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Margolis L, Shattock R. Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved? Nat Rev Microbiol 2006; 4:312-317.
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Transmission and immunopathogenesis of FIV in cats as a model for HIV
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Burkhard MJ, Dean GA. Transmission and immunopathogenesis of FIV in cats as a model for HIV. Curr HIV Res 2003; 1:15-29.
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8
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9
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Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk
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Shapiro RL, Ndung'u T, Lockman S, et al. Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk. J Infect Dis 2005; 192:713-719.
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Ndung'u, T.2
Lockman, S.3
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10
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28944437322
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Transmission of cell-free and cell-associated HIV-1 through breast-feeding
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A well-conducted case-control study comparing the risks of cell-associated versus cell-free virus in breast milk
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Koulinska IN, Villamor E, Chaplin B, et al. Transmission of cell-free and cell-associated HIV-1 through breast-feeding. J Acquir Immune Defic Syndr 2006; 41:93-99. A well-conducted case-control study comparing the risks of cell-associated versus cell-free virus in breast milk.
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J Acquir Immune Defic Syndr
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Koulinska, I.N.1
Villamor, E.2
Chaplin, B.3
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11
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Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission
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Rousseau CM, Nduati RW, Richardson BA, et al. Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission. J Infect Dis 2004; 190:1880-1888.
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Rousseau, C.M.1
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Richardson, B.A.3
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12
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34547630738
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Laboratory indicators of mastitis are not associated with elevated HIV-1 DNA loads or predictive of HIV-1 RNA loads in breast milk
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An excellent study showing the associations of different markers of mastitis with cell-free and cell-associated virus in breast milk
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Gantt S, Shetty AK, Seidel KD, et al. Laboratory indicators of mastitis are not associated with elevated HIV-1 DNA loads or predictive of HIV-1 RNA loads in breast milk. J Infect Dis 2007; 196:570-576. An excellent study showing the associations of different markers of mastitis with cell-free and cell-associated virus in breast milk.
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J Infect Dis
, vol.196
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Gantt, S.1
Shetty, A.K.2
Seidel, K.D.3
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13
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42449126731
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Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first four months of breastfeeding
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Semrau K, Ghosh M, Kankasa C, et al. Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first four months of breastfeeding. J Acquir Immune Defic Syndr 2007; In press.
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J Acquir Immune Defic Syndr
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Semrau, K.1
Ghosh, M.2
Kankasa, C.3
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14
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Transmission of human immunodeficiency virus type 1 (HIV-1) from mother to child correlates with viral phenotype
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Scarlatti, G.1
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Association of HIV-1 viral phenotype in the MT-2 assay with perinatal HIV transmission
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LaRussa P, Magder LS, Pitt J, et al. Association of HIV-1 viral phenotype in the MT-2 assay with perinatal HIV transmission. J Acquir Immune Defic Syndr 2002; 30:88-94.
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J Acquir Immune Defic Syndr
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LaRussa, P.1
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16
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Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women
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Eshleman SH, Lie Y, Hoover DR, et al. Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women. J Infect Dis 2006; 193:1512-1515.
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Eshleman, S.H.1
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17
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Risk of HIV-1 transmission by breastfeeding among mothers infected with recombinant and nonrecombinant HIV-1 genotypes
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Koulinska IN, Villamor E, Msamanga G, et al. Risk of HIV-1 transmission by breastfeeding among mothers infected with recombinant and nonrecombinant HIV-1 genotypes. Virus Res 2006; 120:191-198.
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Virus Res
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18
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Comparison of HIV-1 mother-to-child transmission after single-dose nevirapine prophylaxis among African women with subtypes A, C, and D
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Eshleman SH, Church JD, Chen S, et al. Comparison of HIV-1 mother-to-child transmission after single-dose nevirapine prophylaxis among African women with subtypes A, C, and D. J Acquir Immune Defic Syndr 2006; 42:518-521.
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19
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20
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Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 Study)
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Eshleman SH, Becker-Pergola G, Deseyve M, et al. Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 Study). J Infect Dis 2001; 184:914-917.
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Eshleman, S.H.1
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21
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WHO/FCH/CAH/00.13. Mastitis: causes and management, 13th ed. Geneva, Switzerland: World Health Organization; 2000.
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WHO/FCH/CAH/00.13. Mastitis: causes and management, 13th ed. Geneva, Switzerland: World Health Organization; 2000.
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22
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Breastfeed Rev
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Southern SO. Milk-borne transmission of HIV. Characterization of productively infected cells in breast milk and interactions between milk and saliva. J Hum Virol 1998; 1:328-337.
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Southern, S.O.1
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26
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Postweaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume
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The first study analysing the effects of rapid weaning on breast milk viral load and in addition showing a higher mortality and morbidity associated with the peri-weaning period. This study indicates that rapid weaning may not be appropriate
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Thea DM, Aldrovandi G, Kankasa C, et al. Postweaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume. AIDS 2006; 20:1539-1547. The first study analysing the effects of rapid weaning on breast milk viral load and in addition showing a higher mortality and morbidity associated with the peri-weaning period. This study indicates that rapid weaning may not be appropriate.
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AIDS
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Thea, D.M.1
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27
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Veterinary field test as screening tool for mastitis and HIV-1 viral load in breastmilk from HIV-infected Zambian women
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Dorosko SM, Thea DM, Saperstein G, et al. Veterinary field test as screening tool for mastitis and HIV-1 viral load in breastmilk from HIV-infected Zambian women. Breastfeed Med 2007; 2:172-176.
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Dorosko, S.M.1
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29
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A well conducted cohort study that demonstrated the benefits of exclusive breastfeeding compared with non-exclusive breastfeeding
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Coovadia HM, Rollins NC, Bland RM, et al. Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet 2007; 369:1107-1116. A well conducted cohort study that demonstrated the benefits of exclusive breastfeeding compared with non-exclusive breastfeeding.
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Lancet
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Coovadia, H.M.1
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30
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High uptake of exclusive breastfeeding and reduced postnatal HIV transmission: Prospective results from the Zambia exclusive breastfeeding study
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Sydney, Australia, 22-25 July, A large cohort study demonstrating the benefits of exclusive breastfeeding compared with non-exclusive breastfeeding
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Kuhn L, Aldrovandi G, Sinkala M, et al. High uptake of exclusive breastfeeding and reduced postnatal HIV transmission: prospective results from the Zambia exclusive breastfeeding study. In: 4th International AIDS Society Conference. Sydney, Australia, 22-25 July 2007. A large cohort study demonstrating the benefits of exclusive breastfeeding compared with non-exclusive breastfeeding.
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4th International AIDS Society Conference
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Kuhn, L.1
Aldrovandi, G.2
Sinkala, M.3
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31
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Guay LA, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999; 354:795-802.
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Rollins NC, Filteau SM, Coutsoudis A, et al. Feeding mode, intestinal permeability, and neopterin excretion: a longitudinal study in infants of HIV-infected South African women. J Acquir Immune Defic Syndr 2001; 28:132-139.
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Rollins, N.C.1
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33
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Long-chain n 6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding
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A detailed analysis of the association of fatty acids in breast milk with the risk of mother-to-child HIV transmission
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Villamor E, Koulinska IN, Furtado J, et al. Long-chain n 6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. Am J Clin Nutr 2007; 86:682-689. A detailed analysis of the association of fatty acids in breast milk with the risk of mother-to-child HIV transmission.
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Am J Clin Nutr
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Villamor, E.1
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Synergy between mannose-binding lectin gene polymorphisms and supplementation with vitamin A influences susceptibility to HIV infection in infants born to HIV-positive mothers
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Kuhn L, Coutsoudis A, Trabattoni D, et al. Synergy between mannose-binding lectin gene polymorphisms and supplementation with vitamin A influences susceptibility to HIV infection in infants born to HIV-positive mothers. Am J Clin Nutr 2006; 84:610-615.
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Am J Clin Nutr
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Kuhn, L.1
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Alpha-defensins in the prevention of HIV transmission among breastfed infants
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Kuhn L, Trabattoni D, Kankasa C, et al. Alpha-defensins in the prevention of HIV transmission among breastfed infants. J Acquir Immune Defic Syndr 2005; 39:138-142.
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J Acquir Immune Defic Syndr
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Kuhn, L.1
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36
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African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine
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Kuhn L, Schramm DB, Donninger S, et al. African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine. AIDS 2007; 21:1753-1761.
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Kuhn, L.1
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Donninger, S.3
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37
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33745608710
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Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission
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The first study showing that protein levels of CCL3 are associated with protection against HIV transmission
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Meddows-Taylor S, Donninger SL, Paximadis M, et al. Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission. J Gen Virol 2006; 87:2055-2065. The first study showing that protein levels of CCL3 are associated with protection against HIV transmission.
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J Gen Virol
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Meddows-Taylor, S.1
Donninger, S.L.2
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CC chemokines and protective immunity: Insights gained from mother-to-child transmission of HIV
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Tiemessen CT, Kuhn L. CC chemokines and protective immunity: insights gained from mother-to-child transmission of HIV. Nat Immunol 2007; 8:219-222.
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Tiemessen, C.T.1
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Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants
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Kuhn L, Trabattoni D, Kankasa C, et al. Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants. J Pediatr 2006; 149:611-616.
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Kuhn, L.1
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Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission
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Walter J, Kuhn L, Ghosh MK, et al. Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission. J Acquir Immune Defic Syndr 2007; 46:200-207.
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J Acquir Immune Defic Syndr
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33845532053
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Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-1371. An important paper describing the association between microbial translocation in the gut and immune activation during chronic HIV infection.
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Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-1371. An important paper describing the association between microbial translocation in the gut and immune activation during chronic HIV infection.
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42
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No benefit of early cessation of breastfeeding at 4 months on HIV-free survival of infants born to HIV-infected mothers in Zambia: The Zambia Exclusive Breastfeeding Study
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Los Angeles, CA, USA, 25-28 February, Abstract 74
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Sinkala M, Kuhn L, Kankasa C, et al. No benefit of early cessation of breastfeeding at 4 months on HIV-free survival of infants born to HIV-infected mothers in Zambia: the Zambia Exclusive Breastfeeding Study. In: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, USA, 25-28 February 2007. Abstract 74.
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14th Conference on Retroviruses and Opportunistic Infections
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Sinkala, M.1
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43
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33747099592
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Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: A randomized trial: the Mashi Study
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A large trial exploring alternatives to formula feeding in Botswana and showing that neither breastfeeding plus zidovudine nor formula feeding is safe
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Thior I, Lockman S, Smeaton LM, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA 2006; 296:794-805. A large trial exploring alternatives to formula feeding in Botswana and showing that neither breastfeeding plus zidovudine nor formula feeding is safe.
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JAMA
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Thior, I.1
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Wu X, Parast AB, Richardson BA, et al. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol 2006; 80:835-844. A well conducted study showing that transmission is predominantly by escape mutants to maternal neutralizing antibodies and is associated with structural changes in the envelope domain of HIV.
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Wu X, Parast AB, Richardson BA, et al. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol 2006; 80:835-844. A well conducted study showing that transmission is predominantly by escape mutants to maternal neutralizing antibodies and is associated with structural changes in the envelope domain of HIV.
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46
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Role of maternal autologous neutralizing antibody in selective perinatal transmission of human immunodeficiency virus type 1 escape variants
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This study presents convincing evidence that neutralizing antibodies may confer protection against intrauterine transmission
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Dickover R, Garratty E, Yusim K, et al. Role of maternal autologous neutralizing antibody in selective perinatal transmission of human immunodeficiency virus type 1 escape variants. J Virol 2006; 80:6525-6533. This study presents convincing evidence that neutralizing antibodies may confer protection against intrauterine transmission.
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J Virol
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