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Volumn 134, Issue 4, 2008, Pages 439-451

The presence of carboxypeptidase-M in tumour cells signifies epidermal growth factor receptor expression in lung adenocarcinomas: The coexistence predicts a poor prognosis regardless of EGFR levels

Author keywords

Carboxypeptidase M; CPM; EGFR; Immunohistochemistry; Lung adenocarcinoma; Survival

Indexed keywords

CARBOXYPEPTIDASE; CARBOXYPEPTIDASE M; EPIDERMAL GROWTH FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 40049084926     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0304-z     Document Type: Article
Times cited : (19)

References (50)
  • 1
    • 0032524336 scopus 로고    scopus 로고
    • Potato carboxypeptidase inhibitor, a T-knot protein is an epidermal growth factor antagonist that inhibits tumor cell growth
    • C Blanco-Aparicio MA Molina E Fernandez-Salas 1998 Potato carboxypeptidase inhibitor, a T-knot protein is an epidermal growth factor antagonist that inhibits tumor cell growth J Biol Chem 273 12370 12377 9575190 10.1074/jbc.273.20.12370 1:CAS:528:DyaK1cXjtlSgtLg%3D Blanco-Aparicio C, Molina MA, Fernandez-Salas E et al (1998) Potato carboxypeptidase inhibitor, a T-knot protein is an epidermal growth factor antagonist that inhibits tumor cell growth. J Biol Chem 273:12370–12377
    • (1998) J Biol Chem , vol.273 , pp. 12370-12377
    • Blanco-Aparicio, C1    Molina, MA2    Fernandez-Salas, E3
  • 2
    • 0035691670 scopus 로고    scopus 로고
    • Histologic typing of tumours of lung and pleura: the new World Health Organization classification of tumours
    • E Brambilla WD Travis TV Colby B Y Corrin Shimosato 2001 Histologic typing of tumours of lung and pleura: the new World Health Organization classification of tumours Eur Respir J 18 1059 1068 11829087 10.1183/09031936.01.00275301 1:STN:280:DC%2BD38%2FpvVOqtw%3D%3D Brambilla E, Travis WD, Colby TV, Corrin B Shimosato Y (2001) Histologic typing of tumours of lung and pleura: the new World Health Organization classification of tumours. Eur Respir J 18:1059–1068
    • (2001) Eur Respir J , vol.18 , pp. 1059-1068
    • Brambilla, E1    Travis, WD2    Colby, TV3    Corrin Shimosato, B Y4
  • 3
    • 31544433743 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in cancer treatment
    • F Ciardiello 2005 Epidermal growth factor receptor inhibitors in cancer treatment Future Oncol 1 221 234 16555994 10.1517/14796694.1.2.221 1:CAS:528:DC%2BD2MXktlOmtbo%3D Ciardiello F (2005) Epidermal growth factor receptor inhibitors in cancer treatment. Future Oncol 1:221–234
    • (2005) Future Oncol , vol.1 , pp. 221-234
    • Ciardiello, F1
  • 4
    • 17944402050 scopus 로고    scopus 로고
    • Carboxypeptidase M: variable expression in normal human lung and inactivation in lung cancer
    • AJ Cohen RA Skidgel LB Gilman 1997 Carboxypeptidase M: variable expression in normal human lung and inactivation in lung cancer Chest 11 149S 10.1378/chest.111.6_Supplement.149S Cohen AJ, Skidgel RA, Gilman LB et al (1997) Carboxypeptidase M: variable expression in normal human lung and inactivation in lung cancer. Chest 11:149S
    • (1997) Chest , vol.11 , pp. 149S
    • Cohen, AJ1    Skidgel, RA2    Gilman, LB3
  • 5
    • 33744472217 scopus 로고    scopus 로고
    • Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma
    • S Dacic M Flanagan K Cieply 2006 Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma Am J Clin Pathol 125 860 865 16690485 10.1309/H5UW6CPCWWC92241 1:CAS:528:DC%2BD28XmtVOksLo%3D Dacic S, Flanagan M, Cieply K et al (2006) Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma. Am J Clin Pathol 125:860–865
    • (2006) Am J Clin Pathol , vol.125 , pp. 860-865
    • Dacic, S1    Flanagan, M2    Cieply, K3
  • 6
    • 0030223003 scopus 로고    scopus 로고
    • The mechanism of local tumor irradiation combined with interleukin 2 therapy in murine renal carcinoma: histological evaluation of pulmonary metastases
    • B Dezso PG Haas F Hamzavi 1996 The mechanism of local tumor irradiation combined with interleukin 2 therapy in murine renal carcinoma: histological evaluation of pulmonary metastases Clin Cancer Res 2 1543 1552 9816331 1:CAS:528:DyaK28XmtFSrt7c%3D Dezso B, Haas PG, Hamzavi F et al (1996) The mechanism of local tumor irradiation combined with interleukin 2 therapy in murine renal carcinoma: histological evaluation of pulmonary metastases. Clin Cancer Res 2:1543–1552
    • (1996) Clin Cancer Res , vol.2 , pp. 1543-1552
    • Dezso, B1    Haas, PG2    Hamzavi, F3
  • 7
    • 0029160187 scopus 로고
    • Carboxypeptidase M activity is increased in bronchoalveolar lavage in human lung disease
    • T Dragovic DE Schraufnagel RP Becker M Sekosan EG Votta-Velis EG Erdős 1995 Carboxypeptidase M activity is increased in bronchoalveolar lavage in human lung disease Am J Respir Crit Care Med 152 760 764 7633739 1:STN:280:DyaK2MzmtVemug%3D%3D Dragovic T, Schraufnagel DE, Becker RP, Sekosan M, Votta-Velis EG, Erdős EG (1995) Carboxypeptidase M activity is increased in bronchoalveolar lavage in human lung disease. Am J Respir Crit Care Med 152:760–764
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 760-764
    • Dragovic, T1    Schraufnagel, DE2    Becker, RP3    Sekosan, M4    Votta-Velis, EG5    Erdős, EG6
  • 8
    • 0036892440 scopus 로고    scopus 로고
    • The kinin system: suggestions to broaden some prevailing concepts
    • EG Erdos PA Deddish 2002 The kinin system: suggestions to broaden some prevailing concepts Int Immunopharmacol 2 1741 1746 12489787 10.1016/S1567-5769(02)00166-2 1:CAS:528:DC%2BD38XovFGhtL8%3D Erdos EG, Deddish PA (2002) The kinin system: suggestions to broaden some prevailing concepts. Int Immunopharmacol 2:1741–1746
    • (2002) Int Immunopharmacol , vol.2 , pp. 1741-1746
    • Erdos, EG1    Deddish, PA2
  • 9
    • 0037420716 scopus 로고    scopus 로고
    • Cloning, expression and purification of human epidermal growth factor using different expression systems
    • L Ferrer Soler J Cedano E Querol R Liorens de 2003 Cloning, expression and purification of human epidermal growth factor using different expression systems J Chromatogr B Analyt Technol Biomed Life Sci 788 113 123 12668077 10.1016/S1570-0232(02)01035-8 1:CAS:528:DC%2BD3sXjtlymtb4%3D Ferrer Soler L, Cedano J, Querol E, de Liorens R (2003) Cloning, expression and purification of human epidermal growth factor using different expression systems. J Chromatogr B Analyt Technol Biomed Life Sci 788:113–123
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.788 , pp. 113-123
    • Ferrer Soler, L1    Cedano, J2    Querol, E3    Liorens, R4
  • 10
    • 33846210355 scopus 로고    scopus 로고
    • Differentiation of CD1a− and CD1a+ monocyte-derived dendritic cells is biased by lipid enviroment and PPARγ
    • P Gogolak B Rethi I Szatmári A Lanyi B Dezso L Nagy E Rajnavolgyi 2007 Differentiation of CD1a− and CD1a+ monocyte-derived dendritic cells is biased by lipid enviroment and PPARγ Blood 109 641 652 10.1182/blood-2006-04-016840 1:CAS:528:DC%2BD2sXivVyrs74%3D Gogolak P, Rethi B, Szatmári I, Lanyi A, Dezso B, Nagy L, Rajnavolgyi E (2007) Differentiation of CD1a− and CD1a+ monocyte-derived dendritic cells is biased by lipid enviroment and PPARγ. Blood 109:641–652
    • (2007) Blood , vol.109 , pp. 641-652
    • Gogolak, P1    Rethi, B2    Szatmári, I3    Lanyi, A4    Dezso, B5    Nagy, L6    Rajnavolgyi, E7
  • 11
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced small cell lung cancer
    • RS Herbst D Prager R Herman 2005 TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced small cell lung cancer J Clin Oncol 23 5892 5899 16043829 10.1200/JCO.2005.02.840 1:CAS:528:DC%2BD2MXhtVKgtbzN Herbst RS, Prager D, Herman R et al (2005) TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced small cell lung cancer. J Clin Oncol 23:5892–5899
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, RS1    Prager, D2    Herman, R3
  • 12
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis
    • FR Hirsch M Varella-Garcia PA Bunn MV Di Maria R Veve RM Bremnes AE Baron C Zeng W Franklin 2003 Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J Clin Oncol 21 3798 3807 12953099 10.1200/JCO.2003.11.069 1:CAS:528:DC%2BD2cXpsVKisL8%3D Hirsch FR, Varella-Garcia M, Bunn PA, Di Maria MV, Veve R, Bremnes RM, Baron AE, Zeng C, Franklin W (2003) Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21:3798–3807
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, FR1    Varella-Garcia, M2    Bunn, PA3    Di Maria, MV4    Veve, R5    Bremnes, RM6    Baron, AE7    Zeng, C8    Franklin, W9
  • 13
    • 0034606998 scopus 로고    scopus 로고
    • Lung cancer
    • PC Hoffman AM Mauer EE Vokes 2000 Lung cancer Lancet 355 479 485 10841143 1:STN:280:DC%2BD3c3pslygug%3D%3D Hoffman PC, Mauer AM, Vokes EE (2000) Lung cancer. Lancet 355:479–485
    • (2000) Lancet , vol.355 , pp. 479-485
    • Hoffman, PC1    Mauer, AM2    Vokes, EE3
  • 14
    • 0018888302 scopus 로고
    • Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives
    • MD Hollenberg H Gregorz 1980 Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives Mol Pharmacol 17 314 320 6248761 1:CAS:528:DyaL3cXktlOrtrw%3D Hollenberg MD, Gregorz H (1980) Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives. Mol Pharmacol 17:314–320
    • (1980) Mol Pharmacol , vol.17 , pp. 314-320
    • Hollenberg, MD1    Gregorz, H2
  • 15
    • 0037260139 scopus 로고    scopus 로고
    • Cancer statistics
    • A Jemal T Murray A Samuels 2003 Cancer statistics CA-Cancer J Clin 53 5 26 12568441 10.3322/canjclin.53.1.5 Jemal A, Murray T, Samuels A (2003) Cancer statistics. CA-Cancer J Clin 53:5–26
    • (2003) CA-Cancer J Clin , vol.53 , pp. 5-26
    • Jemal, A1    Murray, T2    Samuels, A3
  • 16
    • 0038140036 scopus 로고    scopus 로고
    • Multicentered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer
    • K Kelly N Hanna A Rosenberg PA Bunn MN Needle 2003 Multicentered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer Proc Am Soc Clin Oncol 22 644 644 Kelly K, Hanna N, Rosenberg A, Bunn PA, Needle MN (2003) Multicentered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer. Proc Am Soc Clin Oncol 22:644–644
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 644-644
    • Kelly, K1    Hanna, N2    Rosenberg, A3    Bunn, PA4    Needle, MN5
  • 17
    • 14144251086 scopus 로고    scopus 로고
    • International Union of Pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences
    • LMF Leeb-Lundberg F Marceau W Müller-Esterl DJ Pettibone BJ Zuraw 2005 International Union of Pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences Pharmacol Rev 57 27 77 15734727 10.1124/pr.57.1.2 1:CAS:528:DC%2BD2MXis1Gmtr0%3D Leeb-Lundberg LMF, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BJ (2005) International Union of Pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 57:27–77
    • (2005) Pharmacol Rev , vol.57 , pp. 27-77
    • Leeb-Lundberg, LMF1    Marceau, F2    Müller-Esterl, W3    Pettibone, DJ4    Zuraw, BJ5
  • 18
    • 0037028497 scopus 로고    scopus 로고
    • Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements
    • J Li M Rehli B Timblin F Tan SW Krause RA Skidgel 2002 Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements Gene 284 189 202 11891060 10.1016/S0378-1119(01)00898-8 1:CAS:528:DC%2BD38Xhslyls78%3D Li J, Rehli M, Timblin B, Tan F, Krause SW, Skidgel RA (2002) Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements. Gene 284:189–202
    • (2002) Gene , vol.284 , pp. 189-202
    • Li, J1    Rehli, M2    Timblin, B3    Tan, F4    Krause, SW5    Skidgel, RA6
  • 19
    • 33645051467 scopus 로고    scopus 로고
    • Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC
    • P Maione C Gridelli T Troiani F Ciardiello 2006 Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC Oncologist 11 274 284 16549812 10.1634/theoncologist.11-3-274 1:CAS:528:DC%2BD28XhtFKrtLnE Maione P, Gridelli C, Troiani T, Ciardiello F (2006) Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC. Oncologist 11:274–284
    • (2006) Oncologist , vol.11 , pp. 274-284
    • Maione, P1    Gridelli, C2    Troiani, T3    Ciardiello, F4
  • 20
    • 32044450314 scopus 로고    scopus 로고
    • A novel second-line targeted therapies in non-small cell lung cancer
    • E Massarelli RS Herbst 2006 A novel second-line targeted therapies in non-small cell lung cancer Semin Oncol 33 S1 9 16 10.1053/j.seminoncol.2005.12.007 1:CAS:528:DC%2BD28XivVSgtLw%3D Massarelli E, Herbst RS (2006) A novel second-line targeted therapies in non-small cell lung cancer. Semin Oncol 33(S1):9–16
    • (2006) Semin Oncol , vol.33 , Issue.S1 , pp. 9-16
    • Massarelli, E1    Herbst, RS2
  • 21
    • 0029083169 scopus 로고
    • Extracellular conversion of epidermal growth factor (EGF) to des-Arg53-EGF by carboxypeptidase M
    • GB McGwire RA Skidgel 1995 Extracellular conversion of epidermal growth factor (EGF) to des-Arg 53-EGF by carboxypeptidase M J Biol Chem 270 17154 17158 7615511 10.1074/jbc.270.29.17154 1:CAS:528:DyaK2MXntVOrsLg%3D McGwire GB, Skidgel RA (1995) Extracellular conversion of epidermal growth factor (EGF) to des-Arg 53-EGF by carboxypeptidase M. J Biol Chem 270:17154–17158
    • (1995) J Biol Chem , vol.270 , pp. 17154-17158
    • McGwire, GB1    Skidgel, RA2
  • 22
    • 0033615654 scopus 로고    scopus 로고
    • Carboxypeptidase M, a glycosylphos-phatidylinositol-anchored protein, is localized on both the apical and the basolateral domains of polarized Madin-Darby Canine Kidney cells
    • GB McGwire RP Becker RA Skidgel 1999 Carboxypeptidase M, a glycosylphos-phatidylinositol-anchored protein, is localized on both the apical and the basolateral domains of polarized Madin-Darby Canine Kidney cells J Biol Chem 274 31632 31640 10531371 10.1074/jbc.274.44.31632 1:CAS:528:DyaK1MXntFOjs74%3D McGwire GB, Becker RP, Skidgel RA (1999) Carboxypeptidase M, a glycosylphos-phatidylinositol-anchored protein, is localized on both the apical and the basolateral domains of polarized Madin-Darby Canine Kidney cells. J Biol Chem 274:31632–31640
    • (1999) J Biol Chem , vol.274 , pp. 31632-31640
    • McGwire, GB1    Becker, RP2    Skidgel, RA3
  • 23
    • 18644377457 scopus 로고    scopus 로고
    • The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis
    • AP Meert B Martin P Delmotte 2001 The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis Eur Respir J 20 975 981 10.1183/09031936.02.00296502 Meert AP, Martin B, Delmotte P et al (2001) The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis. Eur Respir J 20:975–981
    • (2001) Eur Respir J , vol.20 , pp. 975-981
    • Meert, AP1    Martin, B2    Delmotte, P3
  • 24
    • 27944467499 scopus 로고    scopus 로고
    • Resistence to epidermal growth factor receptor-targeted therapy
    • F Morgillo H-Y Lee 2005 Resistence to epidermal growth factor receptor-targeted therapy Drug Resist Updat 8 298 310 16172017 10.1016/j.drup.2005.08.004 1:CAS:528:DC%2BD2MXht1Oms7%2FE Morgillo F, Lee H-Y (2005) Resistence to epidermal growth factor receptor-targeted therapy. Drug Resist Updat 8:298–310
    • (2005) Drug Resist Updat , vol.8 , pp. 298-310
    • Morgillo, F1    Lee, H-Y2
  • 25
    • 0030912190 scopus 로고    scopus 로고
    • Revisions in the international system for staging lung cancer
    • CF Mountain 1997 Revisions in the international system for staging lung cancer Chest 111 1710 1717 9187198 10.1378/chest.111.6.1710 1:STN:280:DyaK2szjtVOguw%3D%3D Mountain CF (1997) Revisions in the international system for staging lung cancer. Chest 111:1710–1717
    • (1997) Chest , vol.111 , pp. 1710-1717
    • Mountain, CF1
  • 26
    • 0027651889 scopus 로고
    • High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells
    • A Nagae M Abe RP Becker PA Deddish RA Skidgel EG Erdös 1993 High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells Am J Respir Cell Mol Biol 9 221 229 8338689 1:CAS:528:DyaK2cXhsF2ms78%3D Nagae A, Abe M, Becker RP, Deddish PA, Skidgel RA, Erdös EG (1993) High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells. Am J Respir Cell Mol Biol 9:221–229
    • (1993) Am J Respir Cell Mol Biol , vol.9 , pp. 221-229
    • Nagae, A1    Abe, M2    Becker, RP3    Deddish, PA4    Skidgel, RA5    Erdös, EG6
  • 27
    • 0034778447 scopus 로고    scopus 로고
    • EGFR and cancer prognosis
    • RI Nicholson JM Gee ME Harper 2001 EGFR and cancer prognosis Eur J Cancer 37/4 S9 S15 10.1016/S0959-8049(01)00231-3 Nicholson RI, Gee JM, Harper ME (2001) EGFR and cancer prognosis. Eur J Cancer 37/4:S9–S15
    • (2001) Eur J Cancer , vol.37/4 , pp. S9-S15
    • Nicholson, RI1    Gee, JM2    Harper, ME3
  • 28
    • 20144379642 scopus 로고    scopus 로고
    • EGFR LI and Ki-67 LI are independent prognostic parameters influencing survivals of surgically treated squamous cell lung cancer patients
    • J Niemiec L Kolodziejski S Dyczek 2005 EGFR LI and Ki-67 LI are independent prognostic parameters influencing survivals of surgically treated squamous cell lung cancer patients Neoplasma 52 231 237 15875085 1:STN:280:DC%2BD2M3jslylsQ%3D%3D Niemiec J, Kolodziejski L, Dyczek S (2005) EGFR LI and Ki-67 LI are independent prognostic parameters influencing survivals of surgically treated squamous cell lung cancer patients. Neoplasma 52:231–237
    • (2005) Neoplasma , vol.52 , pp. 231-237
    • Niemiec, J1    Kolodziejski, L2    Dyczek, S3
  • 29
    • 32044464123 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signalling in cancer
    • N Normanno A Luca De C Bianco L Strizzi M Mancino M Maiello 2005 Epidermal growth factor receptor (EGFR) signalling in cancer Gene 366 2 16 16377102 10.1016/j.gene.2005.10.018 1:CAS:528:DC%2BD28Xht1Crs7k%3D Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello M et al (2005) Epidermal growth factor receptor (EGFR) signalling in cancer. Gene 366:2–16
    • (2005) Gene , vol.366 , pp. 2-16
    • Normanno, N1    Luca, A2    Bianco, C3    Strizzi, L4    Mancino, M5    Maiello, M6
  • 30
    • 18744434862 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression
    • Y Ohsaki S Tanno Y Fujita 2000 Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression Oncol Rep 7 603 607 10767376 1:CAS:528:DC%2BD3cXjtVOisr4%3D Ohsaki Y, Tanno S, Fujita Y et al (2000) Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression. Oncol Rep 7:603–607
    • (2000) Oncol Rep , vol.7 , pp. 603-607
    • Ohsaki, Y1    Tanno, S2    Fujita, Y3
  • 31
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from “never smoker” and are associated with sensitivity of tumors to gefitinib and erlotinib
    • W Pao V Miller M Zakowski J Doherty 2004 EGF receptor gene mutations are common in lung cancers from “never smoker” and are associated with sensitivity of tumors to gefitinib and erlotinib Proc Natl Acad Sci USA 101 13306 13311 15329413 10.1073/pnas.0405220101 1:CAS:528:DC%2BD2cXnvFems70%3D Pao W, Miller V, Zakowski M, Doherty J et al (2004) EGF receptor gene mutations are common in lung cancers from “never smoker” and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 101:13306–13311
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W1    Miller, V2    Zakowski, M3    Doherty, J4
  • 32
    • 0028805436 scopus 로고
    • The human urinary epidermal growth factor (EGF) precursor
    • G Parries K Chen KS Misono S Cohen 1995 The human urinary epidermal growth factor (EGF) precursor J Biol Chem 270 27954 27960 7499272 10.1074/jbc.270.46.27954 1:CAS:528:DyaK2MXpsFShu7w%3D Parries G, Chen K, Misono KS, Cohen S (1995) The human urinary epidermal growth factor (EGF) precursor. J Biol Chem 270:27954–27960
    • (1995) J Biol Chem , vol.270 , pp. 27954-27960
    • Parries, G1    Chen, K2    Misono, KS3    Cohen, S4
  • 33
    • 0036118741 scopus 로고    scopus 로고
    • Molecular structure and alternative splicing of the human carboxypeptidase M gene
    • LG Pessoa ID da Silva HA Baptista JL Pesquero AC Paiva M Bader JB Pesquero 2002 Molecular structure and alternative splicing of the human carboxypeptidase M gene Biol Chem 383 263 269 11934264 10.1515/BC.2002.028 1:CAS:528:DC%2BD38Xjt1eiurs%3D Pessoa LG, da Silva ID, Baptista HA, Pesquero JL, Paiva AC, Bader M, Pesquero JB (2002) Molecular structure and alternative splicing of the human carboxypeptidase M gene. Biol Chem 383:263–269
    • (2002) Biol Chem , vol.383 , pp. 263-269
    • Pessoa, LG1    da Silva, ID2    Baptista, HA3    Pesquero, JL4    Paiva, AC5    Bader, M6    Pesquero, JB7
  • 34
    • 0025690108 scopus 로고
    • Processing and transfer of epidermal growth factor in developing jejunum and ileum
    • RK Rao O Koldovski M Kore PF Pollack S Wright TP Davis 1990 Processing and transfer of epidermal growth factor in developing jejunum and ileum Peptides 11 1093 1102 2087434 10.1016/0196-9781(90)90136-S 1:CAS:528:DyaK3MXnsFOmtw%3D%3D Rao RK, Koldovski O, Kore M, Pollack PF, Wright S, Davis TP (1990) Processing and transfer of epidermal growth factor in developing jejunum and ileum. Peptides 11:1093–1102
    • (1990) Peptides , vol.11 , pp. 1093-1102
    • Rao, RK1    Koldovski, O2    Kore, M3    Pollack, PF4    Wright, S5    Davis, TP6
  • 35
    • 0025797051 scopus 로고
    • Sequential processing of epidermal growth factor in early and late endosomes of rat liver
    • CA Renfrew AL Hubbard 1991 Sequential processing of epidermal growth factor in early and late endosomes of rat liver J Biol Chem 266 4348 4356 1671862 1:CAS:528:DyaK3MXhslyqtrY%3D Renfrew CA, Hubbard AL (1991) Sequential processing of epidermal growth factor in early and late endosomes of rat liver. J Biol Chem 266:4348–4356
    • (1991) J Biol Chem , vol.266 , pp. 4348-4356
    • Renfrew, CA1    Hubbard, AL2
  • 36
    • 1842557330 scopus 로고    scopus 로고
    • Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity
    • D Reverter K Maskos F Tan RA Skidgel W Bode 2004 Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity J Mol Biol 338 257 269 15066430 10.1016/j.jmb.2004.02.058 1:CAS:528:DC%2BD2cXivVelt74%3D Reverter D, Maskos K, Tan F, Skidgel RA, Bode W (2004) Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. J Mol Biol 338:257–269
    • (2004) J Mol Biol , vol.338 , pp. 257-269
    • Reverter, D1    Maskos, K2    Tan, F3    Skidgel, RA4    Bode, W5
  • 37
    • 0030980781 scopus 로고    scopus 로고
    • Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression
    • V Rusch D Klimstra E Venkatraman 1997 Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression Clin Cancer Res 3 515 522 9815714 1:CAS:528:DyaK2sXislGitLk%3D Rusch V, Klimstra D, Venkatraman E et al (1997) Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res 3:515–522
    • (1997) Clin Cancer Res , vol.3 , pp. 515-522
    • Rusch, V1    Klimstra, D2    Venkatraman, E3
  • 38
    • 27944499351 scopus 로고    scopus 로고
    • EGFR and erB2 mutation status in Japanese lung cancer patients
    • H Sasaki S Shimizu K Endo 2006 EGFR and erB2 mutation status in Japanese lung cancer patients Int J Cancer 118 180 184 16003726 10.1002/ijc.21301 1:CAS:528:DC%2BD2MXht1KgsrrE Sasaki H, Shimizu S, Endo K et al (2006) EGFR and erB2 mutation status in Japanese lung cancer patients. Int J Cancer 118:180–184
    • (2006) Int J Cancer , vol.118 , pp. 180-184
    • Sasaki, H1    Shimizu, S2    Endo, K3
  • 39
    • 0022560640 scopus 로고
    • Intracellular modification of 125I-labeled epidermal growth factor by normal human foreskin fibroblasts
    • RP Schaudies CR Savage 1986 Intracellular modification of 125I-labeled epidermal growth factor by normal human foreskin fibroblasts Endocrinology 118 875 882 2867893 1:CAS:528:DyaL28XhtVeitr8%3D 10.1210/endo-118-2-875 Schaudies RP, Savage CR (1986) Intracellular modification of 125I-labeled epidermal growth factor by normal human foreskin fibroblasts. Endocrinology 118:875–882
    • (1986) Endocrinology , vol.118 , pp. 875-882
    • Schaudies, RP1    Savage, CR2
  • 40
    • 9144256014 scopus 로고    scopus 로고
    • Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small cell lung cancer
    • G Selvaggi S Novello V Torri E Leonardo P Giuli De P Borasio C Mossetti F Ardissone P Lausi GV Scagliotti 2004 Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small cell lung cancer Ann Oncol 15 28 32 14679115 10.1093/annonc/mdh011 1:STN:280:DC%2BD3srps1Kntw%3D%3D Selvaggi G, Novello S, Torri V, Leonardo E, De Giuli P, Borasio P, Mossetti C, Ardissone F, Lausi P, Scagliotti GV (2004) Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small cell lung cancer. Ann Oncol 15:28–32
    • (2004) Ann Oncol , vol.15 , pp. 28-32
    • Selvaggi, G1    Novello, S2    Torri, V3    Leonardo, E4    Giuli, P5    Borasio, P6    Mossetti, C7    Ardissone, F8    Lausi, P9    Scagliotti, GV10
  • 41
    • 22844443975 scopus 로고    scopus 로고
    • Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker
    • M Sitja-Arnau MA Molina C Blanco-Aparicio 2005 Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker Cancer Lett 26 169 184 10.1016/j.canlet.2005.01.025 1:CAS:528:DC%2BD2MXmsVaitr0%3D Sitja-Arnau M, Molina MA, Blanco-Aparicio C et al (2005) Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker. Cancer Lett 26:169–184
    • (2005) Cancer Lett , vol.26 , pp. 169-184
    • Sitja-Arnau, M1    Molina, MA2    Blanco-Aparicio, C3
  • 42
    • 0031886603 scopus 로고    scopus 로고
    • Cellular carboxypeptidases
    • RA Skidgel EG Erdős 1998 Cellular carboxypeptidases Immunol Rev 161 129 141 9553770 10.1111/j.1600-065X.1998.tb01577.x 1:CAS:528:DyaK1cXitlymsL4%3D Skidgel RA, Erdős EG (1998) Cellular carboxypeptidases. Immunol Rev 161:129–141
    • (1998) Immunol Rev , vol.161 , pp. 129-141
    • Skidgel, RA1    Erdős, EG2
  • 43
    • 0024552834 scopus 로고
    • Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones
    • RA Skidgel RM Davis F Tan 1989 Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones J Biol Chem 264 2236 2241 2914904 1:CAS:528:DyaL1MXhs1yrtrs%3D Skidgel RA, Davis RM, Tan F (1989) Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones. J Biol Chem 264:2236–2241
    • (1989) J Biol Chem , vol.264 , pp. 2236-2241
    • Skidgel, RA1    Davis, RM2    Tan, F3
  • 44
    • 0029934105 scopus 로고    scopus 로고
    • Membrane anchoring and release of carboxypeptidase M: implications for extracellular hydrolysis of peptide hormones
    • RA Skidgel GB McGwire XY Li 1996 Membrane anchoring and release of carboxypeptidase M: implications for extracellular hydrolysis of peptide hormones Immunopharmacology 32 48 52 8796265 10.1016/0162-3109(96)00008-2 1:CAS:528:DyaK28XjsVOqt7w%3D Skidgel RA, McGwire GB, Li XY (1996) Membrane anchoring and release of carboxypeptidase M: implications for extracellular hydrolysis of peptide hormones. Immunopharmacology 32:48–52
    • (1996) Immunopharmacology , vol.32 , pp. 48-52
    • Skidgel, RA1    McGwire, GB2    Li, XY3
  • 45
    • 32344431514 scopus 로고    scopus 로고
    • Kinin- and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells
    • RA Skidgel S Stanisavljevic EG Erdös 2006 Kinin-and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells Biol Chem 387 159 165 16497147 10.1515/BC.2006.021 1:CAS:528:DC%2BD28XitF2lsrg%3D Skidgel RA, Stanisavljevic S, Erdös EG (2006) Kinin-and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells. Biol Chem 387:159–165
    • (2006) Biol Chem , vol.387 , pp. 159-165
    • Skidgel, RA1    Stanisavljevic, S2    Erdös, EG3
  • 46
    • 33644760776 scopus 로고    scopus 로고
    • High predictive value of epidermal growth factor receptor phosphorylation but not of EGFRvIII mutation in resected stage I non-small cell lung cancer (NSCLC)
    • B Sonnweber M Diaska S Skvortsov 2006 High predictive value of epidermal growth factor receptor phosphorylation but not of EGFRvIII mutation in resected stage I non-small cell lung cancer (NSCLC) J Clin Pathol 59 255 259 16505275 10.1136/jcp.2005.027615 1:STN:280:DC%2BD287hslyktA%3D%3D Sonnweber B, Diaska M, Skvortsov S et al (2006) High predictive value of epidermal growth factor receptor phosphorylation but not of EGFRvIII mutation in resected stage I non-small cell lung cancer (NSCLC). J Clin Pathol 59:255–259
    • (2006) J Clin Pathol , vol.59 , pp. 255-259
    • Sonnweber, B1    Diaska, M2    Skvortsov, S3
  • 47
    • 0021958679 scopus 로고
    • Autocrine growth factors and cancer
    • MB Sporn AB Robert 1985 Autocrine growth factors and cancer Nature 313 745 747 3883191 10.1038/313745a0 1:CAS:528:DyaL2MXhsVKrur8%3D Sporn MB, Robert AB (1985) Autocrine growth factors and cancer. Nature 313:745–747
    • (1985) Nature , vol.313 , pp. 745-747
    • Sporn, MB1    Robert, AB2
  • 48
    • 33646345615 scopus 로고    scopus 로고
    • Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
    • M Suzuki H Shigematsu T Lizasa 2006 Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer Cancer 106 2200 2207 16598760 10.1002/cncr.21853 1:CAS:528:DC%2BD28XkvFOnt7k%3D Suzuki M, Shigematsu H, Lizasa T et al (2006) Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer 106:2200–2207
    • (2006) Cancer , vol.106 , pp. 2200-2207
    • Suzuki, M1    Shigematsu, H2    Lizasa, T3
  • 49
    • 3142688053 scopus 로고    scopus 로고
    • Activation of PPARγ specifies a dendritic cell subtype capable of enhaced induction of iNKT cell expansion
    • I Szatmari P Gogolak SJ Im B Dezso 2004 Activation of PPARγ specifies a dendritic cell subtype capable of enhaced induction of iNKT cell expansion Immunity 21 95 106 15345223 10.1016/j.immuni.2004.06.003 1:CAS:528:DC%2BD2cXmtlKjt78%3D Szatmari I, Gogolak P, Im SJ, Dezso B et al (2004) Activation of PPARγ specifies a dendritic cell subtype capable of enhaced induction of iNKT cell expansion. Immunity 21:95–106
    • (2004) Immunity , vol.21 , pp. 95-106
    • Szatmari, I1    Gogolak, P2    Im, SJ3    Dezso, B4
  • 50
    • 33749318770 scopus 로고    scopus 로고
    • PPAR-gamma controls CD1d expression by turning on retionic acid synthesis in developing human dendritic cell
    • I Szatmari A Pap R Rühl JX Ma E Rajnavolgyi B Dezso L Nagy 2006 PPAR-gamma controls CD1d expression by turning on retionic acid synthesis in developing human dendritic cell J Exp Med 203 2351 2362 16982809 10.1084/jem.20060141 1:CAS:528:DC%2BD28XhtVGlsL7K Szatmari I, Pap A, Rühl R, Ma JX, Rajnavolgyi E, Dezso B, Nagy L (2006) PPAR-gamma controls CD1d expression by turning on retionic acid synthesis in developing human dendritic cell. J Exp Med 203:2351–2362
    • (2006) J Exp Med , vol.203 , pp. 2351-2362
    • Szatmari, I1    Pap, A2    Rühl, R3    Ma, JX4    Rajnavolgyi, E5    Dezso, B6    Nagy, L7


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