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Volumn 17, Issue 2, 2007, Pages 67-77

Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy. A prospective, randomized and plasebo-control trials

Author keywords

Acetyl L carnithine; Chronic nerve compression; Neuroprotective effects

Indexed keywords

ETHER; LEVACECARNINE; PLACEBO; SILICON; ACETYLCARNITINE; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT;

EID: 40149110250     PISSN: 10195149     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (44)
  • 1
    • 0026546762 scopus 로고
    • The Mayo Clinic and carpal tunnel syndrome
    • Amadio PC: The Mayo Clinic and carpal tunnel syndrome. Mayo Clin Proc 67:42-8,1992
    • (1992) Mayo Clin Proc , vol.67 , pp. 42-48
    • Amadio, P.C.1
  • 2
    • 0035163981 scopus 로고    scopus 로고
    • Sciatic nerve transection in neonatal rats induces apoptotic neuronal death in L5 dorsal root ganglion
    • Bahadori MH, Al-Tiraihi T, Valojerdi MR. Sciatic nerve transection in neonatal rats induces apoptotic neuronal death in L5 dorsal root ganglion. J Neurocytol 30(2):125-30, 2001
    • (2001) J Neurocytol , vol.30 , Issue.2 , pp. 125-130
    • Bahadori, M.H.1    Al-Tiraihi, T.2    Valojerdi, M.R.3
  • 3
    • 0035807945 scopus 로고    scopus 로고
    • Bergmark M, Kanje M, Widerberg A, Dahlin LB. Experimental nerve compression and upregulation of CPON in DRG. NeuroRapor 4;12(17):3783-6, 2001
    • Bergmark M, Kanje M, Widerberg A, Dahlin LB. Experimental nerve compression and upregulation of CPON in DRG. NeuroRapor 4;12(17):3783-6, 2001
  • 4
    • 0037031529 scopus 로고    scopus 로고
    • Bigini P, Larini S, Pasquali C, Muzio V, Mennini T. Acetyl-L carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons.Neurosci Lett 6;329(3):334-8, 2002
    • Bigini P, Larini S, Pasquali C, Muzio V, Mennini T. Acetyl-L carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons.Neurosci Lett 6;329(3):334-8, 2002
  • 5
    • 0038389442 scopus 로고    scopus 로고
    • Neuro protective effects of L-carnitine in induced mitochondrial dysfunction
    • discussion 345-9
    • Binienda ZK. Neuro protective effects of L-carnitine in induced mitochondrial dysfunction. Ann N Y Acad Sci 993:289-95; discussion 345-9, 2003
    • (2003) Ann N Y Acad Sci , vol.993 , pp. 289-295
    • Binienda, Z.K.1
  • 7
    • 0025372395 scopus 로고
    • The role of carnitine in intracellular metabolism
    • Bremer J. The role of carnitine in intracellular metabolism. J Clin Chem Clin Biohem 28(5):297-301,1990
    • (1990) J Clin Chem Clin Biohem , vol.28 , Issue.5 , pp. 297-301
    • Bremer, J.1
  • 8
    • 0036788605 scopus 로고    scopus 로고
    • Omental graft improves functional recovery of transected peripheral nerve
    • Castaneda F, Kinne RK. Omental graft improves functional recovery of transected peripheral nerve. Muscle Nerve 26(4):527-32, 2002
    • (2002) Muscle Nerve , vol.26 , Issue.4 , pp. 527-532
    • Castaneda, F.1    Kinne, R.K.2
  • 10
    • 0037411794 scopus 로고    scopus 로고
    • Effect of PPF and ALCAR on the induction of NGF- and p75- mRNA and on APP processing in Tg2576 brain
    • Chauhan NB, Siegel GJ. Effect of PPF and ALCAR on the induction of NGF- and p75- mRNA and on APP processing in Tg2576 brain. Neurochem Int 43(3):225-33, 2003
    • (2003) Neurochem Int , vol.43 , Issue.3 , pp. 225-233
    • Chauhan, N.B.1    Siegel, G.J.2
  • 11
    • 0029566222 scopus 로고    scopus 로고
    • De Angelis C, Scarfo C, Falcinelli M, Perna E, Ramacci MT, Angelucci L. Age- and trauma-dependent modifications of neuromuscular junction and skeletal muscle structure in the rat. Effects of long-term treatment with Acetyl-L-Carnitine. Mech Ageing Dev 3;85(1):37-53, 1995
    • De Angelis C, Scarfo C, Falcinelli M, Perna E, Ramacci MT, Angelucci L. Age- and trauma-dependent modifications of neuromuscular junction and skeletal muscle structure in the rat. Effects of long-term treatment with Acetyl-L-Carnitine. Mech Ageing Dev 3;85(1):37-53, 1995
  • 12
    • 0029558692 scopus 로고
    • L-acetylcarnitine in the treatment of patients with peripheral neuropathies
    • De Grandis D, Santoro L, Di Benedetto P. L-acetylcarnitine in the treatment of patients with peripheral neuropathies. Clin Drug Invest 10:317-322, 1995
    • (1995) Clin Drug Invest , vol.10 , pp. 317-322
    • De Grandis, D.1    Santoro, L.2    Di Benedetto, P.3
  • 13
    • 0036591533 scopus 로고    scopus 로고
    • Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: Roles of oxidative buffering and ATP levels
    • Dhitavat S, Ortiz D, Shea TB, Rivera ER. Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels. Neurochem Res 27(6):501-5, 2002
    • (2002) Neurochem Res , vol.27 , Issue.6 , pp. 501-505
    • Dhitavat, S.1    Ortiz, D.2    Shea, T.B.3    Rivera, E.R.4
  • 14
    • 0019796481 scopus 로고
    • Utilization of citrate, acetylcarnitine acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices
    • Dolezal V, Tucek S. Utilization of citrate, acetylcarnitine acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 36:1323-30, 1981
    • (1981) J Neurochem , vol.36 , pp. 1323-1330
    • Dolezal, V.1    Tucek, S.2
  • 15
    • 0034519580 scopus 로고    scopus 로고
    • Challenges to nerve regeneration
    • Evans GR. Challenges to nerve regeneration. Semin Surg Oncol 19:312-318, 2000
    • (2000) Semin Surg Oncol , vol.19 , pp. 312-318
    • Evans, G.R.1
  • 16
    • 0028814185 scopus 로고
    • Effects of acetyl-L-carnitine treatment and stress exposure on the nerve growth factor receptor (p75NGFR) mRNA level in the central nervous system of aged rats
    • Foreman PJ, Perez-Polo JR, Angelucci L, Ramacci MT, Taglialatela G. Effects of acetyl-L-carnitine treatment and stress exposure on the nerve growth factor receptor (p75NGFR) mRNA level in the central nervous system of aged rats. Prog Neuropsychopharmacol Biol Psychiatry 19(1):117-33, 1995
    • (1995) Prog Neuropsychopharmacol Biol Psychiatry , vol.19 , Issue.1 , pp. 117-133
    • Foreman, P.J.1    Perez-Polo, J.R.2    Angelucci, L.3    Ramacci, M.T.4    Taglialatela, G.5
  • 17
    • 0028107682 scopus 로고
    • Neuroprotective activity of acetyl-L-carnitine: Studies in vitro
    • Forloni G, Angeretti N, Smiroldo S. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J Neurosci Res 37(1):92-6, 1994
    • (1994) J Neurosci Res , vol.37 , Issue.1 , pp. 92-96
    • Forloni, G.1    Angeretti, N.2    Smiroldo, S.3
  • 18
    • 0026755254 scopus 로고
    • Effects of acetyl-L-carnitine on the survival of adult rat sensory neurons in primary cultures
    • Formenti A, Arrigoni E, Sansone V, Arrigoni Martelli E, Mancia M. Effects of acetyl-L-carnitine on the survival of adult rat sensory neurons in primary cultures. Int J Dev Neurosci 10(3):207-9, 1992
    • (1992) Int J Dev Neurosci , vol.10 , Issue.3 , pp. 207-209
    • Formenti, A.1    Arrigoni, E.2    Sansone, V.3    Arrigoni Martelli, E.4    Mancia, M.5
  • 19
    • 0013803903 scopus 로고
    • The role of acylcarnitine esters and carnitine palmityltransferase in the transport of fatty acyl groups across mitochondrial membranes
    • Fritz IB, Marquis NR. The role of acylcarnitine esters and carnitine palmityltransferase in the transport of fatty acyl groups across mitochondrial membranes. Proc Nat Acad Sci 54:1226-33, 1965
    • (1965) Proc Nat Acad Sci , vol.54 , pp. 1226-1233
    • Fritz, I.B.1    Marquis, N.R.2
  • 20
    • 84986764154 scopus 로고
    • Unmyelinated fibers in normal and compressed peripheral nerves of the baboon: A Quantitative electron microscopic study
    • Fowler TS, Ochoa J. Unmyelinated fibers in normal and compressed peripheral nerves of the baboon: A Quantitative electron microscopic study. Neuropath Applied Neurobiol 23:247-254, 1975
    • (1975) Neuropath Applied Neurobiol , vol.23 , pp. 247-254
    • Fowler, T.S.1    Ochoa, J.2
  • 23
    • 0037418653 scopus 로고    scopus 로고
    • Goettl VM, Neff NH, Hadjiconstantinou M. Sciatic nerve axotomy in aged rats: response of motoneurons and the effect of GM1 ganglioside treatment. Brain Res 4;968(1):44-53, 2003
    • Goettl VM, Neff NH, Hadjiconstantinou M. Sciatic nerve axotomy in aged rats: response of motoneurons and the effect of GM1 ganglioside treatment. Brain Res 4;968(1):44-53, 2003
  • 24
    • 0014937264 scopus 로고    scopus 로고
    • Haldeman S, Meyer BJ: The effect of experimental constriction on the structure of the sciatic nerve. S Afr Med J 8 44(31):888-92, 1970
    • Haldeman S, Meyer BJ: The effect of experimental constriction on the structure of the sciatic nerve. S Afr Med J 8 44(31):888-92, 1970
  • 25
    • 0036305545 scopus 로고    scopus 로고
    • Systemic acetyl-L-carnitine eliminates sen sory neuronal loss after peripheral axotomy: A new clinical approach in the management of peripheral nerve trauma
    • Hart AM, Wiberg M, Youle M, Terenghi G. Systemic acetyl-L-carnitine eliminates sen sory neuronal loss after peripheral axotomy: a new clinical approach in the management of peripheral nerve trauma. Exp Brain Res 145(2):182-9, 2002
    • (2002) Exp Brain Res , vol.145 , Issue.2 , pp. 182-189
    • Hart, A.M.1    Wiberg, M.2    Youle, M.3    Terenghi, G.4
  • 26
    • 0242624720 scopus 로고    scopus 로고
    • Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2
    • Inano A, Sai Y, Nikaido H, Hasimoto N, Asano M, Tsuji A, Tamai I. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos 24(8):357-65, 2003
    • (2003) Biopharm Drug Dispos , vol.24 , Issue.8 , pp. 357-365
    • Inano, A.1    Sai, Y.2    Nikaido, H.3    Hasimoto, N.4    Asano, M.5    Tsuji, A.6    Tamai, I.7
  • 27
    • 0021087172 scopus 로고
    • A pharmacological profile of the effects of carnitine and acetylcarnitine on the central nervous system
    • Janiri L, Tempesta E. A pharmacological profile of the effects of carnitine and acetylcarnitine on the central nervous system. Int J Clin Pharm Res 111(4);295-306, 1983.
    • (1983) Int J Clin Pharm Res , vol.111 , Issue.4 , pp. 295-306
    • Janiri, L.1    Tempesta, E.2
  • 28
    • 0032891398 scopus 로고    scopus 로고
    • Effects of ALCAR on the fast axoplasmic transport in cultured sensory neurons of streptozotocin-induced diabetic rats
    • Kano M, Kawakami T, Hori H, Hashimoto Y, Tao Y, Ishikawa Y, Takenaka T. Effects of ALCAR on the fast axoplasmic transport in cultured sensory neurons of streptozotocin-induced diabetic rats. Neurosci Res 33(3):207-13, 1999
    • (1999) Neurosci Res , vol.33 , Issue.3 , pp. 207-213
    • Kano, M.1    Kawakami, T.2    Hori, H.3    Hashimoto, Y.4    Tao, Y.5    Ishikawa, Y.6    Takenaka, T.7
  • 29
    • 0037403831 scopus 로고    scopus 로고
    • Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: A 31P-NMR-spectroscopy study
    • Levine J, Panchalingam K, McClure RJ, Gershon S, Pettegrew JW. Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: a 31P-NMR-spectroscopy study. Neurochem Res 28(5):687-90, 2003
    • (2003) Neurochem Res , vol.28 , Issue.5 , pp. 687-690
    • Levine, J.1    Panchalingam, K.2    McClure, R.J.3    Gershon, S.4    Pettegrew, J.W.5
  • 30
    • 0033605072 scopus 로고    scopus 로고
    • Ljungberg C, Novikov L, Kellerth JO, Ebendal T, Wiberg M. The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after peripheral nerve lesion. Neurosci Lett 26;262(1):29-32, 1999
    • Ljungberg C, Novikov L, Kellerth JO, Ebendal T, Wiberg M. The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after peripheral nerve lesion. Neurosci Lett 26;262(1):29-32, 1999
  • 31
    • 12244288322 scopus 로고    scopus 로고
    • Early nerve repair after injury to the postganglionic plexus: An experimental study of sensory and motor neuronal survival in adult rats
    • Ma J, Novikov LN, Kellerth JO, Wiberg M. Early nerve repair after injury to the postganglionic plexus: an experimental study of sensory and motor neuronal survival in adult rats. Scand J Plast Reconstr Surg Hand Surg 37(1):1-9, 2003
    • (2003) Scand J Plast Reconstr Surg Hand Surg , vol.37 , Issue.1 , pp. 1-9
    • Ma, J.1    Novikov, L.N.2    Kellerth, J.O.3    Wiberg, M.4
  • 33
    • 0038433337 scopus 로고    scopus 로고
    • Acetyl-L-carnitine cytoprotection against 1- methyl-4-phenylpyridinium toxicity in neuroblastoma cells
    • Mazzio E, Yoon KJ, Soliman KF. Acetyl-L-carnitine cytoprotection against 1- methyl-4-phenylpyridinium toxicity in neuroblastoma cells. Biochem Pharmacolv 66(2):297-306, 2003
    • (2003) Biochem Pharmacolv , vol.66 , Issue.2 , pp. 297-306
    • Mazzio, E.1    Yoon, K.J.2    Soliman, K.F.3
  • 34
    • 0242580631 scopus 로고    scopus 로고
    • Brain-specific nutrients: A memory cure?
    • Mc Daniel MA, Maier SF, Einstein GO. "Brain-specific" nutrients: a memory cure? Nutrition 9 (12):957-75, 2003
    • (2003) Nutrition , vol.9 , Issue.12 , pp. 957-975
    • Mc Daniel, M.A.1    Maier, S.F.2    Einstein, G.O.3
  • 35
    • 0037121596 scopus 로고    scopus 로고
    • Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment
    • McKay Hart A, Wiberg M, Terenghi G. Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment. Neurosci Lett1 6;(3):181-5, 2002
    • (2002) Neurosci Lett1 , vol.6 , Issue.3 , pp. 181-185
    • McKay Hart, A.1    Wiberg, M.2    Terenghi, G.3
  • 36
    • 0037019887 scopus 로고    scopus 로고
    • Ori C, Freo U, Pizzolato G, Dam M. Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats. Brain Res 4;951(2):330-5, 2002
    • Ori C, Freo U, Pizzolato G, Dam M. Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats. Brain Res 4;951(2):330-5, 2002
  • 37
    • 0032978522 scopus 로고    scopus 로고
    • Reduction in the MK-801 binding sites of the NMDAsub-type of glutamate receptor in a mouse model of congenital hyperammonemia: Prevention by acetyl-L-carnitine
    • Rao KV, Qureshi IA. Reduction in the MK-801 binding sites of the NMDAsub-type of glutamate receptor in a mouse model of congenital hyperammonemia: prevention by acetyl-L-carnitine. Neuropharmacology 38(3):383-94, 1999
    • (1999) Neuropharmacology , vol.38 , Issue.3 , pp. 383-394
    • Rao, K.V.1    Qureshi, I.A.2
  • 38
    • 0029068577 scopus 로고
    • The effect of neurolysis on the recovery of experimentally induced entrapment neuropathy
    • Shu N. The effect of neurolysis on the recovery of experimentally induced entrapment neuropathy. Nippon Seikeigeka Gakkai Zasshi 69(7):517-27,1995
    • (1995) Nippon Seikeigeka Gakkai Zasshi , vol.69 , Issue.7 , pp. 517-527
    • Shu, N.1
  • 40
    • 0000172776 scopus 로고
    • The pathological changes in rats' nerves subject to moderate compression
    • Weisl H, Osborne GV. The pathological changes in rats' nerves subject to moderate compression. J Bone Joint Surg Br 46:297-306, 1964
    • (1964) J Bone Joint Surg Br , vol.46 , pp. 297-306
    • Weisl, H.1    Osborne, G.V.2
  • 41
  • 42
    • 0344465815 scopus 로고    scopus 로고
    • Primary sensory neuronal rescue with systemic acetyl-L-carnitine following peripheral axotomy. A dose- response analysis
    • Wilson AD, Hart A, Brannstrom T, Wiberg M, Terenghi G. Primary sensory neuronal rescue with systemic acetyl-L-carnitine following peripheral axotomy. A dose- response analysis. Br J Plast Surg 56(8):732-9, 2003
    • (2003) Br J Plast Surg , vol.56 , Issue.8 , pp. 732-739
    • Wilson, A.D.1    Hart, A.2    Brannstrom, T.3    Wiberg, M.4    Terenghi, G.5
  • 43
    • 0037121594 scopus 로고    scopus 로고
    • Yasui F, Matsugo S, Ishibashi M, Kajita T, Ezashi Y, Oomura Y, et al: Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice. Neurosci Lett 16;334(3):177-80, 2002
    • Yasui F, Matsugo S, Ishibashi M, Kajita T, Ezashi Y, Oomura Y, et al: Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice. Neurosci Lett 16;334(3):177-80, 2002
  • 44
    • 0036212751 scopus 로고    scopus 로고
    • Turnover epineural sheath tube in Primary repair of peripheral nerves
    • Yavuzer R, Ayhan S, Latifoglu O, Atabay K. Turnover epineural sheath tube in Primary repair of peripheral nerves. Ann Plast Surg 48 (4): 392-400, 2000
    • (2000) Ann Plast Surg , vol.48 , Issue.4 , pp. 392-400
    • Yavuzer, R.1    Ayhan, S.2    Latifoglu, O.3    Atabay, K.4


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