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Parry AM, Scott RB, Palace J, et al. Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine. Brain 2003; 126:2750-2760. An important study emphasizing that altered patterns of brain activation in disease can be modulated rapidly. The study also illustrates how functional MRI could be used as a method for early screening of drugs with a potential for improving neuronal function after injury with MS. Acetylcholinesterase inhibition is proposed as a candidate treatment for cognitive dysfunction in MS.
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Brain
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Parry, A.M.1
Scott, R.B.2
Palace, J.3
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54
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Short-term correlations between clinical and MR imaging findings in relapsing-remitting multiple sclerosis
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Rovaris M, Comi G, Ladkani D, et al. Short-term correlations between clinical and MR imaging findings in relapsing-remitting multiple sclerosis. Am J Neuroradiol 2003; 24:75-81.
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Am J Neuroradiol
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Rovaris, M.1
Comi, G.2
Ladkani, D.3
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55
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MRI metrics as surrogate endpoints for extended disability status scale progression in SPMS patients treated with IFN beta-1b
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Sormani MP, Bruzzi P, Beckmann K, et al. MRI metrics as surrogate endpoints for extended disability status scale progression in SPMS patients treated with IFN beta-1b. Neurology 2003; 60:1462-1466. A quantitative test of the explanatory power of conventional MRI measures of pathological change in a therapeutically successful drug study. The results emphasize that currently popular MRI measures explained only just over half of the clinical effect.
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(2003)
Neurology
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, pp. 1462-1466
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Sormani, M.P.1
Bruzzi, P.2
Beckmann, K.3
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