5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II: Pharmacokinetics and demonstration of clinical safety

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

Volumn 83, Issue 2, 1997, Pages 231-238

  Khandwala, Atul ^a   Van Inwegen, Richard G ^b   Charney, Martha R ^c   Alfano, Michael C ^d  

^a Shaman Pharmaceuticals Inc   (United States)

^b Access Pharmaceuticals Inc   (United States)

^c Phanos Inc   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE DERIVATIVE; AMLEXANOX; ANTIINFLAMMATORY AGENT;

ADULT; APHTHOUS STOMATITIS; AREA UNDER THE CURVE; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; INTESTINE ABSORPTION; MALE; METABOLIC CLEARANCE RATE; MULTICENTER STUDY; PATCH TEST; RANDOMIZED CONTROLLED TRIAL; SAFETY; SKIN; STATISTICAL MODEL; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; AMINOPYRIDINES; ANTI-INFLAMMATORY AGENTS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION; FEMALE; HUMANS; INTESTINAL ABSORPTION; LOGISTIC MODELS; MALE; METABOLIC CLEARANCE RATE; PATCH TESTS; SAFETY; SKIN; STOMATITIS, APHTHOUS;

EID: 0031068059     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1079-2104(97)90010-X     Document Type: Article

References (5)

1. Greer RO, Lindenmuth JE, Juarez T, Khandwala A. A double-blind study of topically applied 5% Amlexanox in the treatment of aphthous ulcers. J Oral Maxillofac Surg 1993;51:243-8.
2. Khandwala A, Van Inwegen RG, Alfano MC. 5% Amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers. I. clinical demonstration of acceleration of healing and resolution of pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:222-30.
3. Saijo T, Kuriki H, Ashida Y, Makino Y, Maki Y. Mechanism of the action of Amlexanox (AA-673), an orally active anti-allergic agent. Int Archs Allergy Appl Immun 1985;78:43-50.
4. Torii H, Tanayama S. Disposition and metabolism of AA-673. Jpn Pharmacol Ther 1985;13:4933-54.
5. Package insert for Solfa 25 mg and 50 mg tablets. Takeda Chemical Industries Ltd. Osaka, Japan; 1993.