In vivo mutation in gene A of S plenic lymphocytes from ΦX174 transgenic mice

Environmental and Molecular Mutagenesis

Volumn 44, Issue 2, 2004, Pages 128-150

  Valentine, Carrie R ^a   Raney, Jessica L ^a   Shaddock, Joseph G ^a   Dobrovolsky, Vasily N ^a   Delongchamp, Robert R ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

X174; Clonality; Ethylnitrosourea; Forward mutational assay; Mutant spectra; Single burst analysis; Spontaneous mutant frequency; Transgenic

Indexed keywords

DNA; ETHYLNITROSOUREA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; FORWARD MUTATIONAL ASSAY; GENE; GENE A; GENE MUTATION; LYMPHOCYTE; MOUSE; MUTANT; MUTANT SPECTRUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PHIX174 GENE A; SINGLE BURST ANALYSIS; SPLEEN CELL; SPONTANEOUS MUTANT FREQUENCY; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BACTERIOPHAGE PHI X 174; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTES; MICE; MICE, TRANSGENIC; MUTATION; SPLEEN;

ANIMALIA; ESCHERICHIA COLI; MUS MUSCULUS;

EID: 4043128083     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20043     Document Type: Article

References (47)

1. Beier DR. 2002. ENU mutagenesis: a work in progress. Physiol Genom 11:111-113.
2. 2-ethyldeoxythymine in transversion mutagenesis by ethylating agents. Nucl Acid Res 20: 587-594.
3. Bielas JH, Heddle JA. 2000. Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proc Natl Acad Sci USA 97:11391-11396.
4. Brent TP, Dolan ME, Fraenkel-Conrat H, Hall J, Karran P, Laval F, Marigison GP, Montesano R, Pegg AE, Potter PM, Singer B, Swenberg JA, Yarosh DB. 1988. Repair of O-alkylpyrimidines in mammalian cells: a present consensus. Proc Natl Acad Sci USA 85:1759-1762.
5. Brown SD, Balling R. 2001. Systematic approaches to mouse mutagenesis. Curr Opin Genet Dev 11:268-273.
6. Buettner VL, Hill KA, Scaringe WA, Sommer SS. 2000. Evidence that proximal multiple mutations in Big Blue transgenic mice are dependent events. Mutat Res 452:219-229.
7. Burkhart JG, Burkhart BA, Sampson K, Malling HV. 1992. Evidence for a previously undetected CpG methyl-directed restriction system in E. coli. Nucl Acids Res 20:4368.
8. Burkhart JG, Malling HV. 1993. Mutagenesis and transgenic systems: perspective from the mutagen, N-ethyl-N-nitrosourea. Environ Mol Mutagen 22:1-6.
9. Burkhart JG, Burkhart BA, Sampson, KS, Malling HV. 1993. ENU-induced mutagenesis at a single A:T base pair in transgenic mice containing ΦX174. Mutat Res 292:69-81.
10. Cariello NF, Piegorsch WW, Adams WT, Skopek TR. 1994. Computer program for the analysis of mutational spectra: application of p53 mutations. Carcinogenesis 15:2281-2285.
11. Chang PY, Mirsalis J, Riccio ES, Bakke JP, Lee PS, Shimon J, Phillips S, Fairchild D, Hara Y, Crowell JA. 2003. Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E. Environ Mol Mutagen 41:43-54.
12. Colgin LM, Hackmann AFM, Emond MJ, Monnat RJ Jr. 2002. The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage. Proc Natl Acad Sci USA:99:1437-1442.
13. Cruz-Munoz W, Kalair W, Cosentino L, Heddle JA. 2000. ENU induces mutations in the heart of lacZ transgenic mice. Mutat Res 469:23-34.
14. Delongchamp RR, Valentine CR, Malling HV. 2001. Estimation of the average burst size of ΦX174am3,cs70 for use in mutation assays with transgenic mice. Environ Mol Mutagen 37:356-360.
15. (+/-) mice: automated scoring of lymphocyte clones using a fluorescent viability indicator. Environ Mol Mutagen 36:283-291.
16. Dohet C, Wagner R, Radman M. 1985. Repair of single base-pair mismatches in Escherichia coli. Proc Natl Acad Sci USA 82: 503-505.
17. Douglas GR, Jiao J, Gingerich JD, Gossen JA, Soper LM. 1995. Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice. Proc Natl Acad Sci USA 92:7485-7489.
18. Douglas GR, Jiao J, Gingerich JD, Soper LM, Gossen JA. 1996. Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ Mol Mutagen 28:317-324.
19. Ekechukwu MC, Oberste DJ, Fane BA. 1995. Host and ΦX174 mutations affecting the morphogenesis or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate. Genetics 140:1167-1174.
20. 6- alkylguanine-DNA transferase. Proc Natl Acad Sci USA 86:8620-8624.
21. Gossen JA, deLeeuw WJF, Tan CHT, Lohman PHM, Berends F, Knook DL, Zwarthoff EC, Vijg J. 1989. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutation in vivo. Proc Natl Acad Sci USA 85:7981-7985.
22. Gossen JA, Molijn AC, Douglas GR, Vijg J. 1992. Application of galactose-sensitive E. coli strains as selective hosts for lacZ-plasmids. Nucl Acids Res 20:3254.
23. 2-ethylthymidine. Biochemistry 31:4181-4188.
24. Hattman S. 1981. DNA methylation. In: Boyer PD, editor. The enzymes, vol. 14. New York: Academic Press. p 517-548.
25. Hayashi M, Aoyama A, Richardson DL Jr, Hayashi MN. 1988. Biology of the bacteriophage ΦX174. In: Calendar R, editor. The bacteriophages, vol. 2. New York: Plenum Publishing. p 1-71.
26. Hill KA, Buettner VL, Glickman BW, Sommer SS. 1999. Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived. Mutat Res 436:11-19.
27. 4-alkythymines in human cells. J Biol Chem 269:25521-25528.
28. Malling HV, Delongchamp RR. 2001. Direct separation of in vivo and in vitro am3 revertants in transgenic mice carrying the phiX174 am3, cs70 vector. Environ Mol Mutagen 37:345-355.
29. Malling HV, Delongchamp RR, Valentine CR. 2002. Detection of Spontaneous and ENU-induced am3 revertants in transgenic cell cultures. Environ Mol Mutagen 39(Suppl 33):40.
30. Malling, HV, Delongchamp RR, Valentine CR. 2003. Three origins of am3 revertants in transgenic cell cultures. Environ Mol Mutagen 42: 258-273.
31. Marti TM, Kunz C, Fleck O. 2002. DNA mismatch repair and mutation avoidance pathways. J Cell Physiol 191:28-41.
32. McKinzie PB, Delongchamp RR, Heflich RH, Parsons BL. 2001. Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment. Mutat Res 489:47-78.
33. Mientjes EJ, Luiten-Schuite A, van der Wolf E, Borsboom Y, Bergmans A, Berends F, Lohman PHM, Baan RA, van Delft JHM. 1998. DNA adducts, mutant frequencies, and mutant spectra in various organs of klacZ mice exposed to ethylating agents. Environ Mol Mutagen 31:18-31.
34. Meng Q, Skopek TR, Walker DM, Hurley-Leslie S, Chen T, Zimmer DM, Walker VE. 1998. Culture and propagation of hprt mutant T-lymphocytes isolated from mouse spleen. Environ Mol Mutagen 32:236-243.
35. Monroe JJ, Kort KL, Miller JE, Marino DR, Skopek TR. 1998. A comparative study of in vivo mutation assays. Mutat Res 421: 121-136.
36. Nishino H, Buettner VL, Haavik J, Schaid DJ, Sommer SS. 1996. Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ Mol Mutagen 28:299-312.
37. Paashuis-Lew Y, Zhang SB, Heddle JA. 1997. On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice. Mutat Res 373:277-284.
38. Raney JL, Valentine CR. 2004. Mutant frequency and spectrum of mutation in gene A of ΦX174 grown in E. coli. Environ Mol Mutagen 44:000-000.
39. Sanger F, Coulson AR, Friedman T, Air GM, Barrell BG, Brown NL, Fiddes JC, Hutchison CA III, Slocombe PM, Smith M. 1978. The nucleotide sequence of bacteriophage ΦX174. J Mol Biol 125:225-246.
40. Schaaper RM, Dunn RL. 1991. Spontaneous mutation in the Escherichia coli lacI gene. Genetics 129:317-326.
41. Skopek TR. 1995. Of mice and mutants: target size and sensitivity. Mutat Res 331:225-228.
42. Skopek TR, Kort KL, Marino DR. 1995. Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice. Environ Mol Mutagen 26:9-15.
43. Skopek TR, Marino DR, Kort KL, Miller J, Pippert T. 1996. Synthesis of a lacI gene analogue with reduced CpG content. Mutat Res 349: 163-172.
44. Stuart GR, Glickman BW. 2000. Through a glass darkly: reflections of mutation from IacI transgenic mice. Genetics 155:1359-1367.
45. 6-alkylguanine-DNA alkyltransferase defieciency in Eschierichia coli as the host of the detection of mutations in lacI transgenic mice. Environ Mol Mutagen 34:221-226.
46. Suzuki T, Itoh I, Takemoto N, Yajima N, Miura M, Hayashi M, Shimada H, Sofuni T. 1997. Ethyl nitrosourea and methyl methanesulfonate mutagenicity in sperm and testicular germ cells of lacZ transgenic mice (Muta mouse). Mutat Res 388:155-163.
47. Valentine CR, Montgomery BA, Miller SG, Delongchamp RR, Fane BA, Malling HV. 2002. Characterization of mutant spectra generated by a forward mutational assay for gene A of ΦX174 from ENU-treated transgenic mouse embryonic cell line PX-2. Environ Mol Mutagen 39:55-68.