Non-self-discrimination as a driving concept in the identification of an immunodominant HMW-MAA epitopic peptide sequence by autoantibodies from melanoma cancer patients

International Journal of Cancer

Volumn 111, Issue 5, 2004, Pages 720-726

  Dummer, Reinhard ^a   Mittelman, Abraham ^b   Fanizzi, Francesco P ^c   Lucchese, Guglielmo ^d   Willers, Jörg ^a   Kanduc, Darja ^d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c CARSO Cancer Research Center   (Italy)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

Antigenic epitope; Autoantibody; Immunogenic peptide; Melanoma; Non self discrimination

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; AUTOANTIBODY; EPITOPE; HIGH MOLECULAR WEIGHT MELANOMA ASSOCIATED ANTIGEN; MELANOMA ANTIGEN; NITROGEN 15; POLYCLONAL ANTIBODY; PROTEOME; PROTON; SYNTHETIC PEPTIDE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DOT BLOT IMMUNOASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOGENICITY; ISOTOPE LABELING; MELANOMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEOMICS; SKIN TUMOR;

ANTIGENS, NEOPLASM; AUTOANTIBODIES; COMPUTATIONAL BIOLOGY; EPITOPES; HUMANS; IMMUNOASSAY; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA; PROTEOME; SEQUENCE ANALYSIS, PROTEIN; SKIN NEOPLASMS;

EID: 4043057315     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20310     Document Type: Article

References (37)

1. Geller AC, Miller DR, Annas GD, Demierre MF, Gilchrest BA, Koh HK. Melanoma incidence and mortality among US whites, 1969-1999. JAMA 2002;288:1719-20.
2. Kolmel KF, Kulle B, Lippold A, Seebacher C. Survival probabilities and hazard functions of malignant melanoma in Germany 1972-1996, an analysis of 10433 patients. Evolution of gender differences and malignancy. Eur J Cancer 2002;38:1388-94.
3. Hamre MR, Chuba P, Bakhshi S, Thomas R, Severson RK. Cutaneous melanoma in childhood and adolescence. Pediatr Hematol Oncol 2002;19:309-17.
4. Ferrone S, Ming Chu T, Hellstrom I, Hellstrom KE. Tumor antigens recognized by monoclonal antibodies. In: De Vita VT, Hellman S, Rosenberg SA, eds. Biologic therapy of cancer, 2nd ed. Philadelphia: Lippincott, 1995. 77-86.
5. Berzofsky JA. Epitope selection and design of synthetic vaccines. Molecular approaches to enhancing immunogenicity and cross-reactivity of engineered vaccines. Ann NY Acad Sci 1993;690:256-64.
6. Pinilla C, Martin R, Gran B, Appel JR, Boggiano C, Wilson DB, Houghten RA. Exploring immunological specificity using synthetic peptide combinatorial libraries. Curr Opin Immunol 1999;11:193-202.
7. Van Regenmortel MH. Antigenicity and immunogenicity of synthetic peptides. Biologicals 2001;29:209-13.
8. Herlyn M, Koprowski H. Melanoma antigens: immunological and biological characterization and clinical significance. Annu Rev Immunol 1988;6:283-308.
9. Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Proc Natl Acad Sci USA 1996;93:9710-5.
10. Giacomini P, Veglia F, Cordiali FP, Rehle T, Natali PG, Ferrone S. Level of a membrane-bound high-molecular-weight melanoma-associated antigen and a cytoplasmic melanoma-associated antigen in surgically removed tissues and in sera from patients with melanoma. Cancer Res 1984;44:1281-7.
11. Wilson BS, Imai K, Natali PG, Ferrone S. Distribution and molecular characterization of a cell-surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies. Int J Cancer 1981;28:293-300.
12. Ferrone S, Chen ZJ, Liu CC, Hirai S, Kageshita T, Mittelman A. Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibodies MK2-23. Experimental studies and clinical trials in patients with malignant melanoma. Pharmacol Ther 1993;57:259-90.
13. Ferrone S, Kageshita T, Hirai S. Active specific immunotherapy of malignant melanoma with anti-idiotypic monoclonal antibodies. J Dermatol 1993;20:533-9.
14. Mittelman A, Chen ZJ, Yang H, Wong GY, Ferrone S. Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma. Proc Natl Acad Sci USA 1992;89:466-70.
15. Willers J, Lucchese A, Kanduc D, Ferrone S. Molecular mimicry of phage displayed peptides mimicking GD3 ganglioside. Peptides 1999;20:1021-6.
16. Natale C, Giannini T, Lucchese A, Kanduc D. Computer-assisted analysis of molecular mimicry between HPV16 E7 oncoprotein and human protein sequences. Immunol Cell Biol 2000;78:580-5.
17. Kanduc D, Lucchese A, Mittelman A. Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology. Peptides 2001;22:1981-5.
18. Mittelman A, Lucchese A, Sinha AA, Kanduc D. Monoclonal and polyclonal humoral immune response to EC HER-2/neu peptides with low similarity to the host's proteome. Int J Cancer 2002;98:741-7.
19. Wu CH, Huang H, Arminski L, Castro-Alvear J, Chen Y, Hu ZZ, Ledley RS, Lewis KC, Mewes HW, Orcutt BC, Suzek BE, Tsugita A, et al. The Protein Information Resource: an integrated public resource of functional annotation of proteins. Nucleic Acids Res 2002;30:35-7.
20. Schleucher J, Schwendinger M, Sattler M, Schmidt P, Schedletzky O, Glaser SJ, Sorensen OW, Griesinger C. A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients. J Biomol NMR 1994;4:301-6.
21. Schwarzinger S, Kroon GJA, Foss TR, Chung J, Wright PE, Dyson HJ. Sequence-dependent correction of random coil NMR chemical shifts. J Am Chem Soc 2001;123:2970-8.
22. Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, et al. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. J Immunol 2002;169:1102-9.
23. Mosolits S, Steinitz M, Harmenberg U, Ruden U, Eriksson E, Mellstedt H, Fagerberg J. Immunogenic regions of the GA733-2 tumour-associated antigen recognised by autoantibodies of patients with colorectal carcinoma. Cancer Immunol Immunother 2002;51:209-18.
24. Bosscher JR, Gercel-Taylor C, Watkins CS, Taylor DD. Epitope recognition by anti-cathepsin D autoantibodies in endometrial cancer patients. Gynecol Oncol 2001;81:138-43.
25. Lang GA, Yeaman GR. Autoantibodies in endometriosis sera recognize a Thomsen-Friedenreich-like carbohydrate antigen. J Autoimmun 2001;16:151-61.
26. Konstandoulakis MM, Syrigos KN, Leandros M, Charalabopoulos A, Manouras A, Golematis BC. Autoantibodies in the serum of patients with gastric cancer: their prognostic importance. Hybridoma 1998;17:431-5.
27. Huang SK, Okamoto T, Morton DL, Hoon DS. Antibody responses to melanoma/melanocyte autoantigens in melanoma patients. J Invest Dermatol 1998;111:662-7.
28. Bowne WB, Srinivasan R, Wolchok JD, Hawkins WG, Blachere NE, Dyall R, Lewis JJ, Houghton AN. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 1999;190:1717-22.
29. Stockert E, Jager E, Chen YT, Scanlan MJ, Gout I, Karbach J, Arand M, Knuth A, Old LJ. A survey of the humoral immune response of cancer patients to a panel of human tumor antigens. J Exp Med 1998;187:1349-54.
30. Fishman P, Merimski O, Baharav E, Shoenfeld Y. Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo. Cancer 1997;79:1461-4.
31. Desai SA, Wang X, Noronha EJ, Kageshita T, Ferrone S. Characterization of human anti-high molecular weight-melanoma-associated antigen single-chain Fv fragments isolated from a phage display antibody library. Cancer Res 1998;58:2417-25.
32. Tauber AI. Moving beyond the immune self? Semin Immunol 2000;12:241-8.
33. Silverstein AM, Rose NR. On the mystique of the immunological self. Immunol Rev 1997;159:197-206.
34. Tauber AI, Chernyak L. Metchnikoff and the origins of immunology: from metaphor to theory. Oxford: Oxford University Press, 1991.
35. Mitchison NA, Katz DR, Chain B. Self/nonself discrimination among immunoregulatory (CD4) T cells. Semin Immunol 2000;12:179-83.
36. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12:991-1045.
37. Cohn M, Langman RE. The protecton: the evolutionarily selected unit of humoral immunity. Immunol Rev 1990;115:1-131.