High incidence of anti-heparin/platelet factor 4 antibodies after cardiopulmonary bypass surgery

British Journal of Haematology

Volumn 101, Issue 4, 1998, Pages 653-655

  Trossaërt, Marc ^a,c   Gaillard, Anne ^a   Commin, Pierre Louis ^a   Amiral, Jean ^b   Vissac, Anne Marie ^b   Fressinaud, Edith ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b Laboratoire Serbio   (France)

^c INSTITUT DE BIOLOGIE   (France)

Author keywords

Anti heparin platelet factor 4 antibody; Cardiopulmonary bypass; Heparin induced thrombocytopenia

Indexed keywords

HEPARIN ANTAGONIST; THROMBOCYTE ANTIBODY;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; CARDIOPULMONARY BYPASS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPARIN; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PLATELET FACTOR 4; RECOMBINANT PROTEINS; THROMBOCYTOPENIA;

EID: 0031803157     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00750.x     Document Type: Article

References (10)

1. Amiral, J., Bridey, F., Dreyfus, M., Vissac, A.M., Fressinaud, E., Wolf, M. & Meyer, D. (1992) Platelet factor 4 complexed to heparin is the target for antibodies in heparin-induced thrombocytopenia. Thrombosis and Haemostasis, 68, 54-55.
2. Amiral, J., Bridey, F., Wolf, M., Boyer-Neumann, C., Fressinaud, E., Vissac, A.M., Peynaud-Debayle, E., Dreyfus, M. & Meyer, D. (1995) Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thrombosis and Haemostasis, 73, 21-28.
3. Amiral, J., Marfaing-Koka, A., Wolf, M., Alessi, M.C., Tardy, B., Boyer-Neumann, C., Vissac, A.M., Fressinaud, K., Poncz, M. & Meyer, D. (1996a) Presence of antibodies to IL-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood, 88, 410-416.
4. Amiral, J., Wolf, M., Fisher, A.M., Boyer-Neumann, C., Vissac, A.M. & Meyer, D. (1996b) Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. British Journal of Haematology, 92, 954-959.
5. 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. American Journal of Clinical Pathology, 104, 648-654.
6. Bauer, T.L., Arepally, G., Konkle, B.A., Mestichelli, B., Shapiro, S., Cines, D., Poncz, M., McNulty, S., Amiral, J., Hauck, W., Edie, R. & Mannion, J. (1997) Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass. Circulation, 95, 1242-1246.
7. Chong, B.H. (1995) Heparin-induced thrombocytopenia. British Journal of Haematology, 89, 431-439.
8. Chong, B.H., Burgess, J. & Ismail, F. (1993) The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thrombosis and Haemostasis, 69, 988-993.
9. De Maistre, E., Scheid, P., Regnault, V., Vissac, A.M., Amiral, J., Martinet, Y., Anthoine, D. & Lecompte, T. (1996) Association of anti-IL8 IgM antibodies in a patient with multiple thromboses under unfractionated heparin and without sustained thrombo-cytopenia. Haemostasis, 26, (Suppl. 3), 32.
10. Elalamy, I., Potevin, F., Lecrubier, C., Bara, L., Marie, J.P. & Samama, M.M. (1996) A fatal low-molecular weight heparin-associated thrombocytopenia after hip surgery: possible usefulness of PF4-heparin ELISA test. Blood Coagulation and Fibrinolysis, 7, 665-671.