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Volumn 2, Issue 4, 2004, Pages 547-559

Heparin-induced thrombocytopenia

Author keywords

Antibody; Heparin; Platelet; Thrombosis

Indexed keywords

ABCIXIMAB; ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTIVITAMIN K; ARGATROBAN; CLOPIDOGREL; DANAPAROID; DEXTRAN 70; DIPYRIDAMOLE; ENOXAPARIN; EPTIFIBATIDE; FONDAPARINUX; HEPARIN; HIRUDIN; HIRULOG; IMMUNOGLOBULIN G; LEPIRUDIN; PHENPROCOUMON; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOCYTE FACTOR 4; TICLOPIDINE; WARFARIN; XIMELAGATRAN;

EID: 4043094248     PISSN: 14779072     EISSN: None     Source Type: Journal    
DOI: 10.1586/14779072.2.4.547     Document Type: Review
Times cited : (27)

References (100)
  • 1
    • 0028923741 scopus 로고
    • Heparin-induced thrombocytopenia
    • Chong BH. Heparin-induced thrombocytopenia. Br. J. Haematol. 89, 31-439 (1995).
    • (1995) Br. J. Haematol. , vol.89 , pp. 431-439
    • Chong, B.H.1
  • 3
    • 0020404337 scopus 로고
    • Heparin-induced thrombocytopenia: Association of thrombotic complication with a heparin-dependent IgG antibody which induced platelet aggregation, release and thromboxane synthesis
    • Chong BH, Pitney WR, Castaldi PA. Heparin-induced thrombocytopenia: association of thrombotic complication with a heparin-dependent IgG antibody which induced platelet aggregation, release and thromboxane synthesis. Lancet II, 1246-1248 (1982).
    • (1982) Lancet , vol.2 , pp. 1246-1248
    • Chong, B.H.1    Pitney, W.R.2    Castaldi, P.A.3
  • 4
    • 0024449410 scopus 로고
    • The mechanism of heparin-induced platelet aggregation
    • Chong BH, Ismail F. The mechanism of heparin-induced platelet aggregation. Eur. J. Haematol. 43, 245-251 (1989).
    • (1989) Eur. J. Haematol. , vol.43 , pp. 245-251
    • Chong, B.H.1    Ismail, F.2
  • 5
    • 0031007008 scopus 로고    scopus 로고
    • The platelet proaggregating and potentiating effects of unfractionated heparin, low-molecular-weight heparin and heparinoid in intensive care patients and healthy controls
    • Burgess JK, Chong BH. The platelet proaggregating and potentiating effects of unfractionated heparin, low-molecular-weight heparin and heparinoid in intensive care patients and healthy controls. Eur. J. Haematol. 58, 270-285 (1997).
    • (1997) Eur. J. Haematol. , vol.58 , pp. 270-285
    • Burgess, J.K.1    Chong, B.H.2
  • 7
    • 0026638091 scopus 로고
    • Platelet Factor 4 complexed to heparin is die target for antibodies generated in heparin-induced thrombocytopenia
    • Amiral J, Bridey F, Dreyfus M et al. Platelet Factor 4 complexed to heparin is die target for antibodies generated in heparin-induced thrombocytopenia. Thromb. Haemost. 68, 95-96 (1992).
    • (1992) Thromb. Haemost. , vol.68 , pp. 95-96
    • Amiral, J.1    Bridey, F.2    Dreyfus, M.3
  • 8
    • 0018935691 scopus 로고
    • Heparin-associated thrombocytopenia: A comparison of three heparin preparations
    • Bell WR, Royall RM. Heparin-associated thrombocytopenia: a comparison of three heparin preparations. N. Engl. J. Med. 303, 902-907 (1980).
    • (1980) N. Engl. J. Med. , vol.303 , pp. 902-907
    • Bell, W.R.1    Royall, R.M.2
  • 9
    • 0022472239 scopus 로고
    • Heparin-associated thrombocytopenia: A prospective comparison of bovine lung heparin intestinal heparin
    • Bailey RTJ, Ursick JA, Heim KL, Hilleman DE, Reich JW. Heparin-associated thrombocytopenia: a prospective comparison of bovine lung heparin intestinal heparin. Drug Intel. Clin. Pharm. 20, 374-378 (1986).
    • (1986) Drug Intel. Clin. Pharm. , vol.20 , pp. 374-378
    • Bailey, R.T.J.1    Ursick, J.A.2    Heim, K.L.3    Hilleman, D.E.4    Reich, J.W.5
  • 10
    • 0029035681 scopus 로고
    • Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin
    • Warkentin TE, Levine MN, Hirsh J et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N. Engl. J. Med. 332, 1330-1335 (1995).
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1330-1335
    • Warkentin, T.E.1    Levine, M.N.2    Hirsh, J.3
  • 13
    • 3843085315 scopus 로고    scopus 로고
    • Frequency of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, Inc., NY, USA
    • Lee DH, Warkentin TE. Frequency of heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, Inc., NY, USA, 107-148 (2004).
    • (2004) Heparin-Induced Thrombocytopenia , pp. 107-148
    • Lee, D.H.1    Warkentin, T.E.2
  • 14
    • 4043078182 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia
    • Michelson A (Ed.), Academic Press, NY, USA
    • Chong B. Heparin-induced thrombocytopenia. In: Platelets. Michelson A (Ed.), Academic Press, NY, USA, 571-591 (2002).
    • (2002) Platelets , pp. 571-591
    • Chong, B.1
  • 15
    • 0028009642 scopus 로고
    • Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet Factor 4 complexed with heparin or bound to endothelial cells
    • Visentin GP, Ford SE, Scott JP, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet Factor 4 complexed with heparin or bound to endothelial cells. J. Clin. Invest. 93, 81-88 (1994).
    • (1994) J. Clin. Invest. , vol.93 , pp. 81-88
    • Visentin, G.P.1    Ford, S.E.2    Scott, J.P.3    Aster, R.H.4
  • 16
    • 0032728857 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: The major antigenic epitope is on the modified platelet Factor 4 and not on heparin
    • Newman P, Chong BH. Heparin-induced thrombocytopenia: the major antigenic epitope is on the modified platelet Factor 4 and not on heparin. Br. J. Haematol. 107, 303-309 (1999).
    • (1999) Br. J. Haematol. , vol.107 , pp. 303-309
    • Newman, P.1    Chong, B.H.2
  • 17
    • 0033730964 scopus 로고    scopus 로고
    • Pathophysiology of heparin-induced thrombocytopenia. Clinical and diagnostic implications - A review
    • Fabris FAS, Cella G, Jeska WP, Walenga JM, Fareed J. Pathophysiology of heparin-induced thrombocytopenia. Clinical and diagnostic implications - a review. Arch. Pathol. Lab. Med 124, 1657-1666 (2000).
    • (2000) Arch. Pathol. Lab. Med. , vol.124 , pp. 1657-1666
    • Fabris, F.A.S.1    Cella, G.2    Jeska, W.P.3    Walenga, J.M.4    Fareed, J.5
  • 18
    • 0033580605 scopus 로고    scopus 로고
    • Antibodies to platelet Factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin: Clinical implications for heparin-induced thrombocytopenia
    • Pouplard C, May MA, Iochmann S et al. Antibodies to platelet Factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin: clinical implications for heparin-induced thrombocytopenia. Circulation 99, 2530-3536 (1999).
    • (1999) Circulation , vol.99 , pp. 2530-3536
    • Pouplard, C.1    May, M.A.2    Iochmann, S.3
  • 20
    • 0024357798 scopus 로고
    • Heparin-induced thrombocytopenia: Mechanism of interaction of the heparin-dependent antibody with platelets
    • Chong BH, Ismail F, Chesterman CN, Berndt MC. Heparin-induced thrombocytopenia: mechanism of interaction of the heparin-dependent antibody with platelets. Br. J. Haematol. 73, 235-240 (1989).
    • (1989) Br. J. Haematol. , vol.73 , pp. 235-240
    • Chong, B.H.1    Ismail, F.2    Chesterman, C.N.3    Berndt, M.C.4
  • 21
    • 0034235911 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: New evidence for the dynamic binding of purtied anti-PF4-heparin antibodies to platelets and the resulting activation
    • Newman P, Chong BH. Heparin-induced thrombocytopenia: new evidence for the dynamic binding of purtied anti-PF4-heparin antibodies to platelets and the resulting activation. Blood 96, 182-187 (2000).
    • (2000) Blood , vol.96 , pp. 182-187
    • Newman, P.1    Chong, B.H.2
  • 22
    • 0023710994 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Laboratory studies
    • Kelton JG, Sheridan D, Santos A et al. Heparin-induced thrombocytopenia: laboratory studies. Blood 72, 925-930 (1998).
    • (1998) Blood , vol.72 , pp. 925-930
    • Kelton, J.G.1    Sheridan, D.2    Santos, A.3
  • 23
    • 0027971564 scopus 로고
    • Sera from patients with heparin-induced thrombocytopenia generated platelet-derived microparticles with procoagulant activity: An explanation for the thrombotic complications of heparin-induced thrombocytopenia
    • Warkentin TE, Hayward CPM, Boshkov LK et al. Sera from patients with heparin-induced thrombocytopenia generated platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood 84, 3691-3699 (1994).
    • (1994) Blood , vol.84 , pp. 3691-3699
    • Warkentin, T.E.1    Hayward, C.P.M.2    Boshkov, L.K.3
  • 24
    • 0019801715 scopus 로고
    • Heparin-induced thrombocytopenia: Effects of heparin platelet antibody on platelets
    • Chong BH, Grace CS, Rosenberg MC. Heparin-induced thrombocytopenia: effects of heparin platelet antibody on platelets. Brit. J. Haematol. 49, 531-540 (1981).
    • (1981) Brit. J. Haematol. , vol.49 , pp. 531-540
    • Chong, B.H.1    Grace, C.S.2    Rosenberg, M.C.3
  • 25
    • 0035874509 scopus 로고    scopus 로고
    • Induction of monocyte tissue factor expression by antibodies to heparin-platelet Factor 4 complexes developed in heparin-induced thrombocytopenia
    • Pouplard C, Iochmann S, Renard B, Herault O, Gruel Y. Induction of monocyte tissue factor expression by antibodies to heparin-platelet Factor 4 complexes developed in heparin-induced thrombocytopenia. Blood 97, 3300-3302 (2001).
    • (2001) Blood , vol.97 , pp. 3300-3302
    • Pouplard, C.1    Iochmann, S.2    Renard, B.3    Herault, O.4    Gruel, Y.5
  • 26
    • 0035883078 scopus 로고    scopus 로고
    • Antibodies from patients with heparin-induced thrombocytopenia stimulate monocytic cells to express tissue factor and secrete interleukin 8
    • Arepally GM, Mayer IM. Antibodies from patients with heparin-induced thrombocytopenia stimulate monocytic cells to express tissue factor and secrete interleukin 8. Blood 98, 1252-1254 (2001).
    • (2001) Blood , vol.98 , pp. 1252-1254
    • Arepally, G.M.1    Mayer, I.M.2
  • 27
    • 0023109003 scopus 로고
    • Immune endothelial-cell injury in heparin-associated thrombocytopenia
    • Cines DB, Tomaski A, Tannenbaum S. Immune endothelial-cell injury in heparin-associated thrombocytopenia. N. Engl. J. Med. 316, 581-589 (1987).
    • (1987) N. Engl. J. Med. , vol.316 , pp. 581-589
    • Cines, D.B.1    Tomaski, A.2    Tannenbaum, S.3
  • 29
    • 0025255513 scopus 로고
    • The effect of molecular weight on heparin binding to platelets
    • Horne MKI, Chao ES. The effect of molecular weight on heparin binding to platelets. Br. J. Haematol. 74, 306-312 (1990).
    • (1990) Br. J. Haematol. , vol.74 , pp. 306-312
    • Horne, M.K.I.1    Chao, E.S.2
  • 30
    • 0031949732 scopus 로고    scopus 로고
    • Simultaneous binding of heparin and platelet Factor-4 to platelets: Further insights into the mechanism of heparin-induced thrombocycopenia
    • Horne MKI, Hutchinson KJ. Simultaneous binding of heparin and platelet Factor-4 to platelets: further insights into the mechanism of heparin-induced thrombocycopenia. Am. J. Hematol. 58, 24-30 (1998).
    • (1998) Am. J. Hematol. , vol.58 , pp. 24-30
    • Horne, M.K.I.1    Hutchinson, K.J.2
  • 31
    • 0003328223 scopus 로고    scopus 로고
    • Antibodies associated with heparin-induced thrombocytopenia (HM report conformational changes in platelet Factor 4 (PF4) induced by linear polyanionic compounds
    • (Abstract 460a)
    • Visentin GP, Moghaddam M, Collins JI, McFarland JG, Aster RH. Antibodies associated with heparin-induced thrombocytopenia (HM report conformational changes in platelet Factor 4 (PF4) induced by linear polyanionic compounds. Blood 90(Suppl. 1), (1997) (Abstract 460a).
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Visentin, G.P.1    Moghaddam, M.2    Collins, J.I.3    McFarland, J.G.4    Aster, R.H.5
  • 32
    • 8944247264 scopus 로고    scopus 로고
    • Presence of auto-antibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated-thrombocytopenia
    • Amiral J, Marfaing-Koka. A, Wolf M et al. Presence of auto-antibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated-thrombocytopenia. Blood 88, 410-416 (1996).
    • (1996) Blood , vol.88 , pp. 410-416
    • Amiral, J.1    Marfaing-Koka, A.2    Wolf, M.3
  • 33
    • 0029086769 scopus 로고
    • Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia
    • Greinacher A, Alban S, Dummel V, Franz G, Mueller-Eckhardt C. Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia. Thromb. Haemost. 74, 886-892 (1995).
    • (1995) Thromb. Haemost. , vol.74 , pp. 886-892
    • Greinacher, A.1    Alban, S.2    Dummel, V.3    Franz, G.4    Mueller-Eckhardt, C.5
  • 34
    • 0036825957 scopus 로고    scopus 로고
    • Differential effects of clivarin and heparin in patients undergoing hip and knee surgery for the generation of anti-heparin Factor 4 antibodies
    • Ahmad S, Haas S, Hoppensteadt DA et al. Differential effects of clivarin and heparin in patients undergoing hip and knee surgery for the generation of anti-heparin Factor 4 antibodies. Thromb. Res. 108, 49-55 (2002).
    • (2002) Thromb. Res. , vol.108 , pp. 49-55
    • Ahmad, S.1    Haas, S.2    Hoppensteadt, D.A.3
  • 35
    • 0030258647 scopus 로고    scopus 로고
    • Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin platelet Factor 4 complexes
    • Visentin GP, Malik M, Cyganiak KA, Aster RH. Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin platelet Factor 4 complexes. J. Lab. Clin. Med. 128, 376-383 (1996).
    • (1996) J. Lab. Clin. Med. , vol.128 , pp. 376-383
    • Visentin, G.P.1    Malik, M.2    Cyganiak, K.A.3    Aster, R.H.4
  • 36
    • 0029878458 scopus 로고    scopus 로고
    • Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia
    • Amiral J, Wolf M, Fischer AM, Boyer-Neumann C, Vissac AM, Meyer D. Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. Br. J. Haematol. 92, 954-959 (1996).
    • (1996) Br. J. Haematol. , vol.92 , pp. 954-959
    • Amiral, J.1    Wolf, M.2    Fischer, A.M.3    Boyer-Neumann, C.4    Vissac, A.M.5    Meyer, D.6
  • 38
    • 3042689466 scopus 로고    scopus 로고
    • Clinical picture of HIT
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Warkentin TE. Clinical picture of HIT. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Warkentin, T.E.1
  • 39
    • 0002680176 scopus 로고    scopus 로고
    • Frequency of upper limb deep-venous thrombosis (UL-DVT) in relation to central venous catheter (CVC) use in patients with heparin-induced thrombocytopenia (HIT): Evidence for interaction of systemic (HIT) and local (CVC) prothrombotic risk factors
    • (Abstract)
    • Warkentin TE, Hong AP. Frequency of upper limb deep-venous thrombosis (UL-DVT) in relation to central venous catheter (CVC) use in patients with heparin-induced thrombocytopenia (HIT): evidence for interaction of systemic (HIT) and local (CVC) prothrombotic risk factors. Blood 92(Suppl. 1), 500a-510a (1998) (Abstract).
    • (1998) Blood , vol.92 , Issue.SUPPL. 1
    • Warkentin, T.E.1    Hong, A.P.2
  • 40
    • 0014622358 scopus 로고
    • Heparin-induced thrombocytopenia. An unexpected response to treatment of consumption coagulopathy
    • Natelson EA, Lynch EC, Alfrey CP Jr, Gross JB. Heparin-induced thrombocytopenia. An unexpected response to treatment of consumption coagulopathy, Ann. Intern. Med. 71, 1121-1125 (1969).
    • (1969) Ann. Intern. Med. , vol.71 , pp. 1121-1125
    • Natelson, E.A.1    Lynch, E.C.2    Alfrey Jr., C.P.3    Gross, J.B.4
  • 41
    • 0016365620 scopus 로고
    • Disseminated intravascular coagulation during heparin therapy
    • Klein HG, Bell WR. Disseminated intravascular coagulation during heparin therapy. Intern. Med. 80, 477-448 (1974).
    • (1974) Intern. Med. , vol.80 , pp. 448-477
    • Klein, H.G.1    Bell, W.R.2
  • 42
    • 0015598386 scopus 로고
    • Heparin-induced thrombocytopenia with thrombotic and hemorrhagic manifestations
    • Rhodes GR, Dixon RH, Silver D. Heparin-induced thrombocytopenia with thrombotic and hemorrhagic manifestations. Surg. Gynecol. Obstet. 136, 409-416 (1973).
    • (1973) Surg. Gynecol. Obstet. , vol.136 , pp. 409-416
    • Rhodes, G.R.1    Dixon, R.H.2    Silver, D.3
  • 43
    • 0000211498 scopus 로고
    • Acute systemic reactions to intravenous bolus heparin therapy: Characterization and relationship to heparin-induced thrombocytopenia
    • (Abstract 160a)
    • Warkentin TE, Soutar RL, Panju A, Ginsberg JS. Acute systemic reactions to intravenous bolus heparin therapy: characterization and relationship to heparin-induced thrombocytopenia. Blood 80 (Suppl. 1), (1992) (Abstract 160a).
    • (1992) Blood , vol.80 , Issue.SUPPL. 1
    • Warkentin, T.E.1    Soutar, R.L.2    Panju, A.3    Ginsberg, J.S.4
  • 44
    • 0028028417 scopus 로고
    • Transient global amnesia associated with acute heparin-induced thrombocytopenia
    • Warkentin TE, Hirte HW, Anderson DR et al. Transient global amnesia associated with acute heparin-induced thrombocytopenia. Am. J. Med. Sci. 97, 489-491 (1994).
    • (1994) Am. J. Med. Sci. , vol.97 , pp. 489-491
    • Warkentin, T.E.1    Hirte, H.W.2    Anderson, D.R.3
  • 45
    • 0008664440 scopus 로고    scopus 로고
    • Laboratory testing for heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Greinacher A. Wakentin TE. Laboratory testing for heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Greinacher, A.1    Wakentin, T.E.2
  • 46
    • 0027413887 scopus 로고
    • The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia
    • Chong BH, Burgess J, Ismail F. The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thromb. Haemost. 69, 344-350 (1993).
    • (1993) Thromb. Haemost. , vol.69 , pp. 344-350
    • Chong, B.H.1    Burgess, J.2    Ismail, F.3
  • 47
    • 0022640930 scopus 로고
    • A diagnostic test for heparin-induced thrombocytopenia
    • Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin-induced thrombocytopenia. Blood 67, 27-30 (1986).
    • (1986) Blood , vol.67 , pp. 27-30
    • Sheridan, D.1    Carter, C.2    Kelton, J.G.3
  • 48
    • 0025951938 scopus 로고
    • A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia
    • Greinacher A, Michels J, Kiefel V, Mueller-Eckhardt C. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb. Haemost. 66, 734-736 (1991).
    • (1991) Thromb. Haemost. , vol.66 , pp. 734-736
    • Greinacher, A.1    Michels, J.2    Kiefel, V.3    Mueller-Eckhardt, C.4
  • 49
    • 0029027906 scopus 로고
    • Heparin-induced thrombocytopenia: An improved method of detection based on lumi-aggregometry
    • Stewart MW, Etches WS, Boshkov LK, Gordon PA. Heparin-induced thrombocytopenia: an improved method of detection based on lumi-aggregometry. Br. J. Haematol. 91, 173-177 (1995).
    • (1995) Br. J. Haematol. , vol.91 , pp. 173-177
    • Stewart, M.W.1    Etches, W.S.2    Boshkov, L.K.3    Gordon, P.A.4
  • 50
    • 0030964597 scopus 로고    scopus 로고
    • A sensitive and specific functional flow cytometric assay for the diagnosis of heparin-induced thrombocytopenia
    • Tomer A. A sensitive and specific functional flow cytometric assay for the diagnosis of heparin-induced thrombocytopenia. Br. J. Haematol. 98, 648-656 (1997).
    • (1997) Br. J. Haematol. , vol.98 , pp. 648-656
    • Tomer, A.1
  • 51
    • 0032946370 scopus 로고    scopus 로고
    • Determination of heparin-induced thrombocytopenia: A rapid flow cytometric assay for direct demonstration of antibody-mediated platelet activation
    • Tomer A, Masalunga C, Abshire TC. Determination of heparin-induced thrombocytopenia: a rapid flow cytometric assay for direct demonstration of antibody-mediated platelet activation. Am. J. Hematol. 61, 53-61 (1999).
    • (1999) Am. J. Hematol. , vol.61 , pp. 53-61
    • Tomer, A.1    Masalunga, C.2    Abshire, T.C.3
  • 52
    • 0028854433 scopus 로고
    • Antibodies to macromolecular platelet Factor 4-heparin complexes in heparin-induced thrombocytopenia: A study of 44 cases
    • Amiral J, Bridey F, Wolf M et al. Antibodies to macromolecular platelet Factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thromb. Haemost. 73, 21-28 (1995).
    • (1995) Thromb. Haemost. , vol.73 , pp. 21-28
    • Amiral, J.1    Bridey, F.2    Wolf, M.3
  • 53
    • 0031850163 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross reactivity with low-molecular-weight heparin and heparinoid
    • Newman PM, Swanson RL, Chong BH. Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross reactivity with low-molecular-weight heparin and heparinoid. Thromb. Haemost. 80, 292-297 (1998).
    • (1998) Thromb. Haemost. , vol.80 , pp. 292-297
    • Newman, P.M.1    Swanson, R.L.2    Chong, B.H.3
  • 54
    • 4043055528 scopus 로고    scopus 로고
    • New developments in thrombosis and hemostasis with a focus on critical care medicine
    • Wester J. New developments in thrombosis and hemostasis with a focus on critical care medicine. Nederlandse Vereniging voor Intensive Care 6, 20-23 (2002).
    • (2002) Nederlandse Vereniging Voor Intensive Care , vol.6 , pp. 20-23
    • Wester, J.1
  • 55
    • 0037948573 scopus 로고    scopus 로고
    • Laboratory diagnosis of immune heparin-induced thrombocytopenia
    • Warkentin TE, Heddle NM. Laboratory diagnosis of immune heparin-induced thrombocytopenia. Curr. Hematol. Rep. 2, 48-157 (2003).
    • (2003) Curr. Hematol. Rep. , vol.2 , pp. 48-157
    • Warkentin, T.E.1    Heddle, N.M.2
  • 56
    • 0033543081 scopus 로고    scopus 로고
    • Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia
    • Greinacher A, Janssens U, Berg G et al. Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Circulation 100, 587-593 (1999).
    • (1999) Circulation , vol.100 , pp. 587-593
    • Greinacher, A.1    Janssens, U.2    Berg, G.3
  • 57
    • 0345369740 scopus 로고    scopus 로고
    • Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with the immunologic type of heparin-induced thrombocytopenia: A prospective study
    • Greinacher A, Völpel H, Janssens U et al. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with the immunologic type of heparin-induced thrombocytopenia: a prospective study. Circulation 99, 73-80 (1999).
    • (1999) Circulation , vol.99 , pp. 73-80
    • Greinacher, A.1    Völpel, H.2    Janssens, U.3
  • 58
    • 3142656168 scopus 로고    scopus 로고
    • Danaparoid for the treatment of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Chong BH. Danaparoid for the treatment of heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Chong, B.H.1
  • 59
    • 0026689886 scopus 로고
    • Orgaran in heparin-induced thrombocytopenia
    • Chong BH, Magnani HN. Orgaran in heparin-induced thrombocytopenia. Haemostasis 22, 85-91 (1992).
    • (1992) Haemostasis , vol.22 , pp. 85-91
    • Chong, B.H.1    Magnani, H.N.2
  • 60
    • 0035167688 scopus 로고    scopus 로고
    • Prospective randomized open-label comparison of danaparoid wit dextran 70 in the treatment of heparin-induced thrombocytopenia
    • Chong BH. Prospective randomized open-label comparison of danaparoid wit dextran 70 in the treatment of heparin-induced thrombocytopenia. Thromb. Haemost. 86, 1170-1175 (2001).
    • (2001) Thromb. Haemost. , vol.86 , pp. 1170-1175
    • Chong, B.H.1
  • 61
    • 2942633800 scopus 로고    scopus 로고
    • Argatroban therapy in heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Lewis BE, Hursting MJ. Argatroban therapy in heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Lewis, B.E.1    Hursting, M.J.2
  • 62
    • 0030980765 scopus 로고    scopus 로고
    • Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia
    • Amiral J, Lormeau JC, Marfaing-Koka A et al. Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia. Blood Goagul. Fibrinol. 8, 114-117 (1997).
    • (1997) Blood Goagul. Fibrinol. , vol.8 , pp. 114-117
    • Amiral, J.1    Lormeau, J.C.2    Marfaing-Koka, A.3
  • 63
    • 3142656168 scopus 로고    scopus 로고
    • Bivalirudin for the treatment of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Bartholomew J. Bivalirudin for the treatment of heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Bartholomew, J.1
  • 64
    • 0037048939 scopus 로고    scopus 로고
    • Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: The METHRO II randomized trial
    • Eriksson BI, Bergqvist D, Kalebo P et al. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomized trial. Lancet 360, 1441-1447 (2002).
    • (2002) Lancet , vol.360 , pp. 1441-1447
    • Eriksson, B.I.1    Bergqvist, D.2    Kalebo, P.3
  • 66
    • 2542470387 scopus 로고    scopus 로고
    • Lepirudin for the treatment of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Greinacher A. Lepirudin for the treatment of heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Greinacher, A.1
  • 68
    • 0038043835 scopus 로고    scopus 로고
    • Results of a large drug-monitoring program confirms the safety and efficacy of refludan (lepirudin) in patients with immunemediated heparin-induced thrombocytopenia (HIT)
    • (Abstract 502a)
    • Lubenow N, Eichler P, Greinacher A. Results of a large drug-monitoring program confirms the safety and efficacy of refludan (lepirudin) in patients with immunemediated heparin-induced thrombocytopenia (HIT). Blood 100(Suppl.), (2002) (Abstract 502a).
    • (2002) Blood , vol.100 , Issue.SUPPL. 1
    • Lubenow, N.1    Eichler, P.2    Greinacher, A.3
  • 69
    • 0242381320 scopus 로고    scopus 로고
    • Anaphylactic reactions associated with lepirudin in patients with heparin-induced thrombocytopenia (HIT)
    • Greinacher A, Eichler P, Lubenow N. Anaphylactic reactions associated with lepirudin in patients with heparin-induced thrombocytopenia (HIT). Circulation 108, 2062-2065 (2003).
    • (2003) Circulation , vol.108 , pp. 2062-2065
    • Greinacher, A.1    Eichler, P.2    Lubenow, N.3
  • 70
    • 0027442550 scopus 로고
    • Heparin-induced thrombocytopenia (HIT): An overview of 230 patients treated with orgaran (Org. 10172)
    • Magnani HN. Heparin-induced thrombocytopenia (HIT): an overview of 230 patients treated with orgaran (Org. 10172). Thromb. Haemost 70, 554-561 (1993).
    • (1993) Thromb. Haemost. , vol.70 , pp. 554-561
    • Magnani, H.N.1
  • 71
    • 0026741276 scopus 로고
    • Orgaran (Org. 10172): Its pharmacological profile m experimental models
    • Meuleman DG. Orgaran (Org. 10172): its pharmacological profile m experimental models. Haemostasis 22, 58-65 (1992).
    • (1992) Haemostasis , vol.22 , pp. 58-65
    • Meuleman, D.G.1
  • 72
    • 0031793581 scopus 로고    scopus 로고
    • New treatment options for heparin-induced thrombocytopenia
    • Ortel TL, Chong BH. New treatment options for heparin-induced thrombocytopenia. Semin. Hematol. 35(4 Suppl. 5), 3-8 (1998).
    • (1998) Semin. Hematol. , vol.35 , Issue.4 SUPPL. 5 , pp. 3-8
    • Ortel, T.L.1    Chong, B.H.2
  • 73
    • 0000503379 scopus 로고    scopus 로고
    • Danaparoid (orgaran) for the treatment of heparin-induced thrombocytopenia (HIT) and thrombosis: Effects on in vivo thrombin and cross-linked fibrin generation and evaluation of the clinical significance of in vitro cross reactivity of danaparoid for HIT-IgG
    • (Abstract 626a)
    • Warkentin TE. Danaparoid (orgaran) for the treatment of heparin-induced thrombocytopenia (HIT) and thrombosis: effects on in vivo thrombin and cross-linked fibrin generation and evaluation of the clinical significance of in vitro cross reactivity of danaparoid for HIT-IgG. Blood 88, (1996) (Abstract 626a).
    • (1996) Blood , vol.88
    • Warkentin, T.E.1
  • 75
    • 0035836541 scopus 로고    scopus 로고
    • Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia
    • Lewis BE, Wallis DE, Berkowitz SD et al. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 103, 1838-1843 (2001).
    • (2001) Circulation , vol.103 , pp. 1838-1843
    • Lewis, B.E.1    Wallis, D.E.2    Berkowitz, S.D.3
  • 77
    • 0035983918 scopus 로고    scopus 로고
    • Bivalirudin pharmacokinetics and pharmacodynamics: Effect of renal function, dose and gender
    • Robson R, White H, Aylward P, Frampton C. Bivalirudin pharmacokinetics and pharmacodynamics: effect of renal function, dose and gender. Clin. Pharmacol. Ther. 71, 433-439 (2002).
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 433-439
    • Robson, R.1    White, H.2    Aylward, P.3    Frampton, C.4
  • 78
    • 0029074136 scopus 로고
    • Successful treatment of heparin-associated thrombocytopenia and thrombosis using hirulog
    • Chamberlin JR, Lewis B, Leya F et al. Successful treatment of heparin-associated thrombocytopenia and thrombosis using hirulog. Can. J. Cardiol. 11, 511-514 (1995).
    • (1995) Can. J. Cardiol. , vol.11 , pp. 511-514
    • Chamberlin, J.R.1    Lewis, B.2    Leya, F.3
  • 79
    • 0038285885 scopus 로고    scopus 로고
    • Bivalirudin, a direct thrombin inhibitor, in the treatment of heparin-induced thrombocytopenia
    • (Abstract 1909)
    • Francis JL, Drexler A, Gwyn G, Moroose R. Bivalirudin, a direct thrombin inhibitor, in the treatment of heparin-induced thrombocytopenia. Thromb. Haemost. (Suppl. 1) (2003) (Abstract 1909).
    • (2003) Thromb. Haemost. , Issue.SUPPL. 1
    • Francis, J.L.1    Drexler, A.2    Gwyn, G.3    Moroose, R.4
  • 80
    • 0029588344 scopus 로고
    • Pharmacokinetics and tolerance of the natural pentasaccharide (ORG31540/SR90107A) with high affinity to antithrombin III in man
    • Boneu B, Necciari J, Cariou R. Pharmacokinetics and tolerance of the natural pentasaccharide (ORG31540/SR90107A) with high affinity to antithrombin III in man. Thromb. Haemost. 74, 1468-1473 (1995).
    • (1995) Thromb. Haemost. , vol.74 , pp. 1468-1473
    • Boneu, B.1    Necciari, J.2    Cariou, R.3
  • 81
    • 0142182561 scopus 로고    scopus 로고
    • Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism
    • and the Matisse Investigators
    • Buller HR, Davidson BL, Decousus H et al., and the Matisse Investigators. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N. Engl. J. Med. 349, 1695-1702 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1695-1702
    • Buller, H.R.1    Davidson, B.L.2    Decousus, H.3
  • 82
    • 0037256123 scopus 로고    scopus 로고
    • Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor
    • Johansson LC, Frison L, Logren U, Fager G, Gustafsson D, Erikson UG. Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor. Clin. Pharmacokinet. 42, 381-392 (2003).
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 381-392
    • Johansson, L.C.1    Frison, L.2    Logren, U.3    Fager, G.4    Gustafsson, D.5    Erikson, U.G.6
  • 83
    • 0345414673 scopus 로고    scopus 로고
    • Stroke prevention with oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with nonvalvular atrial fibrillation (SPORTIF III): Randomized controlled trial
    • and the Executive Steering Committee on behalf of the SPORTIF III Investigators
    • Olsson SB, and the Executive Steering Committee on behalf of the SPORTIF III Investigators. Stroke prevention with oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with nonvalvular atrial fibrillation (SPORTIF III): randomized controlled trial. Lancet 362, 1691-1698 (2003).
    • (2003) Lancet , vol.362 , pp. 1691-1698
    • Olsson, S.B.1
  • 84
    • 0022246431 scopus 로고
    • Streptokinase therapy of pulmonary emboli with heparin-associated thrombocytopenia
    • Cohen JI, Cooper MR, Greenberg GS. Streptokinase therapy of pulmonary emboli with heparin-associated thrombocytopenia. Arch. Intern. Med. 145, 1725-1726 (1985).
    • (1985) Arch. Intern. Med. , vol.145 , pp. 1725-1726
    • Cohen, J.I.1    Cooper, M.R.2    Greenberg, G.S.3
  • 85
    • 0023750497 scopus 로고
    • Surgical management of heparin-associated thrombocytopenia. Strategies in the treatment of venous and arterial thromboembolism
    • Sobel M, Adelman B, Szentpeterey S, Hofmann M, Posner MP, Jenvey W. Surgical management of heparin-associated thrombocytopenia. Strategies in the treatment of venous and arterial thromboembolism. J. Vasc. Surg. 8, 395-401 (1988).
    • (1988) J. Vasc. Surg. , vol.8 , pp. 395-401
    • Sobel, M.1    Adelman, B.2    Szentpeterey, S.3    Hofmann, M.4    Posner, M.P.5    Jenvey, W.6
  • 86
    • 0024995281 scopus 로고
    • Plasma exchange and heparin-induced thrombocytopenia
    • Thorp D, Canty A, Whiting J et al. Plasma exchange and heparin-induced thrombocytopenia. Prog. Clin. Biol. Res. 337, 521-522 (1990).
    • (1990) Prog. Clin. Biol. Res. , vol.337 , pp. 521-522
    • Thorp, D.1    Canty, A.2    Whiting, J.3
  • 87
    • 0026517902 scopus 로고
    • Heparin-induced thrombocytopenia - Response to intravenous immunoglobulin in vivo and in vitro
    • Grau E, Linares M, Alaso, MA, Ruvira J, Sanchis J. Heparin-induced thrombocytopenia - response to intravenous immunoglobulin in vivo and in vitro. Am. J. Hematol. 39, 312 (1992).
    • (1992) Am. J. Hematol. , vol.39 , pp. 312
    • Grau, E.1    Linares, M.2    Alaso, M.A.3    Ruvira, J.4    Sanchis, J.5
  • 88
    • 0026320692 scopus 로고
    • Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis
    • Gruel Y, Lermusiaux P, Lang M et al. Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis. Ann. Vasc. Surg. 5, 552-555 (1991).
    • (1991) Ann. Vasc. Surg. , vol.5 , pp. 552-555
    • Gruel, Y.1    Lermusiaux, P.2    Lang, M.3
  • 90
    • 0030281338 scopus 로고    scopus 로고
    • A 14-year study of heparin-induced thrombocytopenia
    • Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am. J. Med. Sci. 101, 502-507 (1996).
    • (1996) Am. J. Med. Sci. , vol.101 , pp. 502-507
    • Warkentin, T.E.1    Kelton, J.G.2
  • 91
    • 4644257186 scopus 로고    scopus 로고
    • Management of cardiopulmonary bypass anticoagulation in patients with heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Poetzsch B, Madlener K. Management of cardiopulmonary bypass anticoagulation in patients with heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Poetzsch, B.1    Madlener, K.2
  • 92
    • 1442300128 scopus 로고    scopus 로고
    • Bivalirudin versus heparin and protamine in off pump coronary artery bypass surgery
    • Merry AF, Raudkivi PJ, Middleton NG et al. Bivalirudin versus heparin and protamine in off pump coronary artery bypass surgery. Ann. Thorac. Surg. 77(3), 925-931 (2004).
    • (2004) Ann. Thorac. Surg. , vol.77 , Issue.30 , pp. 925-931
    • Merry, A.F.1    Raudkivi, P.J.2    Middleton, N.G.3
  • 93
    • 0025301187 scopus 로고
    • Intraoperative management of patients with heparin-induced thrombocytopenia
    • Kappa JR, Fisher CA, Todd B et al. Intraoperative management of patients with heparin-induced thrombocytopenia. Ann. Thorac. Surg. 49, 714-722 (1990).
    • (1990) Ann. Thorac. Surg. , vol.49 , pp. 714-722
    • Kappa, J.R.1    Fisher, C.A.2    Todd, B.3
  • 94
    • 0024345606 scopus 로고
    • Re-exposure to heparin of patients with heparin-associated antibodies
    • Laster J, Elfrin R, Silver D. Re-exposure to heparin of patients with heparin-associated antibodies. Vasc. Surg. 9, 677-681 (1989).
    • (1989) Vasc. Surg. , vol.9 , pp. 677-681
    • Laster, J.1    Elfrin, R.2    Silver, D.3
  • 95
    • 0036792725 scopus 로고    scopus 로고
    • ARG-216/310/311 Study Investigators. Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia
    • Lewis BE, Matthai WH Jr, Cohen M, Moses JW, Hursting MJ, Leya F. ARG-216/310/311 Study Investigators. Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. Catheter Cardiovasc. Interv. 57, 177-184 (2002).
    • (2002) Catheter Cardiovasc. Interv. , vol.57 , pp. 177-184
    • Lewis, B.E.1    Matthai Jr., W.H.2    Cohen, M.3    Moses, J.W.4    Hursting, M.J.5    Leya, F.6
  • 96
    • 3843079870 scopus 로고    scopus 로고
    • Combination of a direct thrombin inhibitor, argatroban, and glycoprotein IIb/IIIa inhibitor is effective and safe in patients undergoing percutaneous coronary intervention
    • (Abstract 68a)
    • Jang I-K, Matthai WH, Kleiman NS. Combination of a direct thrombin inhibitor, argatroban, and glycoprotein IIb/IIIa. inhibitor is effective and safe in patients undergoing percutaneous coronary intervention. J. Am. Coll. Cardiol. 91 (Suppl.) (2003) (Abstract 68a).
    • (2003) J. Am. Coll. Cardiol. , vol.91 , Issue.SUPPL.
    • Jang, I.-K.1    Matthai, W.H.2    Kleiman, N.S.3
  • 97
    • 0343580449 scopus 로고    scopus 로고
    • Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischaemia without ST elevation: A pilot study
    • OASIS Investigators
    • OASIS Investigators. Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischaemia without ST elevation: a pilot study. Circulation 96, 769-777 (1997).
    • (1997) Circulation , vol.96 , pp. 769-777
  • 98
    • 0033528281 scopus 로고    scopus 로고
    • Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia wihtout ST elevation: A randominzed trial
    • OASIS-2 Investigators
    • OASIS-2 Investigators. Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia wihtout ST elevation: a randominzed trial. Lancet 353, 429-438 (1999).
    • (1999) Lancet , vol.353 , pp. 429-438
  • 99
    • 10744222644 scopus 로고    scopus 로고
    • The anticoagulant therapy with bivalirudin to assist in the performance of percutaneous coronary intervention in patients with heparin-induced thrombocytopenia (ATRAT) study: Main results
    • and the ATBAT Investigators
    • Mahaffey KW, Lewis BE, Wildermann NM et al., and the ATBAT Investigators. The anticoagulant therapy with bivalirudin to assist in the performance of percutaneous coronary intervention in patients with heparin-induced thrombocytopenia (ATRAT) study: main results. J. Invasive Cardiol. 15 (11), 611-616 (2003).
    • (2003) J. Invasive Cardiol. , vol.15 , Issue.11 , pp. 611-616
    • Mahaffey, K.W.1    Lewis, B.E.2    Wildermann, N.M.3
  • 100
    • 2542472151 scopus 로고    scopus 로고
    • Hemodialysis in heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA
    • Fischer KG. Hemodialysis in heparin-induced thrombocytopenia. In: Heparin-Induced Thrombocytopenia. Warkentin TE, Greinacher A (Eds), Marcel Dekker, NY, USA (2004).
    • (2004) Heparin-Induced Thrombocytopenia
    • Fischer, K.G.1


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