Self/nonself discrimination among immunoregulatory (CD4) T cells

Seminars in Immunology

Volumn 12, Issue 3, 2000, Pages 179-183

  Mitchison, N A ^a   Katz, D R ^a   Chain, B ^a  

^a Windeyer Institute of Medical Sciences   (United Kingdom)

Author keywords

Deletion; T cell; Thymus; Tolerance

Indexed keywords

ANTIGEN; CD4 ANTIGEN;

ANTIGEN RECOGNITION; DENDRITIC CELL; IMMUNOLOGICAL TOLERANCE; REVIEW; T LYMPHOCYTE SUBPOPULATION; THYMUS;

EID: 0034210474     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2000.0229     Document Type: Article

References (50)

1. Weigle W O. The relationship among acquired immunological tolerance and its termination and tolerance to self and autoimmunity. Int Arch Allergy Appl Immunol. 27:1965;368-369.
2. Dresser D W, Mitchison N A. The mechanism of immunological paralysis. Adv Immunol. 8:1968;129-181.
3. Howard J G, Mitchison N A. Immunological tolerance. Prog Allergy. 18:1975;43-96.
4. Dresser D W. Specific inhibition of antibody production II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology. 5:1962;378-388.
5. Dietrich F M, Weigle W O. Induction of tolerance to heterologous proteins and their catabolism. J Exp Med. 117:1963;621-631.
6. Chiller J M, Habicht G S, Weigle W O. Cellular sites of immunologic unresponsiveness. Proc Natl Acad Sci USA. 65:1970;551-556.
7. Iverson G M, Lindenmann J. The role of a carrier-determinant and T cells in the induction of liver-specific autoantibodies in the mouse. Eur J Immunol. 2:1972;195-197.
8. Mitchison N A. Tolerance of erythrocytes in poultry: loss and abolition. Immunology. 55:1962;359-369.
9. Taylor R B. Decay of immunological responsiveness after thymectomy in adult life. Nature. 208:1965;1334-1335.
10. +8+ thymocytes. Nature. 333:1988;742-746.
11. Zal T., Volkmann A., Stockinger B. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J Exp Med. 180:1994;2089-2099.
12. McCormack J E, Callahan J E, Kappler J., Marrack P C. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J Immunol. 150:1993;3785-3792.
13. Bercovici N., Delon J., Cambouris C., Escriou N., Debre P., Liblau R S. Chronic intravenous injections of antigen induce and maintain tolerance in T cell receptor-transgenic mice. Eur J Immunol. 29:1999;345-354.
14. +T cells. J Exp Med. 185:1997;405-414.
15. Iwabuchi K., Nakayama K., McCoy R L, Wang F., Nishimura T., Habu S., Murphy K M, Loh D Y. Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes. Proc Natl Acad Sci USA. 89:1992;9000-9004.
16. Wedderburn L., Lukic M L, Edwards S., Kahan M C, Nardi N., Mitchison N A. Single step immunosorbent preparation of F-protein from mouse liver with conservation of the allo-antigenic site and determination of concentration in liver and serum. Mol Immunol. 21:1984;979-984.
17. Adelstein S., Pritchard-Briscoe H., Anderson T A, Crosbie J., Gammon G., Loblay R H, Basten A., Goodnow C C. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science. 251:1991;1223-1225.
18. Cibotti R., Kanellopoulos J M, Cabaniols J P, Halle-Panenko O., Kosmatopoulos K., Sercarz E., Kourilsky P. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc Natl Acad Sci USA. 89:1992;416-420.
19. Robertson K., Simon K., Schneider S., Timms E., Mitchison A. Tolerance of self induced in thymus organ culture. Eur J Immunol. 22:1992;207-211.
20. Pircher H., Rohrer U H, Moskophidis D., Zinkernagel R M, Hengartner H. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature. 351:1991;482-485.
21. Golub E S, Weigle W O. Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol. 98:1967;1241-1247.
22. Mitchison N A. The dosage requirements for immunological paralysis by soluble proteins. Immunology. 15:1968;509-530.
23. Mitchison N A. T-cell activation states: The next break-through in signaling? The Immunologist. 1:1993;78-80.
24. Mitchison N A. Induction of immunological paralysis in two zones of dosage. Proc Roy Soc B. 161:1964;275-292.
25. Critchfield J M, Racke M K, Zuniga-Pflucker J C, Cannella B., Raine C S, Goverman J., Lenardo M J. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science. 263:1994;1139-1143.
26. Forster I., Lieberam I. Peripheral tolerance of CD4 T cells following local activation in adolescent mice. Eur J Immunol. 26:1996;3194-3202.
27. Ardavin C. Thymic dendritic cells. Immunol Today. 18:1997;350-361.
28. Reiser H., Schneeberger E E. The costimulatory molecule B7 is expressed in the medullary region of the murine thymus. Immunology. 81:1994;532-537.
29. Ohashi P S, Oehen S., Buerki K., Pircher H., Ohashi C T, Odermatt B., Malissen B., Zinkernagel R M, Hengartner H. Ablation of `tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 65:1991;305-317.
30. Oldstone M B, Nerenberg M., Southern P., Price J., Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell. 65:1991;319-331.
31. Nardi N., Mitchison N A. Variable response to a candidate cancer vaccine antigen: MHC control of the antibody response in the rat to avian erythroblastosis virus (AEV)-encoded epithelial growth factor receptor (EGF-R, erbB protein) but not AEV-encoded thyroid hormones receptor (THs-R, erbA Protein). Molecular Medicine. 1:1995;563-567.
32. Gammon G., Sercarz E. How some T cells escape tolerance induction. Nature. 342:1989;183-185.
33. Schneider S C, Mitchison N A. Self-reactive T cell hybridomas and tolerance. Same range of antigen dose dependence but higher numbers of self-reactive T cell hybridomas from mice in which self-tolerance has been broken by antiserum treatment. J Immunol. 154:1995;3796-3805.
34. +T cells persist in vivo following induction of peripheral tolerance. J Immunol. 160:1998;4719-4729.
35. +T lymphocytes. Immunology. 75:1992;311-317.
36. Schonrich G., Alferink J., Klevenz A., Kublbeck G., Auphan N., Schmitt-Verhulst A M, Hammerling G J, Arnold B. Tolerance induction as a multi-step process. Eur J Immunol. 24:1994;285-293.
37. Schwartz R H. T cell clonal anergy. Curr Opin Immunol. 9:1997;351-357.
38. Mitchison N A, Schuhbauer D., Müller B. Natural and induced regulation of Th1/Th2 balance. Springer Semin Immunopathol. 21:1999;199-210.
39. Fowler S., Powrie F. Control of immune pathology by IL-10 secreting regulatory cells. Springer Semin Immunopathol. 21:1999;287-294.
40. Van Parijs L., Ibraghimov A., Abbas A K. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity. 4:1996;321-328.
41. Bertolino P., Trescol-Bi mont M C, Thomas J., de St Groth B F, Pihlgren M., Marvel J., Rabourdin-Combe C. Death by neglect as a deletional mechanism of peripheral tolerance [In Process Citation]. Int Immunol. 11:1999;1225-1238.
42. Guery J C, Galbiati F., Smiroldo S., Adorini L. Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection. J Immunol. 159:1997;2147-2153.
43. Ramsdell F., Seaman M S, Miller R E, Picha K S, Kennedy M K, Lynch D H. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int Immunol. 6:1994;1545-1553.
44. Varadhachary A S, Perdow S N, Hu C., Ramanarayanan M., Salgame P. Differential ability of T cell subsets to undergo activation-induced cell death. Proc Natl Acad Sci USA. 94:1997;5778-5783.
45. Finkelman F D, Lees A., Birnbaum R., Gause W C, Morris S C. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol. 157:1996;1406-1414.
46. Ibrahim M A, Chain B M, Katz D R. The injured cell: the role of the dendritic cell system as a sentinel receptor pathway. Immunol Today. 16:1995;181-186.
47. Woodhead V E, Binks M H, Chain B M, Katz D R. From sentinel to messenger: an extended phenotypic analysis of the monocyte to dendritic cell transition. Immunology. 94:1998;552-559.
48. Ren Y., Savill J. Apoptosis: the importance of being eaten. Cell Death Differ. 5:1998;563-568.
49. Steinman R M, Inaba K. Myeloid dendritic cells. J Leukoc Biol. 66:1999;205-208.
50. Lucas B., Stefanova I., Yasutomo K., Dautigny N., Germain R N. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity. 10:1999;367-376.