Chemoradiotherapy followed by surgery in rectal cancer: Improved local control using a moderately high pelvic radiation dose

Japanese Journal of Clinical Oncology

Volumn 38, Issue 2, 2008, Pages 112-121

  Lee, Seok Ho ^a   Lee, Kyu Chan ^a   Choi, Jin Ho ^a   Oh, Jae Hwan ^a   Baek, Jeong Heum ^a   Park, Se Hoon ^a   Shin, Dong Bok ^a  

^a Gachon University College of Medicine   (South Korea)

Author keywords

Chemoradiotherapy; Rectal cancer; Surgery

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ABDOMINAL DISCOMFORT; ADULT; AGED; ANASTOMOSIS LEAKAGE; ANEMIA; ARTICLE; BLOOD TOXICITY; BOLUS INJECTION; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CONFIDENCE INTERVAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DISEASE FREE SURVIVAL; DRUG RESPONSE; FEMALE; FOLLOW UP; GRAFT OCCLUSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LEUKOPENIA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; PELVIS ABSCESS; PHOTON THERAPY; PREOPERATIVE RADIOTHERAPY; RADIATION DOSE; RECTOVAGINAL FISTULA; RECTUM CARCINOMA; RECTUM RESECTION; SKIN MANIFESTATION; STATISTICAL SIGNIFICANCE; SURGICAL INFECTION; SURVIVAL RATE; TENESMUS; TREATMENT FAILURE; TREATMENT RESPONSE; UNIVARIATE ANALYSIS;

ADENOCARCINOMA; ADULT; AGED; ANAL CANAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG ADMINISTRATION SCHEDULE; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; HUMANS; KAPLAN-MEIERS ESTIMATE; LEUCOVORIN; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 40349113022     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hym164     Document Type: Article

References (46)

1. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731-40.
2. Frykholm GJ, Glimelius B, Pahlman L. Preoperative or postoperative irradiation in adenocarcinoma of the rectum: Final treatment results of a randomized trial and an evaluation of late secondary effects. Dis Colon Rectum 1993;36:564-72.
3. Hyams DM, Mamounas EP, Petrelli N, Rockette H, Jones J, Wieand HS, et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: A progress report of National Surgical Breast and Bowel Project Protocol R-03. Dis Colon Rectum 1997;40:131-9.
4. Folkesson J, Birgisson H, Pahlman L, Cedermark B, Glimelius B, Gunnarsson U. Swedish Rectal Cancer Trial: Long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 2005;23:5644-50.
5. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Eng J Med 1997;336:980-7.
6. Bosset JF, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, et al. Preoperative radiation (Preop RT) in rectal cancer: Effect and timing of additional chemotherapy (CT) 5-year results of the EORTC 22921 trial. J Clin Oncol 2005 (suppl; abstr 3505);23:p247s.
7. Gerard JP, Bonnetain F, Conroy T, Chapet O, Bouche O, Closon-Dejardin M-T, et al. Preoperative (preop) radiotherapy (RT) {+/-} 5 FU/folinic acid (FA) in T3-4 rectal cancers: Results of the FFCD 9203 randomized trial. J Clin Oncol 2005 (suppl; abstr 3504);23:247s.
8. Watanabe T, Kiyomatsu T, Kanazawa T, Tada T, Komuro Y, Tsurita G, et al. Chemoradiotherapy for rectal cancer: Current status and perspectives. Int J Clin Oncol 2004;9:475-83.
9. Pollack A, Zagars GK, Starkschall G, Antolak JA, Lee JJ, Huang E, et al. Prostate cancer radiation dose response: Results of the M. D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys 2002;53:1097-105.
10. Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet JM, et al. Role of a 10-Gy boost in the conservative treatment of early breast cancer: Results of a randomized clinical trial in Lyon, France. J Clin Oncol 1997;15:963-8.
11. Cox JD, Stetz BS, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31:1341-6.
12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
13. Cox D. Regression models and life-tables (with discussion). J R Statist Soc 1972;34:187-220.
14. Glimelius B, Isacsson U, Jung B, Pahlman L. Radiotherapy in addition to radical surgery in rectal cancer: Evidence for a dose-response effect favoring preoperative treatment. Int J Radiat Oncol Biol Phys 1997;37:281-7.
15. Roswit B, Higgins GA, Keehn RJ. Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: Report of a National Veterans Administration randomized study. Cancer 1975;35:1597-602.
16. Stockholm Rectal Cancer Study Group. Short-term preoperative radiotherapy for adenocarcinoma of the rectum. An interim analysis of a randomized multicenter trial. Am J Clin Oncol 1987;10:369-75.
17. Fortier GA, Krochak RJ, Kim JA, Constable WC. Dose response to preoperative irradiation in rectal cancer: Implications for local control and complications associated with sphincter sparing surgery and abdominoperineal resection. Int J Radiat Oncol Biol Phys 1986;12:1559-63.
18. Ahmad NR, Marks G, Mohiuddin M. High-dose preoperative radiation for cancer of the rectum: Impact of radiation dose on patterns of failure and survival. Int J Radiat Oncol Biol Phys 1993;27:773-8.
19. Gerard JP, Chapet O, Nemoz C, Romestaing P, Mornex F, Coquard R, et al. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0-04 phase II trial. J Clin Oncol 2003;21:1119-24.
20. Mohiuddin M, Regine WF, John WJ, Hagihara PF, McGrath PC, Kenady DE, et al. Preoperative chemoradiation in fixed distal rectal cancer: Dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys 2000;46:883-8.
21. Wiltshire KL, Ward IG, Swallow C, Oza AM, Cummings B, Pond GR, et al. Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: Effect of dose escalation on pathologic complete response, local recurrence-free survival, disease-free survival, and overall survival. Int J Radiat Oncol Biol Phys 2006;64:709-16.
22. Farouk R, Nelson H, Radice E, Mercill S, Gunderson L. Accuracy of computed tomography in determining respectability for locally advanced primary or recurrent colorectal cancers. Am J Surg 1998;175:283-7.
23. Rengan R, Paty P, Wong WD, Guillem J, Weiser M, Temple L, et al. Distal cT2N0 rectal cancer: Is there an alternative to abdominoperineal resection? J Clin Oncol 2005;23:4905-12.
24. Valentini V, Coco C, Cellini N, Picciocchi A, Rosetto ME, Mantini G, et al. Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, sphincter preservation. Int J Radiat Oncol Biol Phys 1999;45:1175-84.
25. Grann A, Feng C, Wong D, Saltz L, Paty PP, Guuillem JG, et al. Preoperative combined modality therapy for clinically respectable uT3 rectal adenocarcinoma. Int J Radiat Oncol Biol Phys 2001;49:987-95.
26. Shirouzu K, Isomoto H, Kakegawa T. Distal spread of rectal cancer and optimal distal margin of resection for sphincter-preserving surgery. Cancer 1995;76:388-92.
27. Vernava AM III, Moran M, Rothenberger DA, Wong WD. A prospective evaluation of distal margins in carcinoma of the rectum. Surg Gynecol Obstet 1992;175:333-6.
28. Janjan NA, Khoo VS, Abbruzzese J, Pazdur R, Dubrow R, Cleary KR, et al. Tumor down-staging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: The M.D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 1999;44:1027-38.
29. Shin SS, Ahn YC, Chun HK, Lee WY, Kang WK, Park YS, et al. Preoperative concurrent radiochemotherapy for rectal cancer: Report of early results. J Korean Soc Ther Radiol Oncol 2003;21:125-134.
30. Baek JH, Kim HK, Lee JN, Oh JW. Early results of laparoscopic colorectal surgery. J Korean Soc Coloproctol 2004;20:8-14.
31. Minsky BD, Cohen AM, Enker WE, Saltz L, Guillem JG, Paty PB, et al. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer. Int J Radiat Oncol Biol Phys 1997;37:289-95.
32. Mehta VK, Poen J, Ford J, Edelstein PS, Vierra M, Bastidas AJ, et al. Radiotherapy, concomitant protracted-venous-infusion 5-fluorouracil, and surgery for ultrasound-staged T3 or T4 rectal cancer. Dis Colon Rectum 2001;44:52-8.
33. Read TE, McNevin MS, Gross EK, Whiteford HM, Lewis JL, Ratkin G, et al. Neoadjuvant therapy for adenocarcinoma of the rectum: Tumor response and acute toxicity. Dis Colon Rectum 2001;44:513-22.
34. Francois Y, Nemoz CJ, Baulieux J, Vignal J, Grandjean JP, Partensky C, et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: The Lyon R90-01 randomized trial. J Clin Oncol 1999;17:2396.
35. Kim JS, Kim JS, Cho MJ, Song KS, Yoon WH. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2002;54:403-8.
36. Navarro M, Dotor E, Rivera F, Sanchez-Rovira P, Vega-Villegas ME, Cervantes A, et al. A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2006;66:201-205.
37. Chau I, Brown G, Cunningham D, Tait D, Wotherspoon A, Norman AR, et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 2006;24:668-74.
38. Cheon SH, Lee SH, Kim KH, Park EB. Accuracy of preopereative staging of rectal cancer. J Korean Soc Coloproctol 2003;19:327-33.
39. Pijl MEJ, Chaoui AS, Wahl RL, van Oost-ayen JA. Radiology of colorectal cancer. Eur J Cancer 2002;38:887-98.
40. Laghi A, Ferri M, Catalano C, Baeli I, Iannaccone R, Iafrate F, et al. Local staging of rectal cancer with MRI using a phased array body coil. Abdom Imaging 2002;27:425-31.
41. Gearhart SL, Frassica D, Rosen R, Choti M, Schulick R, Wahl R. Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer. Ann Surg Oncol 2006;13:397-404.
42. Onaitis MW, Noone RB, Hartwig M, Hurwitz H, Morse M, Jowell P, et al. Neoadjuvant chemoradiation for rectal cancer: Analysis of clinical outcomes from a 13-year institutional experience. Ann Surg 2001;233:778-85.
43. Vauthey JN, Marsh RW, Zlotecki RA, Abdalla EK, Solorzano CC, Bray EJ, et al. Recent advances in the treatment and outcome of locally advanced rectal cancer. Ann Surg 1999;229:745-52; discussion 752-4.
44. Chao M, Gibbs P, Tjandra J, Cullinan M, McLaughlin S, Faragher I, et al. Preoperative chemotherapy and radiotherapy for locally advanced rectal cancer. ANZ J Surg. 2005;75:286-91.
45. Bosset J, Calais L, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, et al. Preoperative radiotherapy in rectal cancer; role and place of fluorouracil-based chemotherapy. Final results of the EORTC 22921 phase III trial. Proc Am Soc Clin Oncol 2005;23(255a).
46. Grann A, Feng C, Wong D, Saltz L, Paty PP, Guillem JG, et al. Preoperative combined modality therapy for clinically resectable uT3 rectal adenocarcinoma. Int J Radiat Oncol Biol Phys 2001;49: 987-95.