Oral mucosal disease: Recurrent aphthous stomatitis

British Journal of Oral and Maxillofacial Surgery

Volumn 46, Issue 3, 2008, Pages 198-206

  Scully, Crispian ^a   Porter, Stephen ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aphthae; Autoimmune; Behcets disease; Corticosteroids; Immunosuppressants; Mouth ulcers

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA2 INTERFERON; AMLEXANOX; ANTIALLERGIC AGENT; ANTIINFLAMMATORY AGENT; AZELASTINE; BENZYDAMINE; BETAMETHASONE VALERATE; CHLORHEXIDINE; CHLORTETRACYCLINE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; CYCLOSPORIN; CYTOKINE; DICLOFENAC; DOXYCYCLINE; FLUOCINONIDE; GLYCYRRHIZA EXTRACT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; IRSOGLADINE MALEATE; MESALAZINE; OXOLINIC ACID; PROSTAGLANDIN E2; STEROID; SUCRALFATE; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TRICLOSAN; UNINDEXED DRUG;

ADOLESCENT DISEASE; APHTHOUS STOMATITIS; ARTICLE; BEHCET DISEASE; CHILDHOOD DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; EYE DISEASE; FAMILY HISTORY; GENETIC PREDISPOSITION; GENITAL ULCER; GENOTYPE; HUMAN; MOUTH ULCER; ORAL MUCOSAL DISEASE; PATHOGENESIS; STEROID THERAPY; TOPICAL TREATMENT; UVEITIS;

ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHCET SYNDROME; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MOUTH MUCOSA; RECURRENCE; STOMATITIS, APHTHOUS;

EID: 40149098847     PISSN: 02664356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bjoms.2007.07.201     Document Type: Article

References (170)

1. Jurge S., Kuffer R., Scully C., and Porter S.R. Number VI recurrent aphthous stomatitis. Oral Dis 12 (2006) 1-21
2. Scully C. Aphthous ulceration. N Engl J Med 355 (2006) 165-172
3. Ship I.I. Epidemiologic aspects of recurrent aphthous ulcerations. Oral Surg Oral Med Oral Pathol 33 (1972) 400-406
4. Donatsky O. Epidemiologic study on recurrent aphthous ulcerations among 512 Danish dental students. Community Dent Oral Epidemiol 1 (1973) 37-40
5. Pongissawaranun W., and Laohapand P. Epidemiologic study on recurrent aphthous stomatitis in a Thai dental patient population. Community Dent Oral Epidemiol 19 (1991) 52-53
6. Garcia-Pola Vallejo M.J., Martinez Diaz-Canel A.I., Garcia Martin J.M., and Gonzalez G.M. Risk factors for oral soft tissue lesions in an adult Spanish population. Community Dent Oral Epidemiol 30 (2002) 277-285
7. Zain R.B. Oral recurrent aphthous ulcers/stomatitis: prevalence in Malaysia and an epidemiological update. J Oral Sci 42 (2000) 15-19
8. Kovac-Kavcic M., and Skaleric U. The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia. J Oral Pathol Med 29 (2000) 331-335
9. Embil J.A., Stephens R.G., and Manuel F.R. Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents. Can Med Assoc J 113 (1975) 627-630
10. Kleinman D.V., Swango P.A., and Pindborg J.J. Epidemiology of oral mucosal lesions in United States schoolchildren: 1986-87. Community Dent Oral Epidemiol 22 (1994) 243-253
11. Taylor L.J., Bagg J., Walker D.M., and Peters T.J. Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration. J Oral Pathol Med 21 (1992) 21-25
12. Natah S.S., Hayrinen-Immonen R., Hietanen J., et al. Increased density of lymphocytes bearing gamma/delta T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg 29 (2000) 375-380
13. Savage N.W., Seymour G.J., and Kruger B.J. Expression of class I and class II major histocompatibility complex antigens on epithelial cells in recurrent aphthous stomatitis. J Oral Pathol 15 (1986) 191-195
14. Sun A., Chu C.T., Liu B.Y., Wang J.T., Leu J.S., and Chiang C.P. Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. Proc Natl Sci Counc Repub China B 24 (2000) 116-122
15. Buno I.J., Huff J.C., Weston W.L., Cook D.T., and Brice S.L. Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2,4 and 5, but not interleukin 10, are present in recurrent aphthous stomatitis. Arch Dermatol 134 (1998) 827-831
16. Bazrafshani M.R., Hajeer A.H., Ollier W.E., and Thornhill M.H. Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF-alpha, TNF-beta and the vitamin D receptor: no association detected. Oral Dis 8 (2002) 303-307
17. Pedersen A., and Ryder L.P. Gamma delta T-cell fraction of peripheral blood is increased in recurrent aphthous ulceration. Clin Immunol Immunopathol 72 (1994) 98-104
18. Greenspan J.S., Gadol N., Olson J.A., and Talal N. Antibody-dependent cellular cytotoxicity in recurrent aphthous ulceration. Clin Exp Immunol 44 (1981) 603-610
19. Lehner T. Stimulation of lymphocyte transformation by tissue homogenates in recurrent oral ulceration. Immunology 13 (1967) 159-166
20. Dolby A.E. Recurrent aphthous ulceration. Effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells. Immunology 17 (1969) 709-714
21. Rogers III R.S., Sams Jr. W.M., and Shorter R.G. Lymphocytotoxicity in recurrent aphthous stomatitis. Lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Bechet syndrome. Arch Dermatol 109 (1974) 361-363
22. Rogers III R.S., Movius D.L., and Pierre R.V. Lymphocyte-epithelial cell interactions in oral mucosal inflammatory diseases. J Invest Dermatol 67 (1976) 599-602
23. Burnett P.R., and Wray D. Lytic effects of serum and mononuclear leukocytes on oral epithelial cells in recurrent aphthous stomatitis. Clin Immunol Immunopathol 34 (1985) 197-204
24. Savage N.W., and Seymour G.J. Specific lymphocytotoxic destruction of autologous epithelial cell targets in recurrent aphthous stomatitis. Aust Dent J 39 (1994) 98-104
25. Lehner T., Lavery E., Smith R., van der Z.R., Mizushima Y., and Shinnick T. Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet's syndrome. Infect Immun 59 (1991) 1434-1441
26. Hasan A., Childerstone A., Pervin K., et al. Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers. Clin Exp Immunol 99 (1995) 392-397
27. Sircus W., Church R., and Kelleher J. Recurrent aphthous ulceration of the mouth. Q J Med 26 (1957) 235-249
28. Ship I.I. Inheritance of aphthous ulcers of the mouth. J Dent Res 44 (1965) 837-844
29. Shohat-Zabarski R., Kalderon S., Klein T., and Weinberger A. Close association of HLA-B51 in persons with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 74 (1992) 455-458
30. Mizuki N., Ohno S., Sato T., et al. Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behcet's disease. Hum Immunol 43 (1995) 129-135
31. Wray D., Graykowski E.A., and Notkins A.L. Role of mucosal injury in initiating recurrent aphthous stomatitis. Br Med J (Clin Res Ed) 283 (1981) 1569-1570
32. Ross R., Kutscher A.H., Zegarelli E.V., Silvers H., and Piro J.D. Relationship of mechanical trauma to recurrent ulcerative (aphthae) stomatitis. N Y State Dent J 24 (1958) 101-102
33. Banoczy J., and Sallay K. Comparative cytologic studies in patients with recurrent aphthae and leukoplakia. J Dent Res 48 (1969) 271-273
34. Sallay K. A recidivalo aphtha. [Recurrent aphtha]. Fogorv Sz 61 (1968) 18-22
35. Shapiro S., Olson D.L., and Chellemi S.J. The association between smoking and aphthous ulcers. Oral Surg Oral Med Oral Pathol 30 (1970) 624-630
36. Axell T., and Henricsson V. Association between recurrent aphthous ulcers and tobacco habits. Scand J Dent Res 93 (1985) 239-242
37. Bookman R. Relief of canker sores on resumption of cigarette smoking. Calif Med 93 (1960) 235-236
38. Dorsey C. More observation on relief of aphthous stomatitis on resumption of cigarette smoking. Calif Med 101 (1964) 377-378
39. Chellemi S.J., Olson D.L., and Shapiro S. The association between smoking and aphthous ulcers: a preliminary report. Oral Surg Oral Med Oral Pathol 29 (1970) 832-836
40. Salonen L., Axell T., and Hellden L. Occurrence of oral mucosal lesions, the influence of tobacco habits and an estimate of treatment time in an adult Swedish population. J Oral Pathol Med 19 (1990) 170-176
41. Tuzun B., Wolf R., Tuzun Y., and Serdaroglu S. Recurrent aphthous stomatitis and smoking. Int J Dermatol 39 (2000) 358-360
42. Atkin P.A., Xu X., and Thornhill M.H. Minor recurrent aphthous stomatitis and smoking: an epidemiological study measuring plasma cotinine. Oral Dis 8 (2002) 173-176
43. Krause I., Uziel Y., Guedj D., et al. Childhood Behcet's disease: clinical features and comparison with adult-onset disease. Rheumatology (Oxford) 38 (1999) 457-462
44. Whallett A.J., Thurairajan G., Hamburger J., Palmer R.G., and Murray P.I. Behcet's syndrome: a multidisciplinary approach to clinical care. QJM 92 (1999) 727-740
45. ten Hoopen-Neumann H., van der Meijden W.I., and van Hagen P.M. De ziekte van Behcet. [Behcet's disease]. Ned Tijdschr Geneeskd 143 (1999) 177-180
46. Orme R.L., Nordlund J.J., Barich L., and Brown T. The MAGIC syndrome (mouth and genital ulcers with inflamed cartilage). Arch Dermatol 126 (1990) 940-944
47. Le Thi Huong D., Wechsler B., Piette J.C., et al. Aortic insufficiency and recurrent valve prosthesis dehiscence in MAGIC syndrome. J Rheumatol 20 (1993) 397-398
48. Lange R.D., and Jones J.B. Cyclic neutropenia. Review of clinical manifestations and management. Am J Pediatr Hematol Oncol 3 (1981) 363-367
49. Scully C., MacFadyen E., and Campbell A. Oral manifestations in cyclic neutropenia. Br J Oral Surg 20 (1982) 96-101
50. Lubitz P.A., Dower N., and Krol A.L. Cyclic neutropenia: an unusual disorder of granulopoiesis effectively treated with recombinant granulocyte colony-stimulating factor. Pediatr Dermatol 18 (2001) 426-432
51. Sucker C., and Djawari J. Rezidivierende Gingivostomatitis ulcerosa bei zyklischer Neutropenie. [Recurrent episodes of ulcerative gingivostomatitis associated with cyclic neutropenia]. Hautarzt 50 (1999) 503-506
52. Marshall G.S., Edwards K.M., Butler J., and Lawton A.R. Syndrome of periodic fever, pharyngitis, and aphthous stomatitis. J Pediatr 110 (1987) 43-46
53. Feder Jr. H.M. Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. Curr Opin Pediatr 12 (2000) 253-256
54. Kawashima H., Nishimata S., Shimizu T., Kashiwagi Y., Takekuma K., and Hoshika A. Highly suspected case of FAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) syndrome. Pediatr Int 43 (2001) 103-106
55. Isaacs D., and May M. Recurrent episodes of fever with tonsillitis, mouth ulcers and adenopathy. J Paediatr Child Health 39 (2003) 627-638
56. von den Driesch P. Sweet's syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol 31 (1994) 535-556
57. von den Driesch P., Gomez R.S., Kiesewetter F., and Hornstein O.P. Sweet's syndrome: clinical spectrum and associated conditions. Cutis 44 (1989) 193-200
58. Driban N.E., and Alvarez M.A. Oral manifestations of Sweet's syndrome. Dermatologica 169 (1984) 102-103
59. Delke I., Veridiano N.P., Tancer M.L., Gomez L., and Diamond I. Sweet syndrome with involvement of the female genital tract. Obstet Gynecol 58 (1981) 394-396
60. Mizoguchi M., Matsuki K., Mochizuki M., et al. Human leukocyte antigen in Sweet's syndrome and its relationship to Behçet's disease. Arch Dermatol 124 (1988) 1069-1073
61. Bruyn G.A., Missier E.T., Toonstra J., and Bijlsma J.W. Sweet's syndrome. Neth J Med 36 (1990) 62-68
62. Femiano F., Gombos F., and Scully C. Sweet's syndrome: Recurrent oral ulceration, pyrexia, thrombophlebitis, and cutaneous lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95 (2003) 324-327
63. Eversole L.R. Immunopathology of oral mucosal ulcerative, desquamative, and bullous diseases. Selective review of the literature. Oral Surg Oral Med Oral Pathol 77 (1994) 555-571
64. Grattan C.E., and Scully C. Oral ulceration: a diagnostic problem. Br Med J (Clin Res Ed) 292 (1986) 1093-1094
65. Porter S.R., and Scully C. Orofacial manifestations in primary immunodeficiencies involving IgA deficiency. J Oral Pathol Med 22 (1993) 117-119
66. Porter S.R., and Scully C. Orofacial manifestations in primary immunodeficiencies: polymorphonuclear leukocyte defects. J Oral Pathol Med 22 (1993) 310-311
67. Porter S.R., and Scully C. Orofacial manifestations in primary immunodeficiencies: T lymphocyte defects. J Oral Pathol Med 22 (1993) 308-309
68. Porter S.R., and Scully C. Orofacial manifestations in primary immunodeficiencies: common variable immunodeficiencies. J Oral Pathol Med 22 (1993) 157-158
69. Zakrzewska J.M., Robinson P., and Williams I.G. Severe oral ulceration in patients with HIV infection: a case series. Oral Dis 3 Suppl 1 (1997) S194-S196
70. MacPhail L.A., and Greenspan J.S. Oral ulceration in HIV infection: investigation and pathogenesis. Oral Dis 3 Suppl 1 (1997) S190-S193
71. Wray D., Ferguson M.M., Mason D.K., Hutcheon A.W., and Dagg J.H. Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Br Med J 2 (1975) 490-493
72. Hutcheon A.W., Wray D., Dagg J.H., Ferguson M.M., Mason D.K., and Lucie N.P. Clinical and haematological screening in recurrent aphthae. Postgrad Med J 54 (1978) 779-783
73. Tyldesley W.R. Stomatitis and recurrent oral ulceration: is a full blood screen necessary?. Br J Oral Surg 21 (1983) 27-30
74. Challacombe S.J., Barkhan P., and Lehner T. Haematological features and differentiation of recurrent oral ulceration. Br J Oral Surg 15 (1977) 37-48
75. Challacombe S.J., Scully C., Keevil B., and Lehner T. Serum ferritin in recurrent oral ulceration. J Oral Pathol 12 (1983) 290-299
76. Rogers III R.S., and Hutton K.P. Screening for haematinic deficiencies in patients with recurrent aphthous stomatitis. Australas J Dermatol 27 (1986) 98-103
77. Field E.A., Rotter E., Speechley J.A., and Tyldesley W.R. Clinical haematological assessment of children with recurrent aphthous ulceration. Br Dent J 163 (1987) 19-22
78. Porter S.R., Scully C., and Flint S. Hematologic status in recurrent aphthous stomatitis compared with other oral disease. Oral Surg Oral Med Oral Pathol 66 (1988) 41-44
79. Nolan A., McIntosh W.B., Allam B.F., and Lamey P.J. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med 20 (1991) 389-391
80. Porter S., Flint S., Scully C., and Keith O. Recurrent aphthous stomatitis: the efficacy of replacement therapy in patients with underlying hematinic deficiencies. Ann Dent 51 (1992) 14-16
81. Haisraeli-Shalish M., Livneh A., Katz J., Doolman R., and Sela B.A. Recurrent aphthous stomatitis and thiamine deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82 (1996) 634-636
82. Rehberger A., Puspok A., Stallmeister T., Jurecka W., and Wolf K. Crohn's disease masquerading as aphthous ulcers. Eur J Dermatol 8 (1998) 274-276
83. Hegarty A., Hodgson T., and Porter S. Thalidomide for the treatment of recalcitrant oral Crohn's disease and orofacial granulomatosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95 (2003) 576-585
84. Thornhill M.H., Zakrzewska J.M., and Gilkes J.J. Pyostomatitis vegetans: report of three cases and review of the literature. J Oral Pathol Med 21 (1992) 128-133
85. Ferguson M.M., Wray D., Carmichael H.A., Russell R.I., and Lee F.D. Coeliac disease associated with recurrent aphthae. Gut 21 (1980) 223-226
86. Veloso F.T., and Saleiro J.V. Small-bowel changes in recurrent ulceration of the mouth. Hepatogastroenterology 34 (1987) 36-37
87. Majorana A., Sapelli P.L., Malagoli A., et al. Malattia celiaca e stomatite aftosa ricorrente. Aspetti clinici ed immunogenetici. [Celiac disease and recurrent aphthous stomatitis. The clinical and immunogenetic aspects]. Minerva Stomatol 41 (1992) 33-40
88. Meini A., Pillan M.N., Plebani A., Ugazio A.G., Majorana A., and Sapelli P.L. High prevalence of DRW10 and DQW1 antigens in celiac disease associated with recurrent aphthous stomatitis. Am J Gastroenterol 88 (1993) 972
89. Wray D. Gluten-sensitive recurrent aphthous stomatitis. Dig Dis Sci 26 (1981) 737-740
90. Wright A., Ryan F.P., Willingham S.E., et al. Food allergy or intolerance in severe recurrent aphthous ulceration of the mouth. Br Med J (Clin Res Ed) 292 (1986) 1237-1238
91. Hunter I.P., Ferguson M.M., Scully C., Galloway A.R., Main A.N., and Russell R.I. Effects of dietary gluten elimination in patients with recurrent minor aphthous stomatitis and no detectable gluten enteropathy. Oral Surg Oral Med Oral Pathol 75 (1993) 595-598
92. Field E.A., Brookes V., and Tyldesley W.R. Recurrent aphthous ulceration in children-a review. Int J Paediatr Dent 2 (1992) 1-10
93. Scully C., and Porter S. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med 18 (1989) 21-27
94. Lehner T. Oral ulceration and Behcet's syndrome. Gut 18 (1977) 491-511
95. Porter S., and Scully C. Aphthous ulcers (recurrent). Clin Evid 13 (2005) 1687-1694
96. Scully C., Gorsky M., and Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc 134 (2003) 200-207
97. Siegel M.A. Strategies for management of commonly encountered oral mucosal disorders. J Calif Dent Assoc 27 (1999) 210-219
98. Cooke B., and Armitage P. Recurrent Mikulicz's aphthae treated with topical hydrocortisone hemisuccinate sodium. Br Med J 1 (1960) 764-766
99. Zegarelli E.V., Kutscher A.H., Silvers H.F., et al. Triamcinolone acetonide in the treatment of acute and chronic lesions of the oral mucous membranes. Oral Surg Oral Med Oral Pathol 13 (1960) 170-175
100. Yeoman C.M., Greenspan J.S., and Harding S.M. Recurrent oral ulceration. A double-blind comparison of treatment with betamethasone valerate aerosol and placebo. Br Dent J 144 (1978) 114-116
101. Merchant H.W., Gangarosa L.P., Glassman A.B., and Sobel R.E. Betamethasone-17-benzoate in the treatment of recurrent aphthous ulcers. Oral Surg Oral Med Oral Pathol 45 (1978) 870-875
102. Fisher N. Bextasol and aphthous ulcers. Br Med J 1 (1979) 1357
103. Pimlott S.J., and Walker D.M. A controlled clinical trial of the efficacy of topically applied fluocinonide in the treatment of recurrent aphthous ulceration. Br Dent J 154 (1983) 174-177
104. Scaglione F., Falchi M., Bichisao E., and Fraschini F. Flumethasone pivalate (Locorten) in the treatment of oral diseases. Drugs Exp Clin Res 11 (1985) 523-526
105. Porter S.R., Hegarty A., Kaliakatsou F., Hodgson T.A., and Scully C. Recurrent aphthous stomatitis. Clin Dermatol 18 (2000) 569-578
106. Matthews R.W., Scully C.M., Levers B.G., and Hislop W.S. Clinical evaluation of benzydamine, chlorhexidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 63 (1987) 189-191
107. Khandwala A., Van Inwegen R.G., and Alfano M.C. 5% Amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: I. Clinical demonstration of acceleration of healing and resolution of pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83 (1997) 222-230
108. Khandwala A., Van Inwegen R.G., Charney M.R., and Alfano M.C. 5% Amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83 (1997) 231-238
109. Greer Jr. R.O., Lindenmuth J.E., Juarez T., and Khandwala A. A double-blind study of topically applied 5% amlexanox in the treatment of aphthous ulcers. J Oral Maxillofac Surg 51 (1993) 243-248
110. Binnie W.H., Curro F.A., Khandwala A., and Van Inwegan R.G. Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers. Compend Contin Educ Dent 18 (1997) 1116-2, 1124
111. Murray B., MacGuinness N., Biagioni P., Hyland P., and Lamey P.-J. A comparative study of the efficacy of aphtheal in the management of recurrent minor aphthous ulceration. J Oral Pathol Med 34 (2005) 413-419
112. Murray B., Biagioni A., and Lamey P.-J. The efficacy of amelxanox OraDisc on the prevention of recurrent minor aphthous ulceration. J Oral Pathol Med 35 (2006) 117-122
113. Addy M., Tapper-Jones L., and Seal M. Trial of astringent and antibacterial mouthwashes in the management of recurrent aphthous ulceration. Br Dent J 136 (1974) 452-455
114. Addy M., Carpenter R., and Roberts W.R. Management of recurrent aphthous ulceration. A trial of chlorhexidine gluconate gel. Br Dent J 141 (1976) 118-120
115. Addy M. Hibitane in the treatment of aphthous ulceration. J Clin Periodontol 4 (1977) 108-116
116. Hunter L., and Addy M. Chlorhexidine gluconate mouthwash in the management of minor aphthous ulceration. A double-blind, placebo-controlled cross-over trial. Br Dent J 162 (1987) 106-110
117. Skaare A.B., Herlofson B.B., and Barkvoll P. Mouthrinses containing triclosan reduce the incidence of recurrent aphthous ulcers (RAU). J Clin Periodontol 23 (1996) 778-781
118. Kjaerheim V., Roed A., Brodin P., and Rolla G. Effects of triclosan on the rat phrenic nerve-diaphragm preparation. J Clin Periodontol 22 (1995) 488-493
119. Guggenheimer J., Brightman V.J., and Ship I.I. Effect of chlortetracycline mouthrinses on the healing of recurrent aphthous ulcers: a double-blind controlled trial. J Oral Ther Pharmacol 4 (1968) 406-408
120. Graykowski E.A., and Kingman A. Double-blind trial of tetracycline in recurrent aphthous ulceration. J Oral Pathol 7 (1978) 376-382
121. Denman A.M., and Schiff A.A. Recurrent oral ulceration treated with mysteclin: a controlled study. Br Med J 1 (1979) 1248-1249
122. Hayrinen-Immonen R., Sorsa T., Pettila J., Konttinen Y.T., Teronen O., and Malmstrom M. Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers. J Oral Pathol Med 23 (1994) 269-272
123. Dolby A.E., and Walker D.M. A trial of cromoglycic acid in recurrent aphthous ulceration. Br J Oral Surg 12 (1975) 292-295
124. Kowolik M.J., Muir K.F., and MacPhee I.T. Di-sodium cromoglycate in the treatment of recurrent aphthous ulceration. Br Dent J 144 (1978) 384-386
125. Ueta E., Osaki T., Yoneda K., Yamamoto T., and Kato I. A clinical trial of azelastine in recurrent aphthous ulceration, with an analysis of its actions on leukocytes. J Oral Pathol Med 23 (1994) 123-129
126. Hamuryudan V., Yurdakul S., Serdaroglu S., Tuzun Y., Rosenkaimer F., and Yazici H. Topical alpha interferon in the treatment of oral ulcers in Behcet's syndrome: a preliminary report. Clin Exp Rheumatol 8 (1990) 51-54
127. Hamuryudan V., Yurdakul S., Rosenkaimer F., and Yazici H. Inefficacy of topical alpha interferon in the treatment of oral ulcers of Behcet's syndrome: a randomized, double blind trial. Br J Rheumatol 30 (1991) 395-396
128. Eisen D., and Ellis C.N. Topical cyclosporine for oral mucosal disorders. J Am Acad Dermatol 23 (1990) 1259-1263
129. Das S.K., Das V., Gulati A.K., and Singh V.P. Deglycyrrhizinated liquorice in aphthous ulcers. J Assoc Physicians India 37 (1989) 647
130. Collier P.M., Neill S.M., and Copeman P.W. Topical 5-aminosalicylic acid: a treatment for aphthous ulcers. Br J Dermatol 126 (1992) 185-188
131. Taylor L.J., Walker D.M., and Bagg J. A clinical trial of prostaglandin E2 in recurrent aphthous ulceration. Br Dent J. 175 (1993) 125-129
132. Herranz P., Arribas J.R., Navarro A., et al. Successful treatment of aphthous ulcerations in AIDS patients using topical granulocyte-macrophage colony-stimulating factor. Br J Dermatol 142 (2000) 171-176
133. Ricer R.E. Sucralfate vs. placebo for the treatment of aphthous ulcers: a double-blinded prospective clinical trial. Fam Pract Res J 9 (1989) 33-41
134. Campisi G., Spadari F., and Salvato A. Il sucralfato in odontostomatologia. Nostra esperienza clinica. [Sucralfate in odontostomatology. Clinical experience]. Minerva Stomatol 46 (1997) 297-305
135. Angirish A. Aspirin-mouthwash relieves pain of oral lesions. J R Soc Health 116 (1996) 105-106
136. Saxen M.A., Ambrosius W.T., Rehemtula A., Russell A.L., and Eckert G.J. Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan: a randomized, double-blind clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84 (1997) 356-361
137. Hara A., Murata T., Uemura R., et al. Identification of connexins in human oral mucosa and therapeutic effect of irsogladine maleate on aphthous stomatitis. J Gastroenterol 34 (1999) 1-6
138. Paulo Filho W., Ribeiro J.E., and Pinto D.S. Safety and efficacy of Eupatorium laevigatum paste as therapy for buccal aphthae: randomized, double-blind comparison with triamcinolone 0.1% orabase. Adv Ther 17 (2000) 272-281
139. Prikuls V.F. Fotoforez oksolinovoi mazi v kompleksnom lechenii bol'nykh s khronicheskim retsidiviruiushchim aftoznym stomatitom. [Photophoresis of oxolin ointment in combined therapy of patients with chronic relapsing aphthous stomatitis]. Vopr Kurortol Fizioter Lech Fiz Kult 6 (2000) 39-42
140. Stanley H.R. Management of patients with persistent recurrent aphthous stomatitis and Sutton's disease. Oral Surg Oral Med Oral Pathol 35 (1973) 174-179
141. Brown R.S., and Bottomley W.K. Combination immunosuppressant and topical steroid therapy for treatment of recurrent major aphthae. A case report. Oral Surg Oral Med Oral Pathol 69 (1990) 42-44
142. Pizarro A., Navarro A., Fonseca E., Vidaurrazaga C., and Herranz P. Treatment of recurrent aphthous stomatitis with pentoxifylline. Br J Dermatol 133 (1995) 659-660
143. Wahba-Yahav A.V. Pentoxifylline in intractable recurrent aphthous stomatitis: an open trial. J Am Acad Dermatol 33 (1995) 680-682
144. Wahba-Yahav A.V. Severe idiopathic recurrent aphthous stomatitis: treatment with pentoxifylline. Acta Derm Venereol 75 (1995) 157
145. Chandrasekhar J., Liem A.A., Cox N.H., and Paterson A.W. Oxypentifylline in the management of recurrent aphthous oral ulcers: an open clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87 (1999) 564-567
146. Revuz J., Guillaume J.C., Janier M., et al. Crossover study of thalidomide vs. placebo in severe recurrent aphthous stomatitis. Arch Dermatol 126 (1990) 923-927
147. de Wazieres B., Gil H., Magy N., Berthier S., Vuitton D.A., and Dupond J.L. Traitement de l'aphtose recurrente par thalidomide a faible dose. Etude pilote chez 17 patients. [Treatment of recurrent ulceration with low doses of thalidomide. Pilot study in 17 patients]. Rev Med Interne 20 (1999) 567-570
148. Nicolau D.P., and West T.E. Thalidomide: treatment of severe recurrent aphthous stomatitis in patients with AIDS. DICP 24 (1990) 1054-1056
149. Paterson D.L., Georghiou P.R., Allworth A.M., and Kemp R.J. Thalidomide as treatment of refractory aphthous ulceration related to human immunodeficiency virus infection. Clin Infect Dis 20 (1995) 250-254
150. Mascaro J.M., Lecha M., and Torras H. Thalidomide in the treatment of recurrent, necrotic, and giant mucocutaneous aphthae and aphthosis. Arch Dermatol 115 (1979) 636-637
151. Grinspan D. Significant response of oral aphthosis to thalidomide treatment. J Am Acad Dermatol 12 (1985) 85-90
152. Grinspan D., Blanco G.F., and Aguero S. Treatment of aphthae with thalidomide. J Am Acad Dermatol 20 (1989) 1060-1063
153. Porter S.R., and Jorge Jr. J. Thalidomide: a role in oral oncology?. Oral Oncol 38 (2002) 527-531
154. Bastuji-Garin S., Ochonicky S., Bouche P., et al. Incidence and risk factors for thalidomide neuropathy: a prospective study of 135 dermatological patients. J Invest Dermatol 119 (2002) 1020-1026
155. Genvo M.F., Faure M., and Thivolet J. Traitement de l'aphtose par la thalidomide et la colchicines. [Treatment of aphthosis with thalidomide and with colchicine]. Dermatologica 168 (1984) 182-188
156. Vujevich J., and Zirwas M. Treatment of severe, recalcitrant, major aphthous stomatitis with adalimumab. Cutis 76 (2005) 129-132
157. Ruah C.B., Stram J.R., and Chasin W.D. Treatment of severe recurrent aphthous stomatitis with colchicine. Arch Otolaryngol Head Neck Surg 114 (1988) 671-675
158. Gatot A., and Tovi F. Colchicine therapy in recurrent oral ulcers. Arch Dermatol 120 (1984) 994
159. Katz J., Langevitz P., Shemer J., Barak S., and Livneh A. Prevention of recurrent aphthous stomatitis with colchicine: an open trial. J Am Acad Dermatol 31 (1994) 459-461
160. Lehner T., Wilton J.M., and Ivanyi L. Double blind crossover trial of levamisole in recurrent aphthous ulceration. Lancet 308 (1976) 926-929
161. Meyer J.D., Degraeve M., Clarysse J., De Loose F., and Peremans W. Levamisole in aphthous stomatitis: evaluation of three regimens. Br Med J 1 (1977) 671-674
162. Drinnan A.J., and Fischman S.L. Randomized, double-blind study of levamisole in recurrent aphthous stomatitis. J Oral Pathol 7 (1978) 414-417
163. Gier R.E., George B., Wilson T., et al. Evaluation of the therapeutic effect of levamisole in treatment of recurrent aphthous stomatitis. J Oral Pathol 7 (1978) 405-413
164. Kaplan B., Cardarelli C., and Pinnell S.R. Double-blind study of levamisole in aphthous stomatitis. J Oral Pathol 7 (1978) 400-404
165. Miller M.F., Silvert M.E., Laster L.L., Green P., and Ship I.I. Effect of levamisole on the incidence and prevalence of recurrent aphthous stomatitis. A double-blind clinical trial. J Oral Pathol 7 (1978) 387-392
166. Olson J.A., and Silverman Jr. S. Double-blind study of levamisole therapy in recurrent aphthous stomatitis. J Oral Pathol 7 (1978) 393-399
167. Handfield-Jones S., Allen B.R., and Littlewood S.M. Dapsone use with oral-genital ulcers. Br J Dermatol 113 (1985) 501
168. Schulkind M.L., Heim L.R., South M.A., Jeter W.S., and Small Jr. P.A. A case report of the successful treatment of recurrent aphthous stomatitis with some preparations of orally administered transfer factor. Cell Immunol 84 (1984) 415-421
169. Kaloyannides T.M. Treatment of recurrent aphthous stomatitis with gamma globulin: report of five cases. J Can Dent Assoc 37 (1971) 312-313
170. Alidaee M.R., Taheri A., Mansoori P., and Ghodsi S.Z. Silver nitrate cautery: a randomized controlled trial. Brit J Dermatol 153 (2005) 521-525