Sciatic nerve axotomy in aged rats: Response of motoneurons and the effect of GM1 ganglioside treatment

Brain Research

Volumn 968, Issue 1, 2003, Pages 44-53

  Goettl, Virginia M ^a   Neff, Norton H ^a   Hadjiconstantinou, Maria ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Choline acetyltransferase; GM1 ganglioside; Sciatic nerve transection; Spinal motoneuron

Indexed keywords

CHOLINE ACETYLTRANSFERASE; GANGLIOSIDE GM1;

ADOLESCENT; AGED; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL COUNT; CELL DENSITY; CELL SIZE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; MALE; MORPHOMETRICS; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NEUROPATHY; SPINAL CORD; SPINAL CORD MOTONEURON; STAINING;

EID: 0037418653     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)04247-6     Document Type: Article

References (49)

1. Appel S.H. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Ann. Neurol. 10:1981;499-505.
2. Berg B.N., Wolf A., Simms H.S. Degenerative lesions of spinal roots and peripheral nerves in aging rats. Gerontologia. 6:1962;72-80.
3. Burek J.D., Van Der Kogel A.J., Hollander C.F. Degenerative myelopathy in three strains of aging rats. Vet. Pathol. 13:1976;321-331.
4. Clatterbuck R.E., Price D.L., Koliatsos V.E. Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons. J. Comp. Neurol. 342:1994;45-56.
5. Duchemin A.-M., Ren Q., Mo L., Neff N.H., Hadjiconstantinou M. GM1 ganglioside induces phopshorylation and activation of Trk and Erk in brain. J. Neurochem. 81:2002;696-707.
6. Friedman B., Kleinfeld D., Ip N.Y., Verge V.M.K., Moulton R., Boland P., Zlotchenko E., Lindsay R.M., Liu L. BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons. J. Neurosci. 15:1995;1044-1056.
7. Fong T.G., Neff N.H., Hadjiconstantinou M. Systemic administration of GM1 ganglioside increases choline acetyltransferase activity in the brain of aged rats. Exp. Neurol. 132:1995;157-161.
8. Frolkis V.V., Tanin S.A., Gorban Y.N. Age-related changes in axonal transport. Exp. Gerontol. 32:1997;441-450.
9. Frostick S.P., Yin Q., Kemp G.J. Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery. 18:1998;397-405.
10. Funakoshi H., Frisén J., Barbany G., Timmusk T., Zachrisson O., Verge V.M.K., Persson H. Differential expression of mRNA for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123:1993;455-465.
11. Goettl V.M., Tejwani G.A., Neff N.H., Hadjiconstantinou M. Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside. NeuroReport. 10:1999;513-516.
12. Greensmith L., Vrbová G. Motoneurone survival: a functional approach. Trends Neurosci. 19:1996;450-455.
13. Gutmann E., Hanzlíková V., Vyskoil F. Age changes in cross striated muscle of the rat. J. Physiol. 219:1971;331-343.
14. Hadjiconstantinou M., Karadsheh N.S., Rattan A.K., Tejwani G.A., Fitkin J.G., Neff N.H. GM1 ganglioside enhances cholinergic parameters in the brain of senescent rats. Neuroscience. 46:1992;681-686.
15. Hadjiconstantinou M., Neff N.H. GM1 ganglioside: in vivo and in vitro trophic actions on central neurotransmitter systems. J. Neurochem. 70:1998;1335-1345.
16. Hadjiconstantinou M., Neff N.H. GM1 and the aged brain. Ann. NY Acad. Sci. 845:1998;225-231.
17. Hadjiconstantinou M., Neff N.H. GM1 ganglioside: commonalities of action with neurotrophins. Mocchetti I. Neurobiology of the Neurotrophins. 2000;427-453 F.P. Graham Publishing Co, Johnson City, TN.
18. Hadjiconstantinou M., Ren Q., Duchemin A.-M., Neff N.H. Activation of brain PI-3 kinase by GM1 ganglioside. J. Neurochem. 74:(Supp):2000;S22.
19. Hammarberg H., Piehl F., Risling M., Cullheim S. Differencial regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat. J. Comp. Neurol. 426:2000;587-601.
20. Hashizume K., Kanda K. Differential effects of aging on motoneurons and peripheral nerves innervating the hindlimb and forelimb muscles of rats. Neurosci. Res. 22:1995;189-196.
21. Hashizume K., Kanda K., Burke R.E. Medial gastrocnemius motor nucleus in the rat: age-related changes in the number and size of motoneurons. J. Comp. Neurol. 269:1988;425-430.
22. Jacob J.M. Lumbar motor neuron size and the number is affected by age in male F344 rats. Mech. Ageing Dev. 106:1998;205-216.
23. Jacob J.M., Croes S.A. Acceleration of axonal outgrowth in motor axons from mature and old F344 rats after a conditioning lesion. Exp. Neurol. 152:1998;231-237.
24. Jacob J.M., McQuarrie I.G. Acceleration of axonal outgrowth in rat sciatic nerve at 1 week after axotomy. J. Neurobiol. 24:1993;356-367.
25. Johnson H., Hökfelt T., Ulfhake B. Decreased expression of TrkB and TrkC mRNAs in spinal motoneurons of aged rats. Eur. J. Neurosci. 8:1996;494-499.
26. Johnson H., Mossberg K., Arvidsson U., Piehl F., Hökfelt T., Ulfhake B. Increase in β-CGRP and GAP-43 in aged motoneurons: a study of peptides, growth factors, and ChAT mRNA in the lumbar spinal cord of senescent rats with symptoms of hindlimb incapabilities. J. Comp. Neurol. 359:1995;69-89.
27. Johnson I.P., Duberely R.M. Motoneuron survival and expression of neuropeptides and neurotrophic factor receptors following axotomy in adult and ageing rats. Neuroscience. 84:1998;141-150.
28. Johnson I.P., Sears T.A., Hunter A.S. Retrograde response to axotomy of motoneurons in the thoracic spinal cord of the aging cat. Neurobiol. Aging. 12:1991;151-160.
29. Kerezoudi E., Thomas P.K. Influence of age on regeneration in the peripheral nervous system. Gerontology. 45:1999;301-306.
30. Ko M.L., King M.A., Gordon T.L., Crisp T. The effects of aging on spinal neurochemistry in the rat. Brain Res. Bull. 42:1997;95-98.
31. Koliatsos V.E., Price W.L., Pardo C.A., Price D.L. Ventral root avulsion: an experimetnal model of death of adult motor neurons. J. Comp. Neurol. 342:1994;35-44.
32. Kreutzberg G.W. Reaction of the neuronal cell body to axonal damage. Waxman S.G., Koscis J.D., Stys P.K. The Axon: Structure, Function, and Pathology. 1995;355-374 Oxford University Press, New York.
33. Kullberg S., Ramirez-Leon V., Johnson H., Ulfhake B. Decreased axosomatic input to motoneurons and astrogliosis in the spinal cord of aged rats. J. Gerontol: BIOLOGICAL SCIENCES. 53A:1998;B369-B379.
34. Lieberman A.R. The axon reaction: a review of the principle features of perikaryal responses to axon injury. Int. Rev. Neurobiol. 14:1971;49-125.
35. MacLennan A.J., Devlin B.K., Neitzel K.L., McLaurin D.L., Anderson K.J., Lee N. Regulation of ciliary neurotrophic factor receptor β in sciatic motor neurons following axotomy. Neuroscience. 91:1999;1401-1413.
36. Ming Y., Bergman E., Edström E., Ulfhake B. Reciprocal changes in the expression of neurotrophin mRNA in target tissues and peripheral nerves of aged rats. Neurosci. Lett. 273:1999;187-190.
37. Mo L., Duchemin A.-M., Ren Q., Neff N.H., Hajdiconstantinou M. GM1 signaling transduction in the brain of young and aged rats (Abstracts). Soc. Neurosci. 27:2001;861.10.
38. Naveilhan P., ElShamy W.M., Erfors P. Differential regulation of mRNAs for GDNF and its receptors ret and GDNFR′ after sciatic nerve lesion in the mouse. Eur. J. Neurosci. 9:1997;1450-1460.
39. Oliveira A.L.R., Langone F. GM-1 ganglioside treatment reduces motoneuron death after ventral root avulsion in adult rats. Neurosci. Lett. 293:2000;131-134.
40. Oorschot D.E., MacLennan I.S. The trophic requirements of mature motoneurons. Brain Res. 789:1998;315-321.
41. Oppenheim R.W. Neurotrophic survival molecules for motoneurons: An embarrassment of riches. Neuron. 17:1996;195-197.
42. Piehl F., Arvidsson U., Johnson H., Cullheim S., Dagerlind Å., Ulfhake B., Cao Y., Elde R., Petersson R.F., Terenius L., Hökfelt T. GAP-43, aFGF, CCK and α- and β-CGRP in rat spinal motoneurons subjected to axotomy and/or dorsal root severance. Eur. J. Neurosci. 5:1993;1321-1333.
43. Purves D. Body and Brain: A Trophic Theory of Neural Connections. 1988;Harvard University Press, Cambridge, MA.
44. Rende M., Giambanco I., Buratta M., Tonali P. Axotomy induces a different modulation of both low-affinity nerve growth factor and choline acetyltransferase between adult rat spinal and brain stem motoneurons. J. Comp. Neurol. 363:1995;249-263.
45. Sendtner M., Pei G., Beck M., Schweizer U., Wiese S. Developmental motoneuron cell death and neurotrophic factors. Cell Tissue Res. 301:2000;71-84.
46. Snider W.D., Elliot J.L., Yan Q. Axotomy-induced neuronal death during development. J. Neurobiol. 23:1992;1231-1246.
47. Terenghi G. Peripheral nerve regeneration and neurotrophic factors. J. Anat. 194:1999;1-14.
48. Yin Q., Kemp G.J., Frostick S.P. Neurotrophins, neurons and peripheral nerve regeneration. J. Hand Surg. (Br. Eur. Vol.). 23B:(4):1998;433-437.
49. Vogelsberg V., Fong T.G., Neff N.H., Hadjiconstantinou M. Cholinergic deficits in aged rat spinal cord: restoration by GM1 ganglioside. Brain. Res. 761:1997;250-256.