메뉴 건너뛰기




Volumn 3, Issue 1, 2008, Pages 36-44

Innate immune responses in primary HIV-1 infection

Author keywords

Cytokine; Dendritic cell; Human immunodeficiency virus; Innate immunity; Natural killer cell

Indexed keywords

CD4 ANTIBODY; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4;

EID: 40349112705     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0b013e3282f2bce7     Document Type: Review
Times cited : (23)

References (68)
  • 1
    • 34250683775 scopus 로고    scopus 로고
    • Lakshmanan V, Alter G, et al. Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection. Curr Opin HIV AIDS 2007; 2:189-200. A recent detailed review of pDC-HIV-1 interactions.
    • Lakshmanan V, Alter G, et al. Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection. Curr Opin HIV AIDS 2007; 2:189-200. A recent detailed review of pDC-HIV-1 interactions.
  • 2
    • 33750378183 scopus 로고    scopus 로고
    • Dendritic-cell interactions with HIV: Infection and viral dissemination
    • Wu L, KewalRamani VN. Dendritic-cell interactions with HIV: infection and viral dissemination. Nat Rev Immunol 2006; 6:859-868.
    • (2006) Nat Rev Immunol , vol.6 , pp. 859-868
    • Wu, L.1    KewalRamani, V.N.2
  • 3
    • 33745960827 scopus 로고    scopus 로고
    • APOBEC family proteins: Novel antiviral innate immunity
    • A comprehensive review summarizing the APOBEC family of proteins
    • Takaori-Kondo A. APOBEC family proteins: novel antiviral innate immunity. Int J Hematol 2006; 83:213-216. A comprehensive review summarizing the APOBEC family of proteins.
    • (2006) Int J Hematol , vol.83 , pp. 213-216
    • Takaori-Kondo, A.1
  • 4
    • 33845906383 scopus 로고    scopus 로고
    • APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection
    • A study describing the antiviral role of ABOBEC3G in dendritic cells
    • Pion M, Granelli-Piperno A, Mangeat B, et al. APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection. J Exp Med 2006; 203:2887-2893. A study describing the antiviral role of ABOBEC3G in dendritic cells.
    • (2006) J Exp Med , vol.203 , pp. 2887-2893
    • Pion, M.1    Granelli-Piperno, A.2    Mangeat, B.3
  • 5
    • 34347371436 scopus 로고    scopus 로고
    • Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression
    • Peng G, Greenwell-Wild T, Nares S, et al. Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression. Blood 2007; 110:393-400.
    • (2007) Blood , vol.110 , pp. 393-400
    • Peng, G.1    Greenwell-Wild, T.2    Nares, S.3
  • 6
    • 22344452391 scopus 로고    scopus 로고
    • Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells
    • Lore K, Smed-Sorensen A, Vasudevan J, et al. Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells. J Exp Med 2005; 201:2023-2033.
    • (2005) J Exp Med , vol.201 , pp. 2023-2033
    • Lore, K.1    Smed-Sorensen, A.2    Vasudevan, J.3
  • 7
    • 34447270265 scopus 로고    scopus 로고
    • Maturation of blood-derived dendritic cells enhances human immunodeficiency virus type 1 capture and transmission
    • Izquierdo-Useros N, Blanco J, Erkizia I, et al. Maturation of blood-derived dendritic cells enhances human immunodeficiency virus type 1 capture and transmission. J Virol 2007; 81:7559-7570.
    • (2007) J Virol , vol.81 , pp. 7559-7570
    • Izquierdo-Useros, N.1    Blanco, J.2    Erkizia, I.3
  • 8
    • 33748687966 scopus 로고    scopus 로고
    • Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: Transmission facilitation versus replication inhibition
    • Groot F, van Capel TMM, Kapsenberg ML, et al. Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition. Blood 2006; 108:1957-1964.
    • (2006) Blood , vol.108 , pp. 1957-1964
    • Groot, F.1    van Capel, T.M.M.2    Kapsenberg, M.L.3
  • 9
    • 40349111591 scopus 로고    scopus 로고
    • Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells
    • Meyers JH, Justement JS, Hallahan CW, et al. Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells. PLoS ONE 2007; 2:e458.
    • (2007) PLoS ONE , vol.2
    • Meyers, J.H.1    Justement, J.S.2    Hallahan, C.W.3
  • 10
    • 34249088361 scopus 로고    scopus 로고
    • Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
    • Hodges A, Sharrocks K, Edelmann M, et al. Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication. Nat Immunol 2007; 8:569-577.
    • (2007) Nat Immunol , vol.8 , pp. 569-577
    • Hodges, A.1    Sharrocks, K.2    Edelmann, M.3
  • 11
    • 34247341369 scopus 로고    scopus 로고
    • Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte-derived dendritic cells to autologous T cells
    • Magerus-Chatinet A, Yu H, Garcia S, et al. Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte-derived dendritic cells to autologous T cells. Virology 2007; 362:67-74.
    • (2007) Virology , vol.362 , pp. 67-74
    • Magerus-Chatinet, A.1    Yu, H.2    Garcia, S.3
  • 12
    • 33847197497 scopus 로고    scopus 로고
    • Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN
    • Boggiano C, Manel N, Littman DR. Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN. J Virol 2007; 81:2519-2523.
    • (2007) J Virol , vol.81 , pp. 2519-2523
    • Boggiano, C.1    Manel, N.2    Littman, D.R.3
  • 13
    • 34447534178 scopus 로고    scopus 로고
    • Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1
    • Sabado RL, Babcock E, Kavanagh DG, et al. Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. Eur J Immunol 2007; 37:1752-1763.
    • (2007) Eur J Immunol , vol.37 , pp. 1752-1763
    • Sabado, R.L.1    Babcock, E.2    Kavanagh, D.G.3
  • 14
    • 33847755116 scopus 로고    scopus 로고
    • Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    • A study demonstrating a novel function of Langerin in anti-HIV immunity
    • de Witte L, Nabatov A, Pion M, et al. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med 2007; 13:367-371. A study demonstrating a novel function of Langerin in anti-HIV immunity.
    • (2007) Nat Med , vol.13 , pp. 367-371
    • de Witte, L.1    Nabatov, A.2    Pion, M.3
  • 15
    • 27644513772 scopus 로고    scopus 로고
    • Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions
    • Beignon AS, McKenna K, Skoberne M, et al. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest 2005; 115:3265-3275.
    • (2005) J Clin Invest , vol.115 , pp. 3265-3275
    • Beignon, A.S.1    McKenna, K.2    Skoberne, M.3
  • 16
    • 33750815125 scopus 로고    scopus 로고
    • HIV induces maturation of monocyte-derived dendritic cells and Langerhans cells
    • Harman AN, Wilkinson J, Bye CR, et al. HIV induces maturation of monocyte-derived dendritic cells and Langerhans cells. J Immunol 2006; 177:7103-7113.
    • (2006) J Immunol , vol.177 , pp. 7103-7113
    • Harman, A.N.1    Wilkinson, J.2    Bye, C.R.3
  • 17
    • 34547130280 scopus 로고    scopus 로고
    • MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded toll-like receptor ligands
    • Meier A, Alter G, Frahm N, et al. MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded toll-like receptor ligands. J Virol 2007; 81:8180-8191.
    • (2007) J Virol , vol.81 , pp. 8180-8191
    • Meier, A.1    Alter, G.2    Frahm, N.3
  • 18
    • 2442684197 scopus 로고    scopus 로고
    • HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
    • Granelli-Piperno A, Golebiowska A, Trumpfheller C, et al. HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc Natl Acad Sci U S A 2004; 101:7669-7674.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7669-7674
    • Granelli-Piperno, A.1    Golebiowska, A.2    Trumpfheller, C.3
  • 19
    • 2342648904 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells
    • Fonteneau JF, Larsson M, Beignon AS, et al. Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol 2004; 78:5223-5232.
    • (2004) J Virol , vol.78 , pp. 5223-5232
    • Fonteneau, J.F.1    Larsson, M.2    Beignon, A.S.3
  • 20
    • 34147115208 scopus 로고    scopus 로고
    • HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    • + T cell function
    • + T cell function.
    • (2007) Blood , vol.109 , pp. 3351-3359
    • Boasso, A.1    Herbeuval, J.P.2    Hardy, A.W.3
  • 21
    • 0022573263 scopus 로고
    • Human alpha- and beta-interferon but not gamma- suppress the in vitro replication of LAV, HTLV-III, and ARV-2
    • Yamamoto JK, Barre-Sinoussi F, Bolton V, et al. Human alpha- and beta-interferon but not gamma- suppress the in vitro replication of LAV, HTLV-III, and ARV-2. J Interferon Res 1986; 6:143-152.
    • (1986) J Interferon Res , vol.6 , pp. 143-152
    • Yamamoto, J.K.1    Barre-Sinoussi, F.2    Bolton, V.3
  • 22
    • 27744560468 scopus 로고    scopus 로고
    • CD4+ T-cell death induced by infectious and noninfectious HIV-1: Role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    • Herbeuval JP, Grivel JC, Boasso A, et al. CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 2005; 106:3524-3531.
    • (2005) Blood , vol.106 , pp. 3524-3531
    • Herbeuval, J.P.1    Grivel, J.C.2    Boasso, A.3
  • 23
    • 34247170486 scopus 로고    scopus 로고
    • HIV-1 immunopathogenesis: How good interferon turns bad
    • Herbeuval JP, Shearer GM. HIV-1 immunopathogenesis: how good interferon turns bad. Clin Immunol 2007; 123:121-128.
    • (2007) Clin Immunol , vol.123 , pp. 121-128
    • Herbeuval, J.P.1    Shearer, G.M.2
  • 24
    • 0025049122 scopus 로고
    • Immunological changes in primary HIV-1 infection
    • Gaines H, von Sydow M, von Stedingk LV, et al. Immunological changes in primary HIV-1 infection. AIDS 1990; 4:995-999.
    • (1990) AIDS , vol.4 , pp. 995-999
    • Gaines, H.1    von Sydow, M.2    von Stedingk, L.V.3
  • 25
    • 0025823898 scopus 로고
    • Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection
    • von Sydow M, Sonnerborg A, Gaines H, Strannegard O. Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection. AIDS Res Hum Retroviruses 1991; 7:375-380.
    • (1991) AIDS Res Hum Retroviruses , vol.7 , pp. 375-380
    • von Sydow, M.1    Sonnerborg, A.2    Gaines, H.3    Strannegard, O.4
  • 26
    • 40349107378 scopus 로고    scopus 로고
    • Stacey A, Haygreen E, Taylor E, et al. Elevations in plasma levels of innate cytokines prior to the peak in plasma viremia in acute HIV-1 infection. In: Program and Abstracts of the Keystone Symposium on 'HIV vaccines: from basic research to clinical trials'; Whistler, Canada; 25-30 March 2007. Keystone Symposia.
    • Stacey A, Haygreen E, Taylor E, et al. Elevations in plasma levels of innate cytokines prior to the peak in plasma viremia in acute HIV-1 infection. In: Program and Abstracts of the Keystone Symposium on 'HIV vaccines: from basic research to clinical trials'; Whistler, Canada; 25-30 March 2007. Keystone Symposia.
  • 27
    • 9244245180 scopus 로고    scopus 로고
    • Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection
    • Graziosi C, Gantt KR, Vaccarezza M, et al. Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. Proc Natl Acad Sci U S A 1996; 93:4386-4391.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 4386-4391
    • Graziosi, C.1    Gantt, K.R.2    Vaccarezza, M.3
  • 28
    • 33748757742 scopus 로고    scopus 로고
    • Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV type 1 infection
    • Norris PJ, Pappalardo BL, Custer B, et al. Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV type 1 infection. AIDS Res Hum Retroviruses 2006; 22:757-762.
    • (2006) AIDS Res Hum Retroviruses , vol.22 , pp. 757-762
    • Norris, P.J.1    Pappalardo, B.L.2    Custer, B.3
  • 29
    • 33847219326 scopus 로고    scopus 로고
    • Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes
    • Cameron PU, Handley AJ, Baylis DC, et al. Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes. J Virol 2007; 81:2297-2306.
    • (2007) J Virol , vol.81 , pp. 2297-2306
    • Cameron, P.U.1    Handley, A.J.2    Baylis, D.C.3
  • 30
    • 33745837477 scopus 로고    scopus 로고
    • Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV infection and treatment
    • Killian MS, Fujimura SH, Hecht FM, Levy JA. Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV infection and treatment. AIDS 2006; 20:1247-1252.
    • (2006) AIDS , vol.20 , pp. 1247-1252
    • Killian, M.S.1    Fujimura, S.H.2    Hecht, F.M.3    Levy, J.A.4
  • 31
    • 22244470043 scopus 로고    scopus 로고
    • Type 1 interferon production is profoundly and transiently impaired in primary HIV-1 infection
    • Kamga I, Kahi S, Develioglu L, et al. Type 1 interferon production is profoundly and transiently impaired in primary HIV-1 infection. J Infect Dis 2005; 192:303-310.
    • (2005) J Infect Dis , vol.192 , pp. 303-310
    • Kamga, I.1    Kahi, S.2    Develioglu, L.3
  • 32
    • 33847617830 scopus 로고    scopus 로고
    • HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    • Martinelli E, Cicala C, Van Ryk D, et al. HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 2007; 104:3396-3401.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3396-3401
    • Martinelli, E.1    Cicala, C.2    Van Ryk, D.3
  • 33
    • 0037192549 scopus 로고    scopus 로고
    • Accumulation of DC-SIGN+ CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection
    • Lore K, Sonnerborg A, Brostrom C, et al. Accumulation of DC-SIGN+ CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS 2002; 16:683-692.
    • (2002) AIDS , vol.16 , pp. 683-692
    • Lore, K.1    Sonnerborg, A.2    Brostrom, C.3
  • 34
    • 23844555106 scopus 로고    scopus 로고
    • Natural killer cell immune responses
    • Yokoyama WM. Natural killer cell immune responses. Immunol Res 2005; 32:317-325.
    • (2005) Immunol Res , vol.32 , pp. 317-325
    • Yokoyama, W.M.1
  • 35
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier LL. NK cell recognition. Annu Rev Immunol 2005; 23:225-274.
    • (2005) Annu Rev Immunol , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 36
    • 27144495433 scopus 로고    scopus 로고
    • Strategies of natural killer cell recognition and signaling
    • This informative review describes the receptor-ligand interactions and intracellular signaling pathways controlling NK effector responses
    • Stewart CA, Vivier E, Colonna M. Strategies of natural killer cell recognition and signaling. Curr Top Microbiol Immunol 2006; 298:1-21. This informative review describes the receptor-ligand interactions and intracellular signaling pathways controlling NK effector responses.
    • (2006) Curr Top Microbiol Immunol , vol.298 , pp. 1-21
    • Stewart, C.A.1    Vivier, E.2    Colonna, M.3
  • 37
    • 33947590063 scopus 로고    scopus 로고
    • Whatever turns you on: Accessory-cell-dependent activation of NK cells by pathogens
    • An excellent review of the interactions involved in accessory-cell-dependent activation of NK cells in response to infection with viral, bacterial and protozoan pathogens
    • Newman KC, Riley EM. Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens. Nat Rev Immunol 2007; 7:279-291. An excellent review of the interactions involved in accessory-cell-dependent activation of NK cells in response to infection with viral, bacterial and protozoan pathogens.
    • (2007) Nat Rev Immunol , vol.7 , pp. 279-291
    • Newman, K.C.1    Riley, E.M.2
  • 38
    • 27744523526 scopus 로고    scopus 로고
    • NK cells in HIV infection: Paradigm for protection or targets for ambush
    • Fauci AS, Mavilio D, Kottilil S. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat Rev Immunol 2005; 5:835-843.
    • (2005) Nat Rev Immunol , vol.5 , pp. 835-843
    • Fauci, A.S.1    Mavilio, D.2    Kottilil, S.3
  • 39
    • 33748612442 scopus 로고    scopus 로고
    • NK cell function in HIV-1 infection
    • A well written review covering the effects of HIV infection on NK cell activity and also evidence suggesting that NK cells may impact on the course of HIV infection
    • Alter G, Altfeld M. NK cell function in HIV-1 infection. Curr Mol Med 2006; 6:621-629. A well written review covering the effects of HIV infection on NK cell activity and also evidence suggesting that NK cells may impact on the course of HIV infection.
    • (2006) Curr Mol Med , vol.6 , pp. 621-629
    • Alter, G.1    Altfeld, M.2
  • 40
    • 34250189126 scopus 로고    scopus 로고
    • Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells
    • This study demonstrates the ability of single-stranded RNA derived from HIV to promote NK cell activation via an accessory cell-dependent pathway, illustrating a mechanism that may help to drive NK cell activation in acute infection and contribute to persistent immune activation in chronic infection
    • Alter G, Suscovich TJ, Teigen N, et al. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. J Immunol 2007; 178:7658-7666. This study demonstrates the ability of single-stranded RNA derived from HIV to promote NK cell activation via an accessory cell-dependent pathway, illustrating a mechanism that may help to drive NK cell activation in acute infection and contribute to persistent immune activation in chronic infection.
    • (2007) J Immunol , vol.178 , pp. 7658-7666
    • Alter, G.1    Suscovich, T.J.2    Teigen, N.3
  • 41
    • 27744464537 scopus 로고    scopus 로고
    • Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
    • Alter G, Teigen N, Davis BT, et al. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood 2005; 106:3366-3369.
    • (2005) Blood , vol.106 , pp. 3366-3369
    • Alter, G.1    Teigen, N.2    Davis, B.T.3
  • 42
    • 40349100855 scopus 로고    scopus 로고
    • Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
    • 11 July [Epub ahead of print
    • Titanji K, Sammicheli S, De Milito A, et al. Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection. Immunology 2007; 11 July [Epub ahead of print].
    • (2007) Immunology
    • Titanji, K.1    Sammicheli, S.2    De Milito, A.3
  • 43
    • 34248140162 scopus 로고    scopus 로고
    • Evolution of innate and adaptive effector cell functions during acute HIV-1 infection
    • + T cells in AHI and shows that the NK cell response is activated prior to the detection of adaptive (T cell or antibody) responses, dominating the initial effector lymphocyte response to HIV
    • + T cells in AHI and shows that the NK cell response is activated prior to the detection of adaptive (T cell or antibody) responses, dominating the initial effector lymphocyte response to HIV.
    • (2007) J Infect Dis , vol.195 , pp. 1452-1460
    • Alter, G.1    Teigen, N.2    Ahern, R.3
  • 45
    • 0344585525 scopus 로고    scopus 로고
    • Cutting edge: Increased NK cell activity in HIV-1-exposed but uninfected Vietnamese intravascular drug users
    • Scott-Algara D, Truong LX, Versmisse P, et al. Cutting edge: increased NK cell activity in HIV-1-exposed but uninfected Vietnamese intravascular drug users. J Immunol 2003; 171:5663-5667.
    • (2003) J Immunol , vol.171 , pp. 5663-5667
    • Scott-Algara, D.1    Truong, L.X.2    Versmisse, P.3
  • 46
    • 33746039265 scopus 로고    scopus 로고
    • Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals
    • Montoya CJ, Velilla PA, Chougnet C, et al. Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals. Clin Immunol 2006; 120:138-146.
    • (2006) Clin Immunol , vol.120 , pp. 138-146
    • Montoya, C.J.1    Velilla, P.A.2    Chougnet, C.3
  • 47
    • 4644279778 scopus 로고    scopus 로고
    • Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility class I molecules
    • Bonaparte MI, Barker E. Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility class I molecules. Blood 2004; 104:2087-2094.
    • (2004) Blood , vol.104 , pp. 2087-2094
    • Bonaparte, M.I.1    Barker, E.2
  • 48
    • 0036699528 scopus 로고    scopus 로고
    • Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    • Martin MP, Gao X, Lee JH, et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 2002; 31:429-434.
    • (2002) Nat Genet , vol.31 , pp. 429-434
    • Martin, M.P.1    Gao, X.2    Lee, J.H.3
  • 49
    • 33748067747 scopus 로고    scopus 로고
    • Qi Y, Martin MP, Gao X, et al. KIR/HLA pleiotropism: protection against both HIV and opportunistic infections. PLoS Pathogens 2006; 2:741-745. This group had previously reported an association between the compound genotype KIR3DS1/HLA-B Bw4Ile and delayed disease progression in HIV infection. In this study they dissect the protective effect(s) of this genotype further, demonstrating that it confers dual protection, being associated with early containment of HIV viraemia and late defence against opportunistic infections.
    • Qi Y, Martin MP, Gao X, et al. KIR/HLA pleiotropism: protection against both HIV and opportunistic infections. PLoS Pathogens 2006; 2:741-745. This group had previously reported an association between the compound genotype KIR3DS1/HLA-B Bw4Ile and delayed disease progression in HIV infection. In this study they dissect the protective effect(s) of this genotype further, demonstrating that it confers dual protection, being associated with early containment of HIV viraemia and late defence against opportunistic infections.
  • 50
    • 33846200446 scopus 로고    scopus 로고
    • Carr WH, Rosen DB, Arase H, et al. Cutting edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J Immunol 2007; 178:647-651. When genetic studies first suggested a role for interactions between KIR3DS1 and HLA-Bw4 in determining the course of HIV infection, little was known about the expression and functions of this KIR. Here, and in Ref. [51•], KIR3DS1 expression on a subset of peripheral blood NK cells is demonstrated, and KIR3DS1 ligation is shown to trigger NK cell functional activation.
    • Carr WH, Rosen DB, Arase H, et al. Cutting edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J Immunol 2007; 178:647-651. When genetic studies first suggested a role for interactions between KIR3DS1 and HLA-Bw4 in determining the course of HIV infection, little was known about the expression and functions of this KIR. Here, and in Ref. [51•], KIR3DS1 expression on a subset of peripheral blood NK cells is demonstrated, and KIR3DS1 ligation is shown to trigger NK cell functional activation.
  • 51
    • 34548611299 scopus 로고    scopus 로고
    • Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection
    • As in Ref, 50•, KIR3DS1 expression on a subset of peripheral blood NK cells is demonstrated, and KIR3DS1 ligation is shown to trigger NK cell functional activation
    • Pascal V, Yamada E, Martin MP, et al. Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection. J Immunol 2007; 179:1625-1633. As in Ref. [50•], KIR3DS1 expression on a subset of peripheral blood NK cells is demonstrated, and KIR3DS1 ligation is shown to trigger NK cell functional activation.
    • (2007) J Immunol , vol.179 , pp. 1625-1633
    • Pascal, V.1    Yamada, E.2    Martin, M.P.3
  • 52
    • 34249802335 scopus 로고    scopus 로고
    • Martin MP, Qi Y, Gao X, et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV. Nat Genet 2007; 39:733-740. This is a key large-scale genetic study, in which it is shown that various distinct allelic combinations of the KIR3DL1 and HLA-B loci strongly influence both the viral load and disease course in HIV-infected individuals. The results provide strong evidence to support the hypothesis that NK cells play a critical role in the response to HIV infection; and also illustrate and help to cast light on the complexity of the KIR3DL1 locus.
    • Martin MP, Qi Y, Gao X, et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV. Nat Genet 2007; 39:733-740. This is a key large-scale genetic study, in which it is shown that various distinct allelic combinations of the KIR3DL1 and HLA-B loci strongly influence both the viral load and disease course in HIV-infected individuals. The results provide strong evidence to support the hypothesis that NK cells play a critical role in the response to HIV infection; and also illustrate and help to cast light on the complexity of the KIR3DL1 locus.
  • 53
    • 33750802673 scopus 로고    scopus 로고
    • Jennes W, Verheyden S, Demanet C, et al. Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands. J Immunol 2006; 177:6588-6592. Both this study and Ref. [54•] document patterns of NK receptor and ligand expression that could lower the threshold for NK cell activation in HIV-exposed, seronegative individuals, providing suggestive evidence that NK cells may be involved in mediating resistance to HIV infection.
    • Jennes W, Verheyden S, Demanet C, et al. Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands. J Immunol 2006; 177:6588-6592. Both this study and Ref. [54•] document patterns of NK receptor and ligand expression that could lower the threshold for NK cell activation in HIV-exposed, seronegative individuals, providing suggestive evidence that NK cells may be involved in mediating resistance to HIV infection.
  • 54
    • 34248368553 scopus 로고    scopus 로고
    • Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
    • Both this study and Ref, 53•] document patterns of NK receptor or ligand expression that could lower the threshold for NK cell activation in HIV-exposed, seronegative individuals, providing suggestive evidence that NK cells may be involved in mediating resistance to HIV infection
    • Ravet S, Scott-Algara D, Bonnet E, et al. Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals. Blood 2007; 109:4296-4305. Both this study and Ref. [53•] document patterns of NK receptor or ligand expression that could lower the threshold for NK cell activation in HIV-exposed, seronegative individuals, providing suggestive evidence that NK cells may be involved in mediating resistance to HIV infection.
    • (2007) Blood , vol.109 , pp. 4296-4305
    • Ravet, S.1    Scott-Algara, D.2    Bonnet, E.3
  • 55
    • 0242542670 scopus 로고    scopus 로고
    • Natural killer cells in HIV-1 infection: Role of NK cell-mediated noncytolytic mechanisms in pathogenesis of HIV-1 infection
    • Kottilil S. Natural killer cells in HIV-1 infection: role of NK cell-mediated noncytolytic mechanisms in pathogenesis of HIV-1 infection. Indian J Exp Biol 2003; 41:1219-1225.
    • (2003) Indian J Exp Biol , vol.41 , pp. 1219-1225
    • Kottilil, S.1
  • 56
    • 33846484462 scopus 로고    scopus 로고
    • Natural killer cell inhibits human immunodeficiency virus replication in chronically-infected immune cells
    • Zhang T, Li Y, Wang Y-J, et al. Natural killer cell inhibits human immunodeficiency virus replication in chronically-infected immune cells. Antiviral Res 2007; 73:132-139.
    • (2007) Antiviral Res , vol.73 , pp. 132-139
    • Zhang, T.1    Li, Y.2    Wang, Y.-J.3
  • 57
    • 0037423824 scopus 로고    scopus 로고
    • Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes
    • Bonaparte M, Barker E. Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes. AIDS 2003; 17:487-494.
    • (2003) AIDS , vol.17 , pp. 487-494
    • Bonaparte, M.1    Barker, E.2
  • 58
    • 20444488405 scopus 로고    scopus 로고
    • HLA-E up-regulation induced by HIV infection may directly contribute to CD94-mediated impairment of NK cells
    • Martini F, Agrati C, D'Offizi G, Poccia F. HLA-E up-regulation induced by HIV infection may directly contribute to CD94-mediated impairment of NK cells. Int J Immunopathol Pharmacol 2005; 18:269-276.
    • (2005) Int J Immunopathol Pharmacol , vol.18 , pp. 269-276
    • Martini, F.1    Agrati, C.2    D'Offizi, G.3    Poccia, F.4
  • 59
    • 23344448979 scopus 로고    scopus 로고
    • NK cytotoxicity against CD4+ T cells during HIV-1 infection: A gp41 peptide induces the expression of an NKp44 ligand
    • Vieillard V, Strominger JL, Debre P. NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand. Proc Natl Acad Sci U S A 2005; 102:10981-10986.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10981-10986
    • Vieillard, V.1    Strominger, J.L.2    Debre, P.3
  • 60
    • 34548009372 scopus 로고    scopus 로고
    • Ward J, Bonaparte M, Sacks J, et al. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood 2007; 110:1207-1214. Much less is known about ligands involved in triggering activating NK receptors than those involved in NK cell inhibition. In this study, the expression of ligands for several activating NK cell receptors on HIV-infected target cells is analysed, and their role in triggering NK cell lysis of the target cells addressed.
    • Ward J, Bonaparte M, Sacks J, et al. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood 2007; 110:1207-1214. Much less is known about ligands involved in triggering activating NK receptors than those involved in NK cell inhibition. In this study, the expression of ligands for several activating NK cell receptors on HIV-infected target cells is analysed, and their role in triggering NK cell lysis of the target cells addressed.
  • 61
    • 33846141778 scopus 로고    scopus 로고
    • Human immunodeficiency virus Nef protein downmodulates the ligands of the activating NK receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity
    • In this study, a novel mechanism by which the Nef protein may reduce NK cell lysis of HIV-infected cells is described
    • Cerboni C, Neri F, Casartelli N, et al. Human immunodeficiency virus Nef protein downmodulates the ligands of the activating NK receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. J Gen Virol 2007; 88:242-250. In this study, a novel mechanism by which the Nef protein may reduce NK cell lysis of HIV-infected cells is described.
    • (2007) J Gen Virol , vol.88 , pp. 242-250
    • Cerboni, C.1    Neri, F.2    Casartelli, N.3
  • 62
    • 30744446711 scopus 로고    scopus 로고
    • Innate immune dysfunction in HIV infection: Effect of HIV envelope-NK cell interactions
    • Kottilil S, Shin K, Jackson JO, et al. Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions. J Immunol 2006; 176:1107-1114.
    • (2006) J Immunol , vol.176 , pp. 1107-1114
    • Kottilil, S.1    Shin, K.2    Jackson, J.O.3
  • 63
    • 34547816196 scopus 로고    scopus 로고
    • HIV-1 Nef impairs the dynamic of DC/NK crosstalk: Different outcome of CD56dim and CD56bright NK cell subsets
    • Quaranta MG, Napolitano A, Sanchez M, et al. HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56dim and CD56bright NK cell subsets. FASEB J 2007; 21:2323-2334.
    • (2007) FASEB J , vol.21 , pp. 2323-2334
    • Quaranta, M.G.1    Napolitano, A.2    Sanchez, M.3
  • 64
    • 34247213249 scopus 로고    scopus 로고
    • Contribution of monocytes to viral replication in macaques during acute infection with simian immunodeficiency virus
    • Kuwata T, Kodama M, Sato A, et al. Contribution of monocytes to viral replication in macaques during acute infection with simian immunodeficiency virus. AIDS Res Hum Retroviruses 2007; 23:372-380.
    • (2007) AIDS Res Hum Retroviruses , vol.23 , pp. 372-380
    • Kuwata, T.1    Kodama, M.2    Sato, A.3
  • 65
    • 35448994462 scopus 로고    scopus 로고
    • Clay CC, Rodrigues DS, Ho YS, et al. Neuroinvasion of fluorescein+ monocytes in acute simian immunodeficiency virus infection. J Virol 2007; 22 August [Epub ahead of print]. Using the SIV macaque model, this study shows that there is an increase in peripheral blood monocyte numbers in acute infection and documents monocyte trafficking into the central nervous system coincident with the first detection of virus in the brain.
    • Clay CC, Rodrigues DS, Ho YS, et al. Neuroinvasion of fluorescein+ monocytes in acute simian immunodeficiency virus infection. J Virol 2007; 22 August [Epub ahead of print]. Using the SIV macaque model, this study shows that there is an increase in peripheral blood monocyte numbers in acute infection and documents monocyte trafficking into the central nervous system coincident with the first detection of virus in the brain.
  • 66
    • 0036467364 scopus 로고    scopus 로고
    • Selective decrease in circulating V alpha 24+ V beta 11+ NKT cells during HIV type 1 infection
    • van der Vliet HJ, von Blomberg BM, Hazenberg MD, et al. Selective decrease in circulating V alpha 24+ V beta 11+ NKT cells during HIV type 1 infection. J Immunol 2002; 168:1490-1495.
    • (2002) J Immunol , vol.168 , pp. 1490-1495
    • van der Vliet, H.J.1    von Blomberg, B.M.2    Hazenberg, M.D.3
  • 67
    • 33750299519 scopus 로고    scopus 로고
    • Cutting edge: Rapid recovery of NKT cells upon institution of highly active antiretroviral therapy for HIV-1 infection
    • + NKT cell infection and loss, NKT cell relocation into tissues may also be involved
    • + NKT cell infection and loss, NKT cell relocation into tissues may also be involved.
    • (2006) J Immunol , vol.177 , pp. 5775-5778
    • van der Vliet, H.J.J.1    van Vonderen, M.G.A.2    Molling, J.W.3
  • 68
    • 34548591355 scopus 로고    scopus 로고
    • Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection
    • Vasan S, Poles MA, Horowitz A, et al. Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection. Int Immunol 2007; 19:943-951.
    • (2007) Int Immunol , vol.19 , pp. 943-951
    • Vasan, S.1    Poles, M.A.2    Horowitz, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.