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Volumn 33, Issue SUPPL. 1, 2006, Pages 9-16

Use of novel second-line targeted therapies in non-small cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUORO 2 METHYL 5 INDOLYLOXY) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY]QUINAZOLINE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; BEXAROTENE; CANFOSFAMIDE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; ENZASTAURIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; NAVELBINE; OBLIMERSEN; PACLITAXEL; PEMETREXED; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; ZD 6216;

EID: 32044450314     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2005.12.007     Document Type: Article
Times cited : (31)

References (54)
  • 1
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • N. Hanna, F.A. Shepherd, F.V. Fossella Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy J Clin Oncol 22 2004 1589 1597
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 2
    • 24044554727 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network: Practice guidelines in oncology. Available at: http://www.nccn.org/physician_gls/f_guidelines.html (accessed July 6, 2005)
    • Practice Guidelines in Oncology
  • 3
    • 1342268525 scopus 로고    scopus 로고
    • American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
    • D.G. Pfister, D.H. Johnson, C.G. Azzoli American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline Update 2003 J Clin Oncol 22 2004 330 353
    • (2004) J Clin Oncol , vol.22 , pp. 330-353
    • Pfister, D.G.1    Johnson, D.H.2    Azzoli, C.G.3
  • 4
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial)
    • M. Fukuoka, S. Yano, G. Giaccone Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial) J Clin Oncol 21 2003 2237 2246
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 5
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • M.G. Kris, R.B. Natale, R.S. Herbst Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer A randomized trial JAMA 290 2003 2149 2158
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 6
    • 0037214171 scopus 로고    scopus 로고
    • A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer
    • E. Massarelli, F. Andre, D.D. Liu A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer Lung Cancer 39 2003 55 61
    • (2003) Lung Cancer , vol.39 , pp. 55-61
    • Massarelli, E.1    Andre, F.2    Liu, D.D.3
  • 7
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
    • F.A. Shepherd, J. Dancey, R. Ramlau Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy J Clin Oncol 18 2000 2095 2103
    • (2000) J Clin Oncol , vol.18 , pp. 2095-2103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3
  • 8
    • 21644486065 scopus 로고    scopus 로고
    • Results of a phase III placebo-controlled study (ISEL) of gefitinib (IRESSA) plus best supportive care (BSC) in patients with advanced non-small-cell lung cancer (NSCLC) who had received 1 or 2 prior chemotherapy regimens
    • N. Thatcher, A. Chang, P. Parikh Results of a phase III placebo-controlled study (ISEL) of gefitinib (IRESSA) plus best supportive care (BSC) in patients with advanced non-small-cell lung cancer (NSCLC) who had received 1 or 2 prior chemotherapy regimens Proc Am Assoc Cancer Res 2005 abstr LB-6
    • (2005) Proc Am Assoc Cancer Res
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 9
    • 32044448347 scopus 로고    scopus 로고
    • http://www.iressa-us.com/prof.asp accessed September 12, 2005
  • 10
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • T.J. Lynch, D.W. Bell, R. Sordella Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2004 2129 2139
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 11
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • J.G. Paez, P.A. Janne, J.C. Lee EGFR mutations in lung cancer Correlation with clinical response to gefitinib therapy Science 304 2004 1497 1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 12
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • R. Sordella, D.W. Bell, D.A. Haber Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways Science 305 2004 1163 1167
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3
  • 13
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • W. Pao, V. Miller, M. Zakowski EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib Proc Natl Acad Sci U S A 101 2004 13306 13311
    • (2004) Proc Natl Acad Sci U S a , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 14
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • W. Pao, T.Y. Wang, G.J. Riely KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib PLoS Med 2 2005 57 61
    • (2005) PLoS Med , vol.2 , pp. 57-61
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 15
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • S. Kobayashi, T.J. Boggon, T. Dayaram EGFR mutation and resistance of non-small-cell lung cancer to gefitinib N Engl J Med 352 2005 786 792
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 16
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • W. Pao, V.A. Miller, K.A. Politi Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain PLoS Med 2 2005 225 235
    • (2005) PLoS Med , vol.2 , pp. 225-235
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 17
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • F. Cappuzzo, F.R. Hirsch, E. Rossi Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer J Natl Cancer Inst 97 2005 643 655
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 18
    • 5644303684 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer following failure of 1st line or 2nd line chemotherapy. a National Cancer Institute of Canada Clinical Trials Group trial
    • F.A. Shepherd, J. Pereira, T.E. Ciuleanu A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group trial Proc Am Soc Clin Oncol 23 2004 18 abstr LAB7022
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 18
    • Shepherd, F.A.1    Pereira, J.2    Ciuleanu, T.E.3
  • 19
    • 24644471788 scopus 로고    scopus 로고
    • Smoking history is more predictive of survival benefit from erlotinib for patients with non-small cell lung cancer than EGFR expression
    • G.M. Clark, D. Zborowski, P. Santabárbara Smoking history is more predictive of survival benefit from erlotinib for patients with non-small cell lung cancer than EGFR expression Proc Am Soc Clin Oncol 23 2005 628s abstr 7033
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Clark, G.M.1    Zborowski, D.2    Santabárbara, P.3
  • 20
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • R.S. Herbst, D.H. Johnson, E. Mininberg Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer J Clin Oncol 23 2005 2544 2555
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 21
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • R. Herbst, D. Prager, R. Hermann TRIBUTE A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer J Clin Oncol 23 2005 5892 5899
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.1    Prager, D.2    Hermann, R.3
  • 22
    • 4444377694 scopus 로고    scopus 로고
    • Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer
    • R. Rosell, C. Daniel, R. Ramlau Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer Proc Am Soc Clin Oncol 23 2004 618 abstr 7012
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 618
    • Rosell, R.1    Daniel, C.2    Ramlau, R.3
  • 23
    • 0038140036 scopus 로고    scopus 로고
    • A multi-centered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer
    • K. Kelly, N. Hanna, A. Rosenberg A multi-centered phase I/II study of cetuximab in combination with paclitaxel and carboplatin in untreated patients with stage IV non-small cell lung cancer Proc Am Soc Clin Oncol 22 2003 644 abstr 2592
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 644
    • Kelly, K.1    Hanna, N.2    Rosenberg, A.3
  • 24
    • 0038816710 scopus 로고    scopus 로고
    • Phase Ib/IIa study of anti-epidermal growth factor receptor antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced non-small cell lung cancer
    • F. Robert, G. Blumenschein, K. Dicke Phase Ib/IIa study of anti-epidermal growth factor receptor antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced non-small cell lung cancer Proc Am Soc Clin Oncol 22 2003 643 abstr 2587
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 643
    • Robert, F.1    Blumenschein, G.2    Dicke, K.3
  • 25
    • 33751580192 scopus 로고    scopus 로고
    • A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: Final report
    • E.S. Kim, A.M. Mauer, H.T. Tran A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer Final report Proc Am Soc Clin Oncol 22 2003 642 abstr 2581
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 642
    • Kim, E.S.1    Mauer, A.M.2    Tran, H.T.3
  • 26
    • 24144456717 scopus 로고    scopus 로고
    • A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer: Final results
    • R. Lilenbaum, P. Bonomi, R. Ansari A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer Final results Proc Am Soc Clin Oncol 23 2005 629s abstr 7036
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Lilenbaum, R.1    Bonomi, P.2    Ansari, R.3
  • 28
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 29
    • 0027563591 scopus 로고
    • Review article: Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy
    • J. Denekamp Review article angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy Br J Radiol 66 1993 181 196
    • (1993) Br J Radiol , vol.66 , pp. 181-196
    • Denekamp, J.1
  • 30
    • 0034090097 scopus 로고    scopus 로고
    • Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
    • A.W. Griffioen, G. Molema Angiogenesis potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation Pharmacol Rev 52 2000 237 268
    • (2000) Pharmacol Rev , vol.52 , pp. 237-268
    • Griffioen, A.W.1    Molema, G.2
  • 31
    • 0033636357 scopus 로고    scopus 로고
    • VEGF: An update on biological and therapeutic aspects
    • N. Ferrara VEGF An update on biological and therapeutic aspects Curr Opin Biotechnol 11 2000 617 624
    • (2000) Curr Opin Biotechnol , vol.11 , pp. 617-624
    • Ferrara, N.1
  • 32
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • L.G. Presta, H. Chen, S.J. O'Connor Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders Cancer Res 57 1997 4593 4599
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 33
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • H. Hurwitz, L. Fehrenbacher, W. Novotny Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer N Engl J Med 350 2004 2335 2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 34
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • C.G. Willett, Y. Boucher, E. di Tomaso Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer Nat Med 10 2004 145 147
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    Di Tomaso, E.3
  • 35
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • D.H. Johnson, L. Fehrenbacher, W.F. Novotny Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer J Clin Oncol 22 2004 2184 2191
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 36
    • 0003305378 scopus 로고    scopus 로고
    • Successful long-term therapy with bevacizumab (Avastin) in solid tumors
    • V.K. Langmuir, M.A. Cobleigh, R.S. Herbst Successful long-term therapy with bevacizumab (Avastin) in solid tumors Proc Am Soc Clin Oncol 21 2003 9a abstr 32
    • (2003) Proc Am Soc Clin Oncol , vol.21
    • Langmuir, V.K.1    Cobleigh, M.A.2    Herbst, R.S.3
  • 37
    • 22144471081 scopus 로고    scopus 로고
    • Randomized phase II/III Trial of paclitaxel plus carboplatin with or without bevacizumab (NSC # 704865) in patients with advanced non-squamous non-small cell lung cancer: An Eastern Cooperative Oncology Group (ECOG) Trial - E4599
    • A.B. Sandler, R. Gray, J. Brahmer Randomized phase II/III Trial of paclitaxel plus carboplatin with or without bevacizumab (NSC # 704865) in patients with advanced non-squamous non-small cell lung cancer An Eastern Cooperative Oncology Group (ECOG) Trial - E4599 Proc Am Soc Clin Oncol 23 2005 2s abstr LAB4
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Sandler, A.B.1    Gray, R.2    Brahmer, J.3
  • 38
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • S.R. Wedge, D.J. Ogilvie, M. Dukes ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration Cancer Res 62 2002 4645 4655
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 39
    • 0842306414 scopus 로고    scopus 로고
    • Phase 1 study of VEGF Trap in patients with solid tumors and lymphoma
    • J. Dupont, D. Camastra, M.S. Gordon Phase 1 study of VEGF Trap in patients with solid tumors and lymphoma Proc Am Soc Clin Oncol 22 2003 194 abstr 776
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 194
    • Dupont, J.1    Camastra, D.2    Gordon, M.S.3
  • 40
    • 0141542201 scopus 로고    scopus 로고
    • A phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors
    • H. Minami, H. Ebi, M. Tahara A phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors Proc Am Soc Clin Oncol 22 2003 194 abstr 778
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 194
    • Minami, H.1    Ebi, H.2    Tahara, M.3
  • 41
    • 29244480558 scopus 로고    scopus 로고
    • A randomized, placebo-controlled Phase II trial of ZD6474 plus docetaxel, in patients with NSCLC
    • J.V. Heymach, B.E. Johnson, J.A. Rowbottom A randomized, placebo-controlled Phase II trial of ZD6474 plus docetaxel, in patients with NSCLC Proc Am Soc Clin Oncol 23 2005 197s abstr 3023
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Heymach, J.V.1    Johnson, B.E.2    Rowbottom, J.A.3
  • 42
    • 28444452328 scopus 로고    scopus 로고
    • ZD6474 in combination with carboplatin and paclitaxel as first-line treatment in patients with NSCLC: Results of the run-in phase of a two-part randomized phase II study
    • J. Heymach, H. West, R. Kerr ZD6474 in combination with carboplatin and paclitaxel as first-line treatment in patients with NSCLC Results of the run-in phase of a two-part randomized phase II study Lung Cancer 49 2005 S247 abstr P-497
    • (2005) Lung Cancer , vol.49 , pp. 247
    • Heymach, J.1    West, H.2    Kerr, R.3
  • 43
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • H. Rugo, R.S. Herbst, G. Liu Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors Pharmacokinetic and clinical results J Clin Oncol 23 2005 5474 5483
    • (2005) J Clin Oncol , vol.23 , pp. 5474-5483
    • Rugo, H.1    Herbst, R.S.2    Liu, G.3
  • 44
    • 0141653352 scopus 로고    scopus 로고
    • Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers
    • E. Raymond, S. Faivre, K. Vera Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers Proc Am Soc Clin Oncol 22 2003 192 abstr 769
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 192
    • Raymond, E.1    Faivre, S.2    Vera, K.3
  • 45
    • 0842329999 scopus 로고    scopus 로고
    • Angiogenesis inhibitors in clinical development; Where are we now and where are we going?
    • F.A. Eskens Angiogenesis inhibitors in clinical development; where are we now and where are we going? Br J Cancer 90 2004 1 7
    • (2004) Br J Cancer , vol.90 , pp. 1-7
    • Eskens, F.A.1
  • 46
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • S.R. Wedge, J. Kendrew, L.F. Hennequin AZD2171 A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer Cancer Res 65 2005 4389 4400
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 47
    • 0036278972 scopus 로고    scopus 로고
    • Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
    • D.C. Blakey, F.R. Westwood, M. Walker Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models Clin Cancer Res 8 2002 1974 1983
    • (2002) Clin Cancer Res , vol.8 , pp. 1974-1983
    • Blakey, D.C.1    Westwood, F.R.2    Walker, M.3
  • 48
    • 0036279780 scopus 로고    scopus 로고
    • Receptor selective synthetic retinoids as potential cancer chemotherapy agents
    • D.L. Crowe Receptor selective synthetic retinoids as potential cancer chemotherapy agents Curr Cancer Drug Targets 2 2002 77 86
    • (2002) Curr Cancer Drug Targets , vol.2 , pp. 77-86
    • Crowe, D.L.1
  • 49
    • 0029805772 scopus 로고    scopus 로고
    • Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells
    • H.Y. Lee, M.I. Dawson, G.L. Walsh Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells Cell Growth Differ 7 1996 997 1004
    • (1996) Cell Growth Differ , vol.7 , pp. 997-1004
    • Lee, H.Y.1    Dawson, M.I.2    Walsh, G.L.3
  • 50
    • 32044453191 scopus 로고    scopus 로고
    • Phase II trial of bexarotene capsules in patients with non-small-cell lung cancer (NSCLC) who have failed at least 2 prior systemic therapies for stage IIIB/IV disease
    • R. Govindan, J. Crowley, L. Schwartzberg Phase II trial of bexarotene capsules in patients with non-small-cell lung cancer (NSCLC) who have failed at least 2 prior systemic therapies for stage IIIB/IV disease Proc Am Soc Clin Oncol 23 2005 649s abstr 7116
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Govindan, R.1    Crowley, J.2    Schwartzberg, L.3
  • 51
    • 23844488642 scopus 로고    scopus 로고
    • A randomized phase III trial comparing bexarotene/carboplatin/paclitaxel versus carboplatin/paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer
    • G.R. Blumenschein, F. Khuri, U. Gatzemeier A randomized phase III trial comparing bexarotene/carboplatin/paclitaxel versus carboplatin/paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer Proc Am Soc Clin Oncol 23 2005 621s abstr LBA7001
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Blumenschein, G.R.1    Khuri, F.2    Gatzemeier, U.3
  • 52
    • 32044448596 scopus 로고    scopus 로고
    • Phase 2 study of TLK286 (GST P1-1 activated glutathione analog) in advanced non-small cell lung cancer
    • W.D. Henner, R.A. Figlin, L.L. Garland Phase 2 study of TLK286 (GST P1-1 activated glutathione analog) in advanced non-small cell lung cancer Proc Am Soc Clin Oncol 21 2002 313a abstr 1249
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Henner, W.D.1    Figlin, R.A.2    Garland, L.L.3
  • 53
    • 19444362893 scopus 로고    scopus 로고
    • Phase 1-2a dose ranging study of TLK286 (a novel glutathione analog) in combination with docetaxel in platinum-resistant non-small cell lung cancer
    • V. Papadimitrakopoulou, P. Boasberg, R. Figlin Phase 1-2a dose ranging study of TLK286 (a novel glutathione analog) in combination with docetaxel in platinum-resistant non-small cell lung cancer Proc Am Soc Clin Oncol 23 2004 648 abstr 7140
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 648
    • Papadimitrakopoulou, V.1    Boasberg, P.2    Figlin, R.3
  • 54
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl) suppresses signaling through the Akt pathway, induces apoptosis and suppresses growth of human colon cancer and glioblastoma xenografts
    • J.R. Graff, A.M. McNulty, K.R. Hanna The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl) suppresses signaling through the Akt pathway, induces apoptosis and suppresses growth of human colon cancer and glioblastoma xenografts MA Cancer Res 65 2005 7462 7469
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.