Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis

Journal of Immunology

Volumn 179, Issue 12, 2007, Pages 8509-8518

  Gainers, Madeliene E ^a   Descheny, Leyla ^a   Barthel, Steven R ^a   Liu, Luzheng ^a   Wurbel, Marc André ^a   Dimitroff, Charles J ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUORO N ACETYLGUCOSAMINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOLIPID; HERMES ANTIGEN; HOMING RECEPTOR; N ACETYLGLUCOSAMINE; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PROTEINASE; UNCLASSIFIED DRUG; 2 ACETAMIDO 1,3,6 TRI O ACETYL 4 DEOXY 4 FLUOROGLUCOPYRANOSE; 2-ACETAMIDO-1,3,6-TRI-O-ACETYL-4-DEOXY-4-FLUOROGLUCOPYRANOSE; CYSTEINE RICH FIBROBLAST GROWTH FACTOR RECEPTOR; CYSTEINE-RICH FIBROBLAST GROWTH FACTOR RECEPTOR; DRUG DERIVATIVE; FIBROBLAST GROWTH FACTOR RECEPTOR; HOMEODOMAIN PROTEIN; MEMBRANE PROTEIN; P SELECTIN LIGAND PROTEIN; P-SELECTIN LIGAND PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; SIALOGLYCOPROTEIN;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; DRUG EFFICACY; EFFECTOR CELL; GLYCOGEN METABOLISM; HUMAN; HUMAN CELL; IN VIVO CULTURE; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; LYMPHOCYTE ACTIVATION; METABOLIC INHIBITION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLERGY; T LYMPHOCYTE; ANIMAL; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; ORAL DRUG ADMINISTRATION; SKIN;

ACETYLGLUCOSAMINE; ADMINISTRATION, ORAL; ANIMALS; DERMATITIS, ALLERGIC CONTACT; HOMEODOMAIN PROTEINS; HUMANS; KILLER CELLS, NATURAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, MUTANT STRAINS; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIALOGLYCOPROTEINS; SKIN; T-LYMPHOCYTES;

EID: 40049104113     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.12.8509     Document Type: Article

References (39)

1. Zollner, T. M., K. Asadullah, and M. P. Schon. 2007. Targeting leukocyte trafficking to inflamed skin: still an attractive therapeutic approach? Exp Dermatol. 16: 1-12.
2. O'Leary, J. G., M. Goodarzi, D. L. Drayton, and U. H. von Andrian. 2006. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 7: 507-516.
3. Boehncke, W. H., M. P. Schon, G. Giromolomi, C. Griffiths, J. D. Bos, K. Thestrup-Pedersen, A. Cavani, F. Nestle, B. K. Bonish, J. J. Campbell, C. Brakebusch, and B. Nickoloff. 2005. Leukocyte extravasation as a target for anti-inflammatory therapy: which molecule to choose? Exp. Dermatol. 14: 70-80.
4. Luster, A. D., R. Alon, and U. H. von Andrian. 2005. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 6: 1182-1190.
5. Staite, N. D., J. M. Justen, L. M. Sly, A. L. Beaudet, and D. C. Bullard. 1996. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 88: 2973-2979.
6. Catalina, M. D., P. Estess, and M. H. Siegelman. 1999. Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin. Blood 93: 580-589.
7. Weninger, W., L. H. Ulfman, G. Cheng, N. Souchkova, E. J. Quackenbush, J. B. Lowe, and U. H. von Andrian. 2000. Specialized contributions by α(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Immunity 12: 665-676.
8. Mora, J. R., and U. H. von Andrian. 2006. T-cell homing specificity and plasticity: new concepts and future challenges. Trends Immunol. 27: 235-243.
9. Homeister, J. W., A. D. Thall, B. Petryniak, P. Maly, C. E. Rogers, P. L. Smith, R. J. Kelly, K. M. Gersten, S. W. Askari, G. Cheng, et al. 2001. The α(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15: 115-126.
10. Smithson, G., C. E. Rogers, P. L. Smith, E. P. Scheidegger, B. Petryniak, J. T. Myers, D. S. Kim, J. W. Homeister, and J. B. Lowe. 2001. Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. J. Exp. Med. 194: 601-614.
11. Knibbs, R. N., R. A. Craig, S. Natsuka, A. Chang, M. Cameron, J. B. Lowe, and L. M. Stoolman. 1996. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. J. Cell Biol. 133: 911-920.
12. + T cells specific for a skin-tropic virus. J. Clin. Invest. 110: 537-548.
13. Mora, J. R., G. Cheng, D. Picarella, M. Briskin, N. Buchanan, and U. H. von Andrian. 2005. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J. Exp. Med. 201: 303-316.
14. + T lymphocytes specific for herpes simplex virus type 2. J. Infect. Dis. 191: 243-254.
15. Fuhlbrigge, R. C., J. D. Kieffer, D. Armerding, and T. S. Kupper. 1997. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skinhoming T cells. Nature 389: 978-981.
16. + human T cells. Blood 107: 1421-1426.
17. + regulatory T cells bear functional skin-homing receptors. J. Immunol. 177: 4488-4494.
18. + T cell trafficking after live viral immunization. Immunity 25: 511-520.
19. Dimitroff, C. J., T. S. Kupper, and R. Sackstein. 2003. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J. Clin. Invest. 112: 1008-1018.
20. Dimitroff, C. J., R. J. Bernacki, and R. Sackstein. 2003. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood 101: 602-610.
21. Yago, T., M. Tsukuda, H. Fukushima, H. Yamaoka, K. Kurata-Miura, T. Nishi, and M. Minami. 1998. IL-12 promotes the adhesion of NK cells to endothelial selectins under flow conditions. J. Immunol. 161: 1140-1145.
22. Hirata, T., G. Merrill-Skoloff, M. Aab, J. Yang, B. C. Furie, and B. Furie. 2000. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. J. Exp. Med. 192: 1669-1676.
23. + T lymphocytes into inflamed skin. J. Immunol. 169: 4307-4313.
24. Mangan, P. R., D. O'Quinn, L. Harrington, C. S. Bonder, P. Kubes, D. F. Kucik, D. C. Bullard, and C. T. Weaver. 2005. Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium. Am. J. Pathol. 167: 1661-1675.
25. Matsumoto, M., K. Atarashi, E. Umemoto, Y. Furukawa, A. Shigeta, M. Miyasaka, and T. Hirata. 2005. CD43 functions as a ligand for E-Selectin on activated T cells. J. Immunol. 175: 8042-8050.
26. Matsumoto, M., A. Shigeta, Y. Furukawa, T. Tanaka, M. Miyasaka, and T. Hirata. 2007. CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. J. Immunol. 178: 2499-2506.
27. Alcaide, P., S. L. King, C. J. Dimitroff, Y.-C. Lim, R. C. Fuhlbrigge, and F. W. Luscinskas. In press. The 130-kDa glycoform of CD43 is an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J. Invest. Derm. 127: 1964-1972.
28. Pinola, M., R. Renkonen, M. L. Majuri, S. Tiisala, and E. Saksela. 1994. Characterization of the E-selectin ligand on NK cells. J. Immunol. 152: 3586-3594.
29. Ohmori, K., F. Fukui, M. Kiso, T. Imai, O. Yoshie, H. Hasegawa, K. Matsushima, and R. Kannagi. 2006. Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on a subset of skin-homing helper memory T cells. Blood 107: 3197-3204.
30. Tsuchiyama, J., T. Yoshino, K. Toba, N. Harada, R. Nishiuchi, T. Akagi, T. Furukawa, M. Takahashi, I. Fuse, Y. Aizawa, and M. Harada. 2002. Induction and characterization of cutaneous lymphocyte antigen on natural killer cells. Br. J. Haematol. 118: 654-662.
31. Hunger, R. E., N. Yawalkar, L. R. Braathen, and C. U. Brand. 1999. The HECA-452 epitope is highly expressed on lymph cells derived from human skin. Br. J. Dermatol. 141: 565-569.
32. Dimitroff, C. J., J. Y. Lee, S. Rafii, R. C. Fuhlbrigge, and R. Sackstein. 2001. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J. Cell Biol. 153: 1277-1286.
33. Descheny, L., M. E. Gainers, B. Walcheck, and C. J. Dimitroff. 2006. Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand. J. Invest. Dermatol. 126: 2065-2073.
34. Dimitroff, C. J., L. Descheny, N. Trujillo, R. Kim, V. Nguyen, W. Huang, K. J. Pienta, J. L. Kutok, and M. A. Rubin. 2005. Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells. Cancer Res. 65: 5750-5760.
35. Dimitroff, C. J., M. Lechpammer, D. Long-Woodward, and J. L. Kutok. 2004. Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin. Cancer Res. 64: 5261-5269.
36. Edberg, J. C., and R. P. Kimberly. 1997. Cell type-specific glycoforms of Fc γ RIIIa (CD16): differential ligand binding. J. Immunol. 159: 3849-3857.
37. Underhill, G. H., D. G. Zisoulis, K. P. Kolli, L. G. Ellies, J. D. Marth, and G. S. Kansas. 2005. A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells. Blood 106: 3867-3873.
38. Dagia, N. M., S. Z. Gadhoum, C. A. Knoblauch, J. A. Spencer, P. Zamiri, C. P. Lin, and R. Sackstein. 2006. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat. Med. 12: 1185-1190.
39. Kantele, A., E. Savilahti, H. Tiimonen, K. Iikkanen, S. Autio, and J. M. Kantele. 2003. Cutaneous lymphocyte antigen expression on human effector B cells depends on the site and on the nature of antigen encounter. Eur. J. Immunol. 33: 3275-3283.