Fat and inflammaging: A dual path to unfitness in elderly people?

Journal of the American Geriatrics Society

Volumn 56, Issue 3, 2008, Pages 558-560

  Florez, Hermes ^a,b   Troen, Bruce R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; DISEASE ASSOCIATION; EDITORIAL; HUMAN; INFLAMMATION; LIFESTYLE MODIFICATION; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; OBESITY; PHYSICAL DISABILITY; PHYSICAL PERFORMANCE; RISK FACTOR; RISK REDUCTION; SITTING; SKELETAL MUSCLE; WEIGHT REDUCTION;

AGED; EXERCISE TOLERANCE; HUMANS; INFLAMMATION; MOBILITY LIMITATION; MUSCLE FATIGUE; OBESITY;

EID: 40149091090     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2007.01584.x     Document Type: Editorial

References (31)

1. Rosenberg IH. Sarcopenia: Origins and clinical relevance. J Nutr 1997 127 : 990S 991S.
2. Evans W. Functional and metabolic consequences of sarcopenia. J Nutr 1997 127 : 998S 1003S.
3. Visser M, Deeg DJ, Lips P et al. Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc 2000 48 : 381 386.
4. Wolfson L, Judge J, Whipple R et al. Strength is a major factor in balance, gait, and the occurrence of falls. J Gerontol A Biol Sci Med Sci 1995 50A : S64 S67.
5. Fried LP, Ferrucci L, Darer J et al. Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004 59A : M255 M263.
6. Walston J, McBurnie MA, Cardiovascular Health Study et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the cardiovascular health study. Arch Intern Med 2002 162 : 2333 2341.
7. Blaum CS, Xue QL, Michelon E et al. The association of obesity and the frailty syndrome in older women: The women's health and aging studies. J Am Geriatr Soc 2005 53 : 927 934.
8. Arterburn DE, Crane PK, Sullivan SD. The coming epidemic of obesity in elderly Americans. J Am Geriatr Soc 2004 52 : 1907 1912.
9. McAuley P, Myers J, Abella J et al. Body mass, fitness and survival in veteran patients: Another obesity paradox? Am J Med 2007 120 : 518 524.
10. Al Snih S, Ottenbacher KJ, Markides KS et al. The effect of obesity on disability vs mortality in older Americans. Arch Intern Med 2007 167 : 774 780.
11. Baumgartner RN, Koehler KM, Gallagher D et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998 147 : 755 763.
12. Roubenoff R. Sarcopenic obesity: The confluence of two epidemics. Obes Res 2004 12 : 912 919.
13. Villarreal D, Banks M, Sienere C et al. Physical frailty and body composition in obese elderly men and women. Obes Res 2004 12 : 912 919.
14. Zamboni M, Mazzali G, Zoico E et al. Health consequences of obesity in the elderly: A review of four unresolved questions. Int J Obes 2005 29 : 1011 1029.
15. Pedersen M, Bruunsgaard H, Weis N et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 2003 124 : 495 502.
16. Ferrucci L, Penninx BW, Volpato S et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 2002 50 : 1947 1954.
17. Joseph C, Kenny AM, Taxel P et al. Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk. Mol Aspects Med 2005 26 : 181 201.
18. Cesari M, Kritchevsky SB, Baumgartner RN et al. Sarcopenia, obesity, and inflammation - results from the trial of angiotensin converting enzyme inhibition and novel cardiovascular risk factors study. Am J Clin Nutr 2005 82 : 428 434.
19. Franceschi C, Capri M, Monti D et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007 128 : 92 105.
20. Stenholm S, Rantanen T, Heliövaara M et al. The mediating role of C-reactive protein and handgrip strength between obesity and walking limitation. J Am Geriatr Soc 2008 56 : DOI :.
21. Sharkey JR, Ory MG, Branch LG. Severe elder obesity and 1-year diminished lower extremity physical performance in homebound older adults. J Am Geriatr Soc 2006 54 : 1407 1413.
22. Barzilay JI, Blaum C, Moore T et al. Insulin resistance and inflammation as precursors of frailty: The cardiovascular health study. Arch Intern Med 2007 167 : 635 641.
23. Leng SX, Xue QL, Tian J et al. Inflammation and frailty in older women. J Am Geriatr Soc 2007 55 : 864 871.
24. Bautmans I, Njemini R, Predom H et al. Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating TNF-alpha, IL-6 and Hsp70. J Am Geriatr Soc 2008 56 : DOI :.
25. Bautmans I, Gorus E, Njemini R et al. Handgrip performance in relation to self-perceived fatigue, physical functioning and circulating IL-6 in elderly persons without inflammation. BMC Geriatr 2007 7 : 5.
26. Esposito K, Pontillo A, Di Palo C et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women. A randomized trial. JAMA 2003 289 : 1799 1804.
27. Haffner S, Temprosa M, Crandall J et al. and the Diabetes Prevention Program Research Group et al. Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 2005 54 : 1566 1572.
28. Crandall J, Schade D, Ma Y et al. and the Diabetes Prevention Program Research Group. The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci 2006 61 : 1075 1081.
29. Pahor M, Blair SN, Espeland M et al. and the LIFE Study Investigators. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci 2006 61 : 1157 1165.
30. Villareal DT, Banks M, Sinacore DR et al. Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med 2006 166 : 860 866.
31. Villareal DT, Miller BV III., Banks M et al. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr 2006 84 : 1317 1323.