Genetic polymorphisms of alcohol metabolising enzymes: Their role in susceptibility to oesophageal cancer

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 3, 2008, Pages 323-328

  Li, Dong Ping ^a   Dandara, Collet ^a,c   Walther, Gabi ^b   Parker, M Iqbal ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Alcohol dehydrogenases (ADH2, ADH3); Aldehyde dehydrogenase (ALDH2); Genetic polymorphism; Oesophageal cancer; South African

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ARTICLE; CANCER RISK; CONTROLLED STUDY; ENZYME ACTIVITY; ESOPHAGUS CANCER; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SOUTH AFRICA;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ALLELES; ESOPHAGEAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; SMOKING; SOUTH AFRICA;

EID: 39849104967     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.073     Document Type: Article

References (39)

1. Hendricks D, Parker MI. Oesophageal cancer in Africa. IUBMB Life 2002;53:263-8.
2. Pacella-Norman R, Urban MI, Sitas F, Carrara H, Sur R, Hale M, et al. Risk factors for oesophageal, lung oral, and laryngeal cancers in Black South Africans. Br J Cancer 2002;86:1751-6.
3. Li DP, Dandara C, Parker MI. Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell car cinoma of the oesophagus. Clin Chem Lab Med 2005;43:370-5.
4. Dandara C, Li D-P, Walther G, Parker MI. Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the esophagus. Carcinogenesis 2006;27:791-7.
5. Seitz HK, Oneta CM. Gastrointestinal alcohol dehydrogenases. Nutr Rev 1998;56:52-60.
6. Poschl G, Seitz HK. Alcohol and cancer. Alcohol Alcohol 2004;39:155-65.
7. Purohit V, Khalsa J, Serrano J. Mechanisms of alcohol-associated cancers: introduction and summary of the symposium. Alcohol 2005;35:155-60.
8. Crabb DW, Matsumoto M, Chang D, You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcoholrelated pathology. Proc Nutr Soc 2004;63:49-63.
9. Dellarco VL. A mutagenicity assessment to acetaldehyde. Mut Res 1988;195:1-20.
10. Vaca CE, Fang JL, Schwede EK. Studies of the reaction of acetaldehyde with deoxynucleosides. Chem Biol Interact 1995;98:51-67.
11. Bosron WF, Li T-K. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 1986;6:502-10.
12. 1 by a Cys for Arg-369 substitution which decreases NAD (H) binding. Biochem Biophys Res Commun 1987;146:1227-33.
13. Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, et al. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am J Epidemiol 2004;159:1-16.
14. Ehlers CL, Montane-Jaime K, Moore S, Shafe S, Joseph R, Carr LG. Association of the ADH1B*3 allele with alcohol-related phenotypes in Trinidad. Alcohol Clin Exp Res 2007;31:216-20.
15. Yokoyama T, Yokoyama A, Kato H, Tsujinaka T, Muto M, Omori T, et al. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol Biomarkers Prev 2003;12:1227-33.
16. Yoshida A, Hsu L, Yasunami M. Genetics of human alcohol-metabolizing enzymes. Prog Nucleic Acid Res Mol Biol 1991;40:255-87.
17. Wall T, Carr LG, Ehlers CL. Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in native American Mission Indians. Am J Psychiatry 2003;160:41-6.
18. Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, et al. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of oesophageal cancer. Carcinogenesis 2001;22:913-6.
19. Seitz HK, Matsuzaki S, Yokoyama A, Homann N, Vakevainen S, Wang XD. Alcohol and cancer. Alcohol Clin Exp Res 2001;25:137S-43S.
20. Xu Y, Carr LG, Bosron WF, Li T-K, Edenberg HJ. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 1988;2:209-14.
21. Harada S, Zhang S. New strategy for detection of ALDH2 mutant. Alcohol 1993;(Suppl 1A):11-3.
22. Chao YC, Young TH, Tang HS, Hsu CT. Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. Hepatology 1997;25:112-7.
23. Dandara C, Ballo R, Parker MI. CYP3A5 genotypes and risk of oesophageal cancer in two South African populations. Cancer Lett 2005;225:275-82.
24. Ehlers CL, Carr L, Betancourt M, Montane-Jaime K. Association of the ADH2*3 allele with greater alcohol expectancies in African-American young adults. J Study Alcohol 2003;64:176-81.
25. Sepehr A, Kamangar F, Abnet CC, Fahimi S, Pourshams A, Poustchi H, et al. Genetic polymorphisms in three Iranian populations with different risks for esophageal cancer, an ecologic comparison. Cancer Lett 2004;213:195-202.
26. Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, et al. Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 1992;88:344-6.
27. Wolff PH. Ethnic differences in alcohol sensitivity. Science 1972;175:449-50.
28. Hori H, Kawano T, Endo M, Yuasa Y. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human oesophageal squamous cell carcinoma susceptibility. J Clin Gastroenterol 1997;25:568-75.
29. Lieber CS, Garro AJ, Leo MA, Mak KM, Worner TM. Alcohol and cancer. Hepatology 1986;6:1005-9.
30. Seitz HK, Stickel F, Homann N. Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics. Int J Cancer 2004;108:483-7.
31. Yokoyama A, Omori T. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. Jpn J Clin Oncol 2003;33:111-21.
32. Yokoyama A, Muramatsu T, Omori T, Matsushita S, Yoshimizu H, Higuchi S, et al. Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to oesophageal cancer in Japanese alcoholics. Alcohol Clin Exp Res 1999;23:1705-10.
33. Yokoyama A, Muramatsu T, Omori T, Yokoyama T, Matsushita S, Higuchi S, et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, oesophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 2001;22:433-9.
34. Chao YC, Wang LS, Hsieh TY, Chu CW, Chang FY, Chu HC. Chinese alcohol patients with oesophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. Am J Gastroenterol 2000;95:2958-64.
35. Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H. Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomarkers Prev 1996;5:99-102.
36. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, et al. Alcohol-related cancer and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 1998;19:1383-7.
37. Chen YJ, Chen C, Wu DC, Lee CH, Wu CI, Lee JM, et al. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. Int J Cancer 2006;119:2827-31.
38. Yang CX, Matsuo K, Ito H, Hirose K, Wakai K, Saito T, et al. Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions. Asian Pac J Cancer Prev 2005;6:256-62.
39. Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, et al. Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev 2006;15:696-703.