Effect of weight loss and exercise on frailty in obese older adults

Archives of Internal Medicine

Volumn 166, Issue 8, 2006, Pages 860-866

  Villareal, Dennis T ^a   Banks, Marian ^a   Sinacore, David R ^a   Siener, Catherine ^a   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; OXYGEN;

ADIPOSE TISSUE; ADULT; AGED; AGING; ANALYTIC METHOD; ARTICLE; BALANCE IMPAIRMENT; BEHAVIOR THERAPY; BODY COMPOSITION; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DUAL ENERGY X RAY ABSORPTIOMETRY; EVALUATION; EXERCISE; FEMALE; FRAIL ELDERLY; FUNCTIONAL ASSESSMENT; FUNCTIONAL STATUS; GAIT; GROUPS BY AGE; HEALTH SURVEY; HUMAN; KINESIOTHERAPY; LEG; MALE; OBESITY; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; PARAMETERS OF MEASUREMENT AND ANALYSIS; PATIENT COMPLIANCE; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SHORT FORM 36; STANDING; STATISTICAL ANALYSIS; STRENGTH; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT WITHDRAWAL; WALKING SPEED; WEIGHT REDUCTION;

ACTIVITIES OF DAILY LIVING; AGED; BODY MASS INDEX; EXERCISE; EXERCISE THERAPY; FEMALE; FRAIL ELDERLY; HUMANS; MALE; OBESITY; PATIENT COMPLIANCE; QUALITY OF LIFE; QUESTIONNAIRES; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 33646144460     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.166.8.860     Document Type: Article

References (53)

1. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001;286:1195-1200.
2. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289:76-79.
3. Li F, Fisher KJ, Harmer P. Prevalence of overweight and obesity in older U.S. adults: estimates from the 2003 Behavioral Risk Factor Surveillance System survey. J Am Geriatr Soc. 2005;53:737-739.
4. Villareal DT, Apovian CM, Kushner RF, Klein S; American Society for Nutrition; NAASO, the Obesity Society. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO. Am J Clin Nutr. 2005;82:923-934 [also published in: Obes Res. 2005;13:1849-1863].
5. Apovian CM, Frey CM, Rogers JZ, McDermott EA, Jensen GL. Body mass index and physical function in obese older women. J Am Geriatr Soc. 1996;44:1487-1488.
6. Himes CL. Obesity, disease, and functional limitation in later life. Demography. 2000;37:73-82.
7. Davison KK, Ford ES, Cogswell ME, Dietz WH. Percentage of body fat and body mass index are associated with mobility limitations in people aged 70 and older from NHANES III. J Am Geriatr Soc. 2002;50:1802-1809.
8. Jensen GL, Friedmann JM. Obesity is associated with functional decline in community-dwelling rural older persons. J Am Geriatr Soc. 2002;50:918-923.
9. Launer LJ, Harris T, Rumpel C, Madans J. Body mass index, weight change, and risk of mobility disability in middle-aged and older women: the epidemiologic follow-up study of NHANES I. JAMA. 1994;271:1093-1098.
10. Galanos AN, Pieper CF, Cornoni-Huntley JC, Bales CW, Fillenbaum GG. Nutrition and function: is there a relationship between body mass index and the functional capabilities of community-dwelling elderly? J Am Geriatr Soc. 1994;42:368-373.
11. Jenkins KR. Obesity's effects on the onset of functional impairment among older adults. Gerontologist. 2004;44:206-216.
12. Zizza CA, Herring A, Stevens J, Popkin BM. Obesity affects nursing-care facility admission among whites but not blacks. Obes Res. 2002;10:816-823.
13. Dutta C, Hadley EC. The significance of sarcopenia in old age. J Gerontol A Biol Sci Med Sci. 1995;50(special issue)(suppl 1):1-4.
14. Roubenoff R. Sarcopenia: effects on body composition and function. J Gerontol A Biol Sci Med Sci. 2003;58:1012-1017.
15. Villareal DT, Banks M, Siener C, Sinacore DR, Klein S. Physical frailty and body composition in obese elderly men and women. Obes Res. 2004;12:913-920.
16. Villareal DT, Steger-May K, Schechtman KB, et al. Effects of exercise training on bone mineral density in frail older women and men: a randomised controlled trial. Age Ageing. 2004;33:309-312.
17. Binder EF, Schechtman KB, Ehsani AA, et al. Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial. J Am Geriatr Soc. 2002;50:1921-1928.
18. Villareal DT, Binder EF, Yarasheski KE, et al. Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly women. J Am Geriatr Soc. 2003;51:985-990.
19. Binder EF, Williams DB, Schechtman KB, Jeffe DB, Kohrt WM. Effects of hormone replacement therapy on serum lipids in elderly women: a randomized, placebo-controlled trial. Ann Intern Med. 2001;134:754-760.
20. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332:556-562.
21. Reuben DB, Siu AL. An objective measure of physical function of elderly outpatients: the Physical Performance Test. J Am Geriatr Soc. 1990;38:1105-1112.
22. Reuben DB, Siu AL, Kimpau S. The predictive validity of self-report and performance-based measures of function and health. J Gerontol. 1992;47:M106-M110.
23. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85-M94.
24. Villareal DT, Binder EF, Williams DB, Schechtman KB, Yarasheski KE, Kohrt WM. Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial. JAMA. 2001;286:815-820.
25. Host H, Sinacore D, Brown M, Holloszy J. Reliability of the modified physical performance test in older adults [abstract]. Phys Ther. 1996;76(suppl):S23-S24.
26. Brown M, Sinacore DR, Binder EF, Kohrt WM. Physical and performance measures for the identification of mild to moderate frailty. J Gerontol A Biol Sci Med Sci. 2000;55:M350-M355.
27. 2max to training in 60-71 yr olds. J Appl Physiol. 1991;71:2004-2011.
28. Jette AM, Cleary PD. Functional disability assessment. Phys Ther. 1987;67:1854-1859.
29. Brown M, Holloszy JO. Effects of a low intensity exercise program on selected physical performance characteristics of 60- to 71-year-olds. Aging (Milano). 1991;3:129-139.
30. McHorney CA, Ware JE Jr, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36). II: Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993;31:247-263.
31. Stadnyk K, Calder J, Rockwood K. Testing the measurement properties of the Short Form-36 Health Survey in a frail elderly population. J Clin Epidemiol. 1998;51:827-835.
32. Lyons RA, Perry HM, Littlepage BN. Evidence for the validity of the Short-Form 36 Questionnaire (SF-36) in an elderly population. Age Ageing. 1994;23:182-184.
33. Friedman LM, Furberg C, DeMets DC. Fundamentals of Clinical Trials. Littleton, Mass: John Wright-PSG, Inc; 1980.
34. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report [published correction appears in Obes Res. 1998;6:464]. Obes Res. 1998;6(suppl 2):51S-209S.
35. Harris JABF. A Biometric Study of Basal Metabolism in Man. Washington, DC: Carnegie Institution of Washington; 2005.
36. Diabetes Prevention Program Lifestyle Resource Core. The Diabetes Prevention Program's Lifestyle Change Program. Available at: http://www.bsc.gwu.edu/dpp /lifestyle/lsmop0 pdf. Accessed July 21, 2005.
37. Borushek A. Doctors Pocket Guide of Calorie, Fat and Carbohydrate Counter. Costa Mesa, Calif: Family Health Publications; 2003.
38. Roubenoff R. Sarcopenic obesity: the confluence of two epidemics. Obes Res. 2004;12:887-888.
39. Blaum CS, Xue QL, Michelon E, Semba RD, Fried LP. The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies. J Am Geriatr Soc. 2005;53:927-934.
40. Brown I, Renwick R, Raphael D. Frailty: constructing a common meaning, definition, and conceptual framework. Int J Rehabil Res. 1995;18:93-102.
41. Ory MG, Schechtman KB, Miller JP, et al. Frailty and injuries in later life: the FICSIT trials. J Am Geriatr Soc. 1993;41:283-296.
42. Hamerman D. Toward an understanding of frailty. Ann Intern Med. 1999;130:945-950.
43. Messier SP, Loeser RF, Mitchell MN, et al. Exercise and weight loss in obese older adults with knee osteoarthritis: a preliminary study. J Am Geriatr Soc. 2000;48:1062-1072.
44. Messier SP, Loeser RF, Miller GD, et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum. 2004;50:1501-1510.
45. Rejeski WJ, Focht BC, Messier SP, Morgan T, Pahor M, Penninx B. Obese, older adults with knee osteoarthritis: weight loss, exercise, and quality of life. Health Psychol. 2002;21:419-426.
46. Ballor DL, Katch VL, Becque MD, Marks CR. Resistance weight training during caloric restriction enhances lean body weight maintenance. Am J Clin Nutr. 1988;47:19-25.
47. Roubenoff R, Hughes VA. Sarcopenia: current concepts. J Gerontol A Biol Sci Med Soc. 2000;55:M716-M724.
48. Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr. 1995;49:1-10.
49. Coggan AR, Abduljalil AM, Swanson SC, et al. Muscle metabolism during exercise in young and older untrained and endurance-trained men. J Appl Physiol. 1993;75:2125-2133.
50. Sipila S, Suominen H. Effects of strength and endurance training on thigh and leg muscle mass and composition in elderly women. J Appl Physiol. 1995;78:334-340.
51. Goodpaster BH, Theriault R, Watkins SC, Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism. 2000;49:467-472.
52. Elia M. Obesity in the elderly. Obes Res. 2001;9(suppl 4):244S-248S.
53. Arterburn DE, Crane PK, Sullivan SD. The coming epidemic of obesity in elderly Americans. J Am Geriatr Soc. 2004;52:1907-1912.