Activities of cAMP-dependent protein kinase and protein kinase C are modulated by desensitized nicotinic receptors in the rat brain

Neuroscience Letters

Volumn 367, Issue 1, 2004, Pages 19-22

  Sun, Xiulan ^a,b   Liu, Yue ^a,c   Hu, Gang ^b   Wang, Hai ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c Thadweik Academy of Medicine   (China)

Author keywords

cAMP dependent protein kinase; Desensitization; Nicotine; Nicotinic acetylcholine receptor; Protein kinase C

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; NICOTINE; NICOTINIC RECEPTOR; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVITY; ENZYME ASSAY; EXPERIMENTAL RAT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANCE ABUSE;

ANIMALS; BRAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG ADMINISTRATION SCHEDULE; MALE; NICOTINE; NICOTINIC AGONISTS; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; TIME FACTORS;

EID: 4043110641     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.05.072     Document Type: Article

References (27)

1. Alkondon M., Pereira E.F., Almeida L.E., Randall W.R., Albuquerque E.X. Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. Neuropharmacology. 39:2000;2726-2739
2. Boyd N.D. Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells. J. Physiol. 389:1987;45-67
3. Dagher A., Bleicher C., Aston J.A., Gunn R.N., Clarke P.B., Cumming P. Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers. Synapse. 42:2001;48-53
4. Dani J.A., De Biasi M. Cellular mechanisms of nicotine addiction. Pharmacol. Biochem. Behav. 70:2001;439-446
5. Eilers H., Schaeffer E., Bickler P.E., Forsayeth J.R. Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism. Mol. Pharmacol. 52:1997;1105-1112
6. Gopalakrishnan M., Molinari E.J., Sullivan J.P. Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways. Mol. Pharmacol. 52:1997;524-534
7. Jonnala R.R., Buccafusco J.J. Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists. J. Neurosci. Res. 66:2001;565-572
8. Karlin A., Akabas M.H. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron. 15:1995;1231-1244
9. Konu O., Kane J.K., Barrett T., Vawter M.P., Chang R., Ma J.Z., Donovan D.M., Sharp B., Becker K.G., Li M.D. Region-specific transcriptional response to chronic nicotine in rat brain. Brain Res. 909:2001;194-203
10. Li Y., Papke R.L., He Y.J., Millard W.J., Meyer E.M. Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells. Brain Res. 830:1999;218-225
11. Liu J.G., Anand K.J. Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Res. Brain Res. Rev. 38:2001;1-19
12. Nestler E.J. Molecular mechanisms of drug addiction. J. Neurosci. 12:1992;2439-2450
13. Nestler E.J., Aghajanian G.K. Molecular and cellular basis of addiction. Science. 278:1997;58-63
14. Nishizaki T., Sumikawa K. Effects of PKC and PKA phosphorylation on desensitization of nicotinic acetylcholine receptors. Brain Res. 812:1998;242-245
15. O'Neill M.J., Murray T.K., Lakics V., Visanji N.P., Duty S. The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr. Drug Target CNS Neurol. Disord. 1:2002;399-411
16. Pacheco M.A., Pastoor T.E., Wecker L. Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Brain Res. Mol Brain Res. 114:2003;65-72
17. Rowell P.P., Li M. Dose-response relationship for nicotine-induced up-regulation of rat brain nicotinic receptors. J. Neurochem. 68:1997;1982-1989
18. Ryan R.E., Ross S.A., Drago J., Loiacono R.E. Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice. Br. J. Pharmacol. 132:2001;1650-1656
19. Voitenko S.V., Bobryshev A.Y., Skok V.I. Intracellular regulation of neuronal nicotinic cholinoreceptors. Neurosci. Behav. Physiol. 30:2000;19-25
20. Wan Q., Luo Z.P., Wang H. Muscarinic receptor activities potentiated by desensitization of nicotinic receptors in rat superior cervical ganglia. Acta Pharmacol. Sin. 24:2003;657-662
21. Wang H. Modulation by nicotine on muscarinic receptor-effector systems. Acta Pharmacol. Sin. 18:1997;193-197
22. Wang H., Cui W.Y., Liu C.G. Regulatory effects of acutely repeated nicotine treatment towards central muscarinic receptors. Life Sci. 59:1996;1415-1421
23. Wang H., Cui W.Y., Liu C.G. Characteristics of behavioral and electro-encephalogram convulsions induced by nicotine and its di(+) tartrate. Chin. J. Pharmacol. Toxicol. 10:1996;169-172
24. H. Wang, C.G. Liu, Increase sensitivity of brain muscarinic receptor to its agonists as a result of repeated nicotine pretreatment in rats, mice and rabbits, in: F. Adlkofer, K. Thurau (Eds.), Effects of Nicotine on Biological System, Birkhouser Verlag, Basel, 1991, pp. 263-272.
25. Wecker L., Guo X., Rycerz A.M., Edwards S.C. Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of alpha4 neuronal nicotinic receptor subunits. J. Neurochem. 76:2001;711-720
26. Yoshimasa T., Sibley D.R., Bouvier M., Lefkowitz R.J., Caron M.G. Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. Nature. 327:1987;7-70
27. Zhang Y.N., Liu C.G. Muscarinic and nicotinic components of electroencephalogram seizure discharges induced by soman and phsostigmine in rats. Chin. J. Pharmacol. Toxicol. 10:1996;101-108