로고
    • Regulation of intrarenal angiotensin II in hypertension
    • Navar LG, Harrison-Bernard LM, Nishiyama A, Kobori H. Regulation of intrarenal angiotensin II in hypertension. Hypertension 2002; 39:316-322. This review covers the older data relating to changes in intrarenal angiotensin II in angiotensin II-dependent hypertension.
    • (2002) Hypertension , vol.39 , pp. 316-322
    • Navar, L.G.1    Harrison-Bernard, L.M.2    Nishiyama, A.3    Kobori, H.4
  • 5
    • 0036707873 scopus 로고    scopus 로고
    • Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition
    • Nishiyama A, Seth DM, Navar LG. Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition. J Am Soc Nephrol 2002; 13:2207-2212.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2207-2212
    • Nishiyama, A.1    Seth, D.M.2    Navar, L.G.3
  • 6
    • 0036150620 scopus 로고    scopus 로고
    • Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats
    • Nishiyama A, Seth DM, Navar LG. Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension 2002; 39:129-134.
    • (2002) Hypertension , vol.39 , pp. 129-134
    • Nishiyama, A.1    Seth, D.M.2    Navar, L.G.3
  • 9
    • 0035190220 scopus 로고    scopus 로고
    • Intrarenal angiotensin II: Interstitial and cellular levels and site of production
    • van Kats JP, Schalekamp MA, Verdouw PD, et al. Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int 2001; 60:2311-2317.
    • (2001) Kidney Int , vol.60 , pp. 2311-2317
    • Van Kats, J.P.1    Schalekamp, M.A.2    Verdouw, P.D.3
  • 10
    • 0026718583 scopus 로고
    • Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats
    • Fox J, Guan S, Hymel AA, Navar LG. Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am J Physiol - Renal Physiol 1992; 262:F902-F909.
    • (1992) Am J Physiol - Renal Physiol , vol.262
    • Fox, J.1    Guan, S.2    Hymel, A.A.3    Navar, L.G.4
  • 11
    • 0030801429 scopus 로고    scopus 로고
    • Differential regulation of angiotensin peptides in plasma and kidney: Effects of adrenalectomy and estrogen treatment
    • Campbell DJ. Differential regulation of angiotensin peptides in plasma and kidney: effects of adrenalectomy and estrogen treatment. Clin Exp Hypertens 1997; 19:687-698.
    • (1997) Clin Exp Hypertens , vol.19 , pp. 687-698
    • Campbell, D.J.1
  • 13
    • 0029044090 scopus 로고
    • Renal interstitial fluid angiotensin: Modulation by anesthesia, epinephrine, sodium depletion and renin inhibition
    • Siragy HM, Howell NL, Ragsdale NV, Carey RM. Renal interstitial fluid angiotensin: modulation by anesthesia, epinephrine, sodium depletion and renin inhibition. Hypertension 1995; 25:1021-1024.
    • (1995) Hypertension , vol.25 , pp. 1021-1024
    • Siragy, H.M.1    Howell, N.L.2    Ragsdale, N.V.3    Carey, R.M.4
  • 14
    • 0026409556 scopus 로고
    • Differential regulation of angiotensin peptide levels in plasma and kidney of the rat
    • Campbell DJ, Lawrence AC, Towrie A, et al. Differential regulation of angiotensin peptide levels in plasma and kidney of the rat. Hypertension 1991; 18:763-773.
    • (1991) Hypertension , vol.18 , pp. 763-773
    • Campbell, D.J.1    Lawrence, A.C.2    Towrie, A.3
  • 16
    • 0036839479 scopus 로고    scopus 로고
    • Effects of dietary salt changes on renal renin-angiotensin system in rats
    • Ingert C, Grima M, Coquard C, et al. Effects of dietary salt changes on renal renin-angiotensin system in rats. Am J Physiol Renal Physiol 2002; 283:F995-F1002.
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Ingert, C.1    Grima, M.2    Coquard, C.3
  • 17
    • 0027482060 scopus 로고
    • Renal tissue angiotensin II: Response to infusions of angiotensin I and an angiotensin-converting enzyme inhibitor
    • Reams G, Villarreal D, Wu Z, Bauer JH. Renal tissue angiotensin II: response to infusions of angiotensin I and an angiotensin-converting enzyme inhibitor. Am J Kidney Dis 1993; 22:851-857.
    • (1993) Am J Kidney Dis , vol.22 , pp. 851-857
    • Reams, G.1    Villarreal, D.2    Wu, Z.3    Bauer, J.H.4
  • 18
    • 0036141048 scopus 로고    scopus 로고
    • Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels
    • Komine N, Khang S, Wead LM, et al. Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels. Am J Kidney Dis 2002; 39:159-164. This study demonstrates that the combined treatment of rats maintained on a low-salt diet with captopril and losartan reduced intrarenal angiotensin II levels to a greater extent than treatment with either agent alone. The synergistic actions of these two agents may have important implications for long-term organ protection in hypertension and renal disease.
    • (2002) Am J Kidney Dis , vol.39 , pp. 159-164
    • Komine, N.1    Khang, S.2    Wead, L.M.3
  • 19
    • 0032989024 scopus 로고    scopus 로고
    • Differential response of angiotensin peptides in the urine of hypertensive animals
    • Yamada K, Iyer SN, Chappell MC, et al. Differential response of angiotensin peptides in the urine of hypertensive animals. Regul Pept 1999; 80:57-66.
    • (1999) Regul Pept , vol.80 , pp. 57-66
    • Yamada, K.1    Iyer, S.N.2    Chappell, M.C.3
  • 20
    • 0029797409 scopus 로고    scopus 로고
    • Receptor-mediated intrarenal ANG II augmentation in ANG II-infused rats
    • Zou L, Imig JD, Von Thun AM, et al. Receptor-mediated intrarenal ANG II augmentation in ANG II-infused rats. Hypertension 1996; 28:669-677.
    • (1996) Hypertension , vol.28 , pp. 669-677
    • Zou, L.1    Imig, J.D.2    Von Thun, A.M.3
  • 21
    • 0036314226 scopus 로고    scopus 로고
    • Differential regulation of elevated renal angiotensin II in chronic renal ischemia
    • Tokuyama H, Hayashi K, Matsuda H, et al. Differential regulation of elevated renal angiotensin II in chronic renal ischemia. Hypertension 2002; 40:34-40. This paper provides further data supporting enhanced intrarenal angiotensin II in non-clipped as well as in clipped kidneys. The elevated angiotensin II in clipped kidneys was suppressed by a chymase inhibitor but not by an ACE inhibitor, whereas an ACE inhibitor, but not a chymase inhibitor, inhibited the intrarenal angiotensin II levels in the non-clipped kidneys. The data indicate that chymase activity is enhanced in clipped kidneys, whereas ACE-mediated angiotensin II generation is primarily responsible for elevated angiotensin II contents in nonclipped kidneys.
    • (2002) Hypertension , vol.40 , pp. 34-40
    • Tokuyama, H.1    Hayashi, K.2    Matsuda, H.3
  • 22
    • 0028806178 scopus 로고
    • Effects of dietary salt on angiotensin peptides in kidney
    • Meng QC, Durand J, Chen Y-F, Oparil S. Effects of dietary salt on angiotensin peptides in kidney. J Am Soc Nephrol 1995; 6:1209-1215.
    • (1995) J Am Soc Nephrol , vol.6 , pp. 1209-1215
    • Meng, Q.C.1    Durand, J.2    Chen, Y.-F.3    Oparil, S.4
  • 23
    • 0036674108 scopus 로고    scopus 로고
    • Upregulation of autocrine-paracrine renin-angiotensin systems in chronic renovascular hypertension
    • 1 receptor expression in proximal tubules and adrenal glands was maintained.
    • (2002) J Vasc Surg , vol.36 , pp. 386-392
    • Sadjadi, J.1    Puttaparthi, K.2    Welborn III, M.B.3
  • 28
    • 0346362197 scopus 로고    scopus 로고
    • Renal nuclear angiotensin II receptors in normal and hypertensive rats
    • 1 receptors in renal cells. Neither nuclear nor plasma membrane angiotensin II receptors were diminished in angiotensin II-infused hypertension.
    • (2002) Acta Physiol Hungar , vol.89 , pp. 427-438
    • Licea, H.1    Walters, M.R.2    Navar, L.G.3
  • 29
    • 0032956652 scopus 로고    scopus 로고
    • Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension
    • Harrison-Bernard LM, El-Dahr SS, O'Leary DF, Navar LG. Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension. Hypertension 1999; 33:340-346.
    • (1999) Hypertension , vol.33 , pp. 340-346
    • Harrison-Bernard, L.M.1    El-Dahr, S.S.2    O'Leary, D.F.3    Navar, L.G.4
  • 31
    • 0033848946 scopus 로고    scopus 로고
    • Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats
    • Wang C-T, Chin SY, Navar LG. Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats. Am J Physiol - Renal Physiol 2000; 279:F319-F325.
    • (2000) Am J Physiol - Renal Physiol , vol.279
    • Wang, C.-T.1    Chin, S.Y.2    Navar, L.G.3
  • 32
    • 0042769116 scopus 로고    scopus 로고
    • Evidence for renal vascular remodeling in angiotensin II-induced hypertension
    • Edgley AJ, Kett MM, Anderson WP. Evidence for renal vascular remodeling in angiotensin II-induced hypertension. J Hypertens 2003; 21:1401-1406.
    • (2003) J Hypertens , vol.21 , pp. 1401-1406
    • Edgley, A.J.1    Kett, M.M.2    Anderson, W.P.3
  • 33
    • 0036151567 scopus 로고    scopus 로고
    • Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency
    • Mackie FE, Meyer TW, Campbell DJ. Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency. Kidney Int 2002; 61:555-563. Tissue angiotensin II levels were found to be elevated in the peri-infarct portion of the kidneys in rats subjected to 5/6th renal mass removal. These were reduced by enalapril but increased further with nifedipine.
    • (2002) Kidney Int , vol.61 , pp. 555-563
    • Mackie, F.E.1    Meyer, T.W.2    Campbell, D.J.3
  • 34
    • 0035119535 scopus 로고    scopus 로고
    • Angiotensin II binding to renomedullary interstitial cells is regulated by osmolality
    • Maric C, Casley D, Harris PJ, Alcorn D. Angiotensin II binding to renomedullary interstitial cells is regulated by osmolality. J Am Soc Nephrol 2001; 12:450-455.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 450-455
    • Maric, C.1    Casley, D.2    Harris, P.J.3    Alcorn, D.4
  • 35
    • 0031751333 scopus 로고    scopus 로고
    • Localization and interactions of vasoactive peptide receptors in renomedullary interstitial cells of the kidney
    • Review; 29 refs
    • Zhuo J, Dean R, Maric C, et al. Localization and interactions of vasoactive peptide receptors in renomedullary interstitial cells of the kidney [Review; 29 refs]. Kidney Int 1998; 67 (Suppl.):S22-S28.
    • (1998) Kidney Int , vol.67 , Issue.SUPPL.
    • Zhuo, J.1    Dean, R.2    Maric, C.3
  • 38
    • 0032930191 scopus 로고    scopus 로고
    • 2 receptor in a renal wrap hypertension model
    • 2 receptor in a renal wrap hypertension model. Hypertension 1999; 33:1237-1242.
    • (1999) Hypertension , vol.33 , pp. 1237-1242
    • Siragy, H.M.1    Carey, R.M.2
  • 39
    • 0142042336 scopus 로고    scopus 로고
    • 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension
    • 1 receptor-mediated process, and can be dissociated from the changes in plasma angiotensin II concentrations, thus supporting the independent regulation of RIF angiotensin II concentrations.
    • (2003) J Hypertens , vol.21 , pp. 1897-1903
    • Nishiyama, A.1    Seth, D.M.2    Navar, L.G.3
  • 40
    • 0037331575 scopus 로고    scopus 로고
    • Proximal tubular fluid angiotensin II levels in angiotensin II-induced hypertensive rats
    • Wang C-T, Navar LG, Mitchell KD. Proximal tubular fluid angiotensin II levels in angiotensin II-induced hypertensive rats. J Hypertens 2003; 21:353-360. This paper shows that proximal tubular fluid concentrations of angiotensin II remain elevated in angiotensin II-infused rats and are not suppressed by the elevated arterial pressure. The inappropriate maintenance of nanomolar concentrations of angiotensin II in proximal tubular fluid may contribute to the augmented sodium reabsorption and impaired pressure natriuresis, leading to hypertension.
    • (2003) J Hypertens , vol.21 , pp. 353-360
    • Wang, C.-T.1    Navar, L.G.2    Mitchell, K.D.3
  • 41
    • 0142121056 scopus 로고    scopus 로고
    • 2) receptors modulate renal cellular uptake of angiotensin II
    • 2) receptors modulate renal cellular uptake of angiotensin II [Abstract]. J Hypertens 2000; 18:392.
    • (2000) J Hypertens , vol.18 , pp. 392
    • Siragy, H.M.1    De Gasparo, M.2    Carey, R.M.3
  • 42
    • 0035119735 scopus 로고    scopus 로고
    • Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension
    • Kobori H, Harrison-Bernard LM, Navar LG. Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol 2001; 12:431-439.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 431-439
    • Kobori, H.1    Harrison-Bernard, L.M.2    Navar, L.G.3
  • 43
    • 0025165780 scopus 로고
    • Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat
    • Seikaly MG, Arant BS Jr, Seney FD Jr. Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 1990; 86:1352-1357.
    • (1990) J Clin Invest , vol.86 , pp. 1352-1357
    • Seikaly, M.G.1    Arant Jr., B.S.2    Seney Jr., F.D.3
  • 44
    • 0028524896 scopus 로고
    • Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats
    • Navar LG, Lewis L, Hymel A, et al. Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol 1994; 5:1153-1158.
    • (1994) J Am Soc Nephrol , vol.5 , pp. 1153-1158
    • Navar, L.G.1    Lewis, L.2    Hymel, A.3
  • 45
    • 0031043464 scopus 로고    scopus 로고
    • Effects of reduced renal perfusion pressure and acute volume expansion on proximal tubule and whole kidney angiotensin II content in the rat
    • Boer WH, Braam B, Fransen R, et al. Effects of reduced renal perfusion pressure and acute volume expansion on proximal tubule and whole kidney angiotensin II content in the rat. Kidney Int 1997; 51:44-49.
    • (1997) Kidney Int , vol.51 , pp. 44-49
    • Boer, W.H.1    Braam, B.2    Fransen, R.3
  • 46
    • 0030703598 scopus 로고    scopus 로고
    • Effect of luminal angiotensin II on rabbit proximal convoluted tubule bicarbonate absorption
    • Baum M, Quigley R, Quan A. Effect of luminal angiotensin II on rabbit proximal convoluted tubule bicarbonate absorption. Am J Physiol - Renal Physiol 1997; 273:F595-F600.
    • (1997) Am J Physiol - Renal Physiol , vol.273
    • Baum, M.1    Quigley, R.2    Quan, A.3
  • 47
    • 0029902717 scopus 로고    scopus 로고
    • Endogenous production of angiotensin II modulates rat proximal tubule transport
    • Quan A, Baum M. Endogenous production of angiotensin II modulates rat proximal tubule transport. J Clin Invest 1996; 97:2878-2882.
    • (1996) J Clin Invest , vol.97 , pp. 2878-2882
    • Quan, A.1    Baum, M.2
  • 50
    • 0000353575 scopus 로고
    • Intrarenal actions of angiotensin II in the pathogenesis of experimental hypertension
    • Laragh JH, Brenner BM, editors. New York: Raven Press Ltd.
    • Mitchell KD, Navar LG. Intrarenal actions of angiotensin II in the pathogenesis of experimental hypertension. In: Laragh JH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis, and management. New York: Raven Press Ltd.; 1995. pp. 1437-1450.
    • (1995) Hypertension: Pathophysiology, Diagnosis, and Management , pp. 1437-1450
    • Mitchell, K.D.1    Navar, L.G.2
  • 51
    • 0030819455 scopus 로고    scopus 로고
    • Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats
    • Mitchell KD, Jacinto SM, Mullins JJ. Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol - Renal Physiol 1997; 273:F246-F253.
    • (1997) Am J Physiol - Renal Physiol , vol.273
    • Mitchell, K.D.1    Jacinto, S.M.2    Mullins, J.J.3
  • 52
    • 0038003147 scopus 로고    scopus 로고
    • Regulation of sodium transporters in the thick ascending limb of rat kidney: Response to angiotensin II
    • Kwon TH, Nielsen J, Kim YH, et al. Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II. Am J Physiol Renal Physiol 2003; 285:F152-F165. Chronic treatment with angiotensin II upregulated the expression of proximal tubule sodium/hydrogen exchanger.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Kwon, T.H.1    Nielsen, J.2    Kim, Y.H.3
  • 53
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109:1417-1427. The expression cloning of the human renin receptor binding of renin increased the catalytic efficiency of angiotensin I formation and induced intracellular signaling associated with the activation of MAPKs.
    • (2002) J Clin Invest , vol.109 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burckle, C.3
  • 54
    • 0033035228 scopus 로고    scopus 로고
    • Rat proximal tubule cell line transformed with origin-defective SV40 DNA: Autocrine ANG II feedback
    • Ingelfinger JR, Jung F, Diamant D, et al. Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback. Am J Physiol - Renal Physiol 1999; 276:F218-F227.
    • (1999) Am J Physiol - Renal Physiol , vol.276
    • Ingelfinger, J.R.1    Jung, F.2    Diamant, D.3
  • 55
    • 0026761287 scopus 로고
    • Colocalization and release of angiotensin and renin in renal cortical cells
    • Hunt MK, Ramos SP, Geary KM, et al. Colocalization and release of angiotensin and renin in renal cortical cells. Am J Physiol - Renal Physiol 1992; 263:F363-F373.
    • (1992) Am J Physiol - Renal Physiol , vol.263
    • Hunt, M.K.1    Ramos, S.P.2    Geary, K.M.3
  • 56
    • 0029045305 scopus 로고
    • In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys
    • Darby IA, Sernia C. In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys. Cell Tiss Res 1995; 281:197-206.
    • (1995) Cell Tiss Res , vol.281 , pp. 197-206
    • Darby, I.A.1    Sernia, C.2
  • 57
    • 0030736087 scopus 로고    scopus 로고
    • The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice
    • Ding Y, Davisson RL, Hardy DO, et al. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 1997; 272:28142-28148.
    • (1997) J Biol Chem , vol.272 , pp. 28142-28148
    • Ding, Y.1    Davisson, R.L.2    Hardy, D.O.3
  • 58
    • 0033404955 scopus 로고    scopus 로고
    • Elements of a paracrine tubular renin-angiotensin system along the entire nephron
    • Rohrwasser A, Morgan T, Dillon HF, et al. Elements of a paracrine tubular renin-angiotensin system along the entire nephron. Hypertension 1999; 34:1265-1274.
    • (1999) Hypertension , vol.34 , pp. 1265-1274
    • Rohrwasser, A.1    Morgan, T.2    Dillon, H.F.3
  • 61
    • 0035122983 scopus 로고    scopus 로고
    • Angiotensinogen in essential hypertension: From genetics to nephrology
    • Lalouel J-M, Rohrwasser A, Terreros D, et al. Angiotensinogen in essential hypertension: from genetics to nephrology. J Am Soc Nephrol 2001; 12:606-615.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 606-615
    • Lalouel, J.-M.1    Rohrwasser, A.2    Terreros, D.3
  • 62
    • 0035715157 scopus 로고    scopus 로고
    • Enhancement of angiotensinogen expression in angiotensin II-dependent hypertension
    • Kobori H, Harrison-Bernard LM, Navar LG. Enhancement of angiotensinogen expression in angiotensin II-dependent hypertension. Hypertension 2001; 37:1329-1335.
    • (2001) Hypertension , vol.37 , pp. 1329-1335
    • Kobori, H.1    Harrison-Bernard, L.M.2    Navar, L.G.3
  • 63
    • 0036324130 scopus 로고    scopus 로고
    • High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells
    • Hsieh TJ, Zhang SL, Filep JG, et al. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Endocrinology 2002; 143:2975-2985. This paper shows that angiotensinogen mRNA expression in rat proximal tubular cells is increased by high glucose, but this effect is prevented by the administration of an antioxidant and a p38 MAPK inhibitor. The data indicate that the stimulatory action of high glucose on angiotensinogen gene expression in the proximal tubular cells is mediated via reactive oxygen species generation and subsequent p38 MAPK activation.
    • (2002) Endocrinology , vol.143 , pp. 2975-2985
    • Hsieh, T.J.1    Zhang, S.L.2    Filep, J.G.3
  • 65
    • 0033672308 scopus 로고    scopus 로고
    • Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat
    • Zimpelmann J, Kumar D, Levine DZ, et al. Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat. Kidney Int 2000; 58:2320-2330.
    • (2000) Kidney Int , vol.58 , pp. 2320-2330
    • Zimpelmann, J.1    Kumar, D.2    Levine, D.Z.3
  • 67
    • 0036158053 scopus 로고    scopus 로고
    • Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production
    • Kobori H, Harrison-Bernard LM, Navar LG. Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int 2002; 61:579-585.
    • (2002) Kidney Int , vol.61 , pp. 579-585
    • Kobori, H.1    Harrison-Bernard, L.M.2    Navar, L.G.3
  • 68
    • 0037219640 scopus 로고    scopus 로고
    • Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension
    • Kobori H, Nishiyama A, Harrison-Bernard LM, Navar LG. Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension. Hypertension 2003; 41:42-49. This paper shows that intrarenal angiotensinogen expression and the urinary excretion of angiotensinogen are significantly increased in angiotensin II-dependent, but not in angiotensin II-independent hypertensive rats, indicating a positive feedback system that leads to the further intrarenal production of angiotensin II during the development of angiotensin II-dependent hypertension.
    • (2003) Hypertension , vol.41 , pp. 42-49
    • Kobori, H.1    Nishiyama, A.2    Harrison-Bernard, L.M.3    Navar, L.G.4
  • 69
    • 0037336667 scopus 로고    scopus 로고
    • Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet
    • Kobori H, Nishiyama A, Abe Y, Navar LG. Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension 2003; 41:592-597. This study reports an enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats that is not associated with an increase in the circulating RAS.
    • (2003) Hypertension , vol.41 , pp. 592-597
    • Kobori, H.1    Nishiyama, A.2    Abe, Y.3    Navar, L.G.4
  • 70
    • 0037339306 scopus 로고    scopus 로고
    • The effect of isoprenaline infusion on renal renin and angiotensinogen gene expression in the anaesthetised rat
    • Moosavi SM, Johns EJ. The effect of isoprenaline infusion on renal renin and angiotensinogen gene expression in the anaesthetised rat. Exp Physiol 2003; 88:221-227. The administration of a β-adrenoceptor agonist stimulated both renin and renal angiotensinogen expression, providing evidence that catecholamines are involved in the mechanism that alters the expression of renal RAS genes.
    • (2003) Exp Physiol , vol.88 , pp. 221-227
    • Moosavi, S.M.1    Johns, E.J.2
  • 71
    • 0027394577 scopus 로고
    • Renin expression in renal proximal tubule
    • Moe OW, Ujiie K, Star RA, et al. Renin expression in renal proximal tubule. J Clin Invest 1993; 91:774-779.
    • (1993) J Clin Invest , vol.91 , pp. 774-779
    • Moe, O.W.1    Ujiie, K.2    Star, R.A.3
  • 72
    • 0029884275 scopus 로고    scopus 로고
    • Renin regulation in cultured proximal tubular cells
    • Henrich WL, McAllister EA, Eskue A, et al. Renin regulation in cultured proximal tubular cells. Hypertension 1996; 27:1337-1340.
    • (1996) Hypertension , vol.27 , pp. 1337-1340
    • Henrich, W.L.1    McAllister, E.A.2    Eskue, A.3
  • 73
    • 0027241828 scopus 로고
    • Gene expression and tissue localization of the two isoforms of angiotensin I converting enzyme
    • Sibony M, Gasc J-M, Soubrier F, et al. Gene expression and tissue localization of the two isoforms of angiotensin I converting enzyme. Hypertension 1993; 21:827-535.
    • (1993) Hypertension , vol.21 , pp. 827-1535
    • Sibony, M.1    Gasc, J.-M.2    Soubrier, F.3
  • 74
    • 0030822547 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme activity in tubular fluid along the rat nephron
    • Casarini DE, Boim MA, Stella RCR, et al. Angiotensin I-converting enzyme activity in tubular fluid along the rat nephron. Am J Physiol - Renal Physiol 1997; 272:F405-F409.
    • (1997) Am J Physiol - Renal Physiol , vol.272
    • Casarini, D.E.1    Boim, M.A.2    Stella, R.C.R.3
  • 75
    • 0029736694 scopus 로고    scopus 로고
    • Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
    • Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. Am J Physiol - Renal Physiol 1996; 271:F143-F149.
    • (1996) Am J Physiol - Renal Physiol , vol.271
    • Wang, T.1    Giebisch, G.2
  • 76
    • 0027163984 scopus 로고
    • PCR localization of angiotensin II receptor and angiotensinogen mRNAs in rat kidney
    • Terada Y, Tomita K, Nonoguchi H, Marumo F. PCR localization of angiotensin II receptor and angiotensinogen mRNAs in rat kidney. Kidney Int 1993; 43:1251-1259.
    • (1993) Kidney Int , vol.43 , pp. 1251-1259
    • Terada, Y.1    Tomita, K.2    Nonoguchi, H.3    Marumo, F.4
  • 77
    • 0030031725 scopus 로고    scopus 로고
    • Role of angiotensin II in dietary modulation of rat late distal tubule bicarbonate flux in vivo
    • Levine DZ, Iacovitti M, Buckman S, Burns KD. Role of angiotensin II in dietary modulation of rat late distal tubule bicarbonate flux in vivo. J Clin Invest 1996; 97:120-125.
    • (1996) J Clin Invest , vol.97 , pp. 120-125
    • Levine, D.Z.1    Iacovitti, M.2    Buckman, S.3    Burns, K.D.4
  • 80
    • 0028363812 scopus 로고
    • Urinary angiotensin II: A marker of renal tissue activity?
    • Reams G, Villarreal D, Wu Z, Bauer JH. Urinary angiotensin II: a marker of renal tissue activity? Nephron 1994; 67:450-458.
    • (1994) Nephron , vol.67 , pp. 450-458
    • Reams, G.1    Villarreal, D.2    Wu, Z.3    Bauer, J.H.4
  • 81
    • 0036238776 scopus 로고    scopus 로고
    • Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors
    • Peti-Peterdi J, Warnock DG, Bell PD. Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol 2002; 13:1131-1135. Using isolated perfused cortical collecting duct segments, angiotensin II added to the lumen increased intracellular sodium uptake and this effect was prevented after the blockade of the amiloride-sensitlve sodium channel. The results indicate that distal nephron angiotensin II may regulate amiloride-sensitive sodium channel activity.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1131-1135
    • Peti-Peterdi, J.1    Warnock, D.G.2    Bell, P.D.3
  • 82
    • 0033564984 scopus 로고    scopus 로고
    • Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice
    • Davisson RL, Ding Y, Stec DE, et al. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics 1999; 1:3-9.
    • (1999) Physiol Genomics , vol.1 , pp. 3-9
    • Davisson, R.L.1    Ding, Y.2    Stec, D.E.3
  • 83
    • 0042266232 scopus 로고    scopus 로고
    • Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport
    • Komlosi P, Fuson AL, Fintha A, et al. Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport. Hypertension 2003; 42:195-199. This study reports that angiotensin I added to the perfusate of cortical collecting ducts leads to angiotensin II stimulation of amiloride-sensitive sodium channel activity and that ACE was present in the cortical collecting duct, supporting the hypothesis that angiotensin I to angiotensin II conversion can occur in the cortical collecting duct.
    • (2003) Hypertension , vol.42 , pp. 195-199
    • Komlosi, P.1    Fuson, A.L.2    Fintha, A.3
  • 84
    • 0008429971 scopus 로고    scopus 로고
    • The kidney in blood pressure regulation
    • Wilcox CS, editor. Philadelphia: Current Medicine, Inc.
    • Navar LG, Hamm LL. The kidney in blood pressure regulation. In: Wilcox CS, editor. Atlas of diseases of the kidney. Hypertension and the kidney. Philadelphia: Current Medicine, Inc.; 1999. pp. 1.1-1.22.
    • (1999) Atlas of Diseases of the Kidney. Hypertension and the Kidney , pp. 11-122
    • Navar, L.G.1    Hamm, L.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.