-
1
-
-
0033614446
-
Chronic myeloid leukemia
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999; 340:1330-1340.
-
(1999)
N Engl J Med
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
2
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105:2640-2653.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
3
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
4
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alpha plus cytarabine in newly-diagnosed chronic myeloid leukaemia
-
Hughes T, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alpha plus cytarabine in newly-diagnosed chronic myeloid leukaemia. N Engl J Med 2003; 349:1423-1432.
-
(2003)
N Engl J Med
, vol.349
, pp. 1423-1432
-
-
Hughes, T.1
Kaeda, J.2
Branford, S.3
-
5
-
-
33845444046
-
-
Druker B, Guilhot F, O'Brien SG, et al., for the IRIS investigators. Five-year follow-up of patients receiving imatinib for chronic myeloid leukaemia. N Engl J Med 2006; 355:2408-2417. This report presents long-term follow-up results of patients included in the original IRIS study, demonstrating sustained benefit from imatinib.
-
Druker B, Guilhot F, O'Brien SG, et al., for the IRIS investigators. Five-year follow-up of patients receiving imatinib for chronic myeloid leukaemia. N Engl J Med 2006; 355:2408-2417. This report presents long-term follow-up results of patients included in the original IRIS study, demonstrating sustained benefit from imatinib.
-
-
-
-
6
-
-
34447544253
-
Bcr/abl tyrosine kinase inhibitors for chronic myelogenous leukemia
-
This is a case-based overview of CML management
-
Schiffer CA. Bcr/abl tyrosine kinase inhibitors for chronic myelogenous leukemia. N Engl J Med 2007; 357:258-265. This is a case-based overview of CML management.
-
(2007)
N Engl J Med
, vol.357
, pp. 258-265
-
-
Schiffer, C.A.1
-
7
-
-
33750949760
-
Emerging drugs in chronic myeloid leukemia
-
This report outlines the newer TKIs on the horizon and their potential role
-
Bocchia M, Forconi F, Lauria F. Emerging drugs in chronic myeloid leukemia. Exp Opin Emerg Drugs 2006; 11:651-664. This report outlines the newer TKIs on the horizon and their potential role.
-
(2006)
Exp Opin Emerg Drugs
, vol.11
, pp. 651-664
-
-
Bocchia, M.1
Forconi, F.2
Lauria, F.3
-
8
-
-
33947280081
-
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
-
This report outlines the efficacy of dasatinib in imatinib failures
-
Hochhaus A, Kantarjian H, Baccarani M, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007; 109:2303-2309. This report outlines the efficacy of dasatinib in imatinib failures.
-
(2007)
Blood
, vol.109
, pp. 2303-2309
-
-
Hochhaus, A.1
Kantarjian, H.2
Baccarani, M.3
-
9
-
-
34248324467
-
Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
-
This is a recent article on experience with dasatinib
-
Guilhot F, Apperley J, Kim DW, et al. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 2007; 109:4143-4150. This is a recent article on experience with dasatinib.
-
(2007)
Blood
, vol.109
, pp. 4143-4150
-
-
Guilhot, F.1
Apperley, J.2
Kim, D.W.3
-
10
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
Initial experience with dasatinib in patients who are no longer responding to imatinib treatment is presented
-
Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354:2531-2541. Initial experience with dasatinib in patients who are no longer responding to imatinib treatment is presented.
-
(2006)
N Engl J Med
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
11
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
This report summarizes initial experience with nilotinib in patients who are no longer responding to imatinib treatment
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542-2551. This report summarizes initial experience with nilotinib in patients who are no longer responding to imatinib treatment
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
12
-
-
85117738782
-
-
Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108:28-37. This report provides a detailed review and recommendations regarding CML monitoring, including PCR standardization.
-
Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108:28-37. This report provides a detailed review and recommendations regarding CML monitoring, including PCR standardization.
-
-
-
-
13
-
-
0036207093
-
Cytogenetic and molecular monitoring of residual disease in chronic myeloid leukaemia
-
Kaeda J, Chase A, Goldman JM. Cytogenetic and molecular monitoring of residual disease in chronic myeloid leukaemia. Acta Haematol 2002; 107:64-75.
-
(2002)
Acta Haematol
, vol.107
, pp. 64-75
-
-
Kaeda, J.1
Chase, A.2
Goldman, J.M.3
-
14
-
-
40049084149
-
+ cells are still detectable in chronic myeloid leukemia patients with sustained and prolonged complete cytogenetic remission during treatment with imatinib mesylate
-
9 Aug [Epub ahead of print, This paper emphasizes the presence of residual leukemia in patients with CCyR
-
+ cells are still detectable in chronic myeloid leukemia patients with sustained and prolonged complete cytogenetic remission during treatment with imatinib mesylate. Leukemia 2007; 9 Aug [Epub ahead of print]. This paper emphasizes the presence of residual leukemia in patients with CCyR.
-
(2007)
Leukemia
-
-
Bocchia, M.1
Ippoliti, M.2
Gozzetti, A.3
-
15
-
-
0038454621
-
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
-
Bhatia R, Holtz M, Niu N, et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 2003; 101:4701-4707.
-
(2003)
Blood
, vol.101
, pp. 4701-4707
-
-
Bhatia, R.1
Holtz, M.2
Niu, N.3
-
16
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Persistence of progenitor cells in CML is also demonstrable with dasatinib
-
Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006; 107:4532-4539. Persistence of progenitor cells in CML is also demonstrable with dasatinib.
-
(2006)
Blood
, vol.107
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
17
-
-
0017347991
-
Exclusion of chromosomal mosaicism: Tables of 90%, 95%, and 99% confidence limits and comments on use
-
Hook EB. Exclusion of chromosomal mosaicism: tables of 90%, 95%, and 99% confidence limits and comments on use. Am J Hum Genet 1977; 29:94-97.
-
(1977)
Am J Hum Genet
, vol.29
, pp. 94-97
-
-
Hook, E.B.1
-
18
-
-
0031785825
-
Suppression of cytogenetic clonal evolution with interferon alfa therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia
-
Cortes J, Talpaz M, O'Brien S, et al. Suppression of cytogenetic clonal evolution with interferon alfa therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. J Clin Oncol 1998; 16:3279-3285.
-
(1998)
J Clin Oncol
, vol.16
, pp. 3279-3285
-
-
Cortes, J.1
Talpaz, M.2
O'Brien, S.3
-
19
-
-
0038092769
-
Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
-
Bumm T, Muller C, Al-Ali HK, et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003; 101:1941-1949.
-
(2003)
Blood
, vol.101
, pp. 1941-1949
-
-
Bumm, T.1
Muller, C.2
Al-Ali, H.K.3
-
20
-
-
4644359704
-
Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha
-
Kantarjian HM, Cortes JE, O'Brien S, et al. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha. Blood 2004; 104:1979-1988.
-
(2004)
Blood
, vol.104
, pp. 1979-1988
-
-
Kantarjian, H.M.1
Cortes, J.E.2
O'Brien, S.3
-
21
-
-
0345487506
-
Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: A new strategy for remission asssessment
-
Mühlmann J, Thaler J, Hilbe W, et al. Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: a new strategy for remission asssessment. Genes Chromosomes Cancer 1998; 21:90-100.
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 90-100
-
-
Mühlmann, J.1
Thaler, J.2
Hilbe, W.3
-
22
-
-
0011689252
-
Fluorescence in situ hybridization for the detection and monitoring of the Ph-positive clone in chronic myelogenous leukemia: Comparison with metaphase banding analysis
-
Cuneo A, Bigoni R, Emmanuel B, et al. Fluorescence in situ hybridization for the detection and monitoring of the Ph-positive clone in chronic myelogenous leukemia: comparison with metaphase banding analysis. Leukemia 1998; 12:1718-1723.
-
(1998)
Leukemia
, vol.12
, pp. 1718-1723
-
-
Cuneo, A.1
Bigoni, R.2
Emmanuel, B.3
-
23
-
-
0031016147
-
Detection of the bcr/abl translocation in chronic myeloid leukemia by fluorescence in situ hybridization: Comparison with conventional cytogenetics and implications for minimal residual disease detection
-
Garcia-Isidoro M, Tabernero MD, Garcia JL, et al. Detection of the bcr/abl translocation in chronic myeloid leukemia by fluorescence in situ hybridization: comparison with conventional cytogenetics and implications for minimal residual disease detection. Hum Pathol 1997; 28:154-159.
-
(1997)
Hum Pathol
, vol.28
, pp. 154-159
-
-
Garcia-Isidoro, M.1
Tabernero, M.D.2
Garcia, J.L.3
-
24
-
-
0025221547
-
Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization
-
Tkachuk DC, Westbrook CA, Andreeff M, et al. Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization. Science 1990; 250:559-562.
-
(1990)
Science
, vol.250
, pp. 559-562
-
-
Tkachuk, D.C.1
Westbrook, C.A.2
Andreeff, M.3
-
25
-
-
0032942019
-
Simple and reliably sensitive diagnosis and monitoring of Philadelphia chromosome-positive cells in chronic myeloid leukemia by interphase fluorescence in situ hybridization of peripheral blood cells
-
Yanagi M, Shinjo K, Takeshita A, et al. Simple and reliably sensitive diagnosis and monitoring of Philadelphia chromosome-positive cells in chronic myeloid leukemia by interphase fluorescence in situ hybridization of peripheral blood cells. Leukemia 1999; 13:542-552.
-
(1999)
Leukemia
, vol.13
, pp. 542-552
-
-
Yanagi, M.1
Shinjo, K.2
Takeshita, A.3
-
26
-
-
0030934542
-
Factors influencing the false positive and negative rates of BCRABL fluorescence in-situ hybridization
-
Chase A, Grand F, Zhang JG, et al. Factors influencing the false positive and negative rates of BCRABL fluorescence in-situ hybridization. Genes Chromosomes Cancer 1997; 18:246-253.
-
(1997)
Genes Chromosomes Cancer
, vol.18
, pp. 246-253
-
-
Chase, A.1
Grand, F.2
Zhang, J.G.3
-
27
-
-
33744463354
-
BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML
-
This study demonstrates the co-relation of the level of bcr-abl mRNA levels at the time of CCyR with duration of CCyR
-
Press RD, Love Z, Tronnes AA, Yang R, et al. BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML. Blood 2006; 107:4250-4256. This study demonstrates the co-relation of the level of bcr-abl mRNA levels at the time of CCyR with duration of CCyR.
-
(2006)
Blood
, vol.107
, pp. 4250-4256
-
-
Press, R.D.1
Love, Z.2
Tronnes, A.A.3
Yang, R.4
-
28
-
-
0024551067
-
Polymerase chain reaction for detection of residual leukaemia
-
Wiedemann LM, Bartram CR. Polymerase chain reaction for detection of residual leukaemia. Lancet 1989; 1:928-929.
-
(1989)
Lancet
, vol.1
, pp. 928-929
-
-
Wiedemann, L.M.1
Bartram, C.R.2
-
29
-
-
0025143208
-
Improved results with PCR for chronic myeloid leukaemia
-
Hughes T, Goldman JM. Improved results with PCR for chronic myeloid leukaemia. Lancet 1990; 336:812.
-
(1990)
Lancet
, vol.336
, pp. 812
-
-
Hughes, T.1
Goldman, J.M.2
-
30
-
-
0036038791
-
Serial monitoring of BCR-ABL by peripheral blood real-time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia
-
Wang L, Pearson K, Pilleri L, et al. Serial monitoring of BCR-ABL by peripheral blood real-time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia. Br J Haematol 2002; 118:771-777.
-
(2002)
Br J Haematol
, vol.118
, pp. 771-777
-
-
Wang, L.1
Pearson, K.2
Pilleri, L.3
-
31
-
-
0025141313
-
Significance of residual leukaemia transcripts after bone marrow transplant for CML
-
Hughes T, Martiat P, Morgan G, et al. Significance of residual leukaemia transcripts after bone marrow transplant for CML. Lancet 1990; 335:50.
-
(1990)
Lancet
, vol.335
, pp. 50
-
-
Hughes, T.1
Martiat, P.2
Morgan, G.3
-
32
-
-
0027439395
-
Early detection of relapse after bone marrow transplantation in patients with chronic myelogenous leukaemia
-
Lion T, Henn T, Gaiger A, et al. Early detection of relapse after bone marrow transplantation in patients with chronic myelogenous leukaemia. Lancet 1993; 341:275-276.
-
(1993)
Lancet
, vol.341
, pp. 275-276
-
-
Lion, T.1
Henn, T.2
Gaiger, A.3
-
33
-
-
13344250478
-
Quantification of residual disease in chronic myelogenous leukemia patients on interferon-a therapy by competitive polymerase chain reaction
-
Hochhaus A, Lin F, Reiter A, et al. Quantification of residual disease in chronic myelogenous leukemia patients on interferon-a therapy by competitive polymerase chain reaction. Blood 1996; 87:1549-1555.
-
(1996)
Blood
, vol.87
, pp. 1549-1555
-
-
Hochhaus, A.1
Lin, F.2
Reiter, A.3
-
34
-
-
0028153771
-
An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders
-
Cross NCP, Melo JV, Feng L, Goldman JM. An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia 1994; 8:186-189.
-
(1994)
Leukemia
, vol.8
, pp. 186-189
-
-
Cross, N.C.P.1
Melo, J.V.2
Feng, L.3
Goldman, J.M.4
-
35
-
-
20844447330
-
Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations
-
Branford S, Rudzki Z, Parkinson I, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations. Blood 2004; 104:2926-2932.
-
(2004)
Blood
, vol.104
, pp. 2926-2932
-
-
Branford, S.1
Rudzki, Z.2
Parkinson, I.3
-
36
-
-
0027051832
-
Quantitative determination of the hybrid Bcr-Abl RNA in patients with chronic myelogenous leukaemia under interferon therapy
-
Malinge MC, Mahon FX, Delfau MH, et al. Quantitative determination of the hybrid Bcr-Abl RNA in patients with chronic myelogenous leukaemia under interferon therapy. Br J Haematol 1992; 82:701-707.
-
(1992)
Br J Haematol
, vol.82
, pp. 701-707
-
-
Malinge, M.C.1
Mahon, F.X.2
Delfau, M.H.3
-
37
-
-
0035070738
-
Real-time quantification of different types of bcr-abl transcript in chronic myeloid leukemia
-
Amabile M, Giannini B, Testoni N, et al. Real-time quantification of different types of bcr-abl transcript in chronic myeloid leukemia. Haematologica 2001; 86:252-259.
-
(2001)
Haematologica
, vol.86
, pp. 252-259
-
-
Amabile, M.1
Giannini, B.2
Testoni, N.3
-
38
-
-
0035713108
-
Kinetics of BCR-ABL fusion transcript levels in chronic myeloid leukemia patients treated with STI571 measured by quantitative real-time polymerase chain reaction
-
Stentoft J, Pallisgaard N, Kjeldsen E, et al. Kinetics of BCR-ABL fusion transcript levels in chronic myeloid leukemia patients treated with STI571 measured by quantitative real-time polymerase chain reaction. Eur J Haematol 2001; 67:302-308.
-
(2001)
Eur J Haematol
, vol.67
, pp. 302-308
-
-
Stentoft, J.1
Pallisgaard, N.2
Kjeldsen, E.3
-
39
-
-
0036932844
-
Comparison of competitive-nested PCR and real-time PCR in detecting BCR-ABL fusion transcripts in chronic myeloid leukemia patients
-
Guo JQ, Lin H, Kantarjian H, et al. Comparison of competitive-nested PCR and real-time PCR in detecting BCR-ABL fusion transcripts in chronic myeloid leukemia patients. Leukemia 2002; 16:2447-2453.
-
(2002)
Leukemia
, vol.16
, pp. 2447-2453
-
-
Guo, J.Q.1
Lin, H.2
Kantarjian, H.3
-
40
-
-
27144509746
-
In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML
-
White D, Saunders V, Lyons AB, et al. In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML. Blood 2005; 106:2520-2526.
-
(2005)
Blood
, vol.106
, pp. 2520-2526
-
-
White, D.1
Saunders, V.2
Lyons, A.B.3
-
41
-
-
35348868577
-
Measurement of In vivo BCR-ABL kinase inhibition to monitor imatinib-induced target blockade and predict response in chronic myeloid leukemia
-
The effect of degree of in vivo bcr-abl kinase inhibition on imatinib response. Data from the TIDEL and OCT trials
-
White D, Saunders V, Grigg A, et al. Measurement of In vivo BCR-ABL kinase inhibition to monitor imatinib-induced target blockade and predict response in chronic myeloid leukemia. J Clin Oncol 2007; 25:4445-4451. The effect of degree of in vivo bcr-abl kinase inhibition on imatinib response. Data from the TIDEL and OCT trials.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4445-4451
-
-
White, D.1
Saunders, V.2
Grigg, A.3
-
42
-
-
0036738109
-
Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response to STI571 in chronic phase CML patients
-
Merx K, Müller MC, Kreil S, et al. Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response to STI571 in chronic phase CML patients. Leukemia 2002; 16:1579-1583.
-
(2002)
Leukemia
, vol.16
, pp. 1579-1583
-
-
Merx, K.1
Müller, M.C.2
Kreil, S.3
-
43
-
-
79960970884
-
Early measurement of BCR-ABL mRNA blood levels may be predictive of subsequent achievement of major cytogenetic response to Glivec in chronic myeloid leukaemia [abstract]
-
Branford S, Moore S, Grigg A, et al. Early measurement of BCR-ABL mRNA blood levels may be predictive of subsequent achievement of major cytogenetic response to Glivec in chronic myeloid leukaemia [abstract]. Blood 2001; 98:613a.
-
(2001)
Blood
, vol.98
-
-
Branford, S.1
Moore, S.2
Grigg, A.3
-
44
-
-
0031034771
-
Value of molecular monitoring during treatment of chronic myeloid leukemia: A Cancer and Leukemia Group B Study
-
Stock W, Westbrook CA, Peterson B, et al. Value of molecular monitoring during treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B Study. J Clin Oncol 1997; 15:26-36.
-
(1997)
J Clin Oncol
, vol.15
, pp. 26-36
-
-
Stock, W.1
Westbrook, C.A.2
Peterson, B.3
-
45
-
-
35548971639
-
Chromosomal abnormalities In Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase
-
This report outlines the significance of chromosomal abnormalities in Philadelphia-negative CML cells appearing during treatment with imatinib
-
Jabbour E, Kantarjian H, Abruzzo L, et al. Chromosomal abnormalities In Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood 2007; 110:2991-2995. This report outlines the significance of chromosomal abnormalities in Philadelphia-negative CML cells appearing during treatment with imatinib.
-
(2007)
Blood
, vol.110
, pp. 2991-2995
-
-
Jabbour, E.1
Kantarjian, H.2
Abruzzo, L.3
-
46
-
-
0023841366
-
Characteristics of accelerated disease in chronic myelogenous leukemia
-
Kantarjian HM, Dixon D, Keating MJ, et al. Characteristics of accelerated disease in chronic myelogenous leukemia. Cancer 1988; 61:1441-1446.
-
(1988)
Cancer
, vol.61
, pp. 1441-1446
-
-
Kantarjian, H.M.1
Dixon, D.2
Keating, M.J.3
-
47
-
-
33644516935
-
The role of BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukaemia
-
The authors explain the significance of the rising trend of bcr-abl transcripts and development of kinase domain mutations
-
Wang L, Knight K, Lucas C, Clark RE. The role of BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukaemia. Haematologica 2006; 91:235-239. The authors explain the significance of the rising trend of bcr-abl transcripts and development of kinase domain mutations.
-
(2006)
Haematologica
, vol.91
, pp. 235-239
-
-
Wang, L.1
Knight, K.2
Lucas, C.3
Clark, R.E.4
-
48
-
-
23044458596
-
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
-
This report discusses the significance of ABL mutation in late chronic phase CML
-
Soverini S, Martinelli G, Rosti G, et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2007; 23:4100-4109. This report discusses the significance of ABL mutation in late chronic phase CML.
-
(2007)
J Clin Oncol
, vol.23
, pp. 4100-4109
-
-
Soverini, S.1
Martinelli, G.2
Rosti, G.3
-
49
-
-
34250771536
-
Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: Towards new standards for gene expression measurements
-
Reference gene characterization for RT-PCR is presented
-
Saldanha J, Silvy M, Beaufils N, et al. Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: towards new standards for gene expression measurements. Leukemia 2007; 21:1481-1487. Reference gene characterization for RT-PCR is presented.
-
(2007)
Leukemia
, vol.21
, pp. 1481-1487
-
-
Saldanha, J.1
Silvy, M.2
Beaufils, N.3
-
50
-
-
9144222001
-
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia: A Europe Against Cancer program
-
Gabert J, Beillard E, van der Velden VH, et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia: a Europe Against Cancer program. Leukemia 2003; 17:2318-2357.
-
(2003)
Leukemia
, vol.17
, pp. 2318-2357
-
-
Gabert, J.1
Beillard, E.2
van der Velden, V.H.3
-
51
-
-
85117738014
-
-
Baccarani M, Saglio G, Goldman JM, et al. Evolving concepts in the management of chronic myeloid leukaemia. Recommendations from an expert panel on behalf of the European Leukemia-net. Blood 2006; 108:1809-1820. The authors make a proposal for defining response to imatinib.
-
Baccarani M, Saglio G, Goldman JM, et al. Evolving concepts in the management of chronic myeloid leukaemia. Recommendations from an expert panel on behalf of the European Leukemia-net. Blood 2006; 108:1809-1820. The authors make a proposal for defining response to imatinib.
-
-
-
-
52
-
-
33646259689
-
Anticipating clinical resistance to target-directed agents: The BCR-ABL paradigm
-
Azam M, Daley GQ. Anticipating clinical resistance to target-directed agents: the BCR-ABL paradigm. Mol Diagn Ther 2006; 10:67-76.
-
(2006)
Mol Diagn Ther
, vol.10
, pp. 67-76
-
-
Azam, M.1
Daley, G.Q.2
-
53
-
-
1642453732
-
Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib
-
McLean LA, Gathmann I, Capdeville R, et al. Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib. Clin Cancer Res 2004; 10:155-165.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 155-165
-
-
McLean, L.A.1
Gathmann, I.2
Capdeville, R.3
-
54
-
-
33744466526
-
+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis
-
+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis. Leukemia 2006; 20:1028-1034.
-
(2006)
Leukemia
, vol.20
, pp. 1028-1034
-
-
Zheng, C.1
Li, L.2
Haak, M.3
-
55
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
See annotation to [58•;
-
Kerkela R, Grazette L, Yacobi R, et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 2006; 12:908-916. See annotation to [58•;].
-
(2006)
Nat Med
, vol.12
, pp. 908-916
-
-
Kerkela, R.1
Grazette, L.2
Yacobi, R.3
-
56
-
-
34548030470
-
Congestive heart failure is a rare event in patients receiving imatinib therapy
-
See annotation to [58•;
-
Atallah E, Durand JB, Kantarjian H, Cortes J. Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood 2007; 110:1233-1237. See annotation to [58•;].
-
(2007)
Blood
, vol.110
, pp. 1233-1237
-
-
Atallah, E.1
Durand, J.B.2
Kantarjian, H.3
Cortes, J.4
-
57
-
-
33846059080
-
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'
-
See annotation to [58•;
-
Rosti G, Martinelli G, Baccarani M. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007; 13:15. See annotation to [58•;].
-
(2007)
Nat Med
, vol.13
, pp. 15
-
-
Rosti, G.1
Martinelli, G.2
Baccarani, M.3
-
58
-
-
33646482407
-
Altered bone and mineral metabolism in patients receiving imatinib mesylate
-
This report and [55•;-57•] identify the possible long-term and/or potential serious side effects of imatinib therapy
-
Berman E, Nicolaides M, Maki RG, et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006; 354:2006-2013. This report and [55•;-57•] identify the possible long-term and/or potential serious side effects of imatinib therapy.
-
(2006)
N Engl J Med
, vol.354
, pp. 2006-2013
-
-
Berman, E.1
Nicolaides, M.2
Maki, R.G.3
-
59
-
-
33644560018
-
Molecular remission in chronic myeloid leukemia patients with sustained complete cytogenetic remission after imatinib mesylate treatment
-
Colombat M, Fort MP, Chollet C, et al. Molecular remission in chronic myeloid leukemia patients with sustained complete cytogenetic remission after imatinib mesylate treatment. Haematologica 2006; 91:162-168.
-
(2006)
Haematologica
, vol.91
, pp. 162-168
-
-
Colombat, M.1
Fort, M.P.2
Chollet, C.3
-
60
-
-
1342343034
-
Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission
-
Mauro MJ, Druker BJ, Maziarz RT. Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission. Leuk Res 2004; 28 (Suppl 1):S71-S73.
-
(2004)
Leuk Res
, vol.28
, Issue.SUPPL. 1
-
-
Mauro, M.J.1
Druker, B.J.2
Maziarz, R.T.3
-
61
-
-
20844461336
-
Imatinib mesylate sensitive blast crisis immediately after discontinuation of imatinib mesylate therapy in chronic myelogenous leukemia: Report of two cases
-
Higashi T, Tsukada J, Kato C, et al. Imatinib mesylate sensitive blast crisis immediately after discontinuation of imatinib mesylate therapy in chronic myelogenous leukemia: report of two cases. Am J Hematol 2004; 76:275-278.
-
(2004)
Am J Hematol
, vol.76
, pp. 275-278
-
-
Higashi, T.1
Tsukada, J.2
Kato, C.3
-
62
-
-
33846023983
-
Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than two years
-
This is a case series on effect of imatinib discontinuation
-
Rousselot P, Huguet F, Rea D, et al. Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than two years. Blood 2007; 109:58-60. This is a case series on effect of imatinib discontinuation.
-
(2007)
Blood
, vol.109
, pp. 58-60
-
-
Rousselot, P.1
Huguet, F.2
Rea, D.3
-
63
-
-
34548321398
-
Durable responses in chronic myeloid leukemia patients maintained with lower doses of imatinib mesylate after achieving molecular remission
-
This report explores the possibility of dose reduction of imatinib after MMR
-
Carella AM, Lerma E. Durable responses in chronic myeloid leukemia patients maintained with lower doses of imatinib mesylate after achieving molecular remission. Ann Hematol 2007; 86:749-752. This report explores the possibility of dose reduction of imatinib after MMR.
-
(2007)
Ann Hematol
, vol.86
, pp. 749-752
-
-
Carella, A.M.1
Lerma, E.2
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