Intracellular metabolism and pharmacokinetics of 5′- hydrogenphosphonate of 3′-azido-2′,3′-dideoxythymidine, a prodrug of 3′-azido-2′,3′-dideoxythymidine

Antiviral Research

Volumn 63, Issue 2, 2004, Pages 107-113

  Skoblov, Yurii ^a   Karpenko, Inna ^a   Shirokova, Elena ^a   Popov, Konstantin ^a   Andronova, Valerya ^b   Galegov, Georgii ^b   Kukhanova, Marina ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

Author keywords

5 Hydrogenphosphonate of azidothymidine; HIV inhibitors; Metabolism; Pharmacokinetics

Indexed keywords

PHOSPHONIC ACID DERIVATIVE; PRODRUG; TRITIUM; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; HUMAN; HUMAN CELL; INCUBATION TIME; INTESTINE; ISOTOPE LABELING; LEUKEMIA CELL; LIVER; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; SPLEEN; STOMACH;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; BRAIN; DIHYDROPYRIDINES; HL-60 CELLS; HUMANS; INJECTIONS, INTRAVENOUS; INTESTINES; LIVER; MICE; MUSCLES; PRODRUGS; SPLEEN; STOMACH; THYMINE NUCLEOTIDES; TISSUE DISTRIBUTION; ZIDOVUDINE;

EID: 4043127502     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2004.03.001     Document Type: Article

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